SK4742001A3 - Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection - Google Patents

Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection Download PDF

Info

Publication number: SK4742001A3
Authority: SK; Slovakia
Prior art keywords: compound; formula; effective amount; interferon alpha; represented
Prior art date: 1998-10-16

Application number

SK474-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Ashit K Ganguly

Jinping Mccormick

Raymond G Lovey

Frank Bennet

Anil K Saksena

Viyyoor M Girijavallabhan

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-16

Filing date

1999-10-14

Publication date

2001-11-06

1999-07-07 Priority claimed from US09/348,534 external-priority patent/US6277830B1/en

1999-10-14 Application filed by Schering Corp filed Critical Schering Corp

2001-11-06 Publication of SK4742001A3 publication Critical patent/SK4742001A3/sk

Links

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229940102396 methyl bromide Drugs 0.000 description 1
JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
239000011707 mineral Substances 0.000 description 1
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238000011002 quantification Methods 0.000 description 1
238000010791 quenching Methods 0.000 description 1
230000000171 quenching effect Effects 0.000 description 1
MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
238000012340 reverse transcriptase PCR Methods 0.000 description 1
238000003757 reverse transcription PCR Methods 0.000 description 1
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MOODSJOROWROTO-UHFFFAOYSA-N salicylsulfuric acid Chemical compound OC(=O)C1=CC=CC=C1OS(O)(=O)=O MOODSJOROWROTO-UHFFFAOYSA-N 0.000 description 1
238000009958 sewing Methods 0.000 description 1
238000011125 single therapy Methods 0.000 description 1
239000002002 slurry Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
XYITYKDGJLHYPW-UHFFFAOYSA-M sodium 2-iodohippurate Chemical compound [Na+].[O-]C(=O)CNC(=O)C1=CC=CC=C1I XYITYKDGJLHYPW-UHFFFAOYSA-M 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
239000012064 sodium phosphate buffer Substances 0.000 description 1
229960002920 sorbitol Drugs 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
239000008227 sterile water for injection Substances 0.000 description 1
239000012258 stirred mixture Substances 0.000 description 1
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KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
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239000000829 suppository Substances 0.000 description 1
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238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
150000003536 tetrazoles Chemical class 0.000 description 1
WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
241000701161 unidentified adenovirus Species 0.000 description 1
241001529453 unidentified herpesvirus Species 0.000 description 1
241001430294 unidentified retrovirus Species 0.000 description 1
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239000008096 xylene Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

SK474-2001A 1998-10-16 1999-10-14 Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection SK4742001A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US17405998A	1998-10-16	1998-10-16
US09/348,534 US6277830B1 (en)	1998-10-16	1999-07-07	5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
PCT/US1999/021448 WO2000023454A1 (fr)	1998-10-16	1999-10-14	Therapie combinee ribavirine-interferon alpha permettant de supprimer l'arn de vhc pouvant etre detecte chez des patients atteints de l'hepatite c chronique

Publications (1)

Publication Number	Publication Date
SK4742001A3 true SK4742001A3 (en)	2001-11-06

Family

ID=26869824

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK474-2001A SK4742001A3 (en)	1998-10-16	1999-10-14	Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection

Country Status (20)

Country	Link
EP (1)	EP1121369B1 (fr)
JP (1)	JP2002527522A (fr)
CN (1)	CN1330658A (fr)
AT (1)	ATE284408T1 (fr)
AU (1)	AU762395B2 (fr)
BR (1)	BR9915546A (fr)
CA (1)	CA2346447C (fr)
CZ (1)	CZ20011130A3 (fr)
DE (1)	DE69922529T2 (fr)
ES (1)	ES2229820T3 (fr)
HU (1)	HUP0200447A2 (fr)
ID (1)	ID29187A (fr)
IL (1)	IL142423A0 (fr)
NO (1)	NO20011789L (fr)
NZ (1)	NZ510811A (fr)
PL (1)	PL347268A1 (fr)
RU (1)	RU2001113268A (fr)
SK (1)	SK4742001A3 (fr)
TR (1)	TR200101085T2 (fr)
WO (1)	WO2000023454A1 (fr)

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* Cited by examiner, † Cited by third party
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EP1282632A1 (fr)	2000-04-20	2003-02-12	Schering Corporation	Traitement combine de ribavirine-interferon alfa pour eliminer l'arn-vhc decelable chez un patient souffrant d'infections chroniques par l'hepatite c
TWI332507B (en)	2002-11-19	2010-11-01	Hoffmann La Roche	Antiviral nucleoside derivatives
BRPI0408846A (pt) *	2003-03-28	2006-07-04	Pharmasset Inc	compostos para o tratamento de infecções por flaviviridae
ZA200601181B (en) *	2003-08-13	2007-04-25	Smith Howard J & Ass Pty Ltd	Method of treating viral infections
US7410979B2 (en)	2003-11-19	2008-08-12	Rigel Pharmaceuticals, Inc.	Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
JP2008540425A (ja)	2005-05-02	2008-11-20	ライジェルファーマシューティカルズ，インコーポレイテッド	代謝可能部分を含む複素環式抗ウイルス性化合物およびその使用
WO2009028575A1 (fr)	2007-08-27	2009-03-05	National University Corporation Nagoya University	Activateur pour le promoteur du facteur vii de la coagulation du sang et son utilisation
US20110117054A1 (en)	2007-08-27	2011-05-19	National University Corporation Nagoya University	Use of ribavirin in blood coagulation disorder
WO2011151667A1 (fr)	2010-06-02	2011-12-08	Adbula Kurkayev	Compositions antivirales
US8492386B2 (en)	2011-10-21	2013-07-23	Abbvie Inc.	Methods for treating HCV
CN103826627B (zh)	2011-10-21	2016-02-24	艾伯维公司	包含至少两种直接抗病毒剂和利巴韦林的组合物在制备治疗hcv的药物中的用途
ES2527544T1 (es)	2011-10-21	2015-01-26	Abbvie Inc.	Tratamiento mono (PSI-7977) o de combinación con AAD para su uso en el tratamiento del VHC
US8466159B2 (en)	2011-10-21	2013-06-18	Abbvie Inc.	Methods for treating HCV
JP7129703B2 (ja)	2016-04-28	2022-09-02	エモリーユニバーシティー	アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
WO2018035380A1 (fr)	2016-08-17	2018-02-22	Solstice Biologics, Ltd.	Constructions polynucléotidiques
US11597744B2 (en)	2017-06-30	2023-03-07	Sirius Therapeutics, Inc.	Chiral phosphoramidite auxiliaries and methods of their use
CN107513055B (zh) *	2017-08-11	2018-06-22	广东昊邦医药健康有限责任公司	一种利巴韦林衍生化合物及其药物组合物
WO2023214204A1 (fr)	2022-05-05	2023-11-09	Abdula Kurkayev	Composition pharmaceutique pour la restauration de processus physiologiques et de cellules d'un organisme

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1482736A (en) *	1974-03-18	1977-08-10	Icn Pharmaceuticals	1-(beta-d-ribofuranosyl)-1,2,4-triazole acid derivatives
US4544741A (en) *	1982-03-29	1985-10-01	Robins Roland K	Azole dinucleotide compounds and methods for their production
US4925930A (en) *	1988-11-02	1990-05-15	Nucleic Acid Research Institute	Synthesis and anti-leukemic activity of alkyl-1-(β-D-ribofuranosyl)[1,2,4]triazole-3-carboximidates
GB9307043D0 (en) *	1993-04-05	1993-05-26	Norsk Hydro As	Chemical compounds
US6387365B1 (en) *	1995-05-19	2002-05-14	Schering Corporation	Combination therapy for chronic hepatitis C infection
WO1998021223A1 (fr) *	1996-11-12	1998-05-22	Medivir Ab	Nucleosides

1999
- 1999-10-14 NZ NZ510811A patent/NZ510811A/xx unknown
- 1999-10-14 IL IL14242399A patent/IL142423A0/xx unknown
- 1999-10-14 AU AU11975/00A patent/AU762395B2/en not_active Ceased
- 1999-10-14 SK SK474-2001A patent/SK4742001A3/sk unknown
- 1999-10-14 ID IDW20010844A patent/ID29187A/id unknown
- 1999-10-14 JP JP2000577180A patent/JP2002527522A/ja active Pending
- 1999-10-14 PL PL99347268A patent/PL347268A1/xx not_active Application Discontinuation
- 1999-10-14 DE DE69922529T patent/DE69922529T2/de not_active Expired - Fee Related
- 1999-10-14 AT AT99970662T patent/ATE284408T1/de not_active IP Right Cessation
- 1999-10-14 WO PCT/US1999/021448 patent/WO2000023454A1/fr active IP Right Grant
- 1999-10-14 ES ES99970662T patent/ES2229820T3/es not_active Expired - Lifetime
- 1999-10-14 CN CN99814344A patent/CN1330658A/zh active Pending
- 1999-10-14 BR BR9915546-0A patent/BR9915546A/pt not_active IP Right Cessation
- 1999-10-14 HU HU0200447A patent/HUP0200447A2/hu unknown
- 1999-10-14 RU RU2001113268/04A patent/RU2001113268A/ru not_active Application Discontinuation
- 1999-10-14 EP EP99970662A patent/EP1121369B1/fr not_active Expired - Lifetime
- 1999-10-14 CZ CZ20011130A patent/CZ20011130A3/cs unknown
- 1999-10-14 CA CA002346447A patent/CA2346447C/fr not_active Expired - Fee Related
- 1999-10-14 TR TR2001/01085T patent/TR200101085T2/xx unknown
2001
- 2001-04-09 NO NO20011789A patent/NO20011789L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
DE69922529D1 (de)	2005-01-13
PL347268A1 (en)	2002-03-25
IL142423A0 (en)	2002-03-10
JP2002527522A (ja)	2002-08-27
CZ20011130A3 (cs)	2001-08-15
RU2001113268A (ru)	2003-09-27
AU762395B2 (en)	2003-06-26
BR9915546A (pt)	2001-08-14
HUP0200447A2 (en)	2002-06-29
ES2229820T3 (es)	2005-04-16
CA2346447C (fr)	2006-01-31
EP1121369B1 (fr)	2004-12-08
NZ510811A (en)	2003-06-30
DE69922529T2 (de)	2005-12-15
NO20011789D0 (no)	2001-04-09
NO20011789L (no)	2001-06-11
ID29187A (id)	2001-08-09
ATE284408T1 (de)	2004-12-15
TR200101085T2 (tr)	2001-08-21
CN1330658A (zh)	2002-01-09
AU1197500A (en)	2000-05-08
WO2000023454A1 (fr)	2000-04-27
CA2346447A1 (fr)	2000-04-27
EP1121369A1 (fr)	2001-08-08

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