+

WO1990003810A1 - Compositions a liberation retardee pour soigner les blessures - Google Patents

Compositions a liberation retardee pour soigner les blessures Download PDF

Info

Publication number
WO1990003810A1
WO1990003810A1 PCT/GB1989/001184 GB8901184W WO9003810A1 WO 1990003810 A1 WO1990003810 A1 WO 1990003810A1 GB 8901184 W GB8901184 W GB 8901184W WO 9003810 A1 WO9003810 A1 WO 9003810A1
Authority
WO
WIPO (PCT)
Prior art keywords
growth factor
compositions
wound healing
hydrogel
delayed release
Prior art date
Application number
PCT/GB1989/001184
Other languages
English (en)
Inventor
Peter Geistlich
Original Assignee
Ed Geistlich Söhne Ag Für Chemische Industrie
Holmes, Michael, John
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ed Geistlich Söhne Ag Für Chemische Industrie, Holmes, Michael, John filed Critical Ed Geistlich Söhne Ag Für Chemische Industrie
Publication of WO1990003810A1 publication Critical patent/WO1990003810A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

Definitions

  • This invention relates to wound healing and in particular to novel delayed release compositions for use in wound healing.
  • the growth factors here concerned include
  • Cys Asn Cys Val lie Gly Tyr Ser Gly Asp
  • the above growth factors may be in the natural form or may be made by recombinant DNA technology.
  • sequences may be added at the N- and C-terminal
  • aqueous hydrogels which carry the growth factors are the hydrogels of USP 4,556,056, a commercial embodiment of which is sold under the name Geliperm, and related materials.
  • the hydrogels will normally comprise at least on gellable protein, polypeptide or polysaccharide interspersed with at least one hydrophilic polymer and be swollen with an aqueous solution containing one or more of the said growth factors, optionally together with nutrients and or other growth factors.
  • the hydrophilic polymer in the hydrogel may for example be a polymer of a hydrophilic acrylic or methacrylic acid derivative or vinylpyrrolidine.
  • the acrylic or methacrylic acid derivative is preferably an amide, as in polyacrylamide which is the preferred polymer, or an ester with an alkanol or polyol.
  • the chains of the polymer will normally be interspersed with the chains of the gellable substance preferably by polymerisation in the presence of a solution of the latter.
  • a crosslinking agent such as N,N 1 -methylene-bis- acrylamide may be present.
  • the gellable substance is preferably a poly- saccharide, agar-agar being particularly preferred;
  • gelatin is preferred.
  • solid matrix of the gel may constitute only 2 to
  • the hydrogel will generally take the form
  • the dressings may advantageously be perforated.
  • the aqueous medium within the gel may usefully contain the essential amino acids and trace minerals normally provided for wound alimentation.
  • Hydrogel dressings according to the invention may be used in surgery in the preparation of the wound base for free skin transplantation; in the treatment of the donor site after the removal of split skin grafts in plastic surgery and for covering superficial operation wounds to prevent exposed bradytrophic tissue (tendons, periostium, bone
  • hydrogel dressings may be used in the treatment of both fresh and chronic damage to the epithelium
  • the mixture has a temperature between 50°C
  • the gel is partially dehydrated as described in USP 4 556 056, Example 6 and immersed in a
  • sheet is sterilised by gamma radiation.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

On décrit des compositions à libération retardée pour soigner les blessures comprenant un hydrogel à base d'une ou plusieurs protéines, peptides ou polysaccharides gélifiables entremêlés d'un polymère hydrophile, ledit hydrogel étant gonflé au moyen d'une solution aqueuse contenant un ou plusieurs facteurs de croissance sélectionnés parmi les facteurs de croissance de l'épiderme, les facteurs de croissance du fibroblaste humain, les facteurs de croissance semblables à l'insuline humaine et les facteurs de croissance dérivés de plaquettes.
PCT/GB1989/001184 1988-10-07 1989-10-06 Compositions a liberation retardee pour soigner les blessures WO1990003810A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8823649.2 1988-10-07
GB8823649A GB8823649D0 (en) 1988-10-07 1988-10-07 Chemical compounds

Publications (1)

Publication Number Publication Date
WO1990003810A1 true WO1990003810A1 (fr) 1990-04-19

Family

ID=10644908

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1989/001184 WO1990003810A1 (fr) 1988-10-07 1989-10-06 Compositions a liberation retardee pour soigner les blessures

Country Status (3)

Country Link
CA (1) CA2000337A1 (fr)
GB (1) GB8823649D0 (fr)
WO (1) WO1990003810A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005823A1 (fr) * 1990-01-12 1993-04-01 Baylink David J Composition stimulant la croissance osseuse
WO1993019769A1 (fr) * 1992-03-28 1993-10-14 The Victoria University Of Manchester Guerison de plaies et traitement de troubles fibrotiques
EP0650366A4 (fr) * 1991-08-30 1994-12-20 Life Medical Sciences Inc Composition et procede de traitement de blessures.
US5591709A (en) * 1991-08-30 1997-01-07 Life Medical Sciences, Inc. Compositions and methods for treating wounds
US5662904A (en) * 1991-03-28 1997-09-02 The Victoria University Of Manchester Anti-scarring compositions comprising growth factor neutralizing antibodies
WO1999025395A2 (fr) * 1997-11-14 1999-05-27 Acrymed Pansements perfectionnes
DE102005035879A1 (de) * 2005-07-30 2007-02-01 Paul Hartmann Ag Hydrogel
US8900624B2 (en) 2004-07-30 2014-12-02 Kimberly-Clark Worldwide, Inc. Antimicrobial silver compositions
US9289378B2 (en) 2004-09-20 2016-03-22 Avent, Inc. Antimicrobial amorphous compositions
US9687503B2 (en) 1999-12-30 2017-06-27 Avent, Inc. Devices for delivering oxygen to the wounds
US10251392B2 (en) 2004-07-30 2019-04-09 Avent, Inc. Antimicrobial devices and compositions

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2146335A (en) * 1983-09-07 1985-04-17 Ej Ass Inc Wound healing compositions
EP0137743A2 (fr) * 1983-09-13 1985-04-17 Ed. Geistlich Söhne Ag Für Chemische Industrie Compositions pharmaceutiques administrables par voie topique
EP0267015A2 (fr) * 1986-11-05 1988-05-11 Ethicon, Inc. Compositions stabilisées contenant du facteur de croissance épidermal
DE3744289A1 (de) * 1986-12-30 1988-07-14 Politechnika Lodzka Verfahren zur darstellung von hydrogelverbaenden
EP0312208A1 (fr) * 1987-09-18 1989-04-19 Ethicon, Inc. Formulations de gel contenant des facteurs de croissance
EP0272149B1 (fr) * 1986-12-19 1992-03-11 Coloplast A/S Pansement médical

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2146335A (en) * 1983-09-07 1985-04-17 Ej Ass Inc Wound healing compositions
EP0137743A2 (fr) * 1983-09-13 1985-04-17 Ed. Geistlich Söhne Ag Für Chemische Industrie Compositions pharmaceutiques administrables par voie topique
EP0267015A2 (fr) * 1986-11-05 1988-05-11 Ethicon, Inc. Compositions stabilisées contenant du facteur de croissance épidermal
EP0272149B1 (fr) * 1986-12-19 1992-03-11 Coloplast A/S Pansement médical
DE3744289A1 (de) * 1986-12-30 1988-07-14 Politechnika Lodzka Verfahren zur darstellung von hydrogelverbaenden
EP0312208A1 (fr) * 1987-09-18 1989-04-19 Ethicon, Inc. Formulations de gel contenant des facteurs de croissance

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005823A1 (fr) * 1990-01-12 1993-04-01 Baylink David J Composition stimulant la croissance osseuse
US5461030A (en) * 1991-02-01 1995-10-24 Life Medical Science, Inc. Compositions and methods for enhancing wound healing
US5662904A (en) * 1991-03-28 1997-09-02 The Victoria University Of Manchester Anti-scarring compositions comprising growth factor neutralizing antibodies
EP0650366A4 (fr) * 1991-08-30 1994-12-20 Life Medical Sciences Inc Composition et procede de traitement de blessures.
EP0650366A1 (fr) * 1991-08-30 1995-05-03 Life Medical Sciences, Inc. Composition et procede de traitement de blessures
US5591709A (en) * 1991-08-30 1997-01-07 Life Medical Sciences, Inc. Compositions and methods for treating wounds
US6331298B1 (en) 1992-03-28 2001-12-18 Renovo Limited Wound healing and treatment of fibrotic disorders
WO1993019769A1 (fr) * 1992-03-28 1993-10-14 The Victoria University Of Manchester Guerison de plaies et traitement de troubles fibrotiques
AU673161B2 (en) * 1992-03-28 1996-10-31 Renovo Limited Wound healing and treatment of fibrotic disorders
WO1999025395A2 (fr) * 1997-11-14 1999-05-27 Acrymed Pansements perfectionnes
WO1999025395A3 (fr) * 1997-11-14 1999-08-12 Acrymed Pansements perfectionnes
US6355858B1 (en) 1997-11-14 2002-03-12 Acrymed, Inc. Wound dressing device
US9687503B2 (en) 1999-12-30 2017-06-27 Avent, Inc. Devices for delivering oxygen to the wounds
US8900624B2 (en) 2004-07-30 2014-12-02 Kimberly-Clark Worldwide, Inc. Antimicrobial silver compositions
US9888691B2 (en) 2004-07-30 2018-02-13 Avent, Inc. Antimicrobial silver compositions
US10251392B2 (en) 2004-07-30 2019-04-09 Avent, Inc. Antimicrobial devices and compositions
US9289378B2 (en) 2004-09-20 2016-03-22 Avent, Inc. Antimicrobial amorphous compositions
DE102005035879A1 (de) * 2005-07-30 2007-02-01 Paul Hartmann Ag Hydrogel

Also Published As

Publication number Publication date
CA2000337A1 (fr) 1990-04-07
GB8823649D0 (en) 1988-11-16

Similar Documents

Publication Publication Date Title
US12226535B2 (en) Microneedle adhesive patch based on hydrogel formulation
Downs et al. Calcium alginate beads as a slow‐release system for delivering angiogenic molecules in vivo and in vitro
US4279812A (en) Process for preparing macromolecular biologically active collagen
Gorham et al. Effect of chemical modifications on the susceptibility of collagen to proteolysis. II. Dehydrothermal crosslinking
JP2834155B2 (ja) コラーゲンフレーク体
EP0359996B1 (fr) Copolymères greffés renfermant des acides amino et/ou peptides synthétiques
JP6235104B2 (ja) 止血組成物
RU2640084C2 (ru) Сшиваемые in situ полимерные композиции и способы для них
JPS6236702B2 (fr)
US5015677A (en) Adhesives derived from bioadhesive polyphenolic proteins
US4515637A (en) Collagen-thrombin compositions
AU736784B2 (en) New medicaments based on polymers composed of methacrylamide-modified gelatin
CN1997408A (zh) 包含角蛋白的伤口护理产品
WO1990003810A1 (fr) Compositions a liberation retardee pour soigner les blessures
CN85101396A (zh) 可被生物降介的衬质和生产它的方法
WO2017122216A1 (fr) Procédé d'extraction de collagène à partir d'écailles de poisson et matériaux bioactifs superabsorbants basés sur des polyélectrolytes
JPH11507697A (ja) キチンヒドロゲル、それらの製造方法及び利用
ES2772718T3 (es) Composiciones farmacéuticas que comprenden colágeno e hialuronato de sodio
WO2003097694A1 (fr) Collagene et son procede d'extraction
WO2001064258A1 (fr) Agent de traitement de plaies
US4440680A (en) Macromolecular biologically active collagen articles
US4374121A (en) Macromolecular biologically active collagen articles
JP2510503B2 (ja) 脳由来細胞増殖因子
JPH09500897A (ja) 銅と細胞接着タンパク質との錯体
CN107281545A (zh) 包含聚合物蛋白质偶联物及环境响应性聚合物的组成物及其应用

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CH DE GB JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LU NL SE

WR Later publication of a revised version of an international search report
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载