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WO1982001990A1 - Ciment osseux - Google Patents

Ciment osseux Download PDF

Info

Publication number
WO1982001990A1
WO1982001990A1 PCT/NO1981/000044 NO8100044W WO8201990A1 WO 1982001990 A1 WO1982001990 A1 WO 1982001990A1 NO 8100044 W NO8100044 W NO 8100044W WO 8201990 A1 WO8201990 A1 WO 8201990A1
Authority
WO
WIPO (PCT)
Prior art keywords
silver
bone cement
volume
protheses
quartz
Prior art date
Application number
PCT/NO1981/000044
Other languages
English (en)
Inventor
Karen S Christiansen
Tor Christiansen
Original Assignee
Karen S Christiansen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karen S Christiansen filed Critical Karen S Christiansen
Publication of WO1982001990A1 publication Critical patent/WO1982001990A1/fr
Priority to FI822742A priority Critical patent/FI822742L/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Definitions

  • the invention relates to bone cement especially for cementing protheses, in particular protheses components for joint caps and bone marrow canals.
  • the invention relates to a bone cement which is characterized by comprising polymethylmethacrylate, a filler material and a silver ion-releasing material.
  • the new cement is substantially stronger than the cement used previously, as may be seen from the table found below.
  • the increased strength is obtained by the addition of filler in the form of particles of glass fiber or quartz having a particle size of 4 - 8 microns.
  • a silver ion-releasing material is also added to the cement, preferably in the form of colloidal silver having an express germicidal and anti-bacterial effect.
  • Colloidal silver solutions are combinations of insoluble forms, of silver such as iodides, chlorides, oxides, etc., with protective colloids, usually organic.
  • the insoluble forms of silver are precipitated in the presence of the protective colloids (for example, gelatins) in such manner that the particle size is very small and the particles do not settle but remain in suspension, and the resulting Liquid has many of the advantages of an actual solution.
  • the protective colloids for example, gelatins
  • These small particles of silver compounds act as reservoirs which release silver ions in a controlle manner and in small amounts; the actual concentration of silver ions will vary according to the nature of the silver compound present.
  • this colloidal silver has a so-called oligodynamic effect, in that silver ions are continuously released over a long period of time.
  • the silver ions will pass through the membrane of the bacteria and into the DNA molecule, in this way preventing propagation of the bacteria.
  • the ratio of the three components of the bone cement mixture can vary as may be seen from the table founl below, which shows the results of tests carried out by Det Norske Veritas.
  • the curing time is about 6 - 7 minutes and the curing temperature rises to about 90°C for a 10-mm thick layer.
  • the curing time is 12-14 minutes under similar conditions.
  • the curing time is 20-25 minutes, and. the curing temperature about 45°C. Since a curing time of as long as 20-25 minutes is impractical, the preferred bone cement comprises 65% polymethylmethacrylate with an addition of 30% quartz particles and 5% colloidal silver.
  • the quartz particles are more irregular and thus provide a larger surface area, than glass fiber particles.
  • the particle size for either quartz or glass fiber is between 4 and 8 microns.
  • the larger surface area of the quartz particles may possibly help to make the cement less toxic by absorbing monomers, and one thereby also avoids the harmful high curing temperature. Bending tests were carried out at Det Norske Veritas on test rods made of polymethylmethacrylate alone and on test rods made of the bone cement of the invention. The results were as follows;
  • A pure cement (polymethylmethacrylate).
  • the bone cement of the invention should preferably be used for the cementing of protheses, especially protheses components in joint caps and bone marrow canals, and the results obtained up to now have been very satisfactory.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Dental Preparations (AREA)
  • Materials For Medical Uses (AREA)
  • Catalysts (AREA)

Abstract

Ciment osseux destine a etre utilise dans l'assemblage de protheses, en particulier de composants de protheses pour des articulations et des canaux medullaires. Le ciment osseux comprend un polymethylmethacrylate, un materiau de remplissage sous la forme de particules de fibre de verre ou de quartz possedant des dimensions de 4 a 8 microns, et un materiau liberant des ions argent sous la forme d'argent colloidal (sel-d'argent).
PCT/NO1981/000044 1980-12-09 1981-12-08 Ciment osseux WO1982001990A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI822742A FI822742L (fi) 1980-12-09 1982-08-06 Bencement

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO803713801209 1980-12-09
NO803713A NO146306C (no) 1980-12-09 1980-12-09 Bensement og anvendelse derav.

Publications (1)

Publication Number Publication Date
WO1982001990A1 true WO1982001990A1 (fr) 1982-06-24

Family

ID=19885784

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NO1981/000044 WO1982001990A1 (fr) 1980-12-09 1981-12-08 Ciment osseux

Country Status (5)

Country Link
EP (1) EP0066587A1 (fr)
BE (1) BE891374A (fr)
DK (1) DK352882A (fr)
NO (1) NO146306C (fr)
WO (1) WO1982001990A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0190504A2 (fr) * 1984-12-28 1986-08-13 Johnson Matthey Public Limited Company Compositions antimicrobiennes
EP0219058A2 (fr) * 1985-10-09 1987-04-22 Ernst Mühlbauer KG Mélange polymérisable pour ciment
DE10043151A1 (de) * 2000-08-31 2002-03-28 Peter Steinruecke Knochenzement mit antimikrobieller Wirksamkeit
US7476698B2 (en) 2001-09-18 2009-01-13 Bio-Gate Ag Antimicrobial adhesive and coating substance and method for the production thereof
WO2009036862A2 (fr) 2007-09-12 2009-03-26 Trovotech Gmbh Compositions à effet antimicrobien
ITTO20090518A1 (it) * 2009-07-10 2011-01-11 Torino Politecnico Cementi ossei compositi a matrice di pmma, contenenti vetri e vetroceramici bioattivi ed antibatterici
EP2732830A1 (fr) 2012-11-16 2014-05-21 Heraeus Medical GmbH Ciment osseux en polyméthylméthacrylate antiseptique
DE102016212091A1 (de) 2016-07-04 2018-01-04 Heraeus Medical Gmbh Antiseptischer Polymethylmethacrylat-Knochenzement
US9872501B2 (en) 2007-10-08 2018-01-23 Johnson & Johnson Vision Care, Inc. Methods for forming stabilized metal salt particles

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2347567A (en) * 1943-03-11 1944-04-25 Edward J Kresse Dental implant
US3932627A (en) * 1974-02-04 1976-01-13 Rescue Products, Inc. Siver-heparin-allantoin complex
DE2724814B2 (de) * 1977-06-02 1979-07-26 Kulzer & Co Gmbh, 6380 Bad Homburg Vorprodukt für die Zubereitung von Knochenzement
DE2906413A1 (de) * 1978-02-22 1980-01-10 S E P C S A R L Societe D Expl Zement fuer prothesenimplantate
WO1981002667A1 (fr) * 1980-03-27 1981-10-01 Nat Res Dev Implants chirurgicaux antimicrobiens

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2347567A (en) * 1943-03-11 1944-04-25 Edward J Kresse Dental implant
US3932627A (en) * 1974-02-04 1976-01-13 Rescue Products, Inc. Siver-heparin-allantoin complex
DE2724814B2 (de) * 1977-06-02 1979-07-26 Kulzer & Co Gmbh, 6380 Bad Homburg Vorprodukt für die Zubereitung von Knochenzement
DE2906413A1 (de) * 1978-02-22 1980-01-10 S E P C S A R L Societe D Expl Zement fuer prothesenimplantate
WO1981002667A1 (fr) * 1980-03-27 1981-10-01 Nat Res Dev Implants chirurgicaux antimicrobiens

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0190504A2 (fr) * 1984-12-28 1986-08-13 Johnson Matthey Public Limited Company Compositions antimicrobiennes
EP0190504A3 (en) * 1984-12-28 1987-05-20 Johnson Matthey Public Limited Company Antimicrobial compositions
EP0219058A2 (fr) * 1985-10-09 1987-04-22 Ernst Mühlbauer KG Mélange polymérisable pour ciment
EP0219058A3 (en) * 1985-10-09 1988-03-02 Ernst Muhlbauer Kg Polymerizable cement mixtures
DE10043151A1 (de) * 2000-08-31 2002-03-28 Peter Steinruecke Knochenzement mit antimikrobieller Wirksamkeit
US6984392B2 (en) * 2000-08-31 2006-01-10 Bio-Gate Bioinnovative Materials Gmbh Antimicrobial material for implanting in bones
EP1621217A2 (fr) 2000-08-31 2006-02-01 Bio-Gate Bioinnovative Materials GmbH Poudre et matériau antimicrobiens
EP1621217A3 (fr) * 2000-08-31 2006-06-28 Bio-Gate Bioinnovative Materials GmbH Poudre et matériau antimicrobiens
US7476698B2 (en) 2001-09-18 2009-01-13 Bio-Gate Ag Antimicrobial adhesive and coating substance and method for the production thereof
EP2234496A2 (fr) * 2007-09-12 2010-10-06 Trovotech Gmbh Compositions a effet antimicrobien
WO2009036862A2 (fr) 2007-09-12 2009-03-26 Trovotech Gmbh Compositions à effet antimicrobien
US9872501B2 (en) 2007-10-08 2018-01-23 Johnson & Johnson Vision Care, Inc. Methods for forming stabilized metal salt particles
ITTO20090518A1 (it) * 2009-07-10 2011-01-11 Torino Politecnico Cementi ossei compositi a matrice di pmma, contenenti vetri e vetroceramici bioattivi ed antibatterici
WO2011004355A2 (fr) 2009-07-10 2011-01-13 Politecnico Di Torino Ciments osseux composites à matrice pmma, contenant des verres ou des vitrocéramiques antibactériens bioactifs
WO2011004355A3 (fr) * 2009-07-10 2011-10-13 Politecnico Di Torino Ciments osseux composites à matrice pmma, contenant des verres ou des vitrocéramiques antibactériens bioactifs
EP2732830A1 (fr) 2012-11-16 2014-05-21 Heraeus Medical GmbH Ciment osseux en polyméthylméthacrylate antiseptique
DE102012022419A1 (de) 2012-11-16 2014-05-22 Heraeus Medical Gmbh Antiseptischer Polymethylmethacrylat-Knochenzement
US9833472B2 (en) 2012-11-16 2017-12-05 Heraeus Medical Gmbh Antiseptic polymethylmethacrylate bone cement
DE102016212091A1 (de) 2016-07-04 2018-01-04 Heraeus Medical Gmbh Antiseptischer Polymethylmethacrylat-Knochenzement
EP3266473A1 (fr) 2016-07-04 2018-01-10 Heraeus Medical GmbH Ciment osseux en polyméthylméthacrylate antiseptique
US10322207B2 (en) 2016-07-04 2019-06-18 Heraeus Medical Gmbh Antiseptic polymethylmethacrylate bone cement

Also Published As

Publication number Publication date
BE891374A (fr) 1982-03-31
DK352882A (da) 1982-08-06
NO146306B (no) 1982-06-01
NO146306C (no) 1982-09-08
NO803713L (no) 1982-06-01
EP0066587A1 (fr) 1982-12-15

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