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WO1990006949A3 - Peptide derivatives - Google Patents

Peptide derivatives Download PDF

Info

Publication number
WO1990006949A3
WO1990006949A3 PCT/EP1989/001448 EP8901448W WO9006949A3 WO 1990006949 A3 WO1990006949 A3 WO 1990006949A3 EP 8901448 W EP8901448 W EP 8901448W WO 9006949 A3 WO9006949 A3 WO 9006949A3
Authority
WO
WIPO (PCT)
Prior art keywords
somatostatin
peptide derivatives
detectable element
amino group
group
Prior art date
Application number
PCT/EP1989/001448
Other languages
French (fr)
Other versions
WO1990006949A2 (en
Inventor
Rainer Albert
Eric P Krenning
Steven W J Lamberts
Janos Pless
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828364A external-priority patent/GB8828364D0/en
Priority claimed from GB898916115A external-priority patent/GB8916115D0/en
Priority claimed from GB898916761A external-priority patent/GB8916761D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to DE893991505T priority Critical patent/DE3991505T1/en
Priority to DE3991505A priority patent/DE3991505B4/en
Publication of WO1990006949A2 publication Critical patent/WO1990006949A2/en
Publication of WO1990006949A3 publication Critical patent/WO1990006949A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Somatostatin peptides bearing at least one chelating group for a detectable element, said chelating group being linked to an amino group of said peptide, and said amino group having no significant binding affinity for somatostatin receptors, in free or salt form, are complexed with a detectable element and are useful as a pharmaceutical, e.g. a radiopharmaceutical for in vivo imaging of somatostatin receptor positive tumors or for therapy.
PCT/EP1989/001448 1988-12-05 1989-11-30 Peptide derivatives WO1990006949A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE893991505T DE3991505T1 (en) 1988-12-05 1989-11-30 PEPTIDE DERIVATIVES
DE3991505A DE3991505B4 (en) 1988-12-05 1989-11-30 Somatostatin peptides, their analogs or derivatives, processes for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB888828364A GB8828364D0 (en) 1988-12-05 1988-12-05 Improvements in/relating to organic compounds
GB8828364.3 1988-12-05
GB8916115.2 1989-07-13
GB898916115A GB8916115D0 (en) 1989-07-13 1989-07-13 Improvements in or relating to organic compounds
GB8916761.3 1989-07-21
GB898916761A GB8916761D0 (en) 1989-07-21 1989-07-21 Improvements in or relating to organic compounds

Publications (2)

Publication Number Publication Date
WO1990006949A2 WO1990006949A2 (en) 1990-06-28
WO1990006949A3 true WO1990006949A3 (en) 1990-07-26

Family

ID=27264222

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1989/001448 WO1990006949A2 (en) 1988-12-05 1989-11-30 Peptide derivatives

Country Status (24)

Country Link
JP (2) JP2726320B2 (en)
KR (1) KR0156541B1 (en)
AT (1) AT403476B (en)
AU (1) AU633859B2 (en)
BE (1) BE1002296A5 (en)
CA (1) CA2004532C (en)
CH (1) CH678329A5 (en)
DE (1) DE3991505B4 (en)
DK (1) DK175338B1 (en)
ES (1) ES2023533A6 (en)
FI (1) FI102540B (en)
FR (1) FR2639947B1 (en)
GB (1) GB2225579B (en)
HK (1) HK189995A (en)
HU (2) HUT53375A (en)
IE (1) IE62091B1 (en)
IL (1) IL92534A (en)
LU (1) LU87633A1 (en)
MY (1) MY106120A (en)
NL (1) NL194828C (en)
PT (1) PT92487B (en)
SA (1) SA96160495B1 (en)
SE (1) SE508799C2 (en)
WO (1) WO1990006949A2 (en)

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DE3822557C2 (en) * 1987-07-10 1998-07-02 Ciba Geigy Ag Medicines containing somatostatins
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
ATE181240T1 (en) * 1991-02-08 1999-07-15 Biomeasure Inc USE OF SOMATOSTATIN ANALOGUE FOR THE TREATMENT OF MELANOMA
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
EP0588905A1 (en) * 1991-06-03 1994-03-30 Mallinckrodt Medical, Inc. Radiolabelled somatostatin derivatives, their preparation and use
WO1993004702A1 (en) * 1991-08-29 1993-03-18 Mallinckrodt Medical, Inc. Use of gentisic acid or gentisyl alcohol for stabilising radiolabeled peptides and proteins
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
WO1993012819A1 (en) * 1992-01-03 1993-07-08 Rhomed Incorporated Protein- and peptide-metal ion pharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
JPH08504166A (en) * 1992-02-05 1996-05-07 マリンクロッド・メディカル・インコーポレイテッド Radiolabeled peptide compound
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
CA2131315A1 (en) * 1992-03-25 1993-09-30 Geert J. Ensing Method of intraoperatively detecting and locating tumoral tissues
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
NZ250653A (en) * 1993-01-12 1995-12-21 Sandoz Ltd Somatostatin derivatives and pharmaceutical or diagnostic imaging compositions
EP0683676A4 (en) * 1993-02-02 1998-09-30 Neorx Corp Directed biodistribution of small molecules.
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
DE69426673T2 (en) * 1993-06-23 2001-09-20 Diatide, Inc. RADIO-MARKED SOMATOSTATIN DERIVATIVES FOR IMAGING AND THERAPEUTIC USE
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en) 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
FI965181L (en) * 1996-12-20 1998-06-21 Map Medical Technologies Oy Polyalcohol-peptide derivatives
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
DE19917713A1 (en) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Short-chain peptide-dye conjugates as contrast agents for optical diagnostics
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
CZ20032872A3 (en) 2001-04-23 2005-01-12 Mallinckrodt Inc. Peptide ligand that binds somatostatin receptor
WO2005018682A2 (en) 2003-08-20 2005-03-03 The Regents Of The University Of California Somatostatin analogs with inhibitory activity to growth hormone release
AU2004273911B2 (en) * 2003-09-17 2010-04-15 Board Of Regents, The University Of Texas System Mechanism-based targeted pancreatic beta cell imaging and therapy
EP2067786A1 (en) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Novel non selective analogs of somatostatin
US9480759B2 (en) 2012-11-21 2016-11-01 Serene, Llc Tin-117m somatostatin receptor binding compounds and methods
CN119708199A (en) 2023-09-27 2025-03-28 钱杭江医药科技(嘉兴)有限公司 Somatostatin peptide analogue, chelate and application thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150844A2 (en) * 1984-01-30 1985-08-07 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
DE3511206A1 (en) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Polypeptide derivatives, their preparation and pharmaceutical products which contain these polypeptide derivatives
EP0233619A1 (en) * 1986-02-14 1987-08-26 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
EP0247866A1 (en) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Coupling agents for radiolabeling proteins
EP0248506A1 (en) * 1986-03-05 1987-12-09 Mallinckrodt, Inc. (a Delaware corporation) Metal ion labeling of carrier molecules
WO1989004666A1 (en) * 1987-11-18 1989-06-01 The Administrators Of The Tulane Educational Fund Treatment of cancer with somatostatin and analogs thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
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CA1222691A (en) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3522638A1 (en) * 1985-06-25 1987-01-08 Diamalt Ag NEW SOMATOSTATIN DERIVATIVES
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
CH679045A5 (en) * 1987-06-29 1991-12-13 Sandoz Ag
BE1003762A3 (en) * 1988-11-11 1992-06-09 Sandoz Sa New therapeutic use somatostatin and analogues and derivatives.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150844A2 (en) * 1984-01-30 1985-08-07 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
DE3511206A1 (en) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Polypeptide derivatives, their preparation and pharmaceutical products which contain these polypeptide derivatives
EP0233619A1 (en) * 1986-02-14 1987-08-26 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
EP0248506A1 (en) * 1986-03-05 1987-12-09 Mallinckrodt, Inc. (a Delaware corporation) Metal ion labeling of carrier molecules
EP0247866A1 (en) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Coupling agents for radiolabeling proteins
WO1989004666A1 (en) * 1987-11-18 1989-06-01 The Administrators Of The Tulane Educational Fund Treatment of cancer with somatostatin and analogs thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Life Sciences, Vol. 43, No. 5, 1988 J.E. Taylor et al: "High affinity binding of (125I-Tyr11)somatostatin-14 to human small cell lung carcinoma (NCI-H69) ", *

Also Published As

Publication number Publication date
NL8902981A (en) 1990-07-02
ES2023533A6 (en) 1992-01-16
IE893866L (en) 1990-06-05
DE3991505B4 (en) 2006-04-20
SE508799C2 (en) 1998-11-09
MY106120A (en) 1995-03-31
DK175338B1 (en) 2004-08-30
FI102540B1 (en) 1998-12-31
PT92487A (en) 1990-06-29
GB8927255D0 (en) 1990-01-31
SA96160495B1 (en) 2006-08-23
CH678329A5 (en) 1991-08-30
FI102540B (en) 1998-12-31
GB2225579A (en) 1990-06-06
PT92487B (en) 1996-01-31
JPH02184698A (en) 1990-07-19
IE62091B1 (en) 1994-12-14
KR900009697A (en) 1990-07-05
FR2639947A1 (en) 1990-06-08
LU87633A1 (en) 1991-09-18
AU4587189A (en) 1990-06-14
BE1002296A5 (en) 1990-11-20
SE8904087L (en) 1991-06-05
NL194828C (en) 2003-04-03
JPH1095737A (en) 1998-04-14
HUT53375A (en) 1990-10-28
WO1990006949A2 (en) 1990-06-28
ATA901789A (en) 1997-07-15
HU211468A9 (en) 1995-11-28
DK612689D0 (en) 1989-12-05
IL92534A (en) 1994-06-24
CA2004532C (en) 2000-02-22
JP2726320B2 (en) 1998-03-11
KR0156541B1 (en) 1998-10-15
NL194828B (en) 2002-12-02
FR2639947B1 (en) 1995-04-21
DK612689A (en) 1990-06-06
HU896359D0 (en) 1990-02-28
JP3686503B2 (en) 2005-08-24
AT403476B (en) 1998-02-25
CA2004532A1 (en) 1990-06-05
GB2225579B (en) 1993-03-17
AU633859B2 (en) 1993-02-11
FI895809A0 (en) 1989-12-04
HK189995A (en) 1995-12-29
SE8904087D0 (en) 1989-12-04

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