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WO1989005787A3 - Procedes et composes utiles pour dissoudre de la phenylpropylamine-3 de methyle-1 - Google Patents

Procedes et composes utiles pour dissoudre de la phenylpropylamine-3 de methyle-1 Download PDF

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Publication number
WO1989005787A3
WO1989005787A3 PCT/US1988/004408 US8804408W WO8905787A3 WO 1989005787 A3 WO1989005787 A3 WO 1989005787A3 US 8804408 W US8804408 W US 8804408W WO 8905787 A3 WO8905787 A3 WO 8905787A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenylpropylamine
methyl
benzyl
phenyl
alkyl
Prior art date
Application number
PCT/US1988/004408
Other languages
English (en)
Other versions
WO1989005787A2 (fr
Inventor
Ernst Vogel
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of WO1989005787A2 publication Critical patent/WO1989005787A2/fr
Publication of WO1989005787A3 publication Critical patent/WO1989005787A3/fr
Priority to DK147090A priority Critical patent/DK147090A/da
Priority to NO902688A priority patent/NO902688D0/no
Priority to FI903052A priority patent/FI903052A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C07C209/88—Separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

On peut préparer de la phénylpropylamine-3 de méthyle-1 à partir d'un mélange contenant ledit composé conjointement avec de la phénylpropylamine-3 de méthyle-1-(S) en mettant en contact une solution desdits composés ou de leurs sels solubles avec une quantité efficace d'un composé de formule (I) pour former un sel de formule (II), lequel précipite sélectivement à partir de ladite solution; dans la formule (II) précitée, R est -COR1, -CONR2R3 ou -SO2R4; R1 est H, alkyle, alkoxy, allyloxy, phényle, phényloxy, benzyle, benzyloxy, tous éventuellement substitués, ou bien 2-furanylméthoxy; R2 et R3 peuvent être identiques ou différents et chacun est indépendamment choisi parmi H, alkyle, phényle, benzyle, tous éventuellement substitués; et R4 est alkyle, phényle, benzyle, tous éventuellement substitués.
PCT/US1988/004408 1987-12-18 1988-12-14 Procedes et composes utiles pour dissoudre de la phenylpropylamine-3 de methyle-1 WO1989005787A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DK147090A DK147090A (da) 1987-12-18 1990-06-15 Fremgangsmaade til resolvering af forbindelsen 1-methyl-3-phenylpropylamin
NO902688A NO902688D0 (no) 1987-12-18 1990-06-15 Fremgangsmaate og forbindelse som kan anvendes til opploesning av 1-metyl-3-fenylpropylamin.
FI903052A FI903052A0 (fi) 1987-12-18 1990-06-18 Nyttiga foerfaranden och foereningar foer separering av 1-metyl-3-propylamin.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13467487A 1987-12-18 1987-12-18
US134,674 1987-12-18

Publications (2)

Publication Number Publication Date
WO1989005787A2 WO1989005787A2 (fr) 1989-06-29
WO1989005787A3 true WO1989005787A3 (fr) 1989-07-13

Family

ID=22464434

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/004408 WO1989005787A2 (fr) 1987-12-18 1988-12-14 Procedes et composes utiles pour dissoudre de la phenylpropylamine-3 de methyle-1

Country Status (7)

Country Link
EP (2) EP0320898A3 (fr)
AU (1) AU2916089A (fr)
DK (1) DK147090A (fr)
FI (1) FI903052A0 (fr)
HU (1) HUT56050A (fr)
OA (1) OA09789A (fr)
WO (1) WO1989005787A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0441979B1 (fr) * 1989-09-07 1996-01-31 Daicel Chemical Industries, Ltd. Derive d'acide 2-(phenyl a substitution alkyle)-propionique optiquement actif et resolution optique de ( )-1-methyl-3-phenylpropylamine
DE69511089T2 (de) * 1994-06-22 1999-12-16 British Biotech Pharmaceuticals Ltd., Cowley Metalloproteinase-inhibitoren
DE19641693A1 (de) 1996-10-10 1998-04-16 Bayer Ag Substituierte 2-Amino-4-alkylamino-1,3,5-triazine
DE19641694A1 (de) 1996-10-10 1998-04-16 Bayer Ag Substituierte 2,4-Diamino-1,3,5-triazine
DE19641691A1 (de) 1996-10-10 1998-04-16 Bayer Ag Substituierte 2-Amino-4-alkylamino-1,3,5-triazine

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1182245B (de) * 1961-01-23 1964-11-26 Philips Nv Verfahren zur Herstellung eines uterospasmolytisch wirksamen linksdrehenden 1-(4'-Hy-droxyphenyl)-2-(1"-methyl-3"phenylpropylamino)-propanols
EP0003359A1 (fr) * 1978-01-30 1979-08-08 Ciba-Geigy Ag Isomères optiques spécifiques de 2-aminoéthyl-1,4-benzodioxanes, procédé pour leur préparation et leurs compositions pharmaceutiques
EP0237305A2 (fr) * 1986-03-14 1987-09-16 Sumitomo Chemical Company, Limited Procédé pour la fabrication d'amines optiquement actives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1182245B (de) * 1961-01-23 1964-11-26 Philips Nv Verfahren zur Herstellung eines uterospasmolytisch wirksamen linksdrehenden 1-(4'-Hy-droxyphenyl)-2-(1"-methyl-3"phenylpropylamino)-propanols
EP0003359A1 (fr) * 1978-01-30 1979-08-08 Ciba-Geigy Ag Isomères optiques spécifiques de 2-aminoéthyl-1,4-benzodioxanes, procédé pour leur préparation et leurs compositions pharmaceutiques
EP0237305A2 (fr) * 1986-03-14 1987-09-16 Sumitomo Chemical Company, Limited Procédé pour la fabrication d'amines optiquement actives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Collection of Czechoslovak Chemical Communications, volume 33, 1968, O. Cervinka et al.: "Asymmetric reactions. XXIX. Absolute configuration of w-phenyl-2-alkylamines and their N-methyl derivatives", pages 3551-3557 *

Also Published As

Publication number Publication date
WO1989005787A2 (fr) 1989-06-29
EP0320898A3 (fr) 1989-08-16
DK147090D0 (da) 1990-06-15
EP0320898A2 (fr) 1989-06-21
DK147090A (da) 1990-06-15
FI903052A0 (fi) 1990-06-18
EP0396596A1 (fr) 1990-11-14
HUT56050A (en) 1991-07-29
AU2916089A (en) 1989-07-19
HU890665D0 (en) 1991-03-28
OA09789A (en) 1994-04-15

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