WO1988008972A1 - Systeme mettant en oeuvre un capteur biologique pour controler une caracteristique d'un constituant selectionne dans un milieu - Google Patents
Systeme mettant en oeuvre un capteur biologique pour controler une caracteristique d'un constituant selectionne dans un milieu Download PDFInfo
- Publication number
- WO1988008972A1 WO1988008972A1 PCT/US1988/001494 US8801494W WO8808972A1 WO 1988008972 A1 WO1988008972 A1 WO 1988008972A1 US 8801494 W US8801494 W US 8801494W WO 8808972 A1 WO8808972 A1 WO 8808972A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- component
- binding
- characteristic
- detection
- sensor
- Prior art date
Links
- 230000004044 response Effects 0.000 claims abstract description 45
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- 230000000694 effects Effects 0.000 claims abstract description 6
- 238000012545 processing Methods 0.000 claims description 30
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- 239000012212 insulator Substances 0.000 claims description 21
- 239000011230 binding agent Substances 0.000 claims description 20
- 239000004065 semiconductor Substances 0.000 claims description 19
- 239000000463 material Substances 0.000 claims description 15
- 230000008859 change Effects 0.000 claims description 8
- 238000012544 monitoring process Methods 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 230000003100 immobilizing effect Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims 32
- 239000013110 organic ligand Substances 0.000 claims 16
- 230000000007 visual effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 abstract description 24
- 108090000623 proteins and genes Proteins 0.000 abstract description 24
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- 239000003446 ligand Substances 0.000 abstract description 18
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- 230000002441 reversible effect Effects 0.000 abstract description 4
- 239000000243 solution Substances 0.000 description 41
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 10
- 230000006870 function Effects 0.000 description 10
- 239000000758 substrate Substances 0.000 description 9
- 108091006146 Channels Proteins 0.000 description 8
- 230000000875 corresponding effect Effects 0.000 description 8
- 230000003750 conditioning effect Effects 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 235000012239 silicon dioxide Nutrition 0.000 description 5
- 239000000377 silicon dioxide Substances 0.000 description 5
- 238000011088 calibration curve Methods 0.000 description 4
- 238000010276 construction Methods 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
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- 239000010703 silicon Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
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- 229910044991 metal oxide Inorganic materials 0.000 description 2
- 150000004706 metal oxides Chemical class 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000010865 sewage Substances 0.000 description 2
- 238000001947 vapour-phase growth Methods 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 229910001218 Gallium arsenide Inorganic materials 0.000 description 1
- 108010075750 P-Type Calcium Channels Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 108010092494 Periplasmic binding proteins Proteins 0.000 description 1
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 description 1
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 description 1
- 229910052581 Si3N4 Inorganic materials 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical group [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910052787 antimony Inorganic materials 0.000 description 1
- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
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- 229910052593 corundum Inorganic materials 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
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- 238000000586 desensitisation Methods 0.000 description 1
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- 238000004889 fertilizer analysis Methods 0.000 description 1
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- BPUBBGLMJRNUCC-UHFFFAOYSA-N oxygen(2-);tantalum(5+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ta+5].[Ta+5] BPUBBGLMJRNUCC-UHFFFAOYSA-N 0.000 description 1
- 210000001322 periplasm Anatomy 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000013139 quantization Methods 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- -1 silane compound Chemical class 0.000 description 1
- 150000003376 silicon Chemical class 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000004856 soil analysis Methods 0.000 description 1
- 238000010129 solution processing Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910001936 tantalum oxide Inorganic materials 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 230000036964 tight binding Effects 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000005353 urine analysis Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 229910001845 yogo sapphire Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
Definitions
- the operation of the discrete sensor element 16 is controlled, in part, by instructions introduced through a user input, such as a keypad 22, provided on the instrument console 12.
- a user input such as a keypad 22, provided on the instrument console 12.
- a particular characteristic of the component of interest is monitored via console 12 by the analysis of signals from sensor element 16, as described below.
- the information produced by console 12 is then displayed to the operator via a display 24.
- the means for immobilizing a binding component 32 on semiconducting element 34 depends on the composition of semiconducting element 34.
- the silicon dioxide surface is preferably derivatized using vapor phase deposition of silane compounds, such as 3-aminoprophyltriethoxysilane (APTES). Vapor phase deposition in this manner deposits a chemically active layer of the silane compound covalently bonded to the SIO2 surface.
- the surface can be derivatized using liquid phase deposition.
- a binding protein, selected from those previously described, is then immobilized on the derivatized surface of the semiconductor by a covalent bond.
- the final section of sensor element 16 to be discussed is the binding reversal element 38.
- the particular binding element 32 selected can be induced to release the component bound to the insulative material 50 by increasing the temperature of the gate 52 to approximately 75°C.
- diffused or thin-film resistors 58 can be integrated with the other components or the sensor element 16. The number, location, and resistivity of resistors 58, as well as the voltage applied, determines their power loss and, hence, the heat transferred to sensor element 16.
- a system 10 constructed in accordance with this invention does not require the use of external standard calibration references. More particularly, given the precise nature of the KQ of the binding elements 32, the relationship between the output of sensor element 16 and the concentration of the component in solution does not require adjustment between sensors.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Un instrument de mesure possède une protéine à liaison sélective réversible immobilisée sur la région de la gâchette isolée d'un transistor à effet de champ (IGFET) disposé sur un capteur. Lorsque ce capteur est immergé dans une solution, la protéine lie à la gâchette un constituant choisi de la solution, produisant ainsi un effet sur un courant circulant à travers le IGFET. Une pluralité de ces agencements protéine de liaison-IGFET peuvent être ménagés sur le même capteur, comportant les mêmes protéines de liaison avec différents coefficients de liaison KD ou bien un réseau de protéines présentant une spécificité et/ou une affinité avec les ligands différente. L'analyse par un microprosseur de la réponse du IGFET à cette liaison permet, par exemple, de déterminer la concentration du constituant dans la solution. La mise en oeuvre d'une pluralité de protéines de liaison différentes permet de déterminer la concentration de différents constituants. De la même manière, l'emploi de protéines de liaison ayant des coefficients de liaison KD différents permet d'analyser le signal de sortie du capteur de façon numérique ou analogique, ou les deux combinées. Pour libérer le constituant de la protéine, on applique de la chaleur au capteur au moyen d'un assemblage à résistance intégré dans la puce dudit capteur. Dans une variante, on peut appliquer une polarisation inversée à la gâchette en vue d'accélérer cette libération.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4708087A | 1987-05-05 | 1987-05-05 | |
| US047,080 | 1987-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1988008972A1 true WO1988008972A1 (fr) | 1988-11-17 |
Family
ID=21946965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1988/001494 WO1988008972A1 (fr) | 1987-05-05 | 1988-05-04 | Systeme mettant en oeuvre un capteur biologique pour controler une caracteristique d'un constituant selectionne dans un milieu |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0313629A1 (fr) |
| CA (1) | CA1318353C (fr) |
| WO (1) | WO1988008972A1 (fr) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5328847A (en) * | 1990-02-20 | 1994-07-12 | Case George D | Thin membrane sensor with biochemical switch |
| GB2287296A (en) * | 1994-03-08 | 1995-09-13 | Pektron Ltd | Detecting passage of cleaning liquid in a beer line |
| FR2747785A1 (fr) * | 1996-04-17 | 1997-10-24 | Motorola Inc | Procede et appareil de detection moleculaire a base de transistor |
| EP0751392A3 (fr) * | 1995-06-28 | 1997-11-19 | Motorola, Inc. | Biocapteur ou capteur chimique avec couche indicatrice |
| FR2752616A1 (fr) * | 1996-08-20 | 1998-02-27 | Motorola Inc | Appareil a base de transistor et procede de detection moleculaire et d'accroissement de l'intensite du champ |
| WO2004036203A1 (fr) * | 2002-10-14 | 2004-04-29 | Infineon Technologies Ag | Systeme detecteur et mode de fonctionnement de ce dispositif detecteur |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3831432A (en) * | 1972-09-05 | 1974-08-27 | Texas Instruments Inc | Environment monitoring device and system |
| FR2304083A1 (fr) * | 1975-03-12 | 1976-10-08 | Univ Utah | Dispositif a effet de champ sensible a des produits chimiques, pour appareils detecteurs |
| US4238757A (en) * | 1976-03-19 | 1980-12-09 | General Electric Company | Field effect transistor for detection of biological reactions |
| US4334880A (en) * | 1980-10-20 | 1982-06-15 | Malmros Mark K | Analytical device having semiconductive polyacetylene element associated with analyte-binding substance |
| JPS59125054A (ja) * | 1983-01-05 | 1984-07-19 | Kuraray Co Ltd | イオン濃度測定装置 |
| WO1985004480A1 (fr) * | 1984-03-22 | 1985-10-10 | Stichting Centrum Voor Micro-Electronica Twente | Procede de production d'un isfet, et isfet obtenu par ce procede |
| EP0214805A2 (fr) * | 1985-08-29 | 1987-03-18 | Matsushita Electric Industrial Co., Ltd. | Capteur utilisant un transistor à effet de champ et méthode pour le fabriquer |
-
1988
- 1988-05-04 CA CA000565850A patent/CA1318353C/fr not_active Expired - Fee Related
- 1988-05-04 EP EP19880904377 patent/EP0313629A1/fr not_active Withdrawn
- 1988-05-04 WO PCT/US1988/001494 patent/WO1988008972A1/fr not_active Application Discontinuation
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3831432A (en) * | 1972-09-05 | 1974-08-27 | Texas Instruments Inc | Environment monitoring device and system |
| FR2304083A1 (fr) * | 1975-03-12 | 1976-10-08 | Univ Utah | Dispositif a effet de champ sensible a des produits chimiques, pour appareils detecteurs |
| US4238757A (en) * | 1976-03-19 | 1980-12-09 | General Electric Company | Field effect transistor for detection of biological reactions |
| US4334880A (en) * | 1980-10-20 | 1982-06-15 | Malmros Mark K | Analytical device having semiconductive polyacetylene element associated with analyte-binding substance |
| JPS59125054A (ja) * | 1983-01-05 | 1984-07-19 | Kuraray Co Ltd | イオン濃度測定装置 |
| WO1985004480A1 (fr) * | 1984-03-22 | 1985-10-10 | Stichting Centrum Voor Micro-Electronica Twente | Procede de production d'un isfet, et isfet obtenu par ce procede |
| EP0214805A2 (fr) * | 1985-08-29 | 1987-03-18 | Matsushita Electric Industrial Co., Ltd. | Capteur utilisant un transistor à effet de champ et méthode pour le fabriquer |
Non-Patent Citations (2)
| Title |
|---|
| Patent Abstracts of Japan, volume 8, no. 254 (P-315)(1691), 21. November 1984; & JP-A-59125054 (KURARAY K.K.) 19 July 1984 see abstract * |
| Sensors and Actuators, volume 9, 1986, Elsevier Sequoia, (NL), W.J. Lian et al.: "Flip-flop sensors: a new class of silicon sensors", pages 259-268 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5328847A (en) * | 1990-02-20 | 1994-07-12 | Case George D | Thin membrane sensor with biochemical switch |
| GB2287296A (en) * | 1994-03-08 | 1995-09-13 | Pektron Ltd | Detecting passage of cleaning liquid in a beer line |
| GB2287296B (en) * | 1994-03-08 | 1997-08-20 | Pektron Ltd | Flow sensing apparatus |
| EP0751392A3 (fr) * | 1995-06-28 | 1997-11-19 | Motorola, Inc. | Biocapteur ou capteur chimique avec couche indicatrice |
| FR2747785A1 (fr) * | 1996-04-17 | 1997-10-24 | Motorola Inc | Procede et appareil de detection moleculaire a base de transistor |
| FR2752616A1 (fr) * | 1996-08-20 | 1998-02-27 | Motorola Inc | Appareil a base de transistor et procede de detection moleculaire et d'accroissement de l'intensite du champ |
| EP0858597A1 (fr) * | 1996-08-20 | 1998-08-19 | Motorola, Inc. | Appareil et procede a transistors pour la detection moleculaire et l'amelioration du champ |
| EP0858597A4 (fr) * | 1996-08-20 | 1999-03-10 | Motorola Inc | Appareil et procede a transistors pour la detection moleculaire et l'amelioration du champ |
| WO2004036203A1 (fr) * | 2002-10-14 | 2004-04-29 | Infineon Technologies Ag | Systeme detecteur et mode de fonctionnement de ce dispositif detecteur |
| US7662341B2 (en) | 2002-10-14 | 2010-02-16 | Infineon Technologies Ag | Sensor arrangement and method for operating a sensor arrangement |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1318353C (fr) | 1993-05-25 |
| EP0313629A1 (fr) | 1989-05-03 |
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