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WO1988007576A3 - Proteines vasculaires anticoagulantes, leurs adn de codage, production et utilisation - Google Patents

Proteines vasculaires anticoagulantes, leurs adn de codage, production et utilisation Download PDF

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Publication number
WO1988007576A3
WO1988007576A3 PCT/EP1988/000266 EP8800266W WO8807576A3 WO 1988007576 A3 WO1988007576 A3 WO 1988007576A3 EP 8800266 W EP8800266 W EP 8800266W WO 8807576 A3 WO8807576 A3 WO 8807576A3
Authority
WO
WIPO (PCT)
Prior art keywords
code
application
dnas
manufacture
anticoagulant proteins
Prior art date
Application number
PCT/EP1988/000266
Other languages
German (de)
English (en)
Other versions
WO1988007576A2 (fr
Inventor
Rudolf Hauptmann
Ingrid Maurer-Fogy
Gerhard Bodo
Peter Swetly
Christian Stratowa
Edgar Falkner
Guenther Adolf
Christian Mari Reutlingsperger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19873710364 external-priority patent/DE3710364A1/de
Priority claimed from DE19873710309 external-priority patent/DE3710309A1/de
Priority claimed from DE19873710430 external-priority patent/DE3710430A1/de
Priority claimed from DE19873737367 external-priority patent/DE3737367A1/de
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of WO1988007576A2 publication Critical patent/WO1988007576A2/fr
Priority to DK198806622A priority Critical patent/DK175468B1/da
Priority to NO88885275A priority patent/NO885275L/no
Priority to KR1019880701535A priority patent/KR890700666A/ko
Priority to FI885504A priority patent/FI103892B1/fi
Publication of WO1988007576A3 publication Critical patent/WO1988007576A3/fr
Priority to US08/376,050 priority patent/US5837842A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)

Abstract

Protéines biologiquement actives, molécules d'ADN de codage de ces protéines, leur procédé de production et leur utilisation.
PCT/EP1988/000266 1987-03-28 1988-03-26 Proteines vasculaires anticoagulantes, leurs adn de codage, production et utilisation WO1988007576A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DK198806622A DK175468B1 (da) 1987-03-28 1988-11-25 Vaskulære- antikoagulerende proteiner, DNA som koder for disse og fremgangsmåde til fremstilling deraf
NO88885275A NO885275L (no) 1987-03-28 1988-11-25 Vaskulaere antikoagulantproteiner, dna'er som koder for dem, fremstilling og anvendelse derav.
KR1019880701535A KR890700666A (ko) 1987-03-28 1988-11-25 혈관 항응고 단백질, 이를 암호화하는 dna, 이의 제조방법 및 용도
FI885504A FI103892B1 (fi) 1987-03-28 1988-11-28 Rekombinantti-DNA-molekyyli, joka koodaa polypeptidiä/proteiinia, jolla on oleellisesti vaskulaaristen antikoaguloivien proteiinien biologiset ominaisuudet sekä niiden valmistus
US08/376,050 US5837842A (en) 1987-03-28 1995-01-23 Vascular anticoagulant proteins DNA which codes them, processer for preparing them and their use

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DEP3710430.6 1987-03-28
DE19873710364 DE3710364A1 (de) 1987-03-28 1987-03-28 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DE19873710309 DE3710309A1 (de) 1987-03-28 1987-03-28 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DEP3710309.1 1987-03-28
DEP3710364.4 1987-03-28
DE19873710430 DE3710430A1 (de) 1987-03-28 1987-03-28 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DE19873737367 DE3737367A1 (de) 1987-11-04 1987-11-04 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DEP3737367.6 1987-11-04

Publications (2)

Publication Number Publication Date
WO1988007576A2 WO1988007576A2 (fr) 1988-10-06
WO1988007576A3 true WO1988007576A3 (fr) 1989-01-26

Family

ID=27433878

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1988/000266 WO1988007576A2 (fr) 1987-03-28 1988-03-26 Proteines vasculaires anticoagulantes, leurs adn de codage, production et utilisation

Country Status (17)

Country Link
US (1) US5837842A (fr)
EP (1) EP0293567B1 (fr)
JP (1) JPH01503515A (fr)
KR (1) KR890700666A (fr)
AT (1) ATE133707T1 (fr)
AU (1) AU625214B2 (fr)
DD (1) DD273285A5 (fr)
DE (1) DE3854950D1 (fr)
DK (1) DK175468B1 (fr)
FI (1) FI103892B1 (fr)
HU (1) HUT52544A (fr)
IE (2) IE960853L (fr)
IL (1) IL85878A (fr)
NO (1) NO885275L (fr)
NZ (1) NZ224057A (fr)
PT (1) PT87083B (fr)
WO (1) WO1988007576A2 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2660514B2 (ja) * 1987-02-20 1997-10-08 興和株式会社 抗血液凝固作用を有するポリペプチド
ES2096556T3 (es) * 1988-02-26 1997-03-16 Biogen Inc Secuencias de adn, moleculas de adn recombinante y procedimientos para producir lipocortinas iii, iv, v y vi.
AU3231189A (en) * 1988-03-31 1989-10-05 Rorer International (Overseas) Inc. Recombinant endonexin ii
DE3910240A1 (de) * 1989-03-30 1990-10-04 Behringwerke Ag Pp4-delta, seine herstellung und verwendung
DK0409052T3 (da) * 1989-07-15 1993-06-07 Boehringer Ingelheim Int Middel, der indeholder et antikoagulans
DE3937607A1 (de) * 1989-11-11 1991-05-16 Boehringer Ingelheim Int Verwendung eines antikoagulanz zur behandlung von tumorerkrankungen
EP0806670B1 (fr) * 1989-12-27 2009-04-22 Boehringer Ingelheim International GmbH Utilisation d'un anticoagulant comme moyen de diagnostic
US5627036A (en) * 1989-12-27 1997-05-06 Boehringer Ingelheim International Gmbh Use of an anticoagulant as a diagnostic agent
EP0538459A4 (en) * 1991-05-09 1993-06-16 The Board Of Regents Of The University Of Washington Phospholipid-targeted thrombolytic agents
US5632986A (en) * 1991-05-09 1997-05-27 The University Of Washington Phospholipid-targeted thrombolytic agents
EP0968648A1 (fr) * 1992-07-08 2000-01-05 N.V. Innogenetics S.A. Mammifères non-humains transgéniques exprimant de manière constituve ou inductible le gène de l'endonexine II ou ses fragments ou ses mutéines
US20030220233A1 (en) 1994-01-24 2003-11-27 Neorx Corporation Radiolabeled annexins
US5968477A (en) 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
JP3673522B2 (ja) * 1994-11-11 2005-07-20 昇 金子 抗アネキシンｖモノクローナル抗体並びにその利用及びそれを産生するハイブリドーマ細胞系
US7635676B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
ATE359807T1 (de) * 2001-02-21 2007-05-15 Surromed Inc Modifizierte annexin-proteine und verhinderung und behandlung von thrombose
US20090291086A1 (en) * 2001-02-21 2009-11-26 Alavita Pharmaceuticals, Inc. Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia
US7635680B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
US7645739B2 (en) 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
US20050222030A1 (en) * 2001-02-21 2005-10-06 Anthony Allison Modified annexin proteins and methods for preventing thrombosis
AU784548B2 (en) * 2001-03-16 2006-04-27 Ortho-Clinical Diagnostics, Inc. Reg-like protein
DE60202240T2 (de) * 2001-05-21 2005-12-15 Fuji Photo Film Co., Ltd., Minami-Ashigara Vorrichtung zur Durchführung biochemischer Analysen und Verfahren zu ihrer Herstellung
US7622260B2 (en) 2001-09-05 2009-11-24 The Brigham And Women's Hospital, Inc. Diagnostic and prognostic tests
FR2841558B1 (fr) * 2002-07-01 2004-08-13 Commissariat Energie Atomique Peptides marques ayant une affinite pour un phospholipide et utilisations
FR2841557B1 (fr) * 2002-07-01 2005-12-09 Commissariat Energie Atomique Peptides ayant une affinite pour un phospholipide et utilisations
EP1533619B1 (fr) * 2003-11-20 2009-04-29 F. Hoffmann-Roche AG Marqueurs spécifiques du syndrome métabolique.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0181465A1 (fr) * 1984-09-21 1986-05-21 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Protéines inhibant la coagulation du sang, leur application
WO1986004094A1 (fr) * 1985-01-10 1986-07-17 Biogen .N.V. Sequences d'adn, molecules d'adn recombinant et procedes de production de polypeptides similaires a la lipocortine humaine
WO1986006100A1 (fr) * 1985-04-15 1986-10-23 Biotechnology Research Partners, Limited Proteine anti-inflammatoire d'inhibition de la phospholipase humaine
WO1988005659A1 (fr) * 1987-02-06 1988-08-11 Zymogenetics, Inc. Proteines humaines possedant une activite anticoagulante et anti-inflammatoire

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
US5066788A (en) * 1984-09-21 1991-11-19 Boehringer Ingelheim International Gmbh Blood coagulation inhibiting proteins, processes for preparing them and their uses
CA1265446A (fr) * 1985-09-30 1990-02-06 Masahiro Maki Substance anticoagulante, procede de preparation et anticoagulant comprenant ces substances actives
US4937324A (en) * 1987-02-06 1990-06-26 Zymogenetics, Inc. Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity
US5179081A (en) * 1988-07-21 1993-01-12 Kowa Co., Ltd. Method of treatment using an anticoagulant polypeptide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0181465A1 (fr) * 1984-09-21 1986-05-21 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Protéines inhibant la coagulation du sang, leur application
WO1986004094A1 (fr) * 1985-01-10 1986-07-17 Biogen .N.V. Sequences d'adn, molecules d'adn recombinant et procedes de production de polypeptides similaires a la lipocortine humaine
WO1986006100A1 (fr) * 1985-04-15 1986-10-23 Biotechnology Research Partners, Limited Proteine anti-inflammatoire d'inhibition de la phospholipase humaine
WO1988005659A1 (fr) * 1987-02-06 1988-08-11 Zymogenetics, Inc. Proteines humaines possedant une activite anticoagulante et anti-inflammatoire

Also Published As

Publication number Publication date
IL85878A (en) 1993-07-08
DK175468B1 (da) 2004-11-01
DK662288D0 (da) 1988-11-25
AU1402788A (en) 1988-09-29
NO885275D0 (no) 1988-11-25
PT87083A (pt) 1988-04-01
NZ224057A (en) 1991-04-26
DD273285A5 (de) 1989-11-08
IE880928L (en) 1988-09-28
FI103892B (fi) 1999-10-15
EP0293567B1 (fr) 1996-01-31
KR890700666A (ko) 1989-11-26
ATE133707T1 (de) 1996-02-15
JPH01503515A (ja) 1989-11-30
HUT52544A (en) 1990-07-28
PT87083B (pt) 1992-07-31
US5837842A (en) 1998-11-17
NO885275L (no) 1989-01-25
AU625214B2 (en) 1992-07-02
FI103892B1 (fi) 1999-10-15
WO1988007576A2 (fr) 1988-10-06
FI885504A0 (fi) 1988-11-28
FI885504L (fi) 1988-11-28
IE960853L (en) 1988-09-28
IE74679B1 (en) 1997-07-30
EP0293567A1 (fr) 1988-12-07
DE3854950D1 (de) 1996-03-14
IL85878A0 (en) 1988-09-30
DK662288A (da) 1989-01-25

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