TN2009000530A1 - N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors - Google Patents
N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitorsInfo
- Publication number
- TN2009000530A1 TN2009000530A1 TNP2009000530A TN2009000530A TN2009000530A1 TN 2009000530 A1 TN2009000530 A1 TN 2009000530A1 TN P2009000530 A TNP2009000530 A TN P2009000530A TN 2009000530 A TN2009000530 A TN 2009000530A TN 2009000530 A1 TN2009000530 A1 TN 2009000530A1
- Authority
- TN
- Tunisia
- Prior art keywords
- compound
- treatment
- piperidinedicarboxamide
- ethoxyethyl
- pyridinyl
- Prior art date
Links
- 239000002461 renin inhibitor Substances 0.000 title 1
- 229940086526 renin-inhibitors Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 102100028255 Renin Human genes 0.000 abstract 3
- 108090000783 Renin Proteins 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07012412 | 2007-06-25 | ||
EP07111290 | 2007-06-28 | ||
PCT/EP2008/057964 WO2009000811A1 (fr) | 2007-06-25 | 2008-06-23 | Composés organiques |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2009000530A1 true TN2009000530A1 (en) | 2011-03-31 |
Family
ID=39926743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2009000530A TN2009000530A1 (en) | 2007-06-25 | 2009-12-17 | N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors |
Country Status (26)
Country | Link |
---|---|
US (2) | US8383650B2 (fr) |
EP (2) | EP2181105B1 (fr) |
JP (1) | JP5086433B2 (fr) |
KR (1) | KR101238479B1 (fr) |
CN (1) | CN101687847B (fr) |
AR (1) | AR067132A1 (fr) |
AU (1) | AU2008267287B2 (fr) |
BR (1) | BRPI0813900A2 (fr) |
CA (1) | CA2689109A1 (fr) |
CL (1) | CL2008001872A1 (fr) |
CO (1) | CO6251267A2 (fr) |
CR (1) | CR11153A (fr) |
CU (1) | CU23842B1 (fr) |
EA (1) | EA016446B1 (fr) |
EC (1) | ECSP099825A (fr) |
ES (2) | ES2543641T3 (fr) |
GT (1) | GT200900324A (fr) |
HN (1) | HN2009003463A (fr) |
IL (1) | IL202494A0 (fr) |
MA (1) | MA31538B1 (fr) |
NZ (1) | NZ582098A (fr) |
PE (1) | PE20090425A1 (fr) |
SG (1) | SG182223A1 (fr) |
TN (1) | TN2009000530A1 (fr) |
TW (1) | TWI404714B (fr) |
WO (1) | WO2009000811A1 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0813900A2 (pt) | 2007-06-25 | 2014-12-30 | Novartis Ag | Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina |
US20180048921A1 (en) * | 2016-08-12 | 2018-02-15 | Microsoft Technology Licensing, Llc | Real-time playback diagnostics |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2090956T3 (es) | 1991-12-18 | 1996-10-16 | Schering Corp | Imidazolil o imidazolilalquil sustituido con un anillo heterociclico de cuatro o cinco miembros que contiene nitrogeno. |
IL111176A0 (en) | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them |
HUP9900926A3 (en) | 1995-09-07 | 2002-12-28 | Hoffmann La Roche | New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency |
EP0862435A4 (fr) | 1995-11-22 | 1999-02-03 | Merck & Co Inc | Inhibiteurs de la farnesyl-proteine transferase |
WO1999009984A1 (fr) | 1997-08-28 | 1999-03-04 | Merck & Co., Inc. | Modulateurs de pyrrolidine et de piperidine de l'activite du recepteur de chemokine |
WO1999065867A1 (fr) | 1998-06-17 | 1999-12-23 | Du Pont Pharmaceuticals Company | Acides hydroxamiques cycliques utilises en tant qu'inhibiteurs de metalloproteases |
US6274735B1 (en) | 1998-08-10 | 2001-08-14 | Hoffmann-La Roche Inc. | Process and intermediates for preparation of substituted piperidines |
JP2002528543A (ja) | 1998-10-30 | 2002-09-03 | メルク エンド カムパニー インコーポレーテッド | トロンビン阻害剤 |
AU3386700A (en) | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity |
AU3389300A (en) | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
US6362201B1 (en) | 1999-03-02 | 2002-03-26 | Merck & Co., Inc. | 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity |
WO2000063173A1 (fr) | 1999-04-14 | 2000-10-26 | F. Hoffmann-La Roche Ag | Procede de preparation de piperidines substituees |
US6376672B1 (en) | 1999-04-27 | 2002-04-23 | Hoffmann-La Roche Inc. | Naphthalenylmethoxypiperidines as renin inhibitors |
US6197959B1 (en) | 1999-04-27 | 2001-03-06 | Hoffmann-La Roche Inc. | Piperidine derivatives |
KR20030009391A (ko) | 2000-03-17 | 2003-01-29 | 브리스톨-마이어스 스퀴브 파마 컴파니 | 기질 금속단백분해효소 및 TNF-α의 억제제인 시클릭β-아미노산 유도체 |
FR2811673B1 (fr) | 2000-07-17 | 2002-09-13 | Rhodia Chimie Sa | Utilisation de composes insatures comprenant un heterocycle comme stabilisants de polymeres halogenes |
EP1326619A2 (fr) | 2000-10-11 | 2003-07-16 | Merck & Co., Inc. | Modulateurs a base de pyrrolidine d'activite de recepteur de chimiokines ccr5 |
US20060079533A1 (en) | 2001-03-23 | 2006-04-13 | Nieman James A | Methods of treating alzheimer's disease |
US20030095958A1 (en) | 2001-04-27 | 2003-05-22 | Bhisetti Govinda R. | Inhibitors of bace |
AU2002341715A1 (en) | 2001-09-17 | 2003-04-01 | Bristol-Myers Squibb Company | Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace) |
WO2003031443A1 (fr) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Antibiotiques a action duale renfermant une oxazolidinone et une quinolone ou une fraction de naphthyridinone |
CA2483241C (fr) | 2002-04-29 | 2011-05-31 | Actelion Pharmaceuticals Ltd | Nouveaux derives de diazabicyclononene |
JP4271148B2 (ja) | 2002-05-20 | 2009-06-03 | ブリストル−マイヤーズ スクイブ カンパニー | 置換シクロアルキルp1’c型肝炎ウイルスインヒビター |
PL374860A1 (en) | 2002-07-09 | 2005-11-14 | Bristol-Myers Squibb Company | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
US20040204455A1 (en) | 2003-04-10 | 2004-10-14 | Cody Wayne Livingston | Piperidine derivative rennin inhibitors |
US20040214832A1 (en) | 2003-04-10 | 2004-10-28 | Cuiman Cai | Piperazine derivative renin inhibitors |
US20060217371A1 (en) | 2003-04-28 | 2006-09-28 | Olivier Bezencon | Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors |
RU2005136986A (ru) | 2003-04-29 | 2006-05-27 | Актелион Фармасьютикалз Лтд. (Ch) | Новые 3,4-дизамещенные производные 1,2,3,6-тетрагидропиридина |
BRPI0409878A (pt) | 2003-04-30 | 2006-05-23 | Actelion Pharmaceuticals Ltd | compostos, composições farmacêuticas, método para o tratamento ou profilaxia de doenças, e, usos de compostos e de um ou mais compostos em combinação com outros compostos farmacologicamente ativos |
KR20060008937A (ko) | 2003-04-30 | 2006-01-27 | 액테리온 파마슈티칼 리미티드 | 레닌 억제제로서 3-위치에 헤테로원자를 갖는9-아자비사이클로[3.3.1]논-6-엔 유도체 |
KR20060006069A (ko) | 2003-04-30 | 2006-01-18 | 액테리온 파마슈티칼 리미티드 | 아자비사이클로노넨 유도체 |
WO2004096116A2 (fr) | 2003-05-02 | 2004-11-11 | Actelion Pharmaceuticals Ltd | Derives de diazabicyclononene |
US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
TW200900399A (en) | 2003-10-01 | 2009-01-01 | Speedel Experimenta Ag | Organic compounds |
CA2540543A1 (fr) | 2003-10-09 | 2005-05-06 | Actelion Pharmaceuticals Ltd | Derives de tetrahydropyridine |
CA2600973C (fr) | 2003-11-26 | 2012-08-07 | Novartis Ag | Acide .delta.-amino-.gamma.-hydroxy-.omega.-arylalcanoique |
PL1689712T3 (pl) | 2003-11-26 | 2010-01-29 | Novartis Ag | Pochodne 4-fenylopiperydyny jako inhibitory reniny |
BRPI0506490A (pt) | 2004-01-23 | 2007-02-13 | Speedel Experimenta Ag | compostos orgánicos |
ES2357585T3 (es) | 2004-01-23 | 2011-04-27 | Novartis Ag | Derivados de aminoalcoholes y su actividad como inhibidores de la renina. |
BRPI0507067A (pt) | 2004-01-23 | 2007-06-12 | Speedel Experimenta Ag | diamino álcoois e seu uso como inibidores de renina |
TW200536539A (en) | 2004-03-19 | 2005-11-16 | Speedel Experimenta Ag | Organic compounds |
JP4927704B2 (ja) | 2004-03-19 | 2012-05-09 | シュペーデル・エクスペリメンタ・アーゲー | 有機化合物 |
AR053406A1 (es) | 2004-07-09 | 2007-05-09 | Speedel Experimenta Ag | Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas |
TW200631929A (en) | 2004-12-10 | 2006-09-16 | Speedel Experimenta Ag | ω -phenyloctanamides |
GB0428250D0 (en) | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
GB0500784D0 (en) | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
GB0504850D0 (en) | 2005-03-09 | 2005-04-13 | Novartis Ag | Organic compounds |
JP2008532983A (ja) | 2005-03-11 | 2008-08-21 | シュペーデル・エクスペリメンタ・アーゲー | レニン阻害剤として有用な複素環置換アルカンアミド |
GB0505969D0 (en) | 2005-03-23 | 2005-04-27 | Novartis Ag | Organic compounds |
TW200722424A (en) | 2005-03-31 | 2007-06-16 | Speedel Experimenta Ag | Substituted piperidines |
US20090270380A1 (en) | 2005-03-31 | 2009-10-29 | Peter Herold | 3,4,5-Substituted Piperidines as Renin Inhibitors |
GB0508992D0 (en) * | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
GB0510810D0 (en) | 2005-05-26 | 2005-06-29 | Novartis Ag | Organic compounds |
GB0511063D0 (en) | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
GB0514203D0 (en) * | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
WO2007031558A1 (fr) | 2005-09-17 | 2007-03-22 | Speedel Experimenta Ag | Amides d'acide alcanoïque bicyclo- ou spiro-substitués |
PL1937248T3 (pl) | 2005-09-17 | 2010-11-30 | Novartis Ag | Amidy kwasów alkanowych podstawione nasyconymi grupami O-heterocyklicznymi |
PE20071079A1 (es) * | 2005-11-15 | 2007-12-16 | Cytokinetics Inc | Compuestos de piperidina como inhibidores de la proliferacion celular |
JP5306821B2 (ja) * | 2005-12-30 | 2013-10-02 | ノバルティス アーゲー | レニン阻害剤としての3,5−置換ピペリジン化合物 |
EP1816122A3 (fr) * | 2006-01-19 | 2007-09-19 | Speedel Experimenta AG | Pipéridines substituées 3,4,5 en tant que composants thérapeutiques |
EP1979323A1 (fr) | 2006-01-30 | 2008-10-15 | Speedel Experimenta AG | Procede de preparation de composes organiques |
EP2044059A1 (fr) | 2006-06-08 | 2009-04-08 | Speedel Experimenta AG | Pipéridines 2,5-disubstituées |
GB0611696D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
GB0611697D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
TW200831463A (en) | 2006-09-12 | 2008-08-01 | Speedel Experimenta Ag | Nitrate esters of aminoalcohols |
EP1908471A1 (fr) | 2006-10-04 | 2008-04-09 | Speedel Experimenta AG | Tétrahydropyridines comme inhibiteurs de la renine |
EP1921069A1 (fr) | 2006-11-08 | 2008-05-14 | Speedel Experimenta AG | Procédé de préparation de 2-alkyl-3-hétérocyclyl-prop-2-èn-1-ols |
AR065792A1 (es) | 2007-03-21 | 2009-07-01 | Speedel Experimenta Ag | Proceso para preparar (r o s) -5- (1 -azido-3-(6-metoxi-5-(3-metoxi-propoxi) -piridin-3-ilmetil) -4-metil- pentil) -3-alquil-dihidro-furan-2-ona |
BRPI0813900A2 (pt) | 2007-06-25 | 2014-12-30 | Novartis Ag | Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina |
-
2008
- 2008-06-23 BR BRPI0813900-8A2A patent/BRPI0813900A2/pt not_active IP Right Cessation
- 2008-06-23 JP JP2010513876A patent/JP5086433B2/ja not_active Expired - Fee Related
- 2008-06-23 EA EA201000037A patent/EA016446B1/ru not_active IP Right Cessation
- 2008-06-23 NZ NZ582098A patent/NZ582098A/en not_active IP Right Cessation
- 2008-06-23 AR ARP080102691A patent/AR067132A1/es not_active Application Discontinuation
- 2008-06-23 CA CA002689109A patent/CA2689109A1/fr not_active Abandoned
- 2008-06-23 KR KR1020097027047A patent/KR101238479B1/ko active Active
- 2008-06-23 EP EP08761309.7A patent/EP2181105B1/fr active Active
- 2008-06-23 SG SG2012046132A patent/SG182223A1/en unknown
- 2008-06-23 WO PCT/EP2008/057964 patent/WO2009000811A1/fr active Application Filing
- 2008-06-23 AU AU2008267287A patent/AU2008267287B2/en not_active Ceased
- 2008-06-23 EP EP20120176689 patent/EP2527338B1/fr active Active
- 2008-06-23 ES ES12176689.3T patent/ES2543641T3/es active Active
- 2008-06-23 CN CN2008800218979A patent/CN101687847B/zh not_active Expired - Fee Related
- 2008-06-23 ES ES08761309.7T patent/ES2541107T3/es active Active
- 2008-06-24 TW TW097123556A patent/TWI404714B/zh not_active IP Right Cessation
- 2008-06-24 PE PE2008001078A patent/PE20090425A1/es not_active Application Discontinuation
- 2008-06-24 CL CL2008001872A patent/CL2008001872A1/es unknown
- 2008-06-25 US US12/146,073 patent/US8383650B2/en not_active Expired - Fee Related
-
2009
- 2009-12-03 IL IL202494A patent/IL202494A0/en unknown
- 2009-12-09 CR CR11153A patent/CR11153A/es unknown
- 2009-12-17 TN TNP2009000530A patent/TN2009000530A1/fr unknown
- 2009-12-18 GT GT200900324A patent/GT200900324A/es unknown
- 2009-12-22 HN HN2009003463A patent/HN2009003463A/es unknown
- 2009-12-22 CO CO09146659A patent/CO6251267A2/es active IP Right Grant
- 2009-12-22 CU CU2009000226A patent/CU23842B1/es not_active IP Right Cessation
- 2009-12-23 EC EC2009009825A patent/ECSP099825A/es unknown
-
2010
- 2010-01-22 MA MA32543A patent/MA31538B1/fr unknown
-
2012
- 2012-09-14 US US13/616,081 patent/US8497286B2/en not_active Expired - Fee Related
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