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TN2012000192A1 - N1-pyrazolospirocetones inhibitrices d'acetyl-coa-carboxylase - Google Patents

N1-pyrazolospirocetones inhibitrices d'acetyl-coa-carboxylase

Info

Publication number
TN2012000192A1
TN2012000192A1 TNP2012000192A TN2012000192A TN2012000192A1 TN 2012000192 A1 TN2012000192 A1 TN 2012000192A1 TN P2012000192 A TNP2012000192 A TN P2012000192A TN 2012000192 A TN2012000192 A TN 2012000192A TN 2012000192 A1 TN2012000192 A1 TN 2012000192A1
Authority
TN
Tunisia
Prior art keywords
acetyl
coa
pyrazolospirocetones
carboxylase inhibitor
compound
Prior art date
Application number
TNP2012000192A
Other languages
English (en)
Inventor
Scott William Bagley
David Andrew Griffith
Daniel Wei-Shung Kung
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TN2012000192A1 publication Critical patent/TN2012000192A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un composé de formule (I) ou un sel pharmaceutiquement acceptable du composé, dans lequel R1, R2, R3 et R4 sont tels que présentement décrits; des compositions pharmaceutiques de celui-ci; et l'utilisation de celui-ci dans le traitement de maladies, affections ou troubles modulés par l'inhibition d'une ou des enzyme(s) acétyl-CoA carboxylase(s) chez un animal.
TNP2012000192A 2009-11-10 2012-04-25 N1-pyrazolospirocetones inhibitrices d'acetyl-coa-carboxylase TN2012000192A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25982309P 2009-11-10 2009-11-10
PCT/IB2010/054908 WO2011058474A1 (fr) 2009-11-10 2010-10-29 Inhibiteurs de n1-pyrazolospirocétone acétyl-coa carboxylase

Publications (1)

Publication Number Publication Date
TN2012000192A1 true TN2012000192A1 (fr) 2013-12-12

Family

ID=43357094

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2012000192A TN2012000192A1 (fr) 2009-11-10 2012-04-25 N1-pyrazolospirocetones inhibitrices d'acetyl-coa-carboxylase

Country Status (40)

Country Link
US (4) US8288405B2 (fr)
EP (3) EP2676958B1 (fr)
JP (1) JP5114610B1 (fr)
KR (2) KR101550557B1 (fr)
CN (1) CN102695708B (fr)
AP (1) AP3283A (fr)
AR (1) AR078944A1 (fr)
AU (1) AU2010317501B2 (fr)
BR (1) BR112012011072A2 (fr)
CA (1) CA2778886C (fr)
CL (1) CL2012000999A1 (fr)
CO (1) CO6541569A2 (fr)
CR (1) CR20120190A (fr)
CU (1) CU24077B1 (fr)
DK (1) DK2499139T3 (fr)
DO (1) DOP2012000128A (fr)
EA (1) EA020153B1 (fr)
EC (1) ECSP12011880A (fr)
ES (1) ES2444543T3 (fr)
GE (1) GEP20146169B (fr)
HK (1) HK1173724A1 (fr)
HN (1) HN2012000973A (fr)
HR (1) HRP20140025T1 (fr)
IL (1) IL219373A (fr)
MA (1) MA33734B1 (fr)
MX (1) MX2012005429A (fr)
NI (1) NI201200089A (fr)
NZ (1) NZ599815A (fr)
PE (1) PE20121469A1 (fr)
PH (1) PH12012500903A1 (fr)
PL (1) PL2499139T3 (fr)
PT (1) PT2499139E (fr)
RS (1) RS53156B (fr)
SI (1) SI2499139T1 (fr)
TN (1) TN2012000192A1 (fr)
TW (1) TWI394756B (fr)
UA (1) UA102336C2 (fr)
UY (1) UY33020A (fr)
WO (1) WO2011058474A1 (fr)
ZA (1) ZA201204231B (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2545231T3 (es) 2008-05-28 2015-09-09 Pfizer Inc. Inhibidores de pirazoloespirocetona acetil-CoA carboxilasa
EP2845856A1 (fr) 2009-06-29 2015-03-11 Incyte Corporation Pyrimidinones en tant qu'inhibiteurs de PI3K
PH12012500903A1 (en) 2009-11-10 2014-09-24 Pfizer N1 - pyrazolospiroketone acetyl-coa carboxylase inhibitors
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
EP2345643A1 (fr) * 2009-12-29 2011-07-20 Polichem S.A. Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide et leurs utilisations
WO2011130342A1 (fr) 2010-04-14 2011-10-20 Incyte Corporation Dérivés condensés en tant qu'inhibiteurs de ρi3κδ
WO2011163195A1 (fr) 2010-06-21 2011-12-29 Incyte Corporation Dérivés condensés de pyrrole en tant qu'inhibiteurs de pi3k
US8859577B2 (en) 2010-09-30 2014-10-14 Pfizer Inc. N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors
CN103189377B (zh) 2010-10-29 2015-02-25 辉瑞大药厂 N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂
AR084366A1 (es) 2010-12-20 2013-05-08 Incyte Corp N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (fr) 2011-03-25 2012-10-04 Incyte Corporation Dérivés de pyrimidine-4,6-diamine en tant qu'inhibiteurs de pi3k
AP3499A (en) 2011-04-22 2015-12-31 Pfizer Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors
AR087760A1 (es) 2011-09-02 2014-04-16 Incyte Corp Heterociclilaminas como inhibidores de pi3k
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
EP2961746B1 (fr) 2013-02-28 2018-01-03 Bristol-Myers Squibb Company Dérivés de phénylpyrazole en tant que puissants inhibiteurs de rock1 et rock2
AU2014236711A1 (en) 2013-03-14 2015-09-17 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
CN105530940A (zh) 2013-09-12 2016-04-27 辉瑞大药厂 乙酰辅酶a羧化酶抑制剂用于治疗寻常痤疮的用途
JPWO2015056782A1 (ja) 2013-10-17 2017-03-09 塩野義製薬株式会社 新規アルキレン誘導体
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
CA2961525A1 (fr) 2014-09-16 2016-03-24 Celgene Quanticel Research, Inc. Inhibiteurs de l'histone demethylase
US9896436B2 (en) 2014-09-16 2018-02-20 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
SG11201702119PA (en) * 2014-09-17 2017-04-27 Quanticel Pharmaceuticals Inc Histone demethylase inhibitors
DK3228731T3 (da) 2014-11-10 2020-05-25 Nat Univ Corp Yokohama Nat Univ Oxygen-genererende anode
RS63963B1 (sr) 2015-02-27 2023-03-31 Incyte Holdings Corp Postupak pripreme pi3k inhibitora
WO2016183063A1 (fr) 2015-05-11 2016-11-17 Incyte Corporation Formes cristallines d'un inhibiteur de pi3k
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
EP3644998B1 (fr) 2017-06-30 2024-04-10 Quixgen, Inc. Nouveaux composés spirolactones
MX392203B (es) 2017-11-21 2025-03-21 Pfizer Sal cristalina de 2-amino-2-(hidroximetil)propano-1,3-diol de acido 4-(4-(1-isopropil-7-oxo-1,4,6,7-tetrahidrospiro[indazol-5,4'-piperidina]-1'-carbonil)-6-metoxipiridin-2-il)benzoico
US11465991B2 (en) 2018-03-15 2022-10-11 Yale University Pyrazole-containing macrophage migration inhibitory factor inhibitors
MX2020012826A (es) 2018-06-01 2021-03-09 Incyte Corp Regimen de dosificacion para el tratamiento de trastornos relacionados con fosfatidilinositol 3-cinasas (pi3k).
US20230210822A1 (en) 2020-05-21 2023-07-06 Shionogi & Co., Ltd. Pharmaceutical composition for treating fatty liver disease
US10989621B1 (en) 2020-08-20 2021-04-27 Trinity Bay Equipment Holdings, LLC Online pipe integrity testing system and method
CN112028834B (zh) * 2020-09-11 2022-03-29 济南悟通生物科技有限公司 一种阿贝西利的中间体的合成方法
US20250041279A1 (en) 2021-11-19 2025-02-06 Shionogi & Co., Ltd. Therapeutic medicine for heart disease or skeletal muscle disease
CN115124542A (zh) * 2022-07-08 2022-09-30 河南师范大学 羟基苯取代吡唑酮并吲唑[螺]吡唑酮类化合物的合成方法
WO2024023727A1 (fr) * 2022-07-29 2024-02-01 Pfizer Inc. Nouveaux inhibiteurs de l'acc

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US984083A (en) 1910-03-28 1911-02-14 William J Faber Floor-plane.
ES2287971T3 (es) 1997-08-11 2007-12-16 Pfizer Products Inc. Dispersiones farmaceuticas solidas con biodisponibilidad incrementada.
JP4104983B2 (ja) 2001-02-28 2008-06-18 メルク エンド カムパニー インコーポレーテッド メラノコルチン−４受容体作動薬としてのアシル化ピペリジン誘導体
ES2246481T3 (es) 2002-02-27 2006-02-16 Pfizer Products Inc. Inhibidores de la acc.
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
JPWO2004092179A1 (ja) 2003-04-14 2006-07-06 日本曹達株式会社 スピロ誘導体、製造法および抗酸化薬
JP2005119987A (ja) 2003-10-15 2005-05-12 Ajinomoto Co Inc アシルスルホンアミド誘導体
US20050267221A1 (en) 2004-05-14 2005-12-01 Research Development Foundation Use of curcumin and analogues thereof as inhibitors of ACC2
WO2005116034A1 (fr) 2004-05-25 2005-12-08 Pfizer Products Inc. Derives de tetraazabenzo[e]azulene et analogues de ceux-ci
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
US7935712B2 (en) * 2005-07-19 2011-05-03 Merck Sharp & Dohme Corp. Spirochromanone derivatives as acetyl coenzyme A carboxylase (ACC) inhibitors
CA2617042A1 (fr) * 2005-07-29 2007-02-01 Takeda Pharmaceutical Company Limited Compose spiro-cyclique
DE102006016566B4 (de) * 2005-09-22 2008-06-12 Beru Ag Zusammengesetzter Leiter, insbesondere für Glühkerzen für Dieselmotoren
CA2629406A1 (fr) 2005-11-18 2007-05-31 Merck & Co., Inc. Antagonistes du recepteur cgrp de spirohydatoin aryle
EP1991536A2 (fr) 2006-02-15 2008-11-19 Abbott Laboratories Nouveaux inhibiteurs d'acétyl-coa carboxylase (acc) et leur utilisation dans le traitement du diabète, de l'obésité et du syndrome métabolique
CA2670422C (fr) * 2006-11-29 2011-09-06 Pfizer Products Inc. Inhibiteurs de la spirocetoneacetyl-coa carboxylase
PE20081559A1 (es) * 2007-01-12 2008-11-20 Merck & Co Inc DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA
US20100113418A1 (en) 2007-02-20 2010-05-06 Takeda Pharmaceutical Company Limited Heterocyclic compound
CN101675052A (zh) * 2007-04-12 2010-03-17 辉瑞大药厂 作为蛋白酶c抑制剂的3-酰氨基-吡咯并[3,4-c]吡唑-5(1h,4h,6h)甲醛衍生物
WO2009014455A1 (fr) * 2007-07-20 2009-01-29 Mark Jonathon Brownlee Système de prévision du temps de réponse à un courrier électronique
US7981904B2 (en) * 2008-03-20 2011-07-19 Takeda Pharmaceutical Company Limited Acetyl CoA carboxylase inhibitors
EP2297164A1 (fr) * 2008-05-28 2011-03-23 Pfizer Inc. Inhibiteurs de la pyrazolospirocétone acétyl-coa carboxylase
ES2545231T3 (es) * 2008-05-28 2015-09-09 Pfizer Inc. Inhibidores de pirazoloespirocetona acetil-CoA carboxilasa
CA2729412A1 (fr) 2008-07-04 2010-01-07 Banyu Pharmaceutical Co., Ltd. Nouveaux acides spirochromanone carboxyliques
JP2011528034A (ja) * 2008-07-14 2011-11-10 クロップソリューション，インコーポレイテッド アセチル−補酵素カルボキシラーゼの修飾因子およびその使用方法
BRPI0913457B8 (pt) * 2008-09-18 2021-08-31 Auspex Pharmaceutical Inc Composto e composição farmacêutica
PH12012500903A1 (en) * 2009-11-10 2014-09-24 Pfizer N1 - pyrazolospiroketone acetyl-coa carboxylase inhibitors
EP2499140A1 (fr) 2009-11-10 2012-09-19 Pfizer Inc. Inhibiteurs de n2-pyrazolospirocétone acétyl-coa carboxylase
US8859577B2 (en) * 2010-09-30 2014-10-14 Pfizer Inc. N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors
AP3499A (en) * 2011-04-22 2015-12-31 Pfizer Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors

Also Published As

Publication number Publication date
AU2010317501A1 (en) 2012-05-17
HN2012000973A (es) 2015-03-02
HRP20140025T1 (hr) 2014-02-14
EP2499139B1 (fr) 2013-12-11
US8288405B2 (en) 2012-10-16
US8507681B2 (en) 2013-08-13
KR101550557B1 (ko) 2015-09-04
SI2499139T1 (sl) 2014-01-31
ECSP12011880A (es) 2012-07-31
KR20140034919A (ko) 2014-03-20
MA33734B1 (fr) 2012-11-01
ES2444543T3 (es) 2014-02-25
AR078944A1 (es) 2011-12-14
PL2499139T3 (pl) 2014-04-30
AU2010317501B2 (en) 2013-06-06
UY33020A (es) 2011-06-30
GEP20146169B (en) 2014-09-25
KR20120099460A (ko) 2012-09-10
NI201200089A (es) 2012-08-20
US9139587B2 (en) 2015-09-22
WO2011058474A8 (fr) 2012-04-26
EP2947082A1 (fr) 2015-11-25
US20130296319A1 (en) 2013-11-07
EP2676958B1 (fr) 2015-07-01
IL219373A0 (en) 2012-06-28
PH12012500903A1 (en) 2014-09-24
BR112012011072A2 (pt) 2017-06-20
PE20121469A1 (es) 2012-11-01
CO6541569A2 (es) 2012-10-16
CU24077B1 (es) 2015-03-30
EP2676958A1 (fr) 2013-12-25
DK2499139T3 (da) 2014-01-27
MX2012005429A (es) 2012-06-19
CU20120071A7 (es) 2013-05-31
WO2011058474A1 (fr) 2011-05-19
US8802690B2 (en) 2014-08-12
HK1173724A1 (en) 2013-05-24
CN102695708A (zh) 2012-09-26
EP2499139A1 (fr) 2012-09-19
JP2013510192A (ja) 2013-03-21
IL219373A (en) 2014-04-30
CR20120190A (es) 2012-05-24
JP5114610B1 (ja) 2013-01-09
US20140288111A1 (en) 2014-09-25
CA2778886C (fr) 2014-01-07
AP2012006269A0 (en) 2012-06-30
TW201127838A (en) 2011-08-16
TWI394756B (zh) 2013-05-01
CL2012000999A1 (es) 2012-07-20
NZ599815A (en) 2013-04-26
KR101478517B1 (ko) 2015-01-02
AP3283A (en) 2015-05-31
PT2499139E (pt) 2014-02-10
US20130030181A1 (en) 2013-01-31
DOP2012000128A (es) 2012-08-31
EA020153B1 (ru) 2014-09-30
CN102695708B (zh) 2014-10-15
US20110111046A1 (en) 2011-05-12
CA2778886A1 (fr) 2011-05-19
ZA201204231B (en) 2013-02-27
RS53156B (en) 2014-06-30
UA102336C2 (uk) 2013-06-25
EA201290191A1 (ru) 2012-12-28

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