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WO1988009808A3 - Biocapteurs a recepteurs - Google Patents

Biocapteurs a recepteurs Download PDF

Info

Publication number
WO1988009808A3
WO1988009808A3 PCT/US1988/001853 US8801853W WO8809808A3 WO 1988009808 A3 WO1988009808 A3 WO 1988009808A3 US 8801853 W US8801853 W US 8801853W WO 8809808 A3 WO8809808 A3 WO 8809808A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
analyte
based biosensors
polymeric film
determining
Prior art date
Application number
PCT/US1988/001853
Other languages
English (en)
Other versions
WO1988009808A2 (fr
Inventor
Richard F Taylor
Ingrid G Marenchic
Edward J Cook
Original Assignee
Little Inc A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Little Inc A filed Critical Little Inc A
Publication of WO1988009808A2 publication Critical patent/WO1988009808A2/fr
Publication of WO1988009808A3 publication Critical patent/WO1988009808A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Procédé d'immobilisation et de stabilisation d'un récepteur bilogique actif dans un film polymère et biocapteurs à récepteurs permettant de détecter un analyte déterminé dans un échantillon. Ces biocapteurs à récepteurs comprennent un film polymère possédant un récepteur biologique pouvant fixer un analyte déterminé immobilisé grâce au procédé ci-décrit, et un organe électrique permettant de déterminer la présence de l'analyte et sa quantité. En particulier, le récepteur d'acétylcholine et le récepteur d'opiacés ont été immobilisés dans un film polymère obtenu par la combinaison du récepteur, d'une substance (par e. albumine de sérum bovin, gélatine) pouvant polymériser et d'un agent de polymérisation (par e. glutaraldéhyde).
PCT/US1988/001853 1987-06-05 1988-06-01 Biocapteurs a recepteurs WO1988009808A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US058,389 1987-06-05
US07/058,389 US5001048A (en) 1987-06-05 1987-06-05 Electrical biosensor containing a biological receptor immobilized and stabilized in a protein film

Publications (2)

Publication Number Publication Date
WO1988009808A2 WO1988009808A2 (fr) 1988-12-15
WO1988009808A3 true WO1988009808A3 (fr) 1989-04-06

Family

ID=22016510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/001853 WO1988009808A2 (fr) 1987-06-05 1988-06-01 Biocapteurs a recepteurs

Country Status (4)

Country Link
US (1) US5001048A (fr)
EP (1) EP0367788A1 (fr)
JP (1) JPH02503826A (fr)
WO (1) WO1988009808A2 (fr)

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Also Published As

Publication number Publication date
US5001048A (en) 1991-03-19
JPH02503826A (ja) 1990-11-08
WO1988009808A2 (fr) 1988-12-15
EP0367788A1 (fr) 1990-05-16

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