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WO1990006323A3 - Proteines chimeriques incorporant une proteine de liaison de metaux - Google Patents

Proteines chimeriques incorporant une proteine de liaison de metaux Download PDF

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Publication number
WO1990006323A3
WO1990006323A3 PCT/US1989/005424 US8905424W WO9006323A3 WO 1990006323 A3 WO1990006323 A3 WO 1990006323A3 US 8905424 W US8905424 W US 8905424W WO 9006323 A3 WO9006323 A3 WO 9006323A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
metal binding
binding protein
chimeric proteins
proteins incorporating
Prior art date
Application number
PCT/US1989/005424
Other languages
English (en)
Other versions
WO1990006323A2 (fr
Inventor
Hubert J P Shoemaker
John Ghrayeb
Lee K Sun
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Publication of WO1990006323A2 publication Critical patent/WO1990006323A2/fr
Publication of WO1990006323A3 publication Critical patent/WO1990006323A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1063—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from stomach or intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/825—Metallothioneins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Protéines chimériques comprenant une protéine présentant une affinité pour une cible biologique liée par l'intermédiaire d'une liaison peptidique à une protéine de liaison de métaux ou à un domaine fonctionnel de cette protéine qui n'est pas associé normalement avec ladite protéine. Cette protéine peut être une immunoglobuline spécifique de tumeurs ou d'antigènes associés à la prolifération, ou une immunoglobuline spécifique de marqueurs de maladies cardiovasculaires. Les protéines chimériques ci-décrites sont utilisées par des techniques de diagnostic in vivo telles que l'immunoscintigraphie et également comme agent d'immunothérapie.
PCT/US1989/005424 1988-11-29 1989-11-29 Proteines chimeriques incorporant une proteine de liaison de metaux WO1990006323A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27733088A 1988-11-29 1988-11-29
US277,330 1988-11-29

Publications (2)

Publication Number Publication Date
WO1990006323A2 WO1990006323A2 (fr) 1990-06-14
WO1990006323A3 true WO1990006323A3 (fr) 1990-07-12

Family

ID=23060391

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/005424 WO1990006323A2 (fr) 1988-11-29 1989-11-29 Proteines chimeriques incorporant une proteine de liaison de metaux

Country Status (1)

Country Link
WO (1) WO1990006323A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169764A (en) * 1990-08-08 1992-12-08 Regeneron Pharmaceuticals, Inc. Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
EP0570493B1 (fr) * 1991-02-08 2000-01-05 Diatide, Inc. POLYPEPTIDES MARQUES AU TECHNETIUM 99m POUR LES TECHNIQUES D'IMAGERIE
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US6391590B1 (en) * 1991-10-21 2002-05-21 The Regents Of The University Of California Recombinant streptavidin-metallothionein chimeric protein having biological recognition specificity
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
EP0710228B1 (fr) * 1993-07-19 1998-01-21 Resolution Pharmaceuticals Inc. Chelateurs de radionucleides de type hydrazino presentant une configuration n 3?s
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
CU22640A1 (es) * 1996-03-12 2000-12-22 Centro Inmunologia Molecular Composición farmacéutica y kit que contienen anticuerpos monoclonales para marcaje con isótopos radioactivos. sus usos para el diagnóstico y tratamiento de tumores colorrectales, sus metástasis y recidivas
US20090239215A1 (en) * 2004-12-16 2009-09-24 Brandeis University Clonable Tag for Purification and Electron Microscopy Labeling
GB0621894D0 (en) * 2006-11-02 2006-12-13 Iti Scotland Ltd Magnetic recognition system
GB0808086D0 (en) * 2008-05-02 2008-06-11 Iti Scotland Ltd Magnetic proteins for in vivo imaging
EP3606664A1 (fr) * 2017-04-05 2020-02-12 Archer Daniels Midland Co. Nouveau catalyseur d'estérification et ses utilisations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137457A2 (fr) * 1983-10-06 1985-04-17 E.I. Du Pont De Nemours And Company Conjugués de métallothionéine et de molécules biologiquement actives chercheuses de cible, marqués par un traceur
WO1986001533A1 (fr) * 1984-09-03 1986-03-13 Celltech Limited Production d'anticorps chimeriques

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137457A2 (fr) * 1983-10-06 1985-04-17 E.I. Du Pont De Nemours And Company Conjugués de métallothionéine et de molécules biologiquement actives chercheuses de cible, marqués par un traceur
WO1986001533A1 (fr) * 1984-09-03 1986-03-13 Celltech Limited Production d'anticorps chimeriques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
The Journal of Biological Chemistry, Vol. 261, No. 21, 25 July 1986, The American Society of Biological Chemists, Inc., (US), D.J. DRUCKER et al.: "Cell-Specific Post-Translational Processing of Preproglucagon Expressed From a Metallothionein-glucagon Fusion Gene", pages 9637-9643 *

Also Published As

Publication number Publication date
WO1990006323A2 (fr) 1990-06-14

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