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WO1989011277A3 - Preparations antivirales a base de porphyrine et de phtalocyanine - Google Patents

Preparations antivirales a base de porphyrine et de phtalocyanine Download PDF

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Publication number
WO1989011277A3
WO1989011277A3 PCT/US1989/002256 US8902256W WO8911277A3 WO 1989011277 A3 WO1989011277 A3 WO 1989011277A3 US 8902256 W US8902256 W US 8902256W WO 8911277 A3 WO8911277 A3 WO 8911277A3
Authority
WO
WIPO (PCT)
Prior art keywords
porphyrins
porphyrin
phthalocyanine
phthalocyanines
antiviral compositions
Prior art date
Application number
PCT/US1989/002256
Other languages
English (en)
Other versions
WO1989011277A2 (fr
Inventor
Raymond F Schinazi
Dabney White Dixon
Luigi G Marzilli
Original Assignee
Univ Georgia
Univ Emory
Raymond F Schinazi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgia, Univ Emory, Raymond F Schinazi filed Critical Univ Georgia
Publication of WO1989011277A2 publication Critical patent/WO1989011277A2/fr
Publication of WO1989011277A3 publication Critical patent/WO1989011277A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Préparations permettant d'inhiber la réplication du virus de l'immunodéficience humaine, contenant une ou plusieurs ''porphyrines'' présentant une activité antivirale. Le terme ''porphyrines'' comprend les porphyrines proprement dites, les phtalocyanines, les chlorines, leurs dérivés métallo, ainsi que d'autres composés similaires aux porphyrines. On a découvert que des exemples de porphyrines, phtalocyanines et leurs dérivés, à charge positive, négative ou neutre, présentent une activité sélective anti-HIV qui est indépendante de la présence de la lumière.
PCT/US1989/002256 1988-05-23 1989-05-23 Preparations antivirales a base de porphyrine et de phtalocyanine WO1989011277A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/197,764 US5192788A (en) 1988-05-23 1988-05-23 Porphyrin antiviral compositions
US197,764 1988-05-23
US335,499 1989-05-22

Publications (2)

Publication Number Publication Date
WO1989011277A2 WO1989011277A2 (fr) 1989-11-30
WO1989011277A3 true WO1989011277A3 (fr) 1989-12-28

Family

ID=22730670

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/002256 WO1989011277A2 (fr) 1988-05-23 1989-05-23 Preparations antivirales a base de porphyrine et de phtalocyanine

Country Status (3)

Country Link
US (1) US5192788A (fr)
NZ (1) NZ229246A (fr)
WO (1) WO1989011277A2 (fr)

Families Citing this family (48)

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EP0337598A3 (fr) * 1988-02-26 1991-07-03 Georgia State University Foundation, Inc. Utilisation de porphyrines et de métalloporphyrines dans le traitement de maladies causées par HIV
US5981163A (en) * 1990-05-15 1999-11-09 New York Blood Center, Inc. Process for the sterilization of biological compositions using irradiation and quenchers of type I and type II photodynamic reactions
US5232844A (en) * 1990-05-15 1993-08-03 New York Blood Center Photodynamic inactivation of viruses in cell-containing compositions
US5120649A (en) * 1990-05-15 1992-06-09 New York Blood Center, Inc. Photodynamic inactivation of viruses in blood cell-containing compositions
US5712086A (en) * 1990-05-15 1998-01-27 New York Blood Center, Inc. Process for transfusing cell containing fractions sterilized with radiation and a quencher of type I and type II photodynamic reactions
EP0543902A4 (en) * 1990-07-31 1993-10-27 The Rockefeller University Use of metalloporphyrins to potentiate aids therapy
CA2088982A1 (fr) * 1990-08-09 1992-02-10 Robert J. Leonard Systeme d'administration de plusieurs medicaments
WO1992017182A1 (fr) * 1991-04-03 1992-10-15 Agouron Pharmaceuticals, Inc. Procedes et composes d'inhibition de l'activite de rnase h de la transcriptase inverse
US5230998A (en) * 1991-07-25 1993-07-27 Neurath Alexander R Method for the prescreening of drugs targeted to the V3 hypervariable loop of the HIV-1 envelope glycoprotein gp 120
WO1993003035A1 (fr) * 1991-08-02 1993-02-18 Meiji Milk Products Co., Ltd. Medicament anti-vih
US5371199B1 (en) * 1992-08-14 1995-12-26 Univ Pennsylvania Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5599924A (en) * 1992-08-14 1997-02-04 Trustees Of The University Of Pennsylvania Electron-deficient porphyrins and processes and intermediates for preparing same
US5817830A (en) * 1992-08-14 1998-10-06 Trustees Of The University Of Pennsylvania Pyrrolic compounds
US5493017A (en) * 1992-08-14 1996-02-20 The Trustees Of The University Of Pennsylvania Ring-metalated porphyrins
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
TW247876B (en) 1993-12-28 1995-05-21 New York Blood Ct Inc Pharmaceutical compositions for prevention or treating HIV-1 or HIV-2 infection
US6551618B2 (en) * 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
FR2723694B1 (fr) * 1994-08-19 1996-09-27 Oreal Utilisation de sels de derives cationiques de porphine comme agents photosensibilisants de bacteries de type gram-negatif
US6620805B1 (en) * 1996-03-14 2003-09-16 Yale University Delivery of nucleic acids by porphyrins
US6010890A (en) * 1997-04-29 2000-01-04 New York Blood Center, Inc. Method for viral inactivation and compositions for use in same
IT1294325B1 (it) * 1997-08-14 1999-03-24 Molteni L E C Dei Fratelli Ali Zinco-ftalocianine e relativi coniugati, preparazione e uso nella terapia fotodinamica e come diagnostici
JP2001521939A (ja) 1997-11-03 2001-11-13 デューク・ユニバーシティー 置換されたポルフィリン類
SK284520B6 (sk) * 1997-12-22 2005-05-05 Schering Corporation Rýchlo sa rozpúšťajúci lisovaný ribavirínový prostriedok a spôsob jeho prípravy
US20030215421A1 (en) * 1999-07-21 2003-11-20 Mcdonald John R. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
US7157418B1 (en) 1998-07-22 2007-01-02 Osprey Pharmaceuticals, Ltd. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
IL126953A0 (en) * 1998-11-08 1999-09-22 Yeda Res & Dev Pharmaceutical compositions comprising porphyrins and some novel porphyrin derivatives
DK1616869T3 (da) 1999-01-25 2012-05-07 Nat Jewish Health Substituerede porphyriner og deres terapeutiske anvendelse
US20030069281A1 (en) * 2000-06-14 2003-04-10 Irwin Fridovich Tetrapyrroles
US6403788B1 (en) 2000-07-11 2002-06-11 Eukarion, Inc. Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species
DE60235955D1 (de) * 2001-01-05 2010-05-27 Metaphore Pharmaceuticals Inc Zusammensetzungen und verfahren zur erhöhung der zytokin-aktivität und zur behandlung der hypotension assoziiert mit der verabreichung von zytokinen
JP2004520380A (ja) * 2001-01-19 2004-07-08 ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター 癌治療本出願は、２００１年１月１９日に出願の仮出願番号第６０／２６２，３９０号の優先権を主張し、その全ての内容は、参照により本願明細書に援用したものとする。
EP1439842A4 (fr) * 2001-06-01 2009-09-02 Nat Jewish Med & Res Center Capteurs oxydants destines au traitement du diabete ou a etre utilises dans une transplantation ou a induire une tolerance immunitaire
EP1480638A2 (fr) * 2002-01-08 2004-12-01 Emory University Porphyrines avec activite virucide
JP2005527546A (ja) * 2002-03-26 2005-09-15 イースタン ヴァージニア メディカル スクール 局所用殺菌剤および避妊薬としてのスラミンおよびその誘導体
US7485721B2 (en) * 2002-06-07 2009-02-03 Duke University Substituted porphyrins
GB2397067B (en) * 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
CN1946385A (zh) * 2004-02-20 2007-04-11 罗伯特·F·霍夫曼 靶向氧化治疗制剂在治疗病毒性疾病中的用途
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
WO2006054757A1 (fr) * 2004-11-16 2006-05-26 Astellas Pharma Inc. Inhibiteur de la caspase
GB0519169D0 (en) * 2005-09-21 2005-10-26 Leuven K U Res & Dev Novel anti-viral strategy
GB0602125D0 (en) * 2006-02-03 2006-03-15 Univ Belfast Sensitizer-incorporated biomaterials
AU2009280042B2 (en) 2008-05-23 2015-06-04 National Jewish Health Methods for treating injury associated with exposure to an alkylating species
CA2866612C (fr) 2012-03-08 2018-01-16 Halozyme, Inc. Anticorps recepteur du facteur de croissance epidermique conditionnement actif du variant cetuximab dependant du ph et methode d'utilisation associee
BR112016005526A2 (pt) 2013-09-12 2017-09-12 Halozyme Inc anticorpos receptores de fator de crescimento anti-epidérmido modificado e métodos de uso dos mesmos
WO2017161206A1 (fr) 2016-03-16 2017-09-21 Halozyme, Inc. Conjugués contenant des anticorps à activité conditionnelle ou des fragments de liaison à un antigène associés, et procédés d'utilisation
WO2019118937A1 (fr) 2017-12-15 2019-06-20 Juno Therapeutics, Inc. Molécules de liaison à l'anti-cct5 et procédés d'utilisation associés
US11883376B2 (en) * 2020-04-22 2024-01-30 Nadimpally Satyavarahala Raju Viral infection treatment with 5-aminolevulinic acid
US10987329B1 (en) * 2020-04-22 2021-04-27 Nadimpally Satyavarahala Raju Combination therapy for coronavirus infections including the novel corona virus (COVID-19)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0204989A2 (fr) * 1985-06-08 1986-12-17 ASTA Medica Aktiengesellschaft Utilisation de la pénicillamine pour le traitement des maladies d'immuno-dépression

Family Cites Families (5)

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US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4649151A (en) * 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
EP0127797B1 (fr) * 1983-06-03 1987-06-16 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Molécules marquées pour déterminations par immunofluorescence et procédés et produits intermédiaires pour leur préparation
US4675338A (en) * 1984-07-18 1987-06-23 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
JPS61275228A (ja) * 1985-03-14 1986-12-05 バクスタ−、トラベノ−ル、ラボラトリ−ズ、インコ−ポレイテツド 治療用タンパク組成物中のビ−ルスの光動的不活性化

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0204989A2 (fr) * 1985-06-08 1986-12-17 ASTA Medica Aktiengesellschaft Utilisation de la pénicillamine pour le traitement des maladies d'immuno-dépression

Also Published As

Publication number Publication date
NZ229246A (en) 1991-06-25
WO1989011277A2 (fr) 1989-11-30
US5192788A (en) 1993-03-09

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