WO1983000477A1 - Two-piece hardshell gelatin capsule and method for manufacture - Google Patents
Two-piece hardshell gelatin capsule and method for manufacture Download PDFInfo
- Publication number
- WO1983000477A1 WO1983000477A1 PCT/US1981/001019 US8101019W WO8300477A1 WO 1983000477 A1 WO1983000477 A1 WO 1983000477A1 US 8101019 W US8101019 W US 8101019W WO 8300477 A1 WO8300477 A1 WO 8300477A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- body member
- cap member
- cap
- hardshell
- digestible
- Prior art date
Links
- 239000007903 gelatin capsule Substances 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 title claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 title abstract description 6
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 238000007789 sealing Methods 0.000 claims abstract description 10
- 108010010803 Gelatin Proteins 0.000 claims abstract description 7
- 229920000159 gelatin Polymers 0.000 claims abstract description 7
- 239000008273 gelatin Substances 0.000 claims abstract description 7
- 235000019322 gelatine Nutrition 0.000 claims abstract description 7
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 7
- 230000000295 complement effect Effects 0.000 claims abstract 3
- 239000002775 capsule Substances 0.000 claims description 16
- 238000003466 welding Methods 0.000 claims 7
- 241000282320 Panthera leo Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
Definitions
- Liquid leach and leakage problems have plagued procedures intended for filling and sealing of liquid - containing capsules intended for oral use. Complicated filling and sealing procedures, tried in an effort to remedy the difficulties, have failed to enable production, at low cost, of consistently reliable, leak proof, practical quantity production of such products.
- the invention overcomes the foregoing and other ojections to procedures in the prior art, by providing a hermetically sealed, two-piece, hardshell, liquid filled, elongated gelatin capsule, readily soluble internally of the body when swallowed, and capable of consistently practical reliable quantity production, at low cost, of such capsules.
- the capsule of the invention comprises two-piece hardshell gelatin capsule having a gelatin hardshell cap member formed with a stepped, controured, marginal portion for closing registration 360° with the open end of a hardshell gelatin capsule body, an elongated apron portion depending from the cap portion and telescopically contiguously overlapping the upper end of the body member.
- ultrasonic means are applied to said telescopically overlapping portions of the cap and body member on alignment registration thereof, achieving a 360 hermetic sealing of the capsule, and further achieving a closed gelatin capsule which may be readily swallowed, rapidly dissolved and digested in the body, with prompt release of the contents of the capsule into the bloodstream, and which may be manufacturered in quantities at low cost, in consistently reliable, practical form.
- gelatin is used herein to designate the material of which the capsule of the invention is made, comprises a non-synthetic, substantially tasteless and odorless dried protein, readily soluble, digestible and compatible, when taken orally, and dissolving readily when swallowed. Formed by boiling the bones, shins, and tendons of animals.
- FIGURE 1 is a vertical, sectional, assembled view of a two-part digestible gelatin capsule, comprising a hard shell gelatin cap member and a hardshell gelatin body member, shown assembled preparatory to being inserted into a holding fixture,
- FIGURE 2 is a side elevational view of the assembled capsule positioned in and extending out of a fixture shown in dotted lines,
- FIGURE 3 is a vertical sectional view of an ultrasonic horn fixture which may be used in carrying out the invention
- FIGURE 4 is a side elevational view of the assembled capsule in the fixture (shown in dotted lines), the ultrasonic horn being applied to the capsule to weld the cap and body member, and
- FIGURE 5 is a medial vertical sectional view of the upper portions of the capsule cap and body member so welded together and thus ultrasonically sealed 360o .
- the hard-shelled soluble and digestible gelatin capsule comprises a U-shaped body member 10 wherein may be positioned liquids or pharmaceutical products, and a cap member 11 having a dome end portion 12 and having an outwardly stepped circumferential rim portion 13 formed to telescopically register, on assembly with the free upper end portion 14 of the body member.
- the cap member is provided with a depending skirt portion 15 below the stepped rim portion 13; on assembly of the parts (Fig. 1) the stepped rim portion 13 of the cap overlies the free upper end 14 of the body member 10 in closing relation, the depending skirt portion 15 of the cap member telescopically registering with and contiguously overlying the upper portion 16 of the body member.
- the cap member 11 and body member 10 of the capsule are shown in closed relation in Fig. 1 and positioned in a fixture 17 in Fig. 2, with the stepped rim cap portion 13 and adjacent depending apron portion thereof disposed outwardly of the fixture 17.
- An ultrasonic horn 21 is positioned over the assembled parts (Fig. 4) in overlying relation to the stepped rim portion 13 of the cap and adjacent apron portion 15 telescopically registered with the upper portion 16 of the body member within the horn.
- the horn Upon being energized by any well-known ultrasonic means, the horn will ultrasonically hermetic ally seal for 360o to thereby weld, as noted at 23 (Fig. 5) and unify the outwardly stepped portion 13 of the cap member to the upper end 14 of the body member.
- the fixture 17 may be turntable or other practical form of a multi-unit fixture wherein a large number of capsules may be simultaneously so formed and sealed.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Lining Or Joining Of Plastics Or The Like (AREA)
- Package Closures (AREA)
- Closures For Containers (AREA)
Abstract
An alongated, two-piece, hardshell gelatin capsule (12), to be taken orally, comprising a C-shaped body member (10) into which may be inserted a liquid, and a digestible hard-shell gelatin cap member (11) formed with a stepped free marginal edge portion (13) complementary to the body member, telescopically registrable with the free upper end (14) of the body and welded thereto in overlapping hermetically sealing, closing relation, and method for manufacture.
Description
TWO-PIECE HARDSHELL GELATIN CAPSULE AND METHOD FOR MANUFACTURE
BACKGROUND OF THE INVENTION
Liquid leach and leakage problems have plagued procedures intended for filling and sealing of liquid - containing capsules intended for oral use. Complicated filling and sealing procedures, tried in an effort to remedy the difficulties, have failed to enable production, at low cost, of consistently reliable, leak proof, practical quantity production of such products.
OBJECTS AND SUMMARY OF THE INVENTION
The invention overcomes the foregoing and other ojections to procedures in the prior art, by providing a hermetically sealed, two-piece, hardshell, liquid filled, elongated gelatin capsule, readily soluble internally of the body when swallowed, and capable of consistently practical reliable quantity production, at low cost, of such capsules. The capsule of the invention comprises two-piece hardshell gelatin capsule having a gelatin hardshell cap member formed with a stepped, controured, marginal portion for closing registration 360° with the open end of a hardshell gelatin capsule body, an elongated apron portion depending from the cap portion and telescopically contiguously overlapping the upper end of the body member.
Pursuant to the invention, ultrasonic means are applied to said telescopically overlapping portions of the cap and body member on alignment registration thereof, achieving a 360 hermetic sealing of the capsule, and further achieving a closed gelatin capsule which may be readily swallowed, rapidly dissolved and digested in the body, with prompt release of the contents of the capsule into the bloodstream, and which may be manufacturered in quantities at low cost, in consistently reliable, practical form.
The term "gelatin" is used herein to designate the material of which the capsule of the invention is made, comprises a non-synthetic, substantially tasteless and odorless dried protein, readily
soluble, digestible and compatible, when taken orally, and dissolving readily when swallowed. Formed by boiling the bones, shins, and tendons of animals.
DESCRIPTION OF THE DRAWINGS
In the drawings, illustrating preferred embodiments of the invention, and wherein similar reference characters, indicate like parts: FIGURE 1 is a vertical, sectional, assembled view of a two-part digestible gelatin capsule, comprising a hard shell gelatin cap member and a hardshell gelatin body member, shown assembled preparatory to being inserted into a holding fixture,
FIGURE 2 is a side elevational view of the assembled capsule positioned in and extending out of a fixture shown in dotted lines,
FIGURE 3 is a vertical sectional view of an ultrasonic horn fixture which may be used in carrying out the invention,
FIGURE 4 is a side elevational view of the assembled capsule in the fixture (shown in dotted lines), the ultrasonic horn being applied to the capsule to weld the cap and body member, and
FIGURE 5 is a medial vertical sectional view of the upper portions of the capsule cap and body member so welded together and thus ultrasonically sealed 360º .
DESCRIPTION OF PREFERRED EMBODIMENTS
In preferred embodiments of the invention, as shown in the drawings, the hard-shelled soluble and digestible gelatin capsule comprises a U-shaped body member 10 wherein may be positioned liquids or pharmaceutical products, and a cap member 11 having a dome end portion 12 and having an outwardly stepped circumferential rim portion 13 formed to telescopically register, on assembly with the free upper end portion 14 of the body member. The cap member is provided with a depending skirt portion 15 below the stepped rim portion 13; on assembly of the parts (Fig. 1) the stepped rim portion 13 of the cap overlies the free upper end 14 of the body member 10 in closing relation, the depending skirt portion 15 of the cap member telescopically registering with and contiguously overlying the upper portion 16 of the body member.
The cap member 11 and body member 10 of the capsule are shown in closed relation in Fig. 1 and positioned in a fixture 17 in Fig. 2, with the stepped rim cap portion 13 and adjacent depending apron portion thereof disposed outwardly of the fixture 17. An ultrasonic horn 21 is positioned over the assembled parts (Fig. 4) in overlying relation to the stepped rim portion 13 of the cap and adjacent apron portion 15 telescopically registered with the upper portion 16 of the body member within the horn. Upon being energized by any well-known ultrasonic means, the horn will ultrasonically hermetic ally seal for 360º to thereby weld, as noted at 23
(Fig. 5) and unify the outwardly stepped portion 13 of the cap member to the upper end 14 of the body member.
The fixture 17 may be turntable or other practical form of a multi-unit fixture wherein a large number of capsules may be simultaneously so formed and sealed.
The preferred embodiment of the invention has been set forth above. It is to be understood, however, that variations may be made in such preferred embodiment, which variations may nevertheless be within the scope and spirit of the invention. The invention is therefore to be broadly construed, within the scope and spirit of the appended claims.
Claims
1. The method of forming a hermetically sealed, two-part soluble capsule comprising: forming one part cap member of hardshell gelatin and a stepped rim portion thereon telescopically complementary to said stepped rim portion of the cap member positioning the body member in a fixture in upwardly opening relation, positioning the cap member onto the free upper end of the body member, forming a capsule body member of hardshell gelatin and of C-shaped outline and positioning the outwardly stepped portion of the cap member in registry with the free end of the body member and in overlapping relation thereto, and welding said cap member marginal stepped portion and the free upper end of the body member together.
2. In the method of hermetically sealing a two-part, soluble digestible hardshell gelatin capsule, as set forth in claim 1, the further steps comprising: forming the cap member with an apron portion depending from the marginal stepped rim portion thereof, positioning the cap member with said apron portion in overlying relation to the upper end of the body member, and so welding cap member to the body member with the apron portion of the cap member in overlying parallel relation to the body member.
3. In the method of hermetically sealing a two-part, soluble digestible hardshell gelatin capsule, as set forth in claim 1, the further steps comprising: forming the cap member with an apron portion depending from the marginal stepped rim portion, positioning the cap member with said apron portion in overlying relation ship to the upper end of the body member, and so welding the apron portion of the cap member in overlying parallel relation to the body member.
4. In the method of hermetically sealing a two-part, soluble, digestible liquid containing hardshell gelatin capsule set forth in claim 1, the further step comprising: applying ultrasonic means to the said cap member stepped portion and to the free end of the body member, so welding them together.
5. In the method of hermetically sealing a two-part soluble liquid containig digestible hardshell gelatin capsule as set forth in claim 1, the further step comprising: so forming said weld as a continuous 360º weld.
6. In the method of hermetically sealing a two-part digestible hardshell gelatin capsule, as set forth in claim 1, the further steps comprising: positioning the body member in a fixture with the free end thereof upwardly disposed, and with said rim of the cap registered with said free end, and so welding the so positioned cap member to the body member.
7. In the method of heremetically sealing a two-part soluble, liquid containing digestible hardshell gelatin capsule, as set forth in claim 1, the further steps comprising: positioning the body member in a fixture, with the free end thereof upwardly disposed, and with the rim of the cap disposed on said free end, and so welding the cap member and body member, ultrasonically.
8. A two-piece hardshell, soluble and digestible liquid containing gelatin capsule, comprising: a U-shaped body member, said body member having a closed lower end and an open, free upper end, a cap member formed for complementary registration onto the upper end of the body mmember, an outwardly stepped, contoured marginal rim portion formed on the cap member for so registering it with said upper free end of the body member, said stepped rim portion of said cap member being welded to the upper free end of the body member and thereby closing said capsule.
9. In a two-piece hardshell soluble and digestible gelatin capsule, as set forth in claim 8, an apron portion depending from the offset rim portion of the cap member, the upper end of the body member being received within said apron portion and being held adjacent thereto upon welding the cap member and body member.
10. In a two piece hardshell digestible soluble and gelatin capsule as set forth in claim 8: said stepped rim portion of the cap member being so welded to the upper end of the body member ultrasonically.
11. In a two-piece hardshell soluble and digestible gelatin capsule, as set forth in claim 8: an apron portion on the cap member depending from the stepped rim portion thereof, and said stepped rim portion of the cap member being so welded to the free end of the body member.
12. In a two-piece soluble and digestible hardshell gelatin capsule as set forth in claim 8: said cap member offset rim portion and body member being ultrasonically so welded together for 360º .
13. A two-piece hardshell, soluble and digestible liquid containing gelatin capsule comprising: a U-shaped body member having a closed lowe and an open free end terminating in an upper edge; a cap member for receeiving the upper end of said U-shaped body member, said cap member including a continuous interior rim formed in said cap member for abuttingly engaging said upper edge of said Ushaped body member when said capsule is in the assembled state, said cap member further including an apron portion depending from said interior rim; and substantially continuous and substantially liquid impervious interior ultrasonic weld means for attaching said upper edge of said U-shaped body member to said interior rim thereby forming an interior ultrasonic weld which extends continuously 360 around said upper edge of said U-shaped body member.
14. The apparatus of claim 19 wherein said cap member is shorter in length than said U-shaped body member.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1981/001019 WO1983000477A1 (en) | 1981-07-30 | 1981-07-30 | Two-piece hardshell gelatin capsule and method for manufacture |
| EP81902190A EP0084529B1 (en) | 1981-07-30 | 1981-07-30 | Two-piece hardshell gelatin capsule and method for manufacture |
| JP50268881A JPS58501157A (en) | 1981-07-30 | 1981-07-30 | Two-part hard shell gelatin capsule and method for manufacturing the same |
| AT81902190T ATE23975T1 (en) | 1981-07-30 | 1981-07-30 | TWO-PIECE HARD-SHELL GELATIN CAPSULE AND METHOD OF MANUFACTURE. |
| DE8181902190T DE3175671D1 (en) | 1981-07-30 | 1981-07-30 | Two-piece hardshell gelatin capsule and method for manufacture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1981/001019 WO1983000477A1 (en) | 1981-07-30 | 1981-07-30 | Two-piece hardshell gelatin capsule and method for manufacture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1983000477A1 true WO1983000477A1 (en) | 1983-02-17 |
Family
ID=22161339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1981/001019 WO1983000477A1 (en) | 1981-07-30 | 1981-07-30 | Two-piece hardshell gelatin capsule and method for manufacture |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0084529B1 (en) |
| JP (1) | JPS58501157A (en) |
| AT (1) | ATE23975T1 (en) |
| DE (1) | DE3175671D1 (en) |
| WO (1) | WO1983000477A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0129445A1 (en) * | 1983-06-20 | 1984-12-27 | Cosden Technology Inc. | Process for forming tamper-resistant tamper-indicative capsules |
| CN101953816A (en) * | 2010-09-08 | 2011-01-26 | 浙江昂利康胶囊有限公司 | Medicinal hollow capsules and preparation method and manufacturing equipment thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US525845A (en) * | 1894-09-11 | Riley p | ||
| US2102885A (en) * | 1935-10-21 | 1937-12-21 | John O Carroll | Individual cosmetic container structure |
| US3173840A (en) * | 1962-04-30 | 1965-03-16 | Lilly Co Eli | Separation-resistant capsule |
| US3258115A (en) * | 1965-05-12 | 1966-06-28 | Scherer Corp R P | Two-piece hard gelatin capsule |
| US3438824A (en) * | 1965-05-14 | 1969-04-15 | Cavitron Corp | Method and apparatus for joining a closure to a container by high frequency radial vibrations |
| US3549440A (en) * | 1967-10-26 | 1970-12-22 | United Glass Ltd | Method for sealing a membrane to the mouth of a container utilizing induced radio frequency current |
| US3927195A (en) * | 1974-01-31 | 1975-12-16 | Lilly Industries Ltd | Production of capsules |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1217024B (en) * | 1961-07-10 | 1966-05-18 | Hoefliger & Karg | Filling and closing machine for two-part capsules |
| US3285408A (en) * | 1964-10-16 | 1966-11-15 | Lilly Co Eli | Capsule with integral locking band |
| US3556884A (en) * | 1966-05-02 | 1971-01-19 | Lusteroid Container Co Inc | Plastic tube construction |
-
1981
- 1981-07-30 AT AT81902190T patent/ATE23975T1/en active
- 1981-07-30 DE DE8181902190T patent/DE3175671D1/en not_active Expired
- 1981-07-30 WO PCT/US1981/001019 patent/WO1983000477A1/en active IP Right Grant
- 1981-07-30 JP JP50268881A patent/JPS58501157A/en active Pending
- 1981-07-30 EP EP81902190A patent/EP0084529B1/en not_active Expired
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US525845A (en) * | 1894-09-11 | Riley p | ||
| US2102885A (en) * | 1935-10-21 | 1937-12-21 | John O Carroll | Individual cosmetic container structure |
| US3173840A (en) * | 1962-04-30 | 1965-03-16 | Lilly Co Eli | Separation-resistant capsule |
| US3258115A (en) * | 1965-05-12 | 1966-06-28 | Scherer Corp R P | Two-piece hard gelatin capsule |
| US3438824A (en) * | 1965-05-14 | 1969-04-15 | Cavitron Corp | Method and apparatus for joining a closure to a container by high frequency radial vibrations |
| US3549440A (en) * | 1967-10-26 | 1970-12-22 | United Glass Ltd | Method for sealing a membrane to the mouth of a container utilizing induced radio frequency current |
| US3927195A (en) * | 1974-01-31 | 1975-12-16 | Lilly Industries Ltd | Production of capsules |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0129445A1 (en) * | 1983-06-20 | 1984-12-27 | Cosden Technology Inc. | Process for forming tamper-resistant tamper-indicative capsules |
| CN101953816A (en) * | 2010-09-08 | 2011-01-26 | 浙江昂利康胶囊有限公司 | Medicinal hollow capsules and preparation method and manufacturing equipment thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0084529A4 (en) | 1984-11-22 |
| EP0084529A1 (en) | 1983-08-03 |
| JPS58501157A (en) | 1983-07-21 |
| DE3175671D1 (en) | 1987-01-15 |
| EP0084529B1 (en) | 1986-12-03 |
| ATE23975T1 (en) | 1986-12-15 |
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