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WO1988000841A1 - Systeme d'injection de medicaments a chambre expansible - Google Patents

Systeme d'injection de medicaments a chambre expansible Download PDF

Info

Publication number
WO1988000841A1
WO1988000841A1 PCT/AU1987/000255 AU8700255W WO8800841A1 WO 1988000841 A1 WO1988000841 A1 WO 1988000841A1 AU 8700255 W AU8700255 W AU 8700255W WO 8800841 A1 WO8800841 A1 WO 8800841A1
Authority
WO
WIPO (PCT)
Prior art keywords
reservoir
valve
pump according
pump
balloon
Prior art date
Application number
PCT/AU1987/000255
Other languages
English (en)
Inventor
Edward John Keogh
George Henry Ealing
Barry Maxwell Olney
Alexander George Brian O'neil
Original Assignee
Edward John Keogh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edward John Keogh filed Critical Edward John Keogh
Publication of WO1988000841A1 publication Critical patent/WO1988000841A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/152—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs

Definitions

  • the present invention relates to an improved pump and, in particular, to a pulsatile pump or a continuous pump of small size.
  • Continuous and pulsatile pumps that accurately deliver specific volumes of fluids or drugs are applicable to large areas of medicine, industry and science.
  • fluids may be delivered intra-arterially, intravenously, subcutaneously into*the lumen of the gastrointestinal tract, epidurally into the cerebrospinal fluid space or into a reservoir for delivery to a specific site.
  • These pumps are usually of small sizes and are primarily mechanically driven syringes.
  • These apparatus suffer from the disadvantages due to variation in resistance as the plunger is moved along the syringe and inertia in starting the motor and the moving of the plunger.
  • these mechanically driven syringes require relatively large quantities of energy and are therefore usually bulky due to the size of the motor and respective battery power source, and thus further require frequent battery changes.
  • the present invention seeks to ameliorate these disadvantages by providing a pump comprising: an elastic reservoir; an outlet; and a valve located between said reservoir and said outlet; wherein the reservoir is adapted to be filled under pressure by the liquid to be dispensed to inflate the elastic reservoir thus utilising the energy stored in the material of the reservoir to discharge the liquid from the reservoir.
  • a pump comprising: an elastic reservoir; an outlet; and a valve located between said reservoir and said outlet; wherein the reservoir is adapted to be filled under pressure by the liquid to be dispensed to inflate the elastic reservoir thus utilising the energy stored in the material of the reservoir to discharge the liquid from the reservoir.
  • the infuser system comprises a drug reservoir 1 made of silicone rubber attached to a three-way T* piece 2.
  • the port 3 has a one-way valve, which permits refilling of the reservoir, with the gort 11 connected to a paediatric scalp vein needle 4.
  • FIG. 2 A suitable control valve is shown in figure 2.' his valve mechanism consists of a Dalrin cylinder (5) which has a slot (6) at right angles to the longitudinal axis to accommodate the silicone tubing which connects the "T M piece to the hypodermic needle. Once the tubing is fitted in this slot it is quite secure and can be neatly occluded by the two metal pins.
  • the top pin (7) is fixed while the bottom pin (8) is attached at right angles to a shaft which is the central, moving part of the solenoid. This shaft travels up and down in the centre of the delrin cylinder.
  • the pin (8) slides up and down in a longitudinal slot (9) in the side of the cylinder.
  • a coil spring maintains tension on the shaft forcing the mobile pin against the stationary one squashing the tubing as it passes between the two pins.
  • activation of the solenoid draws pin 8 away from pin 7 and permits flow from the reservoir under pressure of the energy stored in the stretched material of the reservoir 1.
  • the duration of flow is controlled by a programmable electronic circuit contained in an "electronic controller" (10).
  • the device is powered by a nine volt battery, the current drawn during activation of the solenoid is 125 - 175mA, otherwise the current drawn is negligible.
  • a pulsing LED is attached to the electronic controller. It glows red if the battery power is waning or there is an electronic fault.
  • this embodiment of the present invention can be worn, by patients requiring periodic or continuous infusing of drugs, in a shoulder holster, in a pocket or on an arm band due to the small size of the device.
  • An alternative control mechanism is a flow restriction valve.
  • a fine bore tube of .0005 inches (0.1mm) (length 1cm) in the flow restriction valve the flow can be limited to 5 mis/hour without the use of any electro-mechanical parts (pressure head of 250mmHg) .
  • flow rates can be reduced to 0.5ml per hour. We believe this to be the lowest flow, gravity independent, constant infusion pump with no electro-mechanical parts available.
  • the reservoir is in the form of a balloon.
  • Balloons are most frequently produced by rubber dipping, but this was not found to be satisfactory for this purpose.
  • a liquid injected moulded technique was used to produce a rigid collar of 1mm thick sixty duro silicone rubber. This was sufficiently rigid to be tight snap fit onto a polypropylene hub.
  • the hub was designed so that the maximum diameter of the hub was introduced into the silicone collar first.
  • the hub of a balloon suitable for the present invention was tapered (5°) so that when pushed one centimetre into the collar the smallest diameter was at the leading edge of the collar and the largest diameter one centimetre down the collar. This design products a situation where enormous longitudinal pressures are required to detach the hub from the collar.
  • the pulsatile system delivers its fluid by using minimal quantities of energy to move a pinch valve fitting away from the tubing which it is obstructing.
  • the energy for the obstruction is supplied by a spring while the energy for pumping fluid to the tissues is stored in the silicone wall. The majority of the energy required is therefore stored in the silicone rubber and in the spring. Only small batteries are therefore required.
  • the Continuous Flow System mode or embodiment * delivers fluid at a relatively constant rate providing the elastic limit of the balloon is not exceeded upon filling.
  • the flow is controlled by a flow reduction valve which may be constructed with a narrow lumen or a porous material. It is thereforea system which is gravity independent, and provides a constant flow rate above arterial pressures without the use of electromechanical energy to discharge the system.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Une pompe permettant l'injection de médicaments comprend un réservoir flexible (1) destiné à contenir des médicaments et pourvu d'un orifice d'émission commandé par une valve (7, 8). La pompe utilise l'énergie stockée dans les parois du réservoir gonflées pour libérer le médicament du réservoir. La valve est de préférence commandée par une horloge électronique programmable (10) destinée à réguler le flux du médicament.
PCT/AU1987/000255 1986-08-08 1987-08-10 Systeme d'injection de medicaments a chambre expansible WO1988000841A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU734986 1986-08-08
AUPH7349 1986-08-08

Publications (1)

Publication Number Publication Date
WO1988000841A1 true WO1988000841A1 (fr) 1988-02-11

Family

ID=3698021

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1987/000255 WO1988000841A1 (fr) 1986-08-08 1987-08-10 Systeme d'injection de medicaments a chambre expansible

Country Status (1)

Country Link
WO (1) WO1988000841A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034640A1 (fr) * 1995-05-01 1996-11-07 Infusion Technologies Corporation Systeme a soupape et procede de commande d'une pompe a perfusion
EP0885620A3 (fr) * 1997-06-19 1999-06-23 Young Gyu Lee Dispositif pour injecter des médicaments liquides
WO2005004953A3 (fr) * 2003-07-11 2005-03-10 H S Hospital Service Spa Systeme de perfusion de solutions pharmacologiques
WO2020167704A1 (fr) * 2019-02-12 2020-08-20 Amgen Inc. Systèmes et approches de dosage continu

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3469578A (en) * 1965-10-12 1969-09-30 Howard R Bierman Infusion device for ambulatory patients with flow control means
US3486539A (en) * 1965-09-28 1969-12-30 Jacuzzi Bros Inc Liquid dispensing and metering assembly
US3895631A (en) * 1974-02-04 1975-07-22 Alza Corp Liquid infusion unit
AU6831974A (en) * 1973-03-26 1975-10-30 Alza Corporation Liquid dispensing assembly
US4201207A (en) * 1973-03-26 1980-05-06 Alza Corporation Bladder for liquid dispenser
AU6614381A (en) * 1980-01-18 1981-07-23 Alza Corporation Infusor with bladder
GB2093473A (en) * 1981-02-23 1982-09-02 Alza Corp Elastomeric Bladders for Medical Infusers
AU2242883A (en) * 1982-12-16 1984-06-21 Chesebrough-Pond's Inc. Flow control via cam clamp

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3486539A (en) * 1965-09-28 1969-12-30 Jacuzzi Bros Inc Liquid dispensing and metering assembly
US3469578A (en) * 1965-10-12 1969-09-30 Howard R Bierman Infusion device for ambulatory patients with flow control means
AU6831974A (en) * 1973-03-26 1975-10-30 Alza Corporation Liquid dispensing assembly
US4201207A (en) * 1973-03-26 1980-05-06 Alza Corporation Bladder for liquid dispenser
US3895631A (en) * 1974-02-04 1975-07-22 Alza Corp Liquid infusion unit
AU6614381A (en) * 1980-01-18 1981-07-23 Alza Corporation Infusor with bladder
GB2093473A (en) * 1981-02-23 1982-09-02 Alza Corp Elastomeric Bladders for Medical Infusers
AU2242883A (en) * 1982-12-16 1984-06-21 Chesebrough-Pond's Inc. Flow control via cam clamp

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034640A1 (fr) * 1995-05-01 1996-11-07 Infusion Technologies Corporation Systeme a soupape et procede de commande d'une pompe a perfusion
EP0885620A3 (fr) * 1997-06-19 1999-06-23 Young Gyu Lee Dispositif pour injecter des médicaments liquides
WO2005004953A3 (fr) * 2003-07-11 2005-03-10 H S Hospital Service Spa Systeme de perfusion de solutions pharmacologiques
CN1822870B (zh) * 2003-07-11 2010-04-28 H.S.医院服务股份公司 药剂溶液注射系统
US7744566B2 (en) 2003-07-11 2010-06-29 H.S. Hospital Services S.p.A. System of infusion of pharmacological solutions
WO2020167704A1 (fr) * 2019-02-12 2020-08-20 Amgen Inc. Systèmes et approches de dosage continu

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