+

WO1988004664A3 - Renin-inhibitory peptides having an epoxide or glycol moiety - Google Patents

Renin-inhibitory peptides having an epoxide or glycol moiety Download PDF

Info

Publication number
WO1988004664A3
WO1988004664A3 PCT/US1987/003007 US8703007W WO8804664A3 WO 1988004664 A3 WO1988004664 A3 WO 1988004664A3 US 8703007 W US8703007 W US 8703007W WO 8804664 A3 WO8804664 A3 WO 8804664A3
Authority
WO
WIPO (PCT)
Prior art keywords
renin
inhibitory peptides
epoxide
glycol moiety
inhibitory
Prior art date
Application number
PCT/US1987/003007
Other languages
French (fr)
Other versions
WO1988004664A2 (en
Inventor
Suvit Thaisrivongs
Original Assignee
Upjohn Co
Suvit Thaisrivongs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Suvit Thaisrivongs filed Critical Upjohn Co
Priority to JP88501531A priority Critical patent/JPH02501140A/en
Publication of WO1988004664A2 publication Critical patent/WO1988004664A2/en
Publication of WO1988004664A3 publication Critical patent/WO1988004664A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel renin-inhibitory peptides of the formula X-A6-B7-C8-D9-E10-F11, containing C-terminus truncated epoxy or azido or cyano groups or containing a position 10-11 diol and a position 11-12 retro bond. The present invention further provides novel transition-state analogue inserts which are useful as intermediates for the preparation of renin-inhibitory peptides.
PCT/US1987/003007 1986-12-22 1987-11-23 Renin-inhibitory peptides having an epoxide or glycol moiety WO1988004664A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP88501531A JPH02501140A (en) 1986-12-22 1987-11-23 Renin-inhibitory peptides with epoxide or glycol groups

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94534086A 1986-12-22 1986-12-22
US945,340 1986-12-22

Publications (2)

Publication Number Publication Date
WO1988004664A2 WO1988004664A2 (en) 1988-06-30
WO1988004664A3 true WO1988004664A3 (en) 1988-08-11

Family

ID=25482981

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/003007 WO1988004664A2 (en) 1986-12-22 1987-11-23 Renin-inhibitory peptides having an epoxide or glycol moiety

Country Status (4)

Country Link
EP (1) EP0344189A1 (en)
JP (1) JPH02501140A (en)
AU (1) AU1243888A (en)
WO (1) WO1988004664A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8759491A (en) * 1990-10-10 1992-05-20 Upjohn Company, The Peptides containing substituted 1,4-diamines as transition-state inserts

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0173481A2 (en) * 1984-08-06 1986-03-05 The Upjohn Company Peptides
EP0189203A2 (en) * 1985-01-23 1986-07-30 Abbott Laboratories Peptidylaminodiols

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0173481A2 (en) * 1984-08-06 1986-03-05 The Upjohn Company Peptides
EP0189203A2 (en) * 1985-01-23 1986-07-30 Abbott Laboratories Peptidylaminodiols

Also Published As

Publication number Publication date
EP0344189A1 (en) 1989-12-06
AU1243888A (en) 1988-07-15
WO1988004664A2 (en) 1988-06-30
JPH02501140A (en) 1990-04-19

Similar Documents

Publication Publication Date Title
PL307265A1 (en) Compounds containing a phenyl group bonded with aryl or heteroaryl group through their bonding aliphatic group or that containing heteroatom
CA2165694A1 (en) Erythropoietin analogs
GR3020814T3 (en) Method for making intermediates useful in synthesis of retroviral protease inhibitors.
EP0300525A3 (en) Silicone containing amine groups for the wrinkle-proofing of fabrics
DE50200819D1 (en) POLYMERIZABLE PREPARATIONS BASED ON SILICON COMPOUNDS WITH ALIPHATIC AND CYCLOALIPHATIC EPOXY GROUPS
EP1997842A3 (en) Process for the preparation of urethane resins and urethan resin compositions
DK0559079T3 (en) Substituted aminophosphonate derivatives, processes for their preparation and pharmaceutical preparations containing the derivatives
NO903694L (en) ADVANCED RESIN MATERIAL, AND PROCEDURE FOR THE PREPARATION OF SUCH.
DK0487632T3 (en) Stabilized vaccine compositions
AU1634388A (en) Cyclic anticoagulant peptides
AU1634288A (en) Cyclic anticoagulant peptides
BR0312889A (en) Pegged t20 polypeptide
WO1988004664A3 (en) Renin-inhibitory peptides having an epoxide or glycol moiety
EP0160925A3 (en) N-substituted neuraminic acid derivatives and process for preparation thereof
ES8602726A1 (en) Glycidyloxydiketones.
WO1999055718A3 (en) Solution phase biopolymer synthesis
CA2310778A1 (en) Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
CA2237401A1 (en) Novel intermediates and their use to prepare n,n'-bridged bisindolylmaleimides
EP0271808A3 (en) Novel epoxy hardeners
RU2227144C2 (en) Substituted tryptophan-containing dipeptides with cholecystokinin-negative or cholecystokinin-positive activity
EP0926239A3 (en) Beta-lipotropin and uses thereof
EP0161384A3 (en) Human endogenous cancer regulatory factors, method of preparing the same, and pharmaceutical compositions containing the same
IT8323595A0 (en) PROCEDURE FOR THE PREPARATION OF CATIONIC EPOXY RESIN ESTERS.
EP0117252A4 (en) Amino-polyol derivatives.
EP0341658A3 (en) Desensitizer composition

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU DK FI JP KR NO US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE FR GB IT LU NL SE

AK Designated states

Kind code of ref document: A3

Designated state(s): AU DK FI JP KR NO US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE FR GB IT LU NL SE

WWE Wipo information: entry into national phase

Ref document number: 1988901397

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1988901397

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1988901397

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载