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WO1986000533A1 - Implant osseux - Google Patents

Implant osseux Download PDF

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Publication number
WO1986000533A1
WO1986000533A1 PCT/NL1985/000027 NL8500027W WO8600533A1 WO 1986000533 A1 WO1986000533 A1 WO 1986000533A1 NL 8500027 W NL8500027 W NL 8500027W WO 8600533 A1 WO8600533 A1 WO 8600533A1
Authority
WO
WIPO (PCT)
Prior art keywords
poly
fibres
lactide
article according
implant article
Prior art date
Application number
PCT/NL1985/000027
Other languages
English (en)
Inventor
Jan Willem Leenslag
Albert Johan Pennings
René Pieter Hendrick VETH
Henricus Wilhelm Bernhard Jansen
Original Assignee
Rijksuniversiteit Te Groningen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rijksuniversiteit Te Groningen filed Critical Rijksuniversiteit Te Groningen
Publication of WO1986000533A1 publication Critical patent/WO1986000533A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix

Definitions

  • the present invention relates to an implant article for treatment in reconstructive surgery of damage caused to bony material.
  • the meniscus is an important component of the knee-joint in case of injuries the repair or preservation of the undamaged part of which is preferred over the surgical removal of the meniscus .
  • a damaged, e.g. torn, meniscus can only be healed if vascularisation of the injury is possible.
  • implantation of carbon fibres has proved to be a promising method of treating damaged menisci, technical deficiencies have become apparent, in most cases relating to a tendency to dislocation of the bundle of carbon fibres.
  • an implant article of the above-mentioned type which is characterised by a composite of fibre material which may or may not be bio-degradable and is incorporated in a porous matrix of a biodegradable organic polymer material.
  • the bio-degradable organic polymer material used for the matrix may be a polyurethane material, e.g., a polyether urethane, a polyester urethane and a polyether urea urethane; a polylacti.de material, e.g., a poly(L-lactide), a poly(D-lactide) and a poly (D,L-lactide); a polyglycolide material, e.g., a polyglycolic acid and copolymers composed of the different lactide materials, glycol materials and other hydroxycarboxylic acids, as well as homopolymers and copolymers of amino acids.
  • the individual polymer materials of mixtures thereof may be used, if required, with other bio-degradable polymer materials, e.g., with a porous polyamide material.
  • the fibre material for reinforcing the composite according to the invention may be incorporated in the matrix as loose fibres, however, also as a woven fabric, a knitted fabric or another coherent combination of fibres.
  • the fibres to be used according to the invention may or may not be bio-degradable and comprise, e.g., carbon fibres; sufficiently strong polyethylene fibres; poly (L-lactide fibres), if required, with additives, e.g., low-molecular additives or bio-degradeble homopolymers and/or copolymers; polyglycolide fibres; polyaramide fibres, e.g., poly(p-aminobenzoic acid) fibres; polyamide fibres, e.g., nylon fibres, or fibres of glycolide lactide copolymers.
  • the composite according to the invention may also include, e.g., materials capable of accelerating the bio-degradability of the matrix and the bio-degradability of the fibres, promoting ingrowth of tissue, having antibacterial activity and/or analgetic activity.
  • materials capable of accelerating the bio-degradability of the matrix and the bio-degradability of the fibres, promoting ingrowth of tissue, having antibacterial activity and/or analgetic activity are citric acid, sodium citrate, salicylic acid, aspirin, tartaric acid, magnesium chloride and calcium phosphate. It has turned out that the composite according to the invention is a product which, in addition to bio-degradable and bio-compatible properties, is also microporous and is therefore eminently suitable for effecting vascularisation or ingrowth of tissue, without which properties the repair of torn bone material, such as cartilage material of the meniscus, must be ruled out.
  • a composite according to the invention useful in practice for the repair of large wedge-shaped tears of the meniscus in dogs has appeared to be an implant article made of a polyurethane-poly(L-lactide) organic polymer material as the matrix, in combination with carbon fibres.
  • the composite formed therefrom was bio-degradable and bio-compatible and further microporous.
  • the invention is illustrated by the following example.
  • the polyurethane was reprecipitated 5 times (3 times from N,N-dimethylformamide (DMF) , then 1 time from tetrahydrofuran (THF) and finally, 1 more time from DMF) .
  • The.precipitant used was demineralised water. Reprecipitation was carried out at room temperature.
  • the composite involved in the in vivo examination was prepared from a 4% w /vsolution. (For uses requiring larger pores this could be achieved by further diluting the polymer solutions.
  • the final composite was built up of layers of the porous sheets as obtained under C., the polymer sheets with and without carbon fibres being alternately processed in the final composite.
  • the different layers were bonded together with a 1% w /v polymer solution, using the process mentioned under C.
  • the composite was brought to the required dimensions from which the final meniscus prosthesis could be cut to size.
  • DMF/THF 75:25% v /v e.g., also DMF/1.4-dioxane mixtures (75-25% V /v) (or other ratios) may be used.
  • Suitable solvents are further dimethylacetamide and dimethylsulfoxide.
  • a composite was prepared on the basis of a mixture composed of 95 wt.% polyurethane and 5 wt.% poly (L-lactide), using the process described under C.2. (a).
  • the resulting composite was microporous with a pore size of 35-50 /um.
  • the composite was folded double and sewed together, then adapted to the actual size of the damaged meniscus to be treated, placed in the incision and sewed together therein with 3-0 Dexon sewing-thread.
  • the wound was closed and the dogs were given an opportunity to get on their legs again as soon as possible.
  • the progress of the healing process was evaluated arthroscopically, morphologically and histologically in the manner appropriate therefor from a medical point of view. It turned out that all the implant elements except one had remained in position, and that ingrowth of fibrous fibro-cartilaginous material had taken place over a substantial distance from the place where the implant element is in contact with the surrounding meniscus. In two cases the meniscus proved to have healed already completely.
  • the composite according to the invention proves to be easy in handling owing to applying the organic polymer matrix and conducive to ingrowth of tissue and vessels because of the micro porous condition thereof. These last-mentioned properties are necessary for enabling a damaged meniscus to heal, as appears from

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Composite Materials (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Article d'implant pour le traitement d'os endommagés en chirurgie reconstructive, l'article comprenant un composite à base d'un matériau fibreux pouvant être ou non bio-dégradable et est incorporé dans une matrice poreuse d'un matériau organique polymère bio-dégradable.
PCT/NL1985/000027 1984-07-10 1985-07-10 Implant osseux WO1986000533A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8402178A NL8402178A (nl) 1984-07-10 1984-07-10 Entstuk, geschikt voor behandeling door reconstructieve chirurgie van beschadigingen van beenachtig materiaal.
NL8402178 1984-07-10

Publications (1)

Publication Number Publication Date
WO1986000533A1 true WO1986000533A1 (fr) 1986-01-30

Family

ID=19844197

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL1985/000027 WO1986000533A1 (fr) 1984-07-10 1985-07-10 Implant osseux

Country Status (5)

Country Link
EP (1) EP0195012A1 (fr)
JP (1) JPS62500981A (fr)
AU (1) AU4607885A (fr)
NL (1) NL8402178A (fr)
WO (1) WO1986000533A1 (fr)

Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2181438A (en) * 1985-10-07 1987-04-23 South African Inventions Biocompatible material
EP0258692A2 (fr) * 1986-08-27 1988-03-09 American Cyanamid Company Prothèse chirurgicale
DE3644588C1 (de) * 1986-12-27 1988-03-10 Ethicon Gmbh Implantat und Verfahren zu seiner Herstellung
EP0288041A2 (fr) * 1987-04-21 1988-10-26 Daicel Chemical Industries, Ltd. Fibre d'acide polylactique
EP0334046A2 (fr) * 1988-03-24 1989-09-27 American Cyanamid Company Structure chirurgicale composite contenant des composants absorbables et non absorbables
US5092884A (en) * 1988-03-24 1992-03-03 American Cyanamid Company Surgical composite structure having absorbable and nonabsorbable components
WO1992004392A1 (fr) * 1990-09-07 1992-03-19 Holmes, Michael, John Polymeres contenant des unites de diesters
EP0507807A1 (fr) * 1989-12-28 1992-10-14 Procter & Gamble Articles hygieniques jetables.
US5216050A (en) * 1988-08-08 1993-06-01 Biopak Technology, Ltd. Blends of polyactic acid
US5225490A (en) * 1989-11-08 1993-07-06 Director-General Of Agency Of Industrial Science And Technology Biodisintegrable thermoplastic resin moldings and a process for producing same
US5252642A (en) * 1989-03-01 1993-10-12 Biopak Technology, Ltd. Degradable impact modified polyactic acid
WO1994006866A1 (fr) * 1992-09-22 1994-03-31 Biopak Technology, Ltd. Regulation de degradation de materiaux jetables, degradables par l'environnement
US5444113A (en) * 1988-08-08 1995-08-22 Ecopol, Llc End use applications of biodegradable polymers
US5502158A (en) * 1988-08-08 1996-03-26 Ecopol, Llc Degradable polymer composition
US5756651A (en) * 1996-07-17 1998-05-26 Chronopol, Inc. Impact modified polylactide
US5755792A (en) * 1986-01-28 1998-05-26 Thm Biomedical, Inc. Method and apparatus for biodegradable, osteogenic, bone graft substitute device
WO1998030245A3 (fr) * 1997-01-10 1998-09-11 Jenapharm Gmbh Implant injectable
US5904717A (en) * 1986-01-28 1999-05-18 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US5935594A (en) * 1993-10-28 1999-08-10 Thm Biomedical, Inc. Process and device for treating and healing a tissue deficiency
US5981825A (en) * 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US6005019A (en) * 1993-07-21 1999-12-21 United States Surgical Corporation Plasticizers for fibers used to form surgical devices
US6323307B1 (en) 1988-08-08 2001-11-27 Cargill Dow Polymers, Llc Degradation control of environmentally degradable disposable materials
US6355772B1 (en) 1992-10-02 2002-03-12 Cargill, Incorporated Melt-stable lactide polymer nonwoven fabric and process for manufacture thereof
EP1216717A1 (fr) * 2000-12-21 2002-06-26 Ethicon, Inc. Implants tissulaires renforcés, méthodes de fabrication et utilisation de ces derniers
EP1405649A1 (fr) * 2002-09-27 2004-04-07 Ethicon, Inc. Matrice d'échafaudage composite ensemencées de cellules de mammifères
WO2004069890A2 (fr) 2003-02-04 2004-08-19 Osteotech, Inc. Polyurethannes pour implants osseux
EP1466633A1 (fr) * 2003-04-02 2004-10-13 Lifescan, Inc. Matrice d'échafaudage composite ensemencées de cellules de mammifères
US6852330B2 (en) 2000-12-21 2005-02-08 Depuy Mitek, Inc. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6884428B2 (en) 2000-12-21 2005-04-26 Depuy Mitek, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
WO2005063317A1 (fr) * 2003-12-18 2005-07-14 Sdgi Holdings, Inc. Degradation programmee de composites pour implants spinaux
WO2006017845A2 (fr) * 2004-08-11 2006-02-16 California Institute Of Technology Modele a fort allongement et son procede de fabrication
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7699879B2 (en) 2003-10-21 2010-04-20 Warsaw Orthopedic, Inc. Apparatus and method for providing dynamizable translations to orthopedic implants
WO2010088699A3 (fr) * 2009-02-02 2011-03-31 Biomerix Corporation Dispositifs maillés composites et procédés de réparation des tissus mous
US7931695B2 (en) 2003-07-15 2011-04-26 Kensey Nash Corporation Compliant osteosynthesis fixation plate
US8016867B2 (en) 1999-07-23 2011-09-13 Depuy Mitek, Inc. Graft fixation device and method
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US8895045B2 (en) 2003-03-07 2014-11-25 Depuy Mitek, Llc Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
US9511171B2 (en) 2002-10-18 2016-12-06 Depuy Mitek, Llc Biocompatible scaffolds with tissue fragments
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2820415B2 (ja) * 1988-03-14 1998-11-05 ティーエイチエム・バイオメディカル・インコーポレイテッド 生分解性および骨形成性を有する移植骨片代用組成体

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3463158A (en) * 1963-10-31 1969-08-26 American Cyanamid Co Polyglycolic acid prosthetic devices
US3739773A (en) * 1963-10-31 1973-06-19 American Cyanamid Co Polyglycolic acid prosthetic devices
FR2350826A1 (fr) * 1976-05-12 1977-12-09 Battelle Institut E V Materiau de remplacement des os, d'assemblage des os et d'ancrage des protheses et procede pour sa fabrication
FR2364644A1 (fr) * 1976-09-20 1978-04-14 Inst Nat Sante Rech Med Nouveau materiau de prothese osseuse et son application
FR2387028A1 (fr) * 1977-04-14 1978-11-10 Union Carbide Corp Prothese composite comprenant au moins une matiere plastique et son procede de realisation
EP0050215A1 (fr) * 1980-10-20 1982-04-28 American Cyanamid Company Modification de l'acide polyglycolique pour obtenir des propriétés physiques "in vivo" variables
US4411027A (en) * 1979-04-27 1983-10-25 University Of Medicine And Dentistry Of New Jersey Bio-absorbable composite tissue scaffold
WO1984000302A1 (fr) * 1982-07-16 1984-02-02 Univ Groningen Materiaux biocompatibles, antithrombogenes appropries pour la chirurgie reconstituante
EP0011528B1 (fr) * 1978-10-20 1985-02-20 Centre National De La Recherche Scientifique (Cnrs) Pièces d'ostéosynthèse et leur préparation

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3463158A (en) * 1963-10-31 1969-08-26 American Cyanamid Co Polyglycolic acid prosthetic devices
US3739773A (en) * 1963-10-31 1973-06-19 American Cyanamid Co Polyglycolic acid prosthetic devices
FR2350826A1 (fr) * 1976-05-12 1977-12-09 Battelle Institut E V Materiau de remplacement des os, d'assemblage des os et d'ancrage des protheses et procede pour sa fabrication
FR2364644A1 (fr) * 1976-09-20 1978-04-14 Inst Nat Sante Rech Med Nouveau materiau de prothese osseuse et son application
FR2387028A1 (fr) * 1977-04-14 1978-11-10 Union Carbide Corp Prothese composite comprenant au moins une matiere plastique et son procede de realisation
EP0011528B1 (fr) * 1978-10-20 1985-02-20 Centre National De La Recherche Scientifique (Cnrs) Pièces d'ostéosynthèse et leur préparation
US4411027A (en) * 1979-04-27 1983-10-25 University Of Medicine And Dentistry Of New Jersey Bio-absorbable composite tissue scaffold
EP0050215A1 (fr) * 1980-10-20 1982-04-28 American Cyanamid Company Modification de l'acide polyglycolique pour obtenir des propriétés physiques "in vivo" variables
WO1984000302A1 (fr) * 1982-07-16 1984-02-02 Univ Groningen Materiaux biocompatibles, antithrombogenes appropries pour la chirurgie reconstituante

Cited By (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2591486A1 (fr) * 1985-10-07 1987-06-19 South African Inventions Materiau biocompatible pour protheses et dispositifs d'osteosynthese.
GB2181438A (en) * 1985-10-07 1987-04-23 South African Inventions Biocompatible material
GB2181438B (en) * 1985-10-07 1989-10-11 South African Inventions Biocompatible material
US5904717A (en) * 1986-01-28 1999-05-18 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US5755792A (en) * 1986-01-28 1998-05-26 Thm Biomedical, Inc. Method and apparatus for biodegradable, osteogenic, bone graft substitute device
EP0258692A3 (en) * 1986-08-27 1990-04-04 American Cyanamid Company Surgical prothesis
EP0258692A2 (fr) * 1986-08-27 1988-03-09 American Cyanamid Company Prothèse chirurgicale
DE3644588C1 (de) * 1986-12-27 1988-03-10 Ethicon Gmbh Implantat und Verfahren zu seiner Herstellung
EP0274898A2 (fr) * 1986-12-27 1988-07-20 Ethicon, Inc. Implant
EP0274898A3 (fr) * 1986-12-27 1989-10-11 Ethicon, Inc. Implant
EP0288041A3 (fr) * 1987-04-21 1990-01-10 Daicel Chemical Industries, Ltd. Fibre d'acide polylactique
EP0288041A2 (fr) * 1987-04-21 1988-10-26 Daicel Chemical Industries, Ltd. Fibre d'acide polylactique
EP0334046A3 (fr) * 1988-03-24 1990-06-13 American Cyanamid Company Structure chirurgicale composite contenant des composants absorbables et non absorbables
US5092884A (en) * 1988-03-24 1992-03-03 American Cyanamid Company Surgical composite structure having absorbable and nonabsorbable components
EP0334046A2 (fr) * 1988-03-24 1989-09-27 American Cyanamid Company Structure chirurgicale composite contenant des composants absorbables et non absorbables
US5502158A (en) * 1988-08-08 1996-03-26 Ecopol, Llc Degradable polymer composition
US6323307B1 (en) 1988-08-08 2001-11-27 Cargill Dow Polymers, Llc Degradation control of environmentally degradable disposable materials
US5216050A (en) * 1988-08-08 1993-06-01 Biopak Technology, Ltd. Blends of polyactic acid
US5444113A (en) * 1988-08-08 1995-08-22 Ecopol, Llc End use applications of biodegradable polymers
US5760118A (en) * 1988-08-08 1998-06-02 Chronopol, Inc. End use applications of biodegradable polymers
US5252642A (en) * 1989-03-01 1993-10-12 Biopak Technology, Ltd. Degradable impact modified polyactic acid
US5225490A (en) * 1989-11-08 1993-07-06 Director-General Of Agency Of Industrial Science And Technology Biodisintegrable thermoplastic resin moldings and a process for producing same
EP0507807A1 (fr) * 1989-12-28 1992-10-14 Procter & Gamble Articles hygieniques jetables.
EP0507807A4 (en) * 1989-12-28 1992-11-04 Procter & Gamble Disposable sanitary articles
WO1992004392A1 (fr) * 1990-09-07 1992-03-19 Holmes, Michael, John Polymeres contenant des unites de diesters
WO1994006866A1 (fr) * 1992-09-22 1994-03-31 Biopak Technology, Ltd. Regulation de degradation de materiaux jetables, degradables par l'environnement
US6355772B1 (en) 1992-10-02 2002-03-12 Cargill, Incorporated Melt-stable lactide polymer nonwoven fabric and process for manufacture thereof
US6005019A (en) * 1993-07-21 1999-12-21 United States Surgical Corporation Plasticizers for fibers used to form surgical devices
US5935594A (en) * 1993-10-28 1999-08-10 Thm Biomedical, Inc. Process and device for treating and healing a tissue deficiency
US6264701B1 (en) 1994-05-13 2001-07-24 Kensey Nash Corporation Device and methods for in vivo culturing of diverse tissue cells
US5981825A (en) * 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US5756651A (en) * 1996-07-17 1998-05-26 Chronopol, Inc. Impact modified polylactide
US5908918A (en) * 1996-07-17 1999-06-01 Chronopol, Inc. Impact modified polylactide
WO1998030245A3 (fr) * 1997-01-10 1998-09-11 Jenapharm Gmbh Implant injectable
US6303137B1 (en) 1997-01-10 2001-10-16 Jenapharm Gmbh & Co. Kg Injectable implant
US8016867B2 (en) 1999-07-23 2011-09-13 Depuy Mitek, Inc. Graft fixation device and method
EP1216717A1 (fr) * 2000-12-21 2002-06-26 Ethicon, Inc. Implants tissulaires renforcés, méthodes de fabrication et utilisation de ces derniers
AU762895B2 (en) * 2000-12-21 2003-07-10 Ethicon Inc. Reinforced tissue implants and methods of manufacture and use
US6599323B2 (en) 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
EP1987850A1 (fr) * 2000-12-21 2008-11-05 Ethicon, Incorporated Implants de tissu renforcés, leurs procédés de fabrication et leur utilisation
US6852330B2 (en) 2000-12-21 2005-02-08 Depuy Mitek, Inc. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6884428B2 (en) 2000-12-21 2005-04-26 Depuy Mitek, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US8691259B2 (en) 2000-12-21 2014-04-08 Depuy Mitek, Llc Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
EP1405649A1 (fr) * 2002-09-27 2004-04-07 Ethicon, Inc. Matrice d'échafaudage composite ensemencées de cellules de mammifères
US9511171B2 (en) 2002-10-18 2016-12-06 Depuy Mitek, Llc Biocompatible scaffolds with tissue fragments
US10603408B2 (en) 2002-10-18 2020-03-31 DePuy Synthes Products, Inc. Biocompatible scaffolds with tissue fragments
EP1589962A2 (fr) * 2003-02-04 2005-11-02 Osteotech, Inc. Polyurethannes pour implants osseux
EP1589962A4 (fr) * 2003-02-04 2013-02-27 Warsaw Orthopedic Inc Polyurethannes pour implants osseux
WO2004069890A2 (fr) 2003-02-04 2004-08-19 Osteotech, Inc. Polyurethannes pour implants osseux
US8895045B2 (en) 2003-03-07 2014-11-25 Depuy Mitek, Llc Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
EP1466633A1 (fr) * 2003-04-02 2004-10-13 Lifescan, Inc. Matrice d'échafaudage composite ensemencées de cellules de mammifères
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US9211362B2 (en) 2003-06-30 2015-12-15 Depuy Mitek, Llc Scaffold for connective tissue repair
US7931695B2 (en) 2003-07-15 2011-04-26 Kensey Nash Corporation Compliant osteosynthesis fixation plate
US8679164B2 (en) 2003-07-15 2014-03-25 Kensey Nash Corporation Compliant osteosynthesis fixation plate
US8679163B2 (en) 2003-07-15 2014-03-25 Kensey Nash Corporation Compliant osteosynthesis fixation plate
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
US7699879B2 (en) 2003-10-21 2010-04-20 Warsaw Orthopedic, Inc. Apparatus and method for providing dynamizable translations to orthopedic implants
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
EP1952829A3 (fr) * 2003-12-18 2008-12-03 Warsaw Orthopedic, Inc. Dégradation composite conçue pour implants spinaux
WO2005063317A1 (fr) * 2003-12-18 2005-07-14 Sdgi Holdings, Inc. Degradation programmee de composites pour implants spinaux
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
WO2006017845A3 (fr) * 2004-08-11 2007-02-01 California Inst Of Techn Modele a fort allongement et son procede de fabrication
WO2006017845A2 (fr) * 2004-08-11 2006-02-16 California Institute Of Technology Modele a fort allongement et son procede de fabrication
WO2010088699A3 (fr) * 2009-02-02 2011-03-31 Biomerix Corporation Dispositifs maillés composites et procédés de réparation des tissus mous

Also Published As

Publication number Publication date
EP0195012A1 (fr) 1986-09-24
NL8402178A (nl) 1986-02-03
JPS62500981A (ja) 1987-04-23
AU4607885A (en) 1986-02-10

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