SK3362004A3 - Polymorfy hydrochloridu clopidogrelu a ich použitie ako antitrombotických zlúčenín - Google Patents

Polymorfy hydrochloridu clopidogrelu a ich použitie ako antitrombotických zlúčenín Download PDF

Info

Publication number: SK3362004A3
Authority: SK; Slovakia
Prior art keywords: acetate; thieno; chlorophenyl; methyl; dihydro
Prior art date: 2002-02-06

Application number

SK336-2004A

Other languages

English (en)

Slovak (sk)

Inventor

Nagy Pter Ktay

Jzsef Barkczy

Gyula Simig

Kir�Llyi Zsuzsa Szent

Tam�S Gregor

B�La Farkas

Don�Th Gy�Rgyi Vereczkeyn�

Klmn Nagy

Gyul�N� K�Rtv�Lyessy

Original Assignee

Egis Gy�Gyszergy�R Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-06

Filing date

2002-12-20

Publication date

2005-03-04

2002-12-20 Application filed by Egis Gy�Gyszergy�R Rt. filed Critical Egis Gy�Gyszergy�R Rt.

2005-03-04 Publication of SK3362004A3 publication Critical patent/SK3362004A3/sk

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SK336-2004A 2002-02-06 2002-12-20 Polymorfy hydrochloridu clopidogrelu a ich použitie ako antitrombotických zlúčenín SK3362004A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU0200438A HUP0200438A3 (en)	2002-02-06	2002-02-06	Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
PCT/HU2002/000157 WO2003066637A1 (fr)	2002-02-06	2002-12-20	Polymorphes d'hydrochlorure de clopidogrel et utilisation de ceux-ci en tant que composes antithrombotiques

Publications (1)

Publication Number	Publication Date
SK3362004A3 true SK3362004A3 (sk)	2005-03-04

Family

ID=89980128

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK336-2004A SK3362004A3 (sk)	2002-02-06	2002-12-20	Polymorfy hydrochloridu clopidogrelu a ich použitie ako antitrombotických zlúčenín

Country Status (15)

Country	Link
US (1)	US20050113406A1 (fr)
EP (1)	EP1474427A1 (fr)
JP (1)	JP2005522441A (fr)
KR (1)	KR20040079987A (fr)
AU (1)	AU2002353251A1 (fr)
BG (1)	BG108868A (fr)
CZ (1)	CZ2004901A3 (fr)
EA (1)	EA007119B1 (fr)
HR (1)	HRP20040741A2 (fr)
HU (1)	HUP0200438A3 (fr)
IS (1)	IS7385A (fr)
PL (1)	PL370038A1 (fr)
SK (1)	SK3362004A3 (fr)
WO (1)	WO2003066637A1 (fr)
YU (1)	YU69604A (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0321256D0 (en) *	2003-09-11	2003-10-08	Generics Uk Ltd	Novel crystalline compounds
EA008972B1 (ru) *	2004-01-13	2007-10-26	Зентива А.С.	Новые кристаллические формы гидробромида клопидогреля и способы их получения
EP1772455A3 (fr) *	2004-03-05	2007-06-27	IPCA Laboratories Limited	Procede pour la prparation d'un polymorph de l'hydrogensulfate de Clopidogrel
AU2004318214B2 (en) *	2004-04-09	2007-12-06	Hanmi Holdings Co., Ltd.	Crystalline clopidogrel naphthalenesulfonate or hydrate thereof, method for preparing same and pharmaceutical composition containing same
NZ551371A (en) *	2004-04-20	2010-07-30	Sanofi Aventis	Polymorphic forms of methyl (+)-(S)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-C]pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide
KR20070012676A (ko) *	2004-04-20	2007-01-26	사노피-아벤티스	클로피도그렐 염 및 그의 다형성 형태
EP1750701A1 (fr) *	2004-06-01	2007-02-14	IVAX Pharmaceuticals s.r.o.	Hydrochlorure de clopidogrel amorphe et son utilisation en tant qu'antithrombotique
EP1674468A1 (fr) *	2004-12-21	2006-06-28	Ratiopharm GmbH	Polymorphes de l'hydrobromide de clopidogrel
EP1693375A1 (fr) *	2005-02-21	2006-08-23	KRKA, tovarna zdravil, d.d., Novo mesto	Procédé pour la préparation de Clopidrogel hydrogène sulfate forme I
WO2007029096A2 (fr) *	2005-09-05	2007-03-15	Ranbaxy Laboratories Limited	Nouvelles formes polymorphes de chlorhydrate de clopidogrel
WO2007029080A1 (fr) *	2005-09-05	2007-03-15	Ranbaxy Laboratories Limited	Preparation de chlorhydrate de clopidogrel de forme i
KR20070066518A (ko) *	2005-12-22	2007-06-27	에스케이케미칼주식회사	고체상 반응을 이용한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR101235117B1 (ko) *	2005-12-26	2013-02-20	에스케이케미칼주식회사	광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR100742134B1 (ko) *	2006-02-07	2007-07-24	경동제약 주식회사	결정성Ｓ-(+)-메틸-2-(2-클로로페닐)-2-(6,7-디히드로티에노[3,2-ｃ]피리딘-5(4Ｈ)-일)아세테이트·캄실레이트를 포함하는약학적 조성물
WO2008004249A2 (fr) *	2006-07-04	2008-01-10	Msn Laboratories Limited	Procédé amélioré de préparation de clopidogrel et de ses sels pharmaceutiquement acceptables
WO2008060934A2 (fr) *	2006-11-14	2008-05-22	Acusphere, Inc.	Formulations d'agents de tetrahydropyridine antiplaquettes pour administration parentale ou orale
EP1970054A3 (fr)	2007-03-14	2009-06-03	Ranbaxy Laboratories Limited	Comprimés de clopidogrel
DK2152078T3 (da)	2007-04-27	2021-02-08	Cydex Pharmaceuticals Inc	Formuleringer indeholdende clopidogrel og sulfoalkylethercyclodextrin og anvendelsesfremgangsmåder
US7985859B2 (en) *	2007-05-30	2011-07-26	Wockhardt Ltd.	Processes for the preparation of clopidogrel
EP2107061A1 (fr)	2008-04-02	2009-10-07	Krka Tovarna Zdravil, D.D., Novo Mesto	Procédé de préparation de clopidogrel enrichi optiquement
KR20190071006A (ko)	2009-05-13	2019-06-21	사이덱스 파마슈티칼스, 인크.	프라수그렐 및 사이클로덱스트린 유도체를 포함하는 약학 조성물 및 그의 제조 및 사용 방법
CN102120745B (zh) *	2011-01-31	2013-04-10	天津红日药业股份有限公司	一种盐酸氯吡格雷的晶型ⅰ及其制备方法和用途
WO2012123958A1 (fr)	2011-02-14	2012-09-20	Cadila Healthcare Limited	Sels très purs de clopidogrel exempts d'impuretés génotoxiques
CN102367257B (zh) *	2011-11-21	2014-05-07	天津红日药业股份有限公司	氯吡格雷盐酸盐的单晶晶型，它们的制备及应用
HUP1400294A2 (hu)	2014-06-13	2015-12-28	Skillpharm Kft	Clopidogrel új alkalmazása

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2530247B1 (fr) *	1982-07-13	1986-05-16	Sanofi Sa	Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) *	1987-02-17	1992-01-24	Sanofi Sa	Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
US5189170A (en) *	1989-09-29	1993-02-23	Sanofi	Process for the preparation of phenylacetic derivatives of thieno-pyridines
FR2664596B1 (fr) *	1990-07-10	1994-06-10	Sanofi Sa	Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
HU225504B1 (en) *	1997-05-13	2007-01-29	Sanofi Aventis	Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
FR2779726B1 (fr) *	1998-06-15	2001-05-18	Sanofi Sa	Forme polymorphe de l'hydrogenosulfate de clopidogrel
HU226421B1 (en) *	1998-11-09	2008-12-29	Sanofi Aventis	Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides

2002
- 2002-02-06 HU HU0200438A patent/HUP0200438A3/hu unknown
- 2002-12-20 EA EA200401025A patent/EA007119B1/ru not_active IP Right Cessation
- 2002-12-20 YU YU69604A patent/YU69604A/sh unknown
- 2002-12-20 AU AU2002353251A patent/AU2002353251A1/en not_active Abandoned
- 2002-12-20 EP EP02788271A patent/EP1474427A1/fr not_active Withdrawn
- 2002-12-20 SK SK336-2004A patent/SK3362004A3/sk not_active Application Discontinuation
- 2002-12-20 PL PL02370038A patent/PL370038A1/xx unknown
- 2002-12-20 JP JP2003566010A patent/JP2005522441A/ja active Pending
- 2002-12-20 US US10/504,042 patent/US20050113406A1/en not_active Abandoned
- 2002-12-20 WO PCT/HU2002/000157 patent/WO2003066637A1/fr not_active Application Discontinuation
- 2002-12-20 CZ CZ2004901A patent/CZ2004901A3/cs unknown
- 2002-12-20 KR KR10-2004-7012110A patent/KR20040079987A/ko not_active Withdrawn
2004
- 2004-08-05 IS IS7385A patent/IS7385A/is unknown
- 2004-08-17 HR HRP20040741 patent/HRP20040741A2/xx not_active Application Discontinuation
- 2004-09-03 BG BG108868A patent/BG108868A/xx unknown

Also Published As

Publication number	Publication date
IS7385A (is)	2004-08-05
CZ2004901A3 (cs)	2005-02-16
EA007119B1 (ru)	2006-06-30
YU69604A (sh)	2006-08-17
KR20040079987A (ko)	2004-09-16
EA200401025A1 (ru)	2004-12-30
US20050113406A1 (en)	2005-05-26
HUP0200438A3 (en)	2003-10-28
HRP20040741A2 (en)	2004-12-31
WO2003066637A1 (fr)	2003-08-14
BG108868A (en)	2005-09-30
EP1474427A1 (fr)	2004-11-10
JP2005522441A (ja)	2005-07-28
AU2002353251A1 (en)	2003-09-02
HU0200438D0 (en)	2002-04-29
HUP0200438A2 (hu)	2003-09-29
PL370038A1 (en)	2005-05-16

Legal Events

Date	Code	Title	Description
2012-01-04	FC9A	Refused patent application

Publication	Publication Date	Title
SK3362004A3 (sk)	2005-03-04	Polymorfy hydrochloridu clopidogrelu a ich použitie ako antitrombotických zlúčenín
JP4494205B2 (ja)	2010-06-30	カルシウム受容体調節化合物およびその用途
SK2592003A3 (en)	2003-08-05	Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors
JPH09169768A (ja)	1997-06-30	チエノピリミジン誘導体、その製造法および用途
SK50942005A3 (sk)	2006-02-02	Polymorfy hydrochloridu olanzapínu
EP1259515B1 (fr)	2004-11-10	Derives de thienopyridine, leur production et leur utilisation
EP0900223A1 (fr)	1999-03-10	Derives de la thienopyridine et leur utilisation
KR20070012676A (ko)	2007-01-26	클로피도그렐 염 및 그의 다형성 형태
JPH1036374A (ja)	1998-02-10	チエノピリジン誘導体およびそれらを含んでなる医薬
KR20070023185A (ko)	2007-02-28	Ｓ-(＋)-클로피도그렐 헤미나파디실레이트 염 및 그의제조방법
JPH1059977A (ja)	1998-03-03	チエノピリジン誘導体およびそれらを含んでなる医薬
JPH08225577A (ja)	1996-09-03	チエノピリジンまたはチエノピリミジン誘導体およびそれらを含んでなる医薬
WO2003042161A1 (fr)	2003-05-22	Polymorphes de chlorhydrate de venlafaxine