SK8712000A3 - Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors - Google Patents

Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors Download PDF

Info

Publication number: SK8712000A3
Authority: SK; Slovakia
Prior art keywords: compound; acetylamino; ethyl; methyl; pharmaceutically acceptable
Prior art date: 1997-12-17

Application number

SK871-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Babu S Yarlagadda

Chand Pooran

John A Montgomery

Original Assignee

Biocryst Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-17

Filing date

1998-12-17

Publication date

2000-11-07

1998-12-17 Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc

2000-11-07 Publication of SK8712000A3 publication Critical patent/SK8712000A3/sk

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0 CCOC(C(*C)(*C)C(C1)C(*)CC1=O)=O Chemical compound CCOC(C(*C)(*C)C(C1)C(*)CC1=O)=O 0.000 description 8

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/14—Compounds containing azido groups with azido groups bound to carbon atoms of rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Pulmonology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Pyrane Compounds (AREA)
Pyridine Compounds (AREA)

SK871-2000A 1997-12-17 1998-12-17 Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors SK8712000A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US6995697P	1997-12-17	1997-12-17
US8525298P	1998-05-13	1998-05-13
PCT/US1998/026871 WO1999033781A1 (fr)	1997-12-17	1998-12-17	Composes des cyclopentane et cyclopentene convenant comme inhibiteurs de neuraminidase

Publications (1)

Publication Number	Publication Date
SK8712000A3 true SK8712000A3 (en)	2000-11-07

Family

ID=26750600

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK871-2000A SK8712000A3 (en)	1997-12-17	1998-12-17	Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors

Country Status (28)

Country	Link
US (1)	US6562861B1 (fr)
EP (1)	EP1040094B9 (fr)
JP (3)	JP4102022B2 (fr)
KR (1)	KR20010024743A (fr)
CN (1)	CN1282316A (fr)
AR (1)	AR016162A1 (fr)
AT (1)	ATE425955T1 (fr)
AU (1)	AU2200199A (fr)
BE (1)	BE2018C032I2 (fr)
BR (1)	BR9813480A (fr)
CA (1)	CA2315262C (fr)
CY (2)	CY1109153T1 (fr)
DE (1)	DE69840674D1 (fr)
DK (1)	DK1040094T3 (fr)
ES (1)	ES2324746T3 (fr)
FR (1)	FR18C1037I2 (fr)
HU (1)	HUP0100142A3 (fr)
IL (1)	IL136812A0 (fr)
LT (1)	LTC1040094I2 (fr)
NL (1)	NL300952I2 (fr)
NO (1)	NO20003084L (fr)
PL (1)	PL196674B1 (fr)
PT (1)	PT1040094E (fr)
RO (1)	RO121815B1 (fr)
SI (1)	SI1040094T1 (fr)
SK (1)	SK8712000A3 (fr)
WO (1)	WO1999033781A1 (fr)
ZA (1)	ZA9811595B (fr)

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- 1998-12-17 BR BR9813480-9A patent/BR9813480A/pt not_active IP Right Cessation
- 1998-12-17 SK SK871-2000A patent/SK8712000A3/sk unknown
- 1998-12-17 SI SI9830919T patent/SI1040094T1/sl unknown
- 1998-12-17 PL PL341431A patent/PL196674B1/pl unknown
- 1998-12-17 AR ARP980106457A patent/AR016162A1/es not_active Application Discontinuation
- 1998-12-17 ES ES98966003T patent/ES2324746T3/es not_active Expired - Lifetime
- 1998-12-17 JP JP2000526468A patent/JP4102022B2/ja not_active Expired - Lifetime
- 1998-12-17 HU HU0100142A patent/HUP0100142A3/hu unknown
- 1998-12-17 DK DK98966003T patent/DK1040094T3/da active
- 1998-12-17 DE DE69840674T patent/DE69840674D1/de not_active Expired - Lifetime
- 1998-12-17 ZA ZA9811595A patent/ZA9811595B/xx unknown
- 1998-12-17 CA CA002315262A patent/CA2315262C/fr not_active Expired - Lifetime
- 1998-12-17 AU AU22001/99A patent/AU2200199A/en not_active Abandoned
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- 1998-12-17 KR KR1020007006646A patent/KR20010024743A/ko not_active Withdrawn
- 1998-12-17 AT AT98966003T patent/ATE425955T1/de active
- 1998-12-17 PT PT98966003T patent/PT1040094E/pt unknown
- 1998-12-17 EP EP98966003.0A patent/EP1040094B9/fr not_active Expired - Lifetime
- 1998-12-17 US US09/555,131 patent/US6562861B1/en not_active Expired - Lifetime
- 1998-12-17 RO ROA200000635A patent/RO121815B1/ro unknown
- 1998-12-17 IL IL13681298A patent/IL136812A0/xx unknown
2000
- 2000-06-15 NO NO20003084A patent/NO20003084L/no not_active Application Discontinuation
2008
- 2008-02-05 JP JP2008025550A patent/JP5118502B2/ja not_active Expired - Lifetime
2009
- 2009-06-16 CY CY20091100635T patent/CY1109153T1/el unknown
2011
- 2011-08-12 JP JP2011177226A patent/JP5709688B2/ja not_active Expired - Lifetime
2018
- 2018-08-30 CY CY2018023C patent/CY2018023I1/el unknown
- 2018-09-04 BE BE2018C032C patent/BE2018C032I2/fr unknown
- 2018-09-05 FR FR18C1037C patent/FR18C1037I2/fr active Active
- 2018-09-13 LT LTPA2018513C patent/LTC1040094I2/lt unknown
- 2018-09-20 NL NL300952C patent/NL300952I2/nl unknown

Also Published As

Publication number	Publication date
JP2008163035A (ja)	2008-07-17
CY2018023I2 (el)	2018-12-12
EP1040094B1 (fr)	2009-03-18
AR016162A1 (es)	2001-06-20
PT1040094E (pt)	2009-06-03
FR18C1037I1 (fr)	2018-12-10
HUP0100142A3 (en)	2002-01-28
ZA9811595B (en)	2000-06-19
CA2315262A1 (fr)	1999-07-08
FR18C1037I2 (fr)	2019-06-21
JP5709688B2 (ja)	2015-04-30
SI1040094T1 (sl)	2009-10-31
KR20010024743A (ko)	2001-03-26
CN1282316A (zh)	2001-01-31
WO1999033781A1 (fr)	1999-07-08
US6562861B1 (en)	2003-05-13
PL196674B1 (pl)	2008-01-31
CY2018023I1 (el)	2018-12-12
CA2315262C (fr)	2009-11-10
EP1040094A1 (fr)	2000-10-04
DE69840674D1 (de)	2009-04-30
BE2018C032I2 (fr)	2018-10-15
RO121815B1 (ro)	2008-05-30
BR9813480A (pt)	2000-10-10
LTC1040094I2 (lt)	2018-11-26
JP2011256196A (ja)	2011-12-22
CY1109153T1 (el)	2014-07-02
NO20003084D0 (no)	2000-06-15
ES2324746T3 (es)	2009-08-13
IL136812A0 (en)	2001-06-14
LTPA2018513I1 (lt)	2018-10-10
NO20003084L (no)	2000-08-14
JP5118502B2 (ja)	2013-01-16
EP1040094B9 (fr)	2015-09-09
PL341431A1 (en)	2001-04-09
ATE425955T1 (de)	2009-04-15
NL300952I2 (nl)	2018-09-27
AU2200199A (en)	1999-07-19
HUP0100142A2 (hu)	2001-05-28
JP4102022B2 (ja)	2008-06-18
JP2001527058A (ja)	2001-12-25
DK1040094T3 (da)	2009-06-02
EP1040094A4 (fr)	2004-12-08

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