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TN2009000111A1 - Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use - Google Patents

Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use

Info

Publication number
TN2009000111A1
TN2009000111A1 TN2009000111A TN2009000111A TN2009000111A1 TN 2009000111 A1 TN2009000111 A1 TN 2009000111A1 TN 2009000111 A TN2009000111 A TN 2009000111A TN 2009000111 A TN2009000111 A TN 2009000111A TN 2009000111 A1 TN2009000111 A1 TN 2009000111A1
Authority
TN
Tunisia
Prior art keywords
compounds
methods
receptor antagonist
glucagon receptor
compositions containing
Prior art date
Application number
TN2009000111A
Other languages
English (en)
Inventor
John E Stelmach
Emma R Parmee
James R Tata
Keith G Rosauer
Ronald M Kim
Amy R Bittner
Jiang Chang
Christopher Joseph Sinz
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38982644&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2009000111(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of TN2009000111A1 publication Critical patent/TN2009000111A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
TN2009000111A 2006-10-03 2009-03-31 Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use TN2009000111A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84896706P 2006-10-03 2006-10-03
PCT/US2007/020858 WO2008042223A1 (fr) 2006-10-03 2007-09-27 Composés antagonistes du récepteur du glucagon, compositions contenant de tels composés et procédés d'utilisation

Publications (1)

Publication Number Publication Date
TN2009000111A1 true TN2009000111A1 (en) 2010-08-19

Family

ID=38982644

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2009000111A TN2009000111A1 (en) 2006-10-03 2009-03-31 Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use

Country Status (30)

Country Link
US (3) US20100004158A1 (fr)
EP (1) EP2079688B1 (fr)
JP (1) JP2010505828A (fr)
KR (1) KR20090076907A (fr)
CN (1) CN101535252A (fr)
AR (1) AR063022A1 (fr)
AU (1) AU2007305430B2 (fr)
BR (1) BRPI0717305A2 (fr)
CA (1) CA2664004C (fr)
CL (1) CL2007002841A1 (fr)
CO (1) CO6190512A2 (fr)
CR (1) CR10694A (fr)
DK (1) DK2079688T3 (fr)
EA (1) EA017800B1 (fr)
EC (1) ECSP099225A (fr)
ES (1) ES2390296T3 (fr)
GE (1) GEP20125506B (fr)
IL (1) IL197788A0 (fr)
MA (1) MA31963B1 (fr)
MX (1) MX2009003611A (fr)
NO (1) NO342172B1 (fr)
PE (1) PE20080676A1 (fr)
PL (1) PL2079688T3 (fr)
PT (1) PT2079688E (fr)
SI (1) SI2079688T1 (fr)
TN (1) TN2009000111A1 (fr)
TW (1) TW200821284A (fr)
UA (1) UA96308C2 (fr)
WO (1) WO2008042223A1 (fr)
ZA (1) ZA200901694B (fr)

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AU2004309287B2 (en) * 2003-12-29 2008-07-31 Banyu Pharmaceutical Co., Ltd Novel 2-heteroaryl-substituted benzimidazole derivative
EP2001472A2 (fr) * 2006-03-23 2008-12-17 Merck and Co., Inc. Composes antagonistes du recepteur du glucagon, compositions contenant de tels composes et procedes d'utilisation
WO2007136577A2 (fr) * 2006-05-16 2007-11-29 Merck & Co., Inc. Composés antagonistes du récepteur du glucagon, compositions contenant ces composés, et procédés d'utilisation
TW200821284A (en) * 2006-10-03 2008-05-16 Merck & Co Inc Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
AU2008212816B2 (en) 2007-02-09 2014-08-07 Metabasis Therapeutics, Inc. Novel antagonists of the glucagon receptor
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
GEP20135844B (en) 2008-03-05 2013-06-10 Takeda Pharmaceutical Heterocyclic compound
WO2009140342A1 (fr) 2008-05-16 2009-11-19 Schering Corporation Antagonistes du récepteur de glucagon, compostions et procédé d'utilisation de ces composés
MX2011001708A (es) 2008-08-13 2011-04-26 Metabasis Therapeutics Inc Antagonistas de glucagon.
WO2010030722A1 (fr) * 2008-09-15 2010-03-18 Merck Sharp & Dohme Corp. Composés antagonistes du récepteur du glucagon, compositions contenant ces composés et méthodes d'utilisation
EP2350020B1 (fr) * 2008-10-03 2014-08-13 Merck Sharp & Dohme Corp. Dérivés de spiro-imidazolone utilisés en tant qu'antagonistes des récepteurs du glucagon
WO2010071750A1 (fr) * 2008-12-19 2010-06-24 Merck Sharp & Dohme Corp. Composés antagonistes du récepteur du glucagon
WO2010080971A1 (fr) * 2009-01-12 2010-07-15 Merck Sharp & Dohme Corp. Formes polymorphes cristallines d'un composé antidiabétique
WO2010088061A1 (fr) 2009-01-28 2010-08-05 Merck Sharp & Dohme Corp. Composés antagonistes du récepteur du glucagon, compositions contenant ces composés et leurs procédés d'utilisation
WO2010093535A1 (fr) * 2009-02-12 2010-08-19 Merck Sharp & Dohme Corp. Composés antagonistes de récepteur de glucagon, compositions contenant ces composés et procédés d'utilisation
US8809579B2 (en) 2009-02-13 2014-08-19 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
WO2010098994A1 (fr) 2009-02-25 2010-09-02 Merck Sharp & Dohme Corp. Composés antagonistes du récepteur du glucagon, compositions contenant de tels composés et procédés d'utilisation
EP2480077B1 (fr) 2009-09-22 2015-02-18 Merck Sharp & Dohme Corp. Pyrrolidines inédites utilisées en tant qu'antagonistes des récepteurs au glucagon, compositions en contenant et leurs procédés d'utilisation
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2012085745A1 (fr) 2010-12-23 2012-06-28 Pfizer Inc. Modulateurs du récepteur du glucagon
MX2013009140A (es) 2011-02-08 2013-10-01 Pfizer Moduladores del receptor de glucagon.
KR20140023441A (ko) 2011-07-22 2014-02-26 화이자 인코포레이티드 퀴놀린일 글루카곤 수용체 조절제
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013045413A1 (fr) 2011-09-27 2013-04-04 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
TW201427658A (zh) 2012-12-10 2014-07-16 Merck Sharp & Dohme 藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法
US9649294B2 (en) 2013-11-04 2017-05-16 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
US10076504B2 (en) 2014-06-12 2018-09-18 Ligand Pharmaceuticals, Inc. Glucagon antagonists
CN107304180B (zh) * 2016-04-22 2022-04-29 浙江海正药业股份有限公司 苯甲酰胺类衍生物、其制备方法及其在医药上的用途
WO2017215586A1 (fr) * 2016-06-14 2017-12-21 浙江海正药业股份有限公司 Dérivés d'amide, leur procédé de préparation et leur utilisation en médecine
CN107759522B (zh) * 2016-08-15 2023-04-14 浙江海正药业股份有限公司 羧酸类衍生物、其制备方法及其在医药上的用途
CN118236497A (zh) 2016-08-30 2024-06-25 瑞泽恩制药公司 通过干扰胰高血糖素受体的信号传导治疗重度胰岛素抵抗的方法
WO2018075792A1 (fr) 2016-10-20 2018-04-26 Regeneron Pharmaceuticals, Inc. Méthodes d'abaissement de niveaux de glycémie
JP2020531532A (ja) 2017-08-22 2020-11-05 リジェネロン・ファーマシューティカルズ・インコーポレイテッド グルカゴン受容体シグナル伝達に干渉することによって尿素サイクル異常症を治療する方法
EP3752249A1 (fr) 2018-02-13 2020-12-23 Ligand Pharmaceuticals, Inc. Antagonistes de récepteur de glucagon
CN112608378B (zh) * 2020-12-09 2023-09-08 江苏师范大学 一类glp-1/胆囊收缩素-1受体双重激动剂及其应用

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CA2411552A1 (fr) 2000-06-23 2002-01-03 Novo Nordisk A/S Antagonistes/agonistes inverses du glucagon
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WO2006102067A1 (fr) * 2005-03-21 2006-09-28 Merck & Co., Inc. Derives d'aryle et d'heteroaryle substitues
TW200745031A (en) * 2005-10-13 2007-12-16 Merck & Co Inc Acyl indoles, compositions containing such compounds and methods of use
TW200821284A (en) * 2006-10-03 2008-05-16 Merck & Co Inc Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use

Also Published As

Publication number Publication date
EA200970342A1 (ru) 2009-10-30
TW200821284A (en) 2008-05-16
JP2010505828A (ja) 2010-02-25
SI2079688T1 (sl) 2012-12-31
ZA200901694B (en) 2010-01-27
CN101535252A (zh) 2009-09-16
EP2079688B1 (fr) 2012-07-25
ES2390296T3 (es) 2012-11-08
AR063022A1 (es) 2008-12-23
DK2079688T3 (da) 2012-11-05
CA2664004C (fr) 2013-07-23
GEP20125506B (en) 2012-04-25
US7968589B2 (en) 2011-06-28
PL2079688T3 (pl) 2013-01-31
US20100004158A1 (en) 2010-01-07
ECSP099225A (es) 2009-07-31
KR20090076907A (ko) 2009-07-13
CR10694A (es) 2009-05-25
PE20080676A1 (es) 2008-06-12
PT2079688E (pt) 2012-11-22
CO6190512A2 (es) 2010-08-19
US20080085926A1 (en) 2008-04-10
WO2008042223A1 (fr) 2008-04-10
CL2007002841A1 (es) 2008-02-08
AU2007305430A1 (en) 2008-04-10
US20100144824A1 (en) 2010-06-10
MX2009003611A (es) 2009-04-22
NO20091734L (no) 2009-06-04
EA017800B1 (ru) 2013-03-29
CA2664004A1 (fr) 2008-04-10
EP2079688A1 (fr) 2009-07-22
NO342172B1 (no) 2018-04-09
US7687534B2 (en) 2010-03-30
AU2007305430B2 (en) 2011-07-21
IL197788A0 (en) 2009-12-24
UA96308C2 (ru) 2011-10-25
BRPI0717305A2 (pt) 2014-03-25
MA31963B1 (fr) 2011-01-03

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