TN2010000070A1 - Fused bicyclic pyrimidines - Google Patents

Fused bicyclic pyrimidines

Info

Publication number: TN2010000070A1
Authority: TN; Tunisia
Prior art keywords: fused bicyclic; bicyclic pyrimidines; pyrimidines; fused; pi3k
Prior art date: 2007-08-14

Application number

TNP2010000070A

Other languages

English (en)

Inventor

Swen Holder

Matthias Vennemann

Gerrit Beneke

Armin Zülch

Volker Gekeler

Thomas Beckers

Astrid Zimmermann

Hemant Joshi

Original Assignee

Bayer Ip Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-14

Filing date

2010-02-12

Publication date

2011-09-26

2007-10-18 Priority claimed from EP07118736A external-priority patent/EP2050748A1/fr

2010-02-12 Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh

2011-09-26 Publication of TN2010000070A1 publication Critical patent/TN2010000070A1/fr

Links

-1 bicyclic pyrimidines Chemical class 0.000 title 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000037361 pathway Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

TNP2010000070A 2007-08-14 2010-02-12 Fused bicyclic pyrimidines TN2010000070A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IN1572MU2007		2007-08-14
EP07118736A EP2050748A1 (fr)	2007-10-18	2007-10-18	Nouveau pyrimidines fusionnés
PCT/EP2008/060690 WO2009021992A2 (fr)	2007-08-14	2008-08-14	Pyrimidines bicycliques condensées

Publications (1)

Publication Number	Publication Date
TN2010000070A1 true TN2010000070A1 (en)	2011-09-26

Family

ID=40153211

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TNP2010000070A TN2010000070A1 (en)	2007-08-14	2010-02-12	Fused bicyclic pyrimidines

Country Status (38)

Country	Link
US (2)	US7776864B2 (fr)
EP (1)	EP2188291B1 (fr)
JP (1)	JP5344637B2 (fr)
KR (1)	KR20100053556A (fr)
CN (1)	CN101778851B (fr)
AR (1)	AR067945A1 (fr)
AU (1)	AU2008288392B2 (fr)
BR (1)	BRPI0815207A2 (fr)
CA (1)	CA2694058C (fr)
CL (1)	CL2008002398A1 (fr)
CO (1)	CO6260077A2 (fr)
CR (1)	CR11270A (fr)
CY (1)	CY1113486T1 (fr)
DK (1)	DK2188291T3 (fr)
DO (1)	DOP2010000058A (fr)
EA (1)	EA020996B1 (fr)
EC (1)	ECSP109964A (fr)
ES (1)	ES2396177T3 (fr)
HK (1)	HK1146273A1 (fr)
HN (1)	HN2010000313A (fr)
HR (1)	HRP20121022T1 (fr)
IL (1)	IL203163A (fr)
MA (1)	MA31608B1 (fr)
MX (1)	MX2010001746A (fr)
MY (1)	MY169738A (fr)
NZ (1)	NZ583267A (fr)
PA (1)	PA8793201A1 (fr)
PE (1)	PE20090944A1 (fr)
PL (1)	PL2188291T3 (fr)
PT (1)	PT2188291E (fr)
RS (1)	RS52559B (fr)
SI (1)	SI2188291T1 (fr)
SV (1)	SV2010003483A (fr)
TN (1)	TN2010000070A1 (fr)
TW (1)	TWI439272B (fr)
UA (1)	UA99735C2 (fr)
UY (1)	UY31293A1 (fr)
WO (1)	WO2009021992A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5260507B2 (ja) *	2006-10-19	2013-08-14	武田薬品工業株式会社	インドール化合物
ES2396177T3 (es)	2007-08-14	2013-02-19	Bayer Intellectual Property Gmbh	Pirimidinas bicíclicas fusionadas
CA2725014C (fr)	2008-05-30	2014-06-17	Amgen Inc.	Inhibiteurs de la pi3 kinase
ES2435804T3 (es) *	2009-02-13	2013-12-23	Bayer Intellectual Property Gmbh	Pirimidinas condensadas como inhibidores de Akt
ES2580779T3 (es) *	2009-02-13	2016-08-26	Bayer Intellectual Property Gmbh	Pirimidinas fusionadas
WO2010114780A1 (fr)	2009-04-01	2010-10-07	Merck Sharp & Dohme Corp.	Inhibiteurs de l'activité akt
EP2426135A4 (fr)	2009-04-27	2013-02-20	Shionogi & Co	Dérivé d'urée présentant une activité inhibitrice de la pi3k
CN103189379A (zh) *	2010-07-13	2013-07-03	拜耳知识产权有限责任公司	双环嘧啶
CN103384670B (zh)	2010-07-28	2016-05-25	拜耳知识产权有限责任公司	取代的咪唑并[1,2-b]哒嗪
KR20140022057A (ko)	2011-04-07	2014-02-21	바이엘 인텔렉쳐 프로퍼티 게엠베하	Akt 키나제 억제제로서의 이미다조피리다진
MA38287B1 (fr)	2013-01-23	2018-08-31	Astrazeneca Ab	Nouveaux dérivés aminopyrazine pour le traitement ou la prévention du cancer
US20160272861A1 (en) *	2013-03-15	2016-09-22	Bayer Cropscience Lp	Compositions, additives, and methods for mitigating or controlling seed dust
US20140274685A1 (en)	2013-03-15	2014-09-18	Bayer Cropscience Lp	Compositions, additives, and methods for mitigating or controlling seed dust
KR20200032751A (ko)	2017-09-15	2020-03-26	아두로 바이오테크, 인코포레이티드	피라졸로피리미디논 화합물 및 그의 용도

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL152869A0 (en)	2000-06-30	2003-06-24	Wyeth Corp	Substituted triazolopyrimidines as anticancer agents
US7449488B2 (en) *	2002-06-04	2008-11-11	Schering Corporation	Pyrazolopyrimidines as protein kinase inhibitors
JP4616831B2 (ja)	2003-04-24	2011-01-19	メルク・シャープ・エンド・ドーム・コーポレイション	Ａｋｔ活性の阻害剤
JP2007532558A (ja) *	2004-04-09	2007-11-15	メルク　エンド　カムパニー　インコーポレーテッド	Ａｋｔ活性の阻害剤
AR050188A1 (es) *	2004-08-03	2006-10-04	Uriach Y Compania S A J	Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
WO2006036395A2 (fr)	2004-08-23	2006-04-06	Merck & Co., Inc.	Inhibiteurs de l'activite de akt
JP2008524339A (ja)	2004-12-15	2008-07-10	メルクエンドカムパニーインコーポレーテッド	Ａｋｔ活性のインヒビター
ATE543821T1 (de) *	2004-12-28	2012-02-15	Exelixis Inc	Ä1h-pyrazoloä3,4-düpyrimidin-4-ylü-piperidin- oder piperazinverbindungen als serin-threonin- kinasemodulatoren (p70s6k, atk1 und atk2) zur behandlung von immunologischen, entzündlichen und proliferativen erkrankungen
CA2597456A1 (fr)	2005-02-14	2006-08-31	Merck & Co., Inc.	Inhibiteurs d'activite d'akt
PL1898903T3 (pl)	2005-06-10	2013-08-30	Merck Sharp & Dohme	Inhibitory aktywności Akt
ES2396177T3 (es)	2007-08-14	2013-02-19	Bayer Intellectual Property Gmbh	Pirimidinas bicíclicas fusionadas
ES2580779T3 (es) *	2009-02-13	2016-08-26	Bayer Intellectual Property Gmbh	Pirimidinas fusionadas

2008
- 2008-08-14 ES ES08787224T patent/ES2396177T3/es active Active
- 2008-08-14 NZ NZ583267A patent/NZ583267A/en not_active IP Right Cessation
- 2008-08-14 CA CA2694058A patent/CA2694058C/fr not_active Expired - Fee Related
- 2008-08-14 RS RS20120556A patent/RS52559B/en unknown
- 2008-08-14 WO PCT/EP2008/060690 patent/WO2009021992A2/fr active Application Filing
- 2008-08-14 PE PE2008001378A patent/PE20090944A1/es not_active Application Discontinuation
- 2008-08-14 JP JP2010520586A patent/JP5344637B2/ja not_active Expired - Fee Related
- 2008-08-14 KR KR1020107003246A patent/KR20100053556A/ko not_active Abandoned
- 2008-08-14 TW TW097131066A patent/TWI439272B/zh not_active IP Right Cessation
- 2008-08-14 PA PA20088793201A patent/PA8793201A1/es unknown
- 2008-08-14 US US12/191,703 patent/US7776864B2/en not_active Expired - Fee Related
- 2008-08-14 UY UY31293A patent/UY31293A1/es not_active Application Discontinuation
- 2008-08-14 SI SI200830848T patent/SI2188291T1/sl unknown
- 2008-08-14 PT PT87872248T patent/PT2188291E/pt unknown
- 2008-08-14 MX MX2010001746A patent/MX2010001746A/es active IP Right Grant
- 2008-08-14 AU AU2008288392A patent/AU2008288392B2/en not_active Ceased
- 2008-08-14 EP EP08787224A patent/EP2188291B1/fr active Active
- 2008-08-14 DK DK08787224.8T patent/DK2188291T3/da active
- 2008-08-14 UA UAA201002746A patent/UA99735C2/uk unknown
- 2008-08-14 PL PL08787224T patent/PL2188291T3/pl unknown
- 2008-08-14 CN CN2008801031086A patent/CN101778851B/zh not_active Expired - Fee Related
- 2008-08-14 MY MYPI2010000150A patent/MY169738A/en unknown
- 2008-08-14 EA EA201000298A patent/EA020996B1/ru not_active IP Right Cessation
- 2008-08-14 BR BRPI0815207A patent/BRPI0815207A2/pt not_active IP Right Cessation
- 2008-08-14 CL CL2008002398A patent/CL2008002398A1/es unknown
- 2008-08-15 AR ARP080103562A patent/AR067945A1/es unknown
2010
- 2010-01-06 IL IL203163A patent/IL203163A/en not_active IP Right Cessation
- 2010-02-12 CR CR11270A patent/CR11270A/es unknown
- 2010-02-12 DO DO2010000058A patent/DOP2010000058A/es unknown
- 2010-02-12 HN HN2010000313A patent/HN2010000313A/es unknown
- 2010-02-12 CO CO10015919A patent/CO6260077A2/es active IP Right Grant
- 2010-02-12 EC EC2010009964A patent/ECSP109964A/es unknown
- 2010-02-12 TN TNP2010000070A patent/TN2010000070A1/fr unknown
- 2010-02-12 SV SV2010003483A patent/SV2010003483A/es unknown
- 2010-02-12 MA MA32617A patent/MA31608B1/fr unknown
- 2010-03-25 US US12/731,880 patent/US8614218B2/en not_active Expired - Fee Related
2011
- 2011-01-14 HK HK11100395.8A patent/HK1146273A1/xx not_active IP Right Cessation
2012
- 2012-12-12 HR HRP20121022AT patent/HRP20121022T1/hr unknown
- 2012-12-13 CY CY20121101220T patent/CY1113486T1/el unknown

Also Published As

Publication number	Publication date
CR11270A (es)	2010-05-19
MY169738A (en)	2019-05-14
ECSP109964A (es)	2010-03-31
BRPI0815207A2 (pt)	2017-03-28
CY1113486T1 (el)	2016-06-22
JP2010535848A (ja)	2010-11-25
TWI439272B (zh)	2014-06-01
NZ583267A (en)	2012-03-30
WO2009021992A2 (fr)	2009-02-19
HRP20121022T1 (hr)	2013-01-31
US20100184782A1 (en)	2010-07-22
MX2010001746A (es)	2010-03-10
EP2188291B1 (fr)	2012-09-19
HN2010000313A (es)	2013-03-18
CA2694058A1 (fr)	2009-02-19
CN101778851B (zh)	2013-05-08
MA31608B1 (fr)	2010-08-02
PA8793201A1 (es)	2009-04-23
UY31293A1 (es)	2009-03-31
UA99735C2 (uk)	2012-09-25
AU2008288392A1 (en)	2009-02-19
SI2188291T1 (sl)	2013-01-31
KR20100053556A (ko)	2010-05-20
RS52559B (en)	2013-04-30
CO6260077A2 (es)	2011-03-22
EP2188291A2 (fr)	2010-05-26
AU2008288392B2 (en)	2013-10-24
DK2188291T3 (da)	2013-01-07
PL2188291T3 (pl)	2013-06-28
US7776864B2 (en)	2010-08-17
EA020996B1 (ru)	2015-03-31
ES2396177T3 (es)	2013-02-19
CN101778851A (zh)	2010-07-14
EA201000298A1 (ru)	2010-10-29
PT2188291E (pt)	2012-12-20
HK1146273A1 (en)	2011-05-20
JP5344637B2 (ja)	2013-11-20
CA2694058C (fr)	2016-06-07
TW200922592A (en)	2009-06-01
DOP2010000058A (es)	2010-02-28
US8614218B2 (en)	2013-12-24
CL2008002398A1 (es)	2009-07-31
SV2010003483A (es)	2010-07-06
US20090137607A1 (en)	2009-05-28
PE20090944A1 (es)	2009-08-09
AR067945A1 (es)	2009-10-28
WO2009021992A3 (fr)	2009-04-16
IL203163A (en)	2015-01-29

Publication	Publication Date	Title
TN2010000070A1 (en)	2011-09-26	Fused bicyclic pyrimidines
TN2011000404A1 (en)	2013-03-27	Fused pyrimidines
TN2010000071A1 (en)	2011-09-26	Fused imidazoles or cancer treatment
MX2010008040A (es)	2010-08-10	Derivados de pirimidina 5-fluoro como fungicidas.
MX2011012353A (es)	2011-12-14	Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus.
MX2008013582A (es)	2009-01-19	Derivados de pirimidina como inhibidores de fosfatidilinositol-3-c inasa.
WO2008039359A3 (fr)	2008-05-08	Inhibiteurs de pyrimidine kinase bicyclique
GEP20156285B (en)	2015-05-11	Compounds and compositions as trk inhibitors
NZ708909A (en)	2019-11-29	Substituted reverse pyrimidine bmi-1 inhibitors
MX2012009074A (es)	2012-08-23	Compuestos de urea pirrolo [2, 3-d] pirimidina como inhibidores de janus quinasa.
TW201713640A (en)	2017-04-16	Bruton's tyrosine kinase inhibitors
EA201290147A1 (ru)	2012-11-30	Пирроло[2,3-d]пиримидиновые соединения
MX2009010728A (es)	2009-10-26	Compuestos de imidazo[1,2-a]piridina como inhibidores de la tirosina-cinasa repectora.
WO2010120994A3 (fr)	2013-08-01	Composés d'uréido-aryl-pyrimidine et de carbamoylaryl-morpholino-pyrimidine, leur utilisation comme inhibiteurs de la kinase mtor et de la kinase pi-3, et leur synthèse
NZ596488A (en)	2012-11-30	1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
MX2012002542A (es)	2012-04-02	Compuestos y composiciones como inhibidores de cinasa de proteina.
MX2010004263A (es)	2010-05-03	Inhibidores de quinasa c-fms.
MX344335B (es)	2016-12-13	Derivados de benzonitrilo como inhibidores de cinasa.
PH12014500373A1 (en)	2019-08-07	Amino quinazolines as kinase inhibitors
WO2008059368A3 (fr)	2008-10-30	Composés de 2-amino pyridine
MX2014002836A (es)	2014-05-28	Derivados de aminopirimidina para usarse como moduladores de la actividad de cinasa.
EA201170154A1 (ru)	2011-08-30	Производные пиридинопиридинонов, способ их получения и применение в терапии
AU2012204982A8 (en)	2013-08-29	2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors
EA201200891A1 (ru)	2013-01-30	Производные 3,4,4a,10d-тетрагидро-1h-тиопирано[4,3-c]изохинолина
MX2012005155A (es)	2012-08-31	Compuestos de quinazolina.