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WO1986001715A1 - Preparations de triglyceride pour la prevention du catabolisme - Google Patents

Preparations de triglyceride pour la prevention du catabolisme Download PDF

Info

Publication number
WO1986001715A1
WO1986001715A1 PCT/US1985/001747 US8501747W WO8601715A1 WO 1986001715 A1 WO1986001715 A1 WO 1986001715A1 US 8501747 W US8501747 W US 8501747W WO 8601715 A1 WO8601715 A1 WO 8601715A1
Authority
WO
WIPO (PCT)
Prior art keywords
oil
acid
structured lipid
chain triglyceride
pharmaceutical composition
Prior art date
Application number
PCT/US1985/001747
Other languages
English (en)
Inventor
Vigen K. Babayan
George L. Blackburn
Original Assignee
Center For Nutritional Research Charitable Trust
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Center For Nutritional Research Charitable Trust filed Critical Center For Nutritional Research Charitable Trust
Publication of WO1986001715A1 publication Critical patent/WO1986001715A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms

Definitions

  • This invention relates to triglyceride preparations for enteral or parentral administration to prevent catabolism and to increase protein synthesis in subjects undergoing severe metabolic stress.
  • This invention provides medium chain and long chain fatty acids chemically synthesized into structured triglycerides (lipids) for enteral or parentral administration as the lipid calorie source, in subjects undergoing severe metabolic stress.
  • lipids structured triglycerides
  • the structural lipids of this invention are randomly rearranged mixtures of medium chain triglycerides (MCT) and long chain triglycerides (LCT). They may be represented by the following formula,
  • R 1 and R 2 may be independently a C 6 to C 12 acid, or a C 12 to C 18 ' acid, and R 3 may be a C 18 " or C 18 " acid.
  • R 1 may be a C 6 to C 12 acid
  • R 2 a C 12 to C 18 acid.
  • C 18 ', C 18 " and C 18 " represent the number of double bonds in the fatty acid moiety being one, two and three double bonds respectively.
  • the medium chain triglycerides may be lauric oils such as, balassee oil, coconut oil, cohune oil, palm kernel oil, tucum oil and fractions thereof.
  • the preferred medium chain triglyceride oil is coconut oil.
  • the long chain triglycerides may be polyunsaturated vegetable oils such as, corn oil, peanut oil, safflower oil, soybean oil, sunflower seed oil, and fish oils.
  • the preferred long chain triglyceride oils are safflower oil, soybean oil, and sunflower seed oil.
  • the percent composition of mixtures of medium chain triglycerides to long chain triglycerides of this invention may be 70 to 30%, 80 to 20%, 85 to 15%, or 90 to 10%. The 80 to 20% and the 85 to 15% mixtures are most preferred.
  • the structured lipids of this invention may be mixtures of coconut oil and soybean oil, which lipids may have the following fatty acid carbon chain length (CCL) composition.
  • CCL fatty acid carbon chain length
  • the present invention provides enteral and parenteral preparations for use in stressed patients to prevent catabolism and to increase protein synthesis.
  • the preparations provide from about 15 to 85% of the fat calories required in the stressed patient.
  • compositions of this invention provide in a 70 Kg man, from about 0.7 gms of fat/Kg of body weight day to about 4.0 gms of fat/Kg of body weight/day.
  • the lipid compositions are preferably administered with additional amino acids, vitamins and minerals as required. Modified amino acid formulas specifically designed for stressed subjects are preferred.
  • the amino acids, vitamins and minerals can be administered in the same solution as the structured lipids or separately. It is preferred that the component groups be separately packaged to facilitate tailoring the diet to the patients specific needs.
  • formulations may include preservatives or stablizers, as required.
  • a structural lipid preparation of this invention is compared with a medium chain lipid, and a long chain lipid for the oxidation of lipids in traumatized animals.
  • Group I a 20% medium chain lipid emulsion composed of 72.5% capric acid (C 8:0) and 27.5% coprylic acid (C 10:0) (obtained from Travenol Laboratories, Inc; Deerfield/ Illinois).
  • Group II a 20% long chain triglyceride emulsion (20% Travamulsion®, Travenol Laboratories)
  • Group III a 20% lipid emulsion composed of structured triglycerides chemically synthesized from 80% coconut oil and 20% soybean oil.
  • Captex 710A Lot No. KH4022A Capital City Products Co., Columbus, Ohio
  • the rats were placed in metabolic chambers that permitted the collection and analysis of their expired breath. At 15 minute intervals for twelve hours, the specific activity of expired carbon dioxide was determined. At the end of the study, the animals were sacrificed
  • Such structured lipids should be preferable and suitable for both enteral and parenteral nutrition.

Landscapes

  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Des triglycérides structurées (lipides) chimiquement synthétisées sont utilisées comme source lipidique de calories administrées par voie orale ou parentérale à des patients soumis à un stress métabolique grave.
PCT/US1985/001747 1984-09-13 1985-09-13 Preparations de triglyceride pour la prevention du catabolisme WO1986001715A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65077184A 1984-09-13 1984-09-13
US650,771 1984-09-13

Publications (1)

Publication Number Publication Date
WO1986001715A1 true WO1986001715A1 (fr) 1986-03-27

Family

ID=24610217

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1985/001747 WO1986001715A1 (fr) 1984-09-13 1985-09-13 Preparations de triglyceride pour la prevention du catabolisme

Country Status (2)

Country Link
EP (1) EP0193602A1 (fr)
WO (1) WO1986001715A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2618332A1 (fr) * 1987-07-23 1989-01-27 Synthelabo Emulsion lipidique destinee a la nutrition parenterale ou enterale
EP0271909A3 (fr) * 1986-12-17 1989-12-06 Green Cross Corporation Composition à base de triglycérides
EP0365532A4 (en) * 1987-04-01 1990-09-05 New England Deaconess Hospital Corporation Kernel oils and disease treatment
US5227403A (en) * 1986-10-01 1993-07-13 The Nisshin Oil Mills, Ltd. Fats and oils having superior digestibility and absorptivity
WO1999030740A1 (fr) * 1997-12-16 1999-06-24 Abbott Laboratories Procede renforçant l'absorption et le transport de composes liposolubles recourant a des glycerides structures
FR2877577A1 (fr) * 2004-11-09 2006-05-12 Jean Pierre Maloisel Extraits de fruits d'astrocaryum aculeatum a visee anti hypertrophie benigne de la prostate, anti inflammatoire et anti oxydante
CN102846589A (zh) * 2005-12-24 2013-01-02 帝斯曼知识产权资产管理有限公司 长期体重维持
JPWO2011115184A1 (ja) * 2010-03-18 2013-07-04 日清オイリオグループ株式会社 生体内の蛋白質の分解抑制剤

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3268340A (en) * 1965-08-30 1966-08-23 Drew Chem Corp Margarine oil and margarine made therefrom
GB2067587A (en) * 1980-01-14 1981-07-30 Bristol Myers Co Readily assimilable fat compositions
US4329359A (en) * 1979-12-28 1982-05-11 University Of Kentucky Research Foundation Method for improving the metabolic stability and survival of newborn pigs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3268340A (en) * 1965-08-30 1966-08-23 Drew Chem Corp Margarine oil and margarine made therefrom
US4329359A (en) * 1979-12-28 1982-05-11 University Of Kentucky Research Foundation Method for improving the metabolic stability and survival of newborn pigs
GB2067587A (en) * 1980-01-14 1981-07-30 Bristol Myers Co Readily assimilable fat compositions

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227403A (en) * 1986-10-01 1993-07-13 The Nisshin Oil Mills, Ltd. Fats and oils having superior digestibility and absorptivity
EP0271909A3 (fr) * 1986-12-17 1989-12-06 Green Cross Corporation Composition à base de triglycérides
EP0365532A4 (en) * 1987-04-01 1990-09-05 New England Deaconess Hospital Corporation Kernel oils and disease treatment
FR2618332A1 (fr) * 1987-07-23 1989-01-27 Synthelabo Emulsion lipidique destinee a la nutrition parenterale ou enterale
EP0302769A1 (fr) * 1987-07-23 1989-02-08 Clintec Nutrition Company Emulsion lipidique destinée à la nutrition parentérale ou entérale
US5840757A (en) * 1987-07-23 1998-11-24 Clintec Nutrition Company Lipid emulsion intended for parenteral or enteral feeding
WO1999030740A1 (fr) * 1997-12-16 1999-06-24 Abbott Laboratories Procede renforçant l'absorption et le transport de composes liposolubles recourant a des glycerides structures
US6013665A (en) * 1997-12-16 2000-01-11 Abbott Laboratories Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides
US6160007A (en) * 1997-12-16 2000-12-12 Abbott Laboratories Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides
FR2877577A1 (fr) * 2004-11-09 2006-05-12 Jean Pierre Maloisel Extraits de fruits d'astrocaryum aculeatum a visee anti hypertrophie benigne de la prostate, anti inflammatoire et anti oxydante
CN102846589A (zh) * 2005-12-24 2013-01-02 帝斯曼知识产权资产管理有限公司 长期体重维持
EP1981490A4 (fr) * 2005-12-24 2013-01-09 Dsm Ip Assets Bv Maintenance du poids a long terme
JPWO2011115184A1 (ja) * 2010-03-18 2013-07-04 日清オイリオグループ株式会社 生体内の蛋白質の分解抑制剤
EP2548554A4 (fr) * 2010-03-18 2013-08-07 Nisshin Oillio Group Ltd Inhibiteur de protéolyse in vivo
JP5860803B2 (ja) * 2010-03-18 2016-02-16 日清オイリオグループ株式会社 生体内の蛋白質の分解抑制剤

Also Published As

Publication number Publication date
EP0193602A1 (fr) 1986-09-10

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