SK8252001A3 - Controlled release formulation of divalproex sodium - Google Patents
Controlled release formulation of divalproex sodium Download PDFInfo
- Publication number
- SK8252001A3 SK8252001A3 SK825-2001A SK8252001A SK8252001A3 SK 8252001 A3 SK8252001 A3 SK 8252001A3 SK 8252001 A SK8252001 A SK 8252001A SK 8252001 A3 SK8252001 A3 SK 8252001A3
- Authority
- SK
- Slovakia
- Prior art keywords
- weight
- particle size
- controlled release
- weight percent
- silica
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 77
- 238000013270 controlled release Methods 0.000 title claims abstract description 38
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 title claims abstract description 37
- 229940028937 divalproex sodium Drugs 0.000 title claims abstract description 27
- 238000009472 formulation Methods 0.000 title abstract description 39
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims abstract description 75
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 68
- 239000002245 particle Substances 0.000 claims abstract description 41
- 229960000604 valproic acid Drugs 0.000 claims abstract description 40
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 31
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 23
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 23
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 23
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 23
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 21
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 21
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 19
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 17
- 239000008101 lactose Substances 0.000 claims abstract description 17
- 239000002552 dosage form Substances 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 14
- 239000004480 active ingredient Substances 0.000 claims abstract description 12
- 150000002148 esters Chemical class 0.000 claims abstract description 10
- 150000003839 salts Chemical class 0.000 claims abstract description 9
- OMOMUFTZPTXCHP-UHFFFAOYSA-N valpromide Chemical compound CCCC(C(N)=O)CCC OMOMUFTZPTXCHP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960001930 valpromide Drugs 0.000 claims abstract description 8
- 239000007916 tablet composition Substances 0.000 claims abstract description 7
- 206010015037 epilepsy Diseases 0.000 claims abstract description 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract 10
- 239000008187 granular material Substances 0.000 claims description 37
- 238000007906 compression Methods 0.000 claims description 11
- 230000006835 compression Effects 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 8
- 239000004615 ingredient Substances 0.000 claims description 7
- 239000008240 homogeneous mixture Substances 0.000 claims description 6
- 239000011159 matrix material Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 4
- 238000007580 dry-mixing Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 2
- 238000011287 therapeutic dose Methods 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 abstract description 5
- 239000003814 drug Substances 0.000 description 38
- 239000003826 tablet Substances 0.000 description 38
- 229940079593 drug Drugs 0.000 description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 26
- 230000000694 effects Effects 0.000 description 11
- 238000005469 granulation Methods 0.000 description 10
- 230000003179 granulation Effects 0.000 description 10
- 230000036470 plasma concentration Effects 0.000 description 10
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 9
- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 9
- 229960001375 lactose Drugs 0.000 description 9
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- 229920003091 Methocel™ Polymers 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 7
- 238000005299 abrasion Methods 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000000654 additive Substances 0.000 description 4
- 230000000996 additive effect Effects 0.000 description 4
- 150000001408 amides Chemical class 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 235000019359 magnesium stearate Nutrition 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229960001866 silicon dioxide Drugs 0.000 description 4
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 4
- 229940084026 sodium valproate Drugs 0.000 description 4
- 238000013268 sustained release Methods 0.000 description 4
- 239000012730 sustained-release form Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000001856 Ethyl cellulose Substances 0.000 description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 235000019325 ethyl cellulose Nutrition 0.000 description 3
- 229920001249 ethyl cellulose Polymers 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 229920000609 methyl cellulose Polymers 0.000 description 3
- 239000001923 methylcellulose Substances 0.000 description 3
- 235000010981 methylcellulose Nutrition 0.000 description 3
- 229940052586 pro 12 Drugs 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- 229910002054 SYLOID® 244 FP SILICA Inorganic materials 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000001961 anticonvulsive agent Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 229940057948 magnesium stearate Drugs 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000010079 rubber tapping Methods 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 102220487426 Actin-related protein 2/3 complex subunit 3_K15M_mutation Human genes 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000557626 Corvus corax Species 0.000 description 1
- 208000034423 Delivery Diseases 0.000 description 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960004977 anhydrous lactose Drugs 0.000 description 1
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 230000003556 anti-epileptic effect Effects 0.000 description 1
- 229960003965 antiepileptics Drugs 0.000 description 1
- 239000000164 antipsychotic agent Substances 0.000 description 1
- 229940005529 antipsychotics Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 1
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000004049 embossing Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000002875 fluorescence polarization Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000013563 matrix tablet Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004311 natamycin Substances 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- -1 propyl methyl Chemical group 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229960004029 silicic acid Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000007921 solubility assay Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000007939 sustained release tablet Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/216,650 US6419953B1 (en) | 1998-12-18 | 1998-12-18 | Controlled release formulation of divalproex sodium |
US12155799P | 1999-02-25 | 1999-02-25 | |
PCT/US1999/029204 WO2000037055A1 (fr) | 1998-12-18 | 1999-12-09 | Preparation a liberation controlee de divalproex sodium |
Publications (1)
Publication Number | Publication Date |
---|---|
SK8252001A3 true SK8252001A3 (en) | 2001-12-03 |
Family
ID=26819594
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK825-2001A SK8252001A3 (en) | 1998-12-18 | 1999-12-09 | Controlled release formulation of divalproex sodium |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1140034B1 (fr) |
JP (1) | JP2003513882A (fr) |
KR (1) | KR20010101295A (fr) |
CN (1) | CN1335769A (fr) |
AR (1) | AR021443A1 (fr) |
AT (1) | ATE254907T1 (fr) |
AU (1) | AU2478900A (fr) |
BG (1) | BG105665A (fr) |
BR (1) | BR9916361A (fr) |
CA (1) | CA2330480C (fr) |
CO (1) | CO5160287A1 (fr) |
CZ (1) | CZ20012201A3 (fr) |
DE (1) | DE69913197T2 (fr) |
DK (1) | DK1140034T3 (fr) |
ES (1) | ES2212667T3 (fr) |
HK (1) | HK1043043B (fr) |
HU (1) | HUP0105463A3 (fr) |
IL (1) | IL143407A0 (fr) |
NO (1) | NO20012986L (fr) |
PL (1) | PL356899A1 (fr) |
PT (1) | PT1140034E (fr) |
SI (1) | SI20624A (fr) |
SK (1) | SK8252001A3 (fr) |
TW (1) | TW585788B (fr) |
WO (1) | WO2000037055A1 (fr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6419953B1 (en) | 1998-12-18 | 2002-07-16 | Abbott Laboratories | Controlled release formulation of divalproex sodium |
US20020025341A1 (en) * | 1998-12-18 | 2002-02-28 | Yihong Qiu | Controlled release formulation of divalproex sodium |
US6528090B2 (en) | 1998-12-18 | 2003-03-04 | Abbott Laboratories | Controlled release formulation of divalproex sodium |
US6511678B2 (en) | 1998-12-18 | 2003-01-28 | Abbott Laboratories | Controlled release formulation of divalproex sodium |
US6713086B2 (en) | 1998-12-18 | 2004-03-30 | Abbott Laboratories | Controlled release formulation of divalproex sodium |
WO2002051402A1 (fr) * | 2000-12-22 | 2002-07-04 | Abbott Laboratories | Controlled release formulation of divalproex sodium |
ES2281527T3 (es) * | 2001-05-25 | 2007-10-01 | Cephalon, Inc. | Formulaciones farmaceuticas solidas que comprenden modafinilo. |
US7229644B2 (en) * | 2002-05-23 | 2007-06-12 | Cephalon, Inc. | Pharmaceutical formulations of modafinil |
US20040005357A1 (en) * | 2002-07-03 | 2004-01-08 | Sherman Bernard Charles | Extended-release tablets comprising divalproex sodium |
US20040048931A1 (en) | 2002-07-12 | 2004-03-11 | Craig Heacock | Modafinil pharmaceutical compositions |
US20040116532A1 (en) | 2002-09-13 | 2004-06-17 | Craig Heacock | Pharmaceutical formulations of modafinil |
MXPA05009886A (es) * | 2003-03-14 | 2006-05-04 | Nirmal Mulye | Un proceso para preparar tabletas de liberacion constante. |
HUP0301537A3 (en) * | 2003-06-03 | 2005-07-28 | Egis Gyogyszergyar Nyilvanosan | Deramcyclane fumarate tablets and process for producing them |
US7713550B2 (en) | 2004-06-15 | 2010-05-11 | Andrx Corporation | Controlled release sodium valproate formulation |
WO2006025029A2 (fr) * | 2004-08-31 | 2006-03-09 | Ranbaxy Laboratories Limited | Composition de divalproex a liberation prolongee |
BRPI0606932A2 (pt) * | 2005-01-26 | 2009-07-28 | Elan Pharma Int Ltd | formulação, forma de dosagem, e, uso de uma quantidade terapeuticamente efetiva de uma formulação |
US20070202164A1 (en) * | 2006-02-28 | 2007-08-30 | Hutchison Medipharma Enterprises Limited | Andrographis Extract Formulations |
US8952060B2 (en) * | 2009-05-12 | 2015-02-10 | Amorepacific Corporation | Composition for preventing hair loss or for stimulating hair growth |
WO2012121862A2 (fr) * | 2011-02-17 | 2012-09-13 | University Of Florida Research Foundation | Composés dérivés de l'acide valproïque |
CN102138911B (zh) * | 2011-03-28 | 2012-12-12 | 孙卫东 | 一种双丙戊酸钠缓释片及其制备方法 |
CN102895201B (zh) * | 2011-07-26 | 2014-09-10 | 北大方正集团有限公司 | 丙戊酸半钠片剂及其制备方法 |
WO2014078435A1 (fr) | 2012-11-14 | 2014-05-22 | W. R. Grace & Co.-Conn. | Compositions contenant un matériau biologiquement actif et un oxyde inorganique non ordonné |
CN105012264B (zh) * | 2014-04-16 | 2019-11-29 | 四川科瑞德制药股份有限公司 | 丙戊酸钠缓释片及其制备工艺和用途 |
CN106389368B (zh) * | 2015-07-29 | 2021-11-12 | 四川科瑞德制药股份有限公司 | 一种丙戊酸钠缓释制剂及其制备工艺和用途 |
CN105456218A (zh) * | 2015-12-07 | 2016-04-06 | 黑龙江省智诚医药科技有限公司 | 一种丙戊酸镁缓释片及其制备方法 |
CN107028907B (zh) * | 2016-02-04 | 2021-05-14 | 成都康弘药业集团股份有限公司 | 一种双丙戊酸钠缓释片 |
CN114681419A (zh) * | 2020-12-28 | 2022-07-01 | 湖南省湘中制药有限公司 | 一种丙戊酰胺缓释片的组合物及其制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5009897A (en) * | 1988-06-24 | 1991-04-23 | Abbott Laboratories | Pharmaceutical granules and tablets made therefrom |
US5169642A (en) * | 1988-06-24 | 1992-12-08 | Abbott Laboratories | Sustained-release drug dosage units |
FR2643556B1 (fr) * | 1989-02-27 | 1993-03-05 | Sanofi Sa | Composition pharmaceutique a liberation prolongee d'acide valproique |
IL96311A (en) * | 1989-12-01 | 1995-05-26 | Abbott Lab | Medications with delayed release |
US5075114A (en) * | 1990-05-23 | 1991-12-24 | Mcneil-Ppc, Inc. | Taste masking and sustained release coatings for pharmaceuticals |
TW224049B (fr) * | 1991-12-31 | 1994-05-21 | Sunkyong Ind Ltd | |
TW222585B (fr) * | 1992-09-11 | 1994-04-21 | Hoechst Ag | |
JP3552285B2 (ja) * | 1993-08-03 | 2004-08-11 | 三菱化学株式会社 | 経口コレステロール低下剤 |
GB9501127D0 (en) * | 1995-01-20 | 1995-03-08 | Wellcome Found | Tablet |
CA2216215A1 (fr) * | 1997-04-05 | 1998-10-05 | Isa Odidi | Formulations a liberation prolongee, utilisant des polymeres intelligents, avec caracteristiques de mouillabilite opposees, correspondant a une hydrophobie et a une hydrophilie |
-
1999
- 1999-12-09 SK SK825-2001A patent/SK8252001A3/sk unknown
- 1999-12-09 PT PT99968104T patent/PT1140034E/pt unknown
- 1999-12-09 CA CA002330480A patent/CA2330480C/fr not_active Expired - Fee Related
- 1999-12-09 ES ES99968104T patent/ES2212667T3/es not_active Expired - Lifetime
- 1999-12-09 PL PL99356899A patent/PL356899A1/xx not_active Application Discontinuation
- 1999-12-09 EP EP99968104A patent/EP1140034B1/fr not_active Expired - Lifetime
- 1999-12-09 JP JP2000589166A patent/JP2003513882A/ja active Pending
- 1999-12-09 AU AU24789/00A patent/AU2478900A/en not_active Abandoned
- 1999-12-09 HU HU0105463A patent/HUP0105463A3/hu unknown
- 1999-12-09 CZ CZ20012201A patent/CZ20012201A3/cs unknown
- 1999-12-09 DE DE69913197T patent/DE69913197T2/de not_active Expired - Lifetime
- 1999-12-09 IL IL14340799A patent/IL143407A0/xx unknown
- 1999-12-09 SI SI9920100A patent/SI20624A/sl not_active IP Right Cessation
- 1999-12-09 AT AT99968104T patent/ATE254907T1/de active
- 1999-12-09 DK DK99968104T patent/DK1140034T3/da active
- 1999-12-09 CN CN99814629A patent/CN1335769A/zh active Pending
- 1999-12-09 KR KR1020017007649A patent/KR20010101295A/ko not_active Ceased
- 1999-12-09 WO PCT/US1999/029204 patent/WO2000037055A1/fr not_active Application Discontinuation
- 1999-12-09 BR BR9916361-6A patent/BR9916361A/pt not_active Application Discontinuation
- 1999-12-15 CO CO99078240A patent/CO5160287A1/es unknown
- 1999-12-17 AR ARP990106552A patent/AR021443A1/es not_active Application Discontinuation
- 1999-12-18 TW TW088122338A patent/TW585788B/zh not_active IP Right Cessation
-
2001
- 2001-06-15 NO NO20012986A patent/NO20012986L/no not_active Application Discontinuation
- 2001-07-03 BG BG105665A patent/BG105665A/bg unknown
-
2002
- 2002-03-28 HK HK02102407.1A patent/HK1043043B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2330480A1 (fr) | 2000-06-29 |
IL143407A0 (en) | 2002-04-21 |
EP1140034A1 (fr) | 2001-10-10 |
BR9916361A (pt) | 2002-11-05 |
HUP0105463A2 (hu) | 2002-05-29 |
KR20010101295A (ko) | 2001-11-14 |
CO5160287A1 (es) | 2002-05-30 |
AR021443A1 (es) | 2002-07-17 |
NO20012986L (no) | 2001-08-15 |
DE69913197D1 (de) | 2004-01-08 |
BG105665A (bg) | 2002-03-29 |
CZ20012201A3 (cs) | 2001-09-12 |
CA2330480C (fr) | 2002-05-21 |
HK1043043A1 (en) | 2002-09-06 |
SI20624A (sl) | 2002-02-28 |
WO2000037055A1 (fr) | 2000-06-29 |
AU2478900A (en) | 2000-07-12 |
EP1140034B1 (fr) | 2003-11-26 |
CN1335769A (zh) | 2002-02-13 |
DE69913197T2 (de) | 2004-09-02 |
TW585788B (en) | 2004-05-01 |
PL356899A1 (en) | 2004-07-12 |
NO20012986D0 (no) | 2001-06-15 |
ES2212667T3 (es) | 2004-07-16 |
DK1140034T3 (da) | 2004-03-08 |
PT1140034E (pt) | 2004-03-31 |
HUP0105463A3 (en) | 2003-03-28 |
JP2003513882A (ja) | 2003-04-15 |
ATE254907T1 (de) | 2003-12-15 |
HK1043043B (zh) | 2004-09-10 |
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