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WO1985000527A1 - Irradiation apparatus for photobiological and photochemical purposes - Google Patents

Irradiation apparatus for photobiological and photochemical purposes Download PDF

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Publication number
WO1985000527A1
WO1985000527A1 PCT/EP1984/000226 EP8400226W WO8500527A1 WO 1985000527 A1 WO1985000527 A1 WO 1985000527A1 EP 8400226 W EP8400226 W EP 8400226W WO 8500527 A1 WO8500527 A1 WO 8500527A1
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WO
WIPO (PCT)
Prior art keywords
filter
filters
irradiation device
beam path
curve
Prior art date
Application number
PCT/EP1984/000226
Other languages
German (de)
French (fr)
Inventor
Maximilian Mutzhas
Original Assignee
Mutzhas Maximilian F
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mutzhas Maximilian F filed Critical Mutzhas Maximilian F
Publication of WO1985000527A1 publication Critical patent/WO1985000527A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0616—Skin treatment other than tanning
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
    • F21V9/00—Elements for modifying spectral properties, polarisation or intensity of the light emitted, e.g. filters
    • F21V9/06—Elements for modifying spectral properties, polarisation or intensity of the light emitted, e.g. filters for filtering out ultraviolet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0644—Handheld applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent

Definitions

  • Irradiation device for photobiological and photochemical purposes
  • the invention relates to an irradiation device (according to the preamble of claim 1) for photobiological and photochemical purposes, preferably for dermatological purposes.
  • SUP therapy selective UV therapy
  • dermatoses in particular psoriasis
  • UV radiation in the wavelength range between 290 and 335 n, in particular between 300 and 320 nm, generally starting with radiation times that are still not cause erythema.
  • a photosensitizing medication is administered orally or applied to the skin, after which irradiation with UV-A in the wavelength range between 310 and 440 nm.
  • the photosensitizing drug is used to make the skin more sensitive to long-wave UV-A radiation.
  • the SUN diagnosis is used for the phototest (polymorphic light dermatoses) and the photopatch test.
  • SUN therapy is used to compensate for a radiation deficit.
  • SUN diagnosis and therapy take place in the UV wavelength range between 300 and 440 nm. It is essential that no DNA damage is caused by radiation between 440 and 460 nm.
  • the UVA diagnosis works with UV radiation in the wavelength range between 320 and 440 nm. It enables a photopatch test without carcinogenic radiation. Here, too, DNA damage caused by radiation between 440 and 460 nm is avoided.
  • UVA therapy (in the same wavelength range between 320 and 440 nm mentioned above) serves for photoprotection (pigmentation, protection against polymorphic light dermatoses, skin cancer and premature skin aging) and for photoreactivation (monomerization of the pyrimidine dimers in the DNA).
  • the invention is therefore based on the object of designing an irradiation device of the type required in the preamble of claim 1 in such a way that it can be used for various purposes without any particular operating effort.
  • a large number of filter combinations can be produced by using n • m filters, which are combined to form n filter groups, the m filters of each filter group being connected for common actuation and alternatively insertable into the beam path.
  • filter combinations can be produced by inserting a filter from both filter groups into the beam path. With three filter groups with three filters each, 27 filter combinations are already possible.
  • FIG. 3 shows a diagram which illustrates the degree of spectral transmission of the four filters used
  • 4 shows a diagram which shows the spectral transmittance of the four filter combinations
  • 5 shows a diagram of the spectral irradiance distribution of the UV radiation source
  • the radiation device for dermatological purposes schematically illustrated in FIGS. 1 and 2 contains in a housing 1 a few UV radiation sources 2, 3, 4, which are formed by high-pressure mercury vapor lamps, preferably with metal halides are doped with iron iodide.
  • the UV radiation sources 2, 3 and 4 are surrounded by a reflector 5, which allows the radiation to pass through a window of the housing 1, in front of which there is a filter arrangement.
  • this filter arrangement contains four filters 6, 7, 8 and 9, which are combined in pairs to form two filter groups (6 and 7 and 8 and 9).
  • the two filter groups 6, 7 and 8, 9 can be shifted within a fixed frame 10 on rollers 11 in the horizontal direction in such a way that two filters of the two " filter groups lie one behind the other in the beam path (in the position of the filters illustrated in FIG. 2) are the filters 7 and 8 in the beam path of the UV radiation sources).
  • Suitable handles are provided for moving the filters. Markings and position indicators give the user an unmistakable indication of which filter combination is currently switched on.
  • the UV radiation sources 2, 3 and 4 are cooled by an air stream which enters from below from a fan 12 in the direction of arrows 13 through openings provided in the reflector 5 into the interior enclosed by the reflector 5 Interior in the upper area of the
  • a further fan 16 generates a cooling air flow, which enters the space 17 between adjacent filters (for example 7,8) of the two filter groups, flows through this space in the direction of the arrows 18 from bottom to top, and then from the upper area 19 to exit the housing 1 to the outside. In this way, good cooling of the filters switched on in the beam path is ensured.
  • the necessary ballasts are housed in the base 20 of the housing 1.
  • OMP ⁇ 3 illustrates the spectral transmittance of filters 6 to 9 for the following practical implementation:
  • the spectral transmittance C as a function of the wavelength A is shown in FIG. 3 for the filters 6 to 9 by the corresponding curves 6 to 9.
  • Filters 6 + 8 SUP (selective UV phototherapy) Filters 6 + 9: SUN (solar UV and near infrared radiation) Filters 7 + 8: PUVA (photochemotherapy with UV-A radiation) Filters 7 + 9: UVA ( Irradiation with UV-A)
  • FIG. 4 illustrates the resulting spectral transmittance which results from superimposing the transmission curves of the two filters connected in series.
  • the corresponding curves in FIG. 4 are designated with the treatment method evident from the above list.
  • 5 also shows the spectral distribution of the relative spectral irradiance E (rel) of the high-pressure mercury vapor lamps used (with iron iodide doping).

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

Irradiation apparatus, particularly for dermatological applications, wherein are provided a plurality of filters (6, 7, 8, 9) assembled in sets of filters, the filters of each set of filters being connected in order to be simultaneously operated and which may be alternatingly inserted in the path of the beams. It is thus possible, by choosing appropriate filters, to execute different therapeutic treatments and diagnoses with the same apparatus.

Description

Bestrahlungsgerät für photobiologische und photochemische Zwecke Irradiation device for photobiological and photochemical purposes
Die Erfindung betrifft ein Bestrahlungsgerät (entsprechend dem Oberbegriff des Anspruches 1) für photobiologische und photochemische Zwecke, vorzugsweise für dermatologische Zwecke.The invention relates to an irradiation device (according to the preamble of claim 1) for photobiological and photochemical purposes, preferably for dermatological purposes.
Für dermatologische Zwecke sind verschiedene, mit Ultraviolett-Bestrahlung arbeitende Diagnose- und Therapie-verfahren bekannt.Various diagnostic and therapeutic methods using ultraviolet radiation are known for dermatological purposes.
Bei der sog. SUP-Therapie (selektive UV-Therapie) werden Dermatosen, insbesondere Psoriasis, durch UV-Bestrahlung im Wellenlängenbereich zwischen 290 und 335 n , insbesondere zwischen 300 und 320 nm, behandelt, wobei man im allgemeinen mit Bestrahlungszeiten beginnt, die noch kein Erythem hervorrufen.In so-called SUP therapy (selective UV therapy), dermatoses, in particular psoriasis, are treated by UV radiation in the wavelength range between 290 and 335 n, in particular between 300 and 320 nm, generally starting with radiation times that are still not cause erythema.
Während die SUP-Therapie ohne Medikamente arbei¬ tet, wird bei der PUVA-Therapie (zur Behandlung von Dermatosen, inbesondere Psoriasis) ein photo- sensibilisierendes Medikament oral verabreicht oder auf die Haut aufgetragen, wonach eine Be¬ strahlung mit UV-A im Wellenlängenbereich zwischen 310 und 440 nm erfolgt. Das photosensibilisieren- de Medikament dient hierbei dazu, die Haut für die langwellige UV-A-Strahlung empfindlicher zu machen.While the SUP therapy works without medication, in the PUVA therapy (for the treatment of dermatoses, in particular psoriasis) a photosensitizing medication is administered orally or applied to the skin, after which irradiation with UV-A in the wavelength range between 310 and 440 nm. The photosensitizing drug is used to make the skin more sensitive to long-wave UV-A radiation.
O PI Die SUN-Diagnose wird zum Phototest (polymorphe Lichtdermatosen) sowie zum Photopatchtest verwendet. Die SUN-Therapie dient zum Ausgleich eines Strahlungsdefizits. SUN-Diagnose und -Thera- pie erfolgen im UV-Wellenlängenbereich zwischen 300 und 440 nm. Wesentlich ist, daß keine DNS- Schäden durch Strahlung zwischen 440 und 460 nm hervorgerufen werden.O PI The SUN diagnosis is used for the phototest (polymorphic light dermatoses) and the photopatch test. SUN therapy is used to compensate for a radiation deficit. SUN diagnosis and therapy take place in the UV wavelength range between 300 and 440 nm. It is essential that no DNA damage is caused by radiation between 440 and 460 nm.
Die UVA-Diagnose arbeitet mit einer UV-Strahlung im Wellenlängenbereich zwischen 320 und 440 nm. Sie ermöglicht damit einen Photopatchtest ohne karzinogene Strahlung. Auch hierbei werden DNS- Schäden durch Strahlung zwischen 440 und 460 nm vermieden.The UVA diagnosis works with UV radiation in the wavelength range between 320 and 440 nm. It enables a photopatch test without carcinogenic radiation. Here, too, DNA damage caused by radiation between 440 and 460 nm is avoided.
Die UVA-Therapie (im gleichen vorstehend genannten Wellenlängenbereich zwischen 320 und 440 nm) dient zur Photoprotektion (Pigmentierung, Schutz gegen polymorphe Lichtdermatosen, Hautkrebs und vor¬ zeitige Hautalterung) sowie zur Photoreaktivie- rung (Monomerisierung der Pyrimidin-Dimere in der DNS) .UVA therapy (in the same wavelength range between 320 and 440 nm mentioned above) serves for photoprotection (pigmentation, protection against polymorphic light dermatoses, skin cancer and premature skin aging) and for photoreactivation (monomerization of the pyrimidine dimers in the DNA).
Für diese verschiedenen UV-Therapie-und -Diagnose- Verfahren sind bisher gesonderte Geräte erforder¬ lich, was für Arzt und Klinik einen beträchtlichen Aufwand darstellt und auch einen unerwünscht großen Raumbedarf in den Behandlungsräumen ver- ursacht.Separate devices have hitherto been required for these various UV therapy and diagnosis methods, which represents a considerable outlay for doctors and clinics and also causes an undesirably large space requirement in the treatment rooms.
O PI Der Erfindung liegt daher die Aufgabe zugrunde, ein Bestrahlungsgerät der im Oberbegriff des An¬ spruches 1 vorausgesetzten Art so auszubilden, daß es ohne besonderen Bedienungsaufwand für ver- schiedenartige Zwecke verwendbar ist.O PI The invention is therefore based on the object of designing an irradiation device of the type required in the preamble of claim 1 in such a way that it can be used for various purposes without any particular operating effort.
Diese Aufgabe wird erfindungsgemäß durch die kenn¬ zeichnenden Merkmale des Anspruches 1 gelöst.This object is achieved according to the invention by the characterizing features of claim 1.
Durch die Verwendung von n • m Filter, die zu n Filtergruppen zusammengefaßt sind, wobei die m Filter jeder Filtergruppe zur gemeinsamen Betäti¬ gung verbunden und alternativ in den Strahlengang einfügbar sind, lassen sich eine Vielzahl von Fil- terko binationen herstellen.A large number of filter combinations can be produced by using n • m filters, which are combined to form n filter groups, the m filters of each filter group being connected for common actuation and alternatively insertable into the beam path.
Werden beispielsweise vier Filter vorgesehen, die paarweise zu zwei Filtergruppen zusammengefaßt sind, so können vier Filterkombinationen herge¬ stellt werden, indem jeweils ein Filter beider Filtergruppen in den Strahlengang eingeführt wird. Bei drei Filtergruppen mit je drei Filtern sind bereits 27 Filterkombinationen möglich.If, for example, four filters are provided, which are combined in pairs to form two filter groups, four filter combinations can be produced by inserting a filter from both filter groups into the beam path. With three filter groups with three filters each, 27 filter combinations are already possible.
Für Arzt und Klinik eröffnet sich damit die Mög¬ lichkeit, mit Hilfe eines einzigen Bestrahlungs¬ gerätes, das lediglich vier Filter enthält, die paarweise zu zwei Filtergruppen zusammengefaßt sind, die eingangs genannten vier gebräuchlichen Diagnose- und Therapie-Verfahren durchzuführen. Zur Umschaltung von der einen auf die andere Be¬ triebsweise ist dabei nicht mehr erforderlich, alsThis opens up the possibility for doctor and clinic to carry out the four common diagnostic and therapy methods mentioned at the beginning with the aid of a single irradiation device which contains only four filters, which are combined in pairs to form two filter groups. To switch from one mode of operation to the other, no more is required than
O PI die einzelnen Filter in den Strahlengang einzu¬ schieben oder einzuschwenken. Dadurch ergibt sich nicht nur eine wesentliche Senkung der Anlage¬ kosten, sondern auch eine beachtliche Verringerung des Raumbedarfes sowie - durch die bessere Aus¬ lastung des Gerätes - eine Senkung der laufenden Betriebskosten.O PI to insert or pivot the individual filters into the beam path. This results not only in a significant reduction in the system costs, but also in a considerable reduction in the space requirement and - due to the better utilization of the device - a reduction in the running operating costs.
Zweckmäßige Ausgestaltungen der Erfindung sind Gegenstand der Unteransprüche und werden im Zu¬ sammenhang mit der Beschreibung eines in der Zeich¬ nung veranschaulichten AusfuhrungsbeiSpieles näher erläutert.Appropriate embodiments of the invention are the subject of the subclaims and are explained in more detail in connection with the description of an exemplary embodiment illustrated in the drawing.
in der Zeichnung zeigenshow in the drawing
Fig.1 einen schematischen Vertikalschnitt durch ein erfindungsgemäßes Bestrahlungsgerät,1 shows a schematic vertical section through an irradiation device according to the invention,
Fig.2 einen Horizontalschnitt längs der Linie II-II der Fig.l,2 shows a horizontal section along the line II-II of Fig.l,
Fig.3 ein Diagramm, das den spektralen Trans¬ missionsgrad der vier verwendeten Filter veranschaulicht,3 shows a diagram which illustrates the degree of spectral transmission of the four filters used,
Fig.4 ein Diagramm, das den spektralen Trans- missionsgrad der vier Filterkombinationen zeigt, Fig.5 ein Diagramm der spektralen Bestrahlungs¬ stärke-Verteilung der UV-Strahlungsquelle,4 shows a diagram which shows the spectral transmittance of the four filter combinations, 5 shows a diagram of the spectral irradiance distribution of the UV radiation source,
Fig.6, 7, 8 und 9 Diagramme der spektralen Öe-Fig. 6, 7, 8 and 9 diagrams of the spectral Öe
.strahlungstärke-Verteilung bei den 4 Fil- terkombination.. Radiance distribution with the 4 filter combinations.
Das in den Fig.1 und 2 schematisch veranschaulichte Bestrahlungsgerät für dermatologische Zwecke ent¬ hält in einem Gehäuse 1 einige UV-Strahlungs- quellen 2, 3, 4, die durch Quecksilberdampf-Hoch¬ druckstrahler gebildet werden, die mit Metallhalo- geniden, vorzugsweise mit Eiseniodid, dotiert sind.The radiation device for dermatological purposes schematically illustrated in FIGS. 1 and 2 contains in a housing 1 a few UV radiation sources 2, 3, 4, which are formed by high-pressure mercury vapor lamps, preferably with metal halides are doped with iron iodide.
Die UV-Strahlungsquellen 2, 3 und 4 sind von einem Reflektor 5 umgeben, der die Strahlung durch ein Fenster des Gehäuses 1 hindurchtreten läßt, vor dem sich eine Filteranordnung befindet.The UV radiation sources 2, 3 and 4 are surrounded by a reflector 5, which allows the radiation to pass through a window of the housing 1, in front of which there is a filter arrangement.
Diese Filteranordnung enthält beim dargestellten Ausfuhrungsbeispiel vier Filter 6, 7, 8 und 9, die paarweise zu zwei Filtergruppen (6 und 7 sowie 8 und 9) zusammengefaßt sind.In the exemplary embodiment shown, this filter arrangement contains four filters 6, 7, 8 and 9, which are combined in pairs to form two filter groups (6 and 7 and 8 and 9).
Die beiden Filtergruppen 6, 7 und 8, 9 sind innerhalb eines feststehenden Rahmens 10 auf Rollen 11 in horizontaler Richtung derart ver¬ schiebbar, daß jeweils zwei Filter der beiden "Filtergruppen hintereinander im Strahlengang liegen (bei der in Fig.2 veranschaulichten Stellung der Filter befinden sich die Filter 7 und 8 im Strahlengang der UV-Strahlungsquellen) .The two filter groups 6, 7 and 8, 9 can be shifted within a fixed frame 10 on rollers 11 in the horizontal direction in such a way that two filters of the two " filter groups lie one behind the other in the beam path (in the position of the filters illustrated in FIG. 2) are the filters 7 and 8 in the beam path of the UV radiation sources).
Zur Verschiebung der Filter sind geeignete, in der Zeichnung nicht veranschaulichte Handhaben vorgesehen. Markierungen und Stellungsanzeiger geben dem Benutzer einen unmißverständlichen Hin¬ weis darauf, welche Filterkombination gerade ein¬ geschaltet ist.Suitable handles, not illustrated in the drawing, are provided for moving the filters. Markings and position indicators give the user an unmistakable indication of which filter combination is currently switched on.
Die Kühlung der UV-Strahlungsquellen 2, 3 und 4 erfolgt durch einen Luftstrom, der von einem Ven¬ tilator 12 in Richtung der Pfeile 13 durch im Reflektor 5 vorgesehene Öffnungen in den vom Re¬ flektor 5 umschlossenen Innenraum von unten ein- tritt, diesen Innenraum im oberen Bereich desThe UV radiation sources 2, 3 and 4 are cooled by an air stream which enters from below from a fan 12 in the direction of arrows 13 through openings provided in the reflector 5 into the interior enclosed by the reflector 5 Interior in the upper area of the
Reflektors 5 verläßt und aus dem hinteren Bereich 15 des Gehäuses 1 durch nicht veranschaulichte Öffnungen ins Freie abströmt.Leaves reflector 5 and flows out of the rear region 15 of the housing 1 through openings, not shown, to the outside.
Ein weiterer Ventilator 16 erzeugt einen Kühlluft¬ strom, der in den Raum 17 zwischen benachbarten Filtern (z.B. 7,8)der beiden Filtergruppen ein¬ tritt, diesen Raum in Richtung der Pfeile 18 von unten nach oben durchströmt, um dann aus dem oberen Bereich 19 des Gehäuses 1 nach außen auszu¬ treten. Auf diese Weise wird eine gute Kühlung der jeweils in den Strahlengang eingeschalteten Filter gewährleistet.A further fan 16 generates a cooling air flow, which enters the space 17 between adjacent filters (for example 7,8) of the two filter groups, flows through this space in the direction of the arrows 18 from bottom to top, and then from the upper area 19 to exit the housing 1 to the outside. In this way, good cooling of the filters switched on in the beam path is ensured.
Die erforderlichen Vorschaltgeräte sind im Sockel 20 des Gehäuses 1 untergebracht.The necessary ballasts are housed in the base 20 of the housing 1.
OMPΓ Fig.3 veranschaulicht den spektralen Transmissions¬ grad der Filter 6 bis 9 für folgende praktische Ausführung:OMPΓ 3 illustrates the spectral transmittance of filters 6 to 9 for the following practical implementation:
Filter 6 Plexiglas Nr. 2058 (Fa. Röhm) 6 mm Stärk Filter 7 Uvacryl-Clear (Fa. Mutzhas) 6 mm Stärke Filter 8 Te pax (Fa. Schott) 3,5 mm Stärke Filter 9 Uvisol (Fa. Desag) 3 mm StärkeFilter 6 Plexiglas No. 2058 (Röhm) 6 mm thick filter 7 Uvacryl-Clear (Mutzhas) 6 mm thick filter 8 Te pax (Schott) 3.5 mm thick filter 9 Uvisol (Desag) 3 mm thickness
Der spektrale Transmissionsgrad C in Abhängigkeit von der Wellenlänge A, ist in Fig.3 für die Filter 6 bis 9 durch die entsprechenden Kurven 6 bis 9 wiedergegeben.The spectral transmittance C as a function of the wavelength A is shown in FIG. 3 for the filters 6 to 9 by the corresponding curves 6 to 9.
Durch unterschiedliche Kombination dieser vier Filter können damit folgende dermatologische •Behandlungen durchgeführt werden:By combining these four filters differently, the following dermatological • treatments can be carried out:
Filter 6 + 8: SUP (selektive UV-Phototherapie) Filter 6 + 9: SUN (solare UV- und nahe Infra¬ rotstrahlung) Filter 7 + 8: PUVA (Photochemotherapie mit UV-A¬ Strahlung) Filter 7 + 9: UVA (Bestrahlung mit UV-A)Filters 6 + 8: SUP (selective UV phototherapy) Filters 6 + 9: SUN (solar UV and near infrared radiation) Filters 7 + 8: PUVA (photochemotherapy with UV-A radiation) Filters 7 + 9: UVA ( Irradiation with UV-A)
Fig.4 veranschaulicht den resultierenden spektra¬ len Transmissionsgrad, der sich durch Überlagerung der Transmissionskurven der beiden in Reihe geschal¬ teten Filter ergibt. Die entsprechenden Kurven in Fig.4 sind mit der aus der vorstehenden Aufstellung ersichtlichen Behandlungsweise bezeichnet. Fig.5 zeigt weiterhin die SpektralVerteilung der relativen spektralen Bestrahlungsstärke E(rel) der verwendeten Quecksilberdampf-Hochdruckstrahler (mit Eiseniodid-Dotierung) .4 illustrates the resulting spectral transmittance which results from superimposing the transmission curves of the two filters connected in series. The corresponding curves in FIG. 4 are designated with the treatment method evident from the above list. 5 also shows the spectral distribution of the relative spectral irradiance E (rel) of the high-pressure mercury vapor lamps used (with iron iodide doping).
Die Fig.6 bis 9 zeigen für die vier erläuterten Filterkombinationen die Spektralverteilung der relativen spektralen Bestrahlungsstärke. Sie ergibt sich durch Überlagerung der Kurven gemäß den Fig.4 und 5.6 to 9 show the spectral distribution of the relative spectral irradiance for the four filter combinations explained. It results from the superimposition of the curves according to FIGS. 4 and 5.
Dabei zeigenShow
Fig. 6 SUPFig. 6 SUP
Fig. 7 SUNFig. 7 SUN
Fig. 8 PUVAFig. 8 PUVA
Fig. 9 UVAFig. 9 UVA
OMPI OMPI

Claims

- 3 -Patentansprüche: - 3 patent claims:
1. Bestrahlungsgerät für photobiologische und photochemische Zwecke, vorzugsweise für der¬ matologische Zwecke, enthaltend wenigstens eine Ultraviolett-Strahlungsquelle sowie im Strahlen¬ gang angeordnete Filter, gekennzeichnet durch folgende Merkmale:1. Irradiation device for photobiological and photochemical purposes, preferably for dermatological purposes, containing at least one ultraviolet radiation source and filters arranged in the beam path, characterized by the following features:
a) es sind n* Filter (6, 7, 8, 9) vorgesehen, die zu n Filtergruppen zusammengefaßt sind;a) n * filters (6, 7, 8, 9) are provided, which are combined into n filter groups;
b) die m Filter jeder Filtergruppe sind zur ge¬ meinsamen Betätigung verbunden und alternativ in den Strahlengang einfügbar;b) the m filters of each filter group are connected for joint operation and can alternatively be inserted into the beam path;
c) die n Filtergruppen sind im Strahlengang hin¬ tereinander angeordnet und unabhängig vonein¬ ander betätigbar.c) the n filter groups are arranged one behind the other in the beam path and can be actuated independently of one another.
2. Bestrahlungsgerät nach Anspruch 1, dadurch ge¬ kennzeichnet, daß vier Filter (6, 7, 8, 9) vor¬ gesehen sind, die paarweise zu zwei Filter¬ gruppen (6, 7 und 8, 9) zusammengefaßt sind. 3. Bestrahlungsgerät nach den Ansprüchen 1 und 2, gekennzeichnet durch folgende Filter:2. Irradiation device according to claim 1, characterized ge indicates that four filters (6, 7, 8, 9) are seen vor¬, which are combined in pairs to two Filter¬ groups (6, 7 and 8, 9). 3. Irradiation device according to claims 1 and 2, characterized by the following filters:
a) in der ersten Filtergruppea) in the first filter group
a..) einen Filter (6) mit einem spektralen Transmissionsgrad gemäß Fig.3 (Kurve 6),a ..) a filter (6) with a spectral transmittance according to FIG. 3 (curve 6),
a2) einen Filter (7) mit einem spektralen Transmissionsgrad gemäß Fig.4 (Kurve 7),a 2 ) a filter (7) with a spectral transmittance according to FIG. 4 (curve 7),
b) in der zweiten Filtergruppeb) in the second filter group
b1) einen Filter (8) mit einem spektralen Transmissionsgrad gemäß Fig.3 (Kurve 8),b 1 ) a filter (8) with a spectral transmittance according to FIG. 3 (curve 8),
b~) einen Filter (9) mit einem spektralen Transmissionsgrad gemäß Fig.b ~) a filter (9) with a spectral transmittance according to FIG.
3 (Kurve 9) .3 (curve 9).
4. Bestrahlungsgerät nach Anspruch 1, dadurch ge¬ kennzeichnet, daß die m Filter jeder Filter¬ gruppe alternativ in den Strahlengang schiebbar oder schwenkbar sind.4. Irradiation device according to claim 1, characterized in that the m filters of each filter group are alternatively slidable or pivotable in the beam path.
5. Bestrahlungsgerät nach Anspruch 1, dadurch ge¬ kennzeichnet, daß die Strahlungsquelle durch wenigstens einen mit Metallhalogeniden, vor¬ zugsweise mit Eiseniodid, dotierten Queck¬ silberdampf-Hochdruckstrahler gebildet wird.5. Irradiation device according to claim 1, characterized in that the radiation source is formed by at least one mercury-vapor high-pressure lamp doped with metal halides, preferably with iron iodide.
O PI - I I -O PI - II -
Bestrahlungsgerät nach Anspruch 1 , enthaltend wenigstens einen Ventilator zur Luftkühlung der Strahlungsquelle und der Filter, dadurch gekenn¬ zeichnet, daß der Raum (17) zwischen benachbar¬ ten Filtergruppen einen .Strömungsraum für die Kühlluft bildet.Irradiation apparatus according to claim 1, comprising at least one fan for air cooling of the radiation source and the filter, characterized in that the space (17) between adjacent filter groups forms a flow space for the cooling air.
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PCT/EP1984/000226 1983-07-22 1984-07-20 Irradiation apparatus for photobiological and photochemical purposes WO1985000527A1 (en)

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DE19833326513 DE3326513A1 (en) 1983-07-22 1983-07-22 RADIATION DEVICE FOR PHOTOBIOLOGICAL AND PHOTOCHEMICAL PURPOSES
DEP3326513.5 1983-07-22

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DE3532780A1 (en) * 1985-09-13 1987-03-26 Maximilian F Prof Dr I Mutzhas RADIATION PROTECTION FILTER
DE3717393A1 (en) * 1987-05-22 1988-12-01 Mutzhas Maximilian F Irradiation unit
DE3721937A1 (en) * 1987-07-02 1989-01-12 Mutzhas Maximilian F Irradiation unit
DE3731841A1 (en) * 1986-02-03 1989-03-30 Maximilian F Prof Dr I Mutzhas Irradiation unit for improvement of the immune system
US4950903A (en) * 1988-02-09 1990-08-21 Frankena Johannes A Irradiation device
DE3927301A1 (en) * 1989-08-18 1991-04-25 Kratz Josef Gmbh Tanning appts. using UV radiator(s) - has two=part reflector for absorbing, reflecting or transmitting UV-A and B radiation
DE4026022A1 (en) * 1990-08-17 1992-02-20 Mutzhas Maximilian F UV irradiating appts. for photo-therapy of neuro-dermatitis - has spectral characteristic such that portion between 250 and 350 nm is below 1 per cent of that between 250 and 400
EP0602362A1 (en) * 1992-11-11 1994-06-22 LUXMEDICA GESELLSCHAFT FÜR LICHTTECHNIK mbH Irradiation device
EP0606897A3 (en) * 1993-01-14 1995-01-11 Imab Stiftung UV light filter.
FR2718037A1 (en) * 1994-04-04 1995-10-06 Fujishima Akira Tumor treatment apparatus.
DE19647676A1 (en) * 1996-11-19 1998-05-20 Andreas Dipl Ing Schulze Radiation production method with different light spectra
US20100234835A1 (en) * 2006-03-22 2010-09-16 Matsushita Electric Industrial Co., Ltd. Laser perforation device and laser perforation method
US7963985B2 (en) * 2004-09-21 2011-06-21 Nec Lighting, Ltd Instrument for ultraviolet irradiation and ultraviolet irradiating apparatus
EP2724747B1 (en) * 2012-10-26 2020-09-23 Sunshower Medical B.V. Medical device intended for light therapy for patients with chronic skin disease

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US1544973A (en) * 1923-09-10 1925-07-07 Dinshah P Ghadiali Color-wave-projection apparatus
GB494128A (en) * 1937-07-16 1938-10-20 Patent Treuhand Ges Fuer Elektrische Gluehlampen Mbh Improvements in lamps adapted to emit ultra-violet radiation accompanied by substantially no visible light
US2324384A (en) * 1941-06-30 1943-07-13 Warren G Grimes Ultraviolet screen for fluorescent lamps
CH546921A (en) * 1972-12-27 1974-03-15 Niethammer Fa Hellmut COLOR CHANGING DEVICE ON A STAGE OR STUDIO SPOTLIGHT.
DE2437078A1 (en) * 1974-08-01 1976-02-19 Original Hanau Quarzlampen Adjustable ultra violet lamp - has sliding and rotating filter tubes with ends slanted and overlapping
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WO1983002233A1 (en) * 1981-12-24 1983-07-07 Mutzhas, Maximilian, F. Ultra-violet radiation apparatus for the phototherapy of dermatosis and particularly of psoriasis

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3532780A1 (en) * 1985-09-13 1987-03-26 Maximilian F Prof Dr I Mutzhas RADIATION PROTECTION FILTER
DE3731841A1 (en) * 1986-02-03 1989-03-30 Maximilian F Prof Dr I Mutzhas Irradiation unit for improvement of the immune system
DE3734852A1 (en) * 1986-02-03 1989-04-27 Mutzhas Maximilian F Irradiation unit for forming (endogenous) cancer-inhibiting matter
DE3717393A1 (en) * 1987-05-22 1988-12-01 Mutzhas Maximilian F Irradiation unit
DE3721937A1 (en) * 1987-07-02 1989-01-12 Mutzhas Maximilian F Irradiation unit
DE3732241A1 (en) * 1987-07-02 1989-04-20 Mutzhas Maximilian F Irradiation unit
US4950903A (en) * 1988-02-09 1990-08-21 Frankena Johannes A Irradiation device
DE3927301A1 (en) * 1989-08-18 1991-04-25 Kratz Josef Gmbh Tanning appts. using UV radiator(s) - has two=part reflector for absorbing, reflecting or transmitting UV-A and B radiation
DE4026022A1 (en) * 1990-08-17 1992-02-20 Mutzhas Maximilian F UV irradiating appts. for photo-therapy of neuro-dermatitis - has spectral characteristic such that portion between 250 and 350 nm is below 1 per cent of that between 250 and 400
EP0602362A1 (en) * 1992-11-11 1994-06-22 LUXMEDICA GESELLSCHAFT FÜR LICHTTECHNIK mbH Irradiation device
EP0606897A3 (en) * 1993-01-14 1995-01-11 Imab Stiftung UV light filter.
FR2718037A1 (en) * 1994-04-04 1995-10-06 Fujishima Akira Tumor treatment apparatus.
US5855595A (en) * 1994-04-04 1999-01-05 Asahi Kogaku Kogyo Kabushiki Kaisha Tumor treatment apparatus
FR2777466A1 (en) * 1994-04-04 1999-10-22 Akira Fujishima TUMOR TREATMENT APPARATUS
DE19647676A1 (en) * 1996-11-19 1998-05-20 Andreas Dipl Ing Schulze Radiation production method with different light spectra
US7963985B2 (en) * 2004-09-21 2011-06-21 Nec Lighting, Ltd Instrument for ultraviolet irradiation and ultraviolet irradiating apparatus
US20100234835A1 (en) * 2006-03-22 2010-09-16 Matsushita Electric Industrial Co., Ltd. Laser perforation device and laser perforation method
US8394085B2 (en) * 2006-03-22 2013-03-12 Panasonic Corporation Laser perforation device and laser perforation method
EP2724747B1 (en) * 2012-10-26 2020-09-23 Sunshower Medical B.V. Medical device intended for light therapy for patients with chronic skin disease

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DE3326513A1 (en) 1985-01-31
EP0149663A1 (en) 1985-07-31

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