WO1990003170A3 - Derives de prostaglandine ayant une activite antithrombotique - Google Patents
Derives de prostaglandine ayant une activite antithrombotique Download PDFInfo
- Publication number
- WO1990003170A3 WO1990003170A3 PCT/IT1989/000061 IT8900061W WO9003170A3 WO 1990003170 A3 WO1990003170 A3 WO 1990003170A3 IT 8900061 W IT8900061 W IT 8900061W WO 9003170 A3 WO9003170 A3 WO 9003170A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- branched
- linear
- prostaglandin
- derivatives
- antithrombotic activity
- Prior art date
Links
- 230000002785 anti-thrombosis Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 239000003146 anticoagulant agent Substances 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical group N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 1
- 230000000702 anti-platelet effect Effects 0.000 abstract 1
- 229960004676 antithrombotic agent Drugs 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000007717 exclusion Effects 0.000 abstract 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne les composés de formule (I) dans laquelle n = 2, 3; m = 4, 5, 6, 7; X = NHR, CH2NHR, NHNH2; R = H, un (C1-C4)alkyle linéaire ou ramifié, un (C1-C4)acyle linéaire ou ramifié; Y = CH2NH2, COOH, CONH2 (à l'exclusion des composés dans lesquels n = 2, m = 5, X = NHR avec R = H, un (C1-C4)alkyle linéaire ou ramifié, un (C1-C4)acyle linéaire ou ramifié; Y = COOH, CONH2) comprenant tous les isomères optiques et/ou géométriques, seuls ou mélangés, ainsi que leurs sels, inhibant l'agrégation de plaquettes dans le sang, et pouvant être préparés pour une utilisation comme agents antithrombotiques, antiplaquettes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK124390A DK124390A (da) | 1988-09-20 | 1990-05-18 | Prostaglandinderivater med antitrombotisk virkning |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8822012A IT1227129B (it) | 1988-09-20 | 1988-09-20 | Prostanoici ad attivita' antiaggregante piastrinica, antitrombotica e composizioni farmaceutiche che li contengono |
| IT22012A/88 | 1988-09-20 | ||
| IT8920927A IT1230879B (it) | 1989-06-20 | 1989-06-20 | Procedimenti per la preparazione di composti prostanoici ad attivita' antiaggregante piastrinica, antitrombotica, composizioni farmaceutiche che li contengono. |
| IT20927A/89 | 1989-06-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1990003170A2 WO1990003170A2 (fr) | 1990-04-05 |
| WO1990003170A3 true WO1990003170A3 (fr) | 1990-05-17 |
Family
ID=26327704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IT1989/000061 WO1990003170A2 (fr) | 1988-09-20 | 1989-09-12 | Derives de prostaglandine ayant une activite antithrombotique |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0425584A1 (fr) |
| JP (1) | JPH03502103A (fr) |
| AU (1) | AU628400B2 (fr) |
| DK (1) | DK124390A (fr) |
| WO (1) | WO1990003170A2 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5385945A (en) * | 1992-10-21 | 1995-01-31 | Allergan, Inc. | 7-(5-substituted cyclopentyl) and (5-substituted cyclopentenyl) heptyl alcohols, heptylamines and heptanoic acid amides, and method of lowering intraocular pressure in the eye of a mammal by administration of these novel compounds |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0218953A2 (fr) * | 1985-10-04 | 1987-04-22 | IBI- Istituto Biochimico Italiano Giovanni Lorenzini S.p.A. | Dérivés de l'acide 19,20-bis-nor-prostanoique à activité anti-ulcéreuse et anorétique, leur procédé de préparation et compositions pharmaceutiques |
| WO1988010252A1 (fr) * | 1987-06-25 | 1988-12-29 | Ibi Istituto Biochimico Italiano Giovanni Lorenzin | Derives de prostaglandines, leur procede de preparation et compositions pharmaceutiques |
-
1989
- 1989-09-12 AU AU43138/89A patent/AU628400B2/en not_active Expired - Fee Related
- 1989-09-12 WO PCT/IT1989/000061 patent/WO1990003170A2/fr not_active Application Discontinuation
- 1989-09-12 EP EP89910462A patent/EP0425584A1/fr not_active Withdrawn
- 1989-09-12 JP JP1509780A patent/JPH03502103A/ja active Pending
-
1990
- 1990-05-18 DK DK124390A patent/DK124390A/da not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0218953A2 (fr) * | 1985-10-04 | 1987-04-22 | IBI- Istituto Biochimico Italiano Giovanni Lorenzini S.p.A. | Dérivés de l'acide 19,20-bis-nor-prostanoique à activité anti-ulcéreuse et anorétique, leur procédé de préparation et compositions pharmaceutiques |
| WO1988010252A1 (fr) * | 1987-06-25 | 1988-12-29 | Ibi Istituto Biochimico Italiano Giovanni Lorenzin | Derives de prostaglandines, leur procede de preparation et compositions pharmaceutiques |
Non-Patent Citations (1)
| Title |
|---|
| The Merck Manual of Diagnosis and Therapy, 15th Edition, 1987, Edited by R. BERKOW et al., publ. by Merck Sharp & Dohme Research Laboratories, (Rahway, N.J. US), pages 2513-2516 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1990003170A2 (fr) | 1990-04-05 |
| DK124390D0 (da) | 1990-05-18 |
| JPH03502103A (ja) | 1991-05-16 |
| DK124390A (da) | 1990-05-18 |
| EP0425584A1 (fr) | 1991-05-08 |
| AU4313889A (en) | 1990-04-18 |
| AU628400B2 (en) | 1992-09-17 |
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