SK8842001A3 - Azepinoindole derivatives, the production and use thereof - Google Patents

Azepinoindole derivatives, the production and use thereof Download PDF

Info

Publication number: SK8842001A3
Authority: SK; Slovakia
Prior art keywords: alkyl; formula; hydrogen; phenyl; treatment
Prior art date: 1999-09-28

Application number

SK884-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Wilfried Lubisch

Michael Kock

Thomas Hoger

Sabine Schult

Roland Grandel

Reinhold Muller

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-28

Filing date

2000-09-15

Publication date

2002-01-07

1999-09-28 Priority claimed from DE19946289A external-priority patent/DE19946289A1/de

2000-08-09 Priority claimed from DE10039610A external-priority patent/DE10039610A1/de

2000-09-15 Application filed by Basf Ag filed Critical Basf Ag

2002-01-07 Publication of SK8842001A3 publication Critical patent/SK8842001A3/sk

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Hematology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SK884-2001A 1999-09-28 2000-09-15 Azepinoindole derivatives, the production and use thereof SK8842001A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19946289A DE19946289A1 (de)	1999-09-28	1999-09-28	Benzodiazepin-Derivate, deren Herstellung und Anwendung
DE10039610A DE10039610A1 (de)	2000-08-09	2000-08-09	Azepinoindol-Derivate, deren Herstellung und Anwendung
PCT/EP2000/009024 WO2001023390A2 (fr)	1999-09-28	2000-09-15	Derives d'azepinoindol, preparation et utilisation desdits derives

Publications (1)

Publication Number	Publication Date
SK8842001A3 true SK8842001A3 (en)	2002-01-07

Family

ID=26006691

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK884-2001A SK8842001A3 (en)	1999-09-28	2000-09-15	Azepinoindole derivatives, the production and use thereof

Country Status (17)

Country	Link
EP (1)	EP1183259A2 (fr)
JP (1)	JP2003510328A (fr)
KR (1)	KR20010087401A (fr)
CN (1)	CN1374961A (fr)
AU (1)	AU1271201A (fr)
BG (1)	BG105650A (fr)
BR (1)	BR0007174A (fr)
CA (1)	CA2352194A1 (fr)
CZ (1)	CZ20012373A3 (fr)
HK (1)	HK1048999A1 (fr)
HU (1)	HUP0104917A3 (fr)
IL (1)	IL143349A0 (fr)
NO (1)	NO20012567L (fr)
PL (1)	PL347885A1 (fr)
SK (1)	SK8842001A3 (fr)
TR (1)	TR200101499T1 (fr)
WO (1)	WO2001023390A2 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA004989B1 (ru)	1999-01-11	2004-10-28	Агурон Фармасьютикалз, Инк.	Трициклические ингибиторы поли(adp-рибозо)полимераз
US7151102B2 (en)	2000-10-30	2006-12-19	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
AU3652102A (en) *	2000-12-01	2002-06-11	Guilford Pharm Inc	Compounds and their uses
US7026311B2 (en)	2002-01-10	2006-04-11	Abbott Gmbh & Co., Kg	Dibenzodiazepine derivatives, their preparation and use
CA2482806A1 (fr)	2002-04-30	2003-11-13	Kudos Pharmaceuticals Limited	Derives de phthalazinone
ATE405658T1 (de)	2002-07-26	2008-09-15	Basf Plant Science Gmbh	Neue selektionsverfahren
GB0305681D0 (en)	2003-03-12	2003-04-16	Kudos Pharm Ltd	Phthalazinone derivatives
US7449464B2 (en)	2003-03-12	2008-11-11	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
US7223759B2 (en)	2003-09-15	2007-05-29	Anadys Pharmaceuticals, Inc.	Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
RU2413515C2 (ru)	2003-12-01	2011-03-10	Кудос Фармасьютикалс Лимитед	Ингибиторы репарации повреждения днк для лечения рака
AU2005275181A1 (en)	2004-07-14	2006-02-23	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7868037B2 (en)	2004-07-14	2011-01-11	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7772271B2 (en)	2004-07-14	2010-08-10	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7781478B2 (en)	2004-07-14	2010-08-24	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
AU2005275182A1 (en)	2004-07-22	2006-02-23	Ptc Therapeutics, Inc.	Thienopyridines for treating Hepatitis C
GB0419072D0 (en)	2004-08-26	2004-09-29	Kudos Pharm Ltd	Phthalazinone derivatives
CN102925479A (zh)	2005-03-08	2013-02-13	巴斯福植物科学有限公司	增强表达的内含子序列
WO2006101937A1 (fr)	2005-03-18	2006-09-28	Janssen Pharmaceutica N.V.	Acylhydrazones en tant que modulateurs de kinase
GB0521373D0 (en)	2005-10-20	2005-11-30	Kudos Pharm Ltd	Pthalazinone derivatives
TWI404716B (zh)	2006-10-17	2013-08-11	Kudos Pharm Ltd	酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物
CA2699038A1 (fr)	2007-09-14	2009-03-19	Astrazeneca Ab	Derives de phtalazinone
UY31603A1 (es)	2008-01-23	2009-08-31		Derivados de ftalazinona
GB0804755D0 (en) *	2008-03-14	2008-04-16	Angeletti P Ist Richerche Bio	Therapeutic compounds
ES2598178T5 (es)	2008-10-07	2023-12-26	Kudos Pharm Ltd	Formulación farmacéutica 514
WO2011058367A2 (fr)	2009-11-13	2011-05-19	Astrazeneca Ab	Test de diagnostic pour prédire la sensibilité à un traitement par un inhibiteur de poly(adp-ribose) polymérase
AU2010325564A1 (en)	2009-11-27	2012-07-12	Basf Plant Science Company Gmbh	Chimeric endonucleases and uses thereof
US10316304B2 (en)	2009-11-27	2019-06-11	Basf Plant Science Company Gmbh	Chimeric endonucleases and uses thereof
AU2010325549B2 (en)	2009-11-27	2017-04-20	Basf Plant Science Company Gmbh	Optimized endonucleases and uses thereof
AU2011261375B2 (en)	2010-06-04	2016-09-22	Albany Molecular Research, Inc.	Glycine transporter-1 inhibitors, methods of making them, and uses thereof
EP3594343B1 (fr)	2015-07-23	2021-04-21	Institut Curie	Utilisation d'une combinaison d'une molecule dbait et d'inhibiteurs de parp pour le traitement du cancer
GB201519573D0 (en)	2015-11-05	2015-12-23	King S College London	Combination
WO2018162439A1 (fr)	2017-03-08	2018-09-13	Onxeo	Nouveau biomarqueur prédictif de la sensibilité à un traitement du cancer avec une molécule dbait
WO2018197461A1 (fr)	2017-04-28	2018-11-01	Akribes Biomedical Gmbh	Inhibiteur de parp en combinaison avec un glucocorticoïde et/ou l'acide ascorbique et/ou un facteur de croissance de protéine pour le traitement d'une mauvaise cicatrisation de plaie
JP7264489B2 (ja) *	2017-05-24	2023-04-25	ザトラスティーズオブザユニバーシティオブペンシルバニア	イメージング及び放射線療法のための放射標識された蛍光性ｐａｒｐ阻害剤
WO2019175132A1 (fr)	2018-03-13	2019-09-19	Onxeo	Molécule dbait contre la résistance acquise dans le traitement du cancer
CA3121202A1 (fr)	2018-11-30	2020-06-04	Nuvation Bio Inc.	Composes pyrrole et pyrazole et leurs procedes d'utilisation
JP2022519268A (ja) *	2019-02-02	2022-03-22	チアタイティエンチンファーマシューティカルグループカンパニーリミテッド	Ｐａｒｐ阻害剤としてのインドロヘプタアシルオキシム類似体
WO2021018298A1 (fr) *	2019-08-01	2021-02-04	南京明德新药研发有限公司	Composés acyloxime à sept chaînons indolo servant d'inhibiteurs de parp
GB201913030D0 (en)	2019-09-10	2019-10-23	Francis Crick Institute Ltd	Treatment of hr deficient cancer
WO2021148581A1 (fr)	2020-01-22	2021-07-29	Onxeo	Nouvelle molécule dbait et son utilisation
JP2023537220A (ja) *	2020-07-31	2023-08-31	チアタイティエンチンファーマシューティカルグループカンパニーリミテッド	Ｐａｒｐ阻害剤としてのインドロヘプタアシルオキシム類似体の結晶及びその製造方法
WO2024261243A1 (fr)	2023-06-21	2024-12-26	Hemispherian As	Combinaison comprenant un dérivé de désoxycytidine et un inhibiteur de parp destiné à être utilisé dans une méthode de traitement du cancer déficient en hr

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU9298198A (en) *	1997-09-03	1999-03-22	Guilford Pharmaceuticals Inc.	Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity
EA004989B1 (ru) *	1999-01-11	2004-10-28	Агурон Фармасьютикалз, Инк.	Трициклические ингибиторы поли(adp-рибозо)полимераз
ECSP003637A (es) *	1999-08-31	2002-03-25	Agouron Pharma	Inhibidores triciclicos de poli (adp-ribosa) polimerasas

2000
- 2000-09-15 WO PCT/EP2000/009024 patent/WO2001023390A2/fr not_active Application Discontinuation
- 2000-09-15 TR TR2001/01499T patent/TR200101499T1/xx unknown
- 2000-09-15 EP EP00974379A patent/EP1183259A2/fr not_active Withdrawn
- 2000-09-15 PL PL00347885A patent/PL347885A1/xx not_active Application Discontinuation
- 2000-09-15 KR KR1020017006614A patent/KR20010087401A/ko not_active Ceased
- 2000-09-15 HU HU0104917A patent/HUP0104917A3/hu unknown
- 2000-09-15 CA CA002352194A patent/CA2352194A1/fr not_active Abandoned
- 2000-09-15 BR BR0007174-9A patent/BR0007174A/pt not_active IP Right Cessation
- 2000-09-15 IL IL14334900A patent/IL143349A0/xx unknown
- 2000-09-15 SK SK884-2001A patent/SK8842001A3/sk unknown
- 2000-09-15 CN CN00802408A patent/CN1374961A/zh active Pending
- 2000-09-15 CZ CZ20012373A patent/CZ20012373A3/cs unknown
- 2000-09-15 JP JP2001526542A patent/JP2003510328A/ja active Pending
- 2000-09-15 AU AU12712/01A patent/AU1271201A/en not_active Abandoned
2001
- 2001-05-25 NO NO20012567A patent/NO20012567L/no not_active Application Discontinuation
- 2001-06-26 BG BG105650A patent/BG105650A/xx unknown
2003
- 2003-02-18 HK HK03101179.8A patent/HK1048999A1/zh unknown

Also Published As

Publication number	Publication date
KR20010087401A (ko)	2001-09-15
EP1183259A2 (fr)	2002-03-06
WO2001023390A2 (fr)	2001-04-05
PL347885A1 (en)	2002-04-22
WO2001023390A3 (fr)	2001-12-27
BR0007174A (pt)	2001-09-04
CA2352194A1 (fr)	2001-04-05
CZ20012373A3 (cs)	2002-05-15
NO20012567L (no)	2001-06-25
JP2003510328A (ja)	2003-03-18
TR200101499T1 (tr)	2002-09-23
HUP0104917A2 (hu)	2002-04-29
NO20012567D0 (no)	2001-05-25
IL143349A0 (en)	2002-04-21
HK1048999A1 (zh)	2003-04-25
HUP0104917A3 (en)	2002-12-28
BG105650A (en)	2002-02-28
CN1374961A (zh)	2002-10-16
AU1271201A (en)	2001-04-30

Publication	Publication Date	Title
SK8842001A3 (en)	2002-01-07	Azepinoindole derivatives, the production and use thereof
US7087637B2 (en)	2006-08-08	Substituted indoles which are PARP inhibitors
US6448271B1 (en)	2002-09-10	Substituted benzimidazoles and their use as parp inhibitors
US7041675B2 (en)	2006-05-09	Heterocyclic compounds and their use as PARP inhibitors
ES2251405T3 (es)	2006-05-01	Derivados de benzodiazepina, su obtencion y aplicacion.
SK6742001A3 (en)	2001-12-03	2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof
SK286676B6 (sk)	2009-03-05	Použitie ftalazínových derivátov
US7026311B2 (en)	2006-04-11	Dibenzodiazepine derivatives, their preparation and use
MXPA01005199A (en)	2002-06-05	Azepinoindole derivatives, the production and use thereof
DE10039610A1 (de)	2002-02-28	Azepinoindol-Derivate, deren Herstellung und Anwendung
MXPA01010673A (es)	2002-06-05	Benzimidazoles ciclo-alquil substituidos y su uso como inhibidores parp