SK3052000A3 - Transdermal therapeutic system containing the active substance scopolamine base - Google Patents

Transdermal therapeutic system containing the active substance scopolamine base Download PDF

Info

Publication number: SK3052000A3
Authority: SK; Slovakia
Prior art keywords: adhesive; active substance; transdermal therapeutic; therapeutic system; layer
Prior art date: 1997-09-04

Application number

SK305-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Walter Muller

Original Assignee

Lohmann Therapie Syst Lts

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-04

Filing date

1998-08-18

Publication date

2000-12-11

1998-08-18 Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts

2000-12-11 Publication of SK3052000A3 publication Critical patent/SK3052000A3/sk

Links

229930000680 A04AD01 - Scopolamine Natural products 0.000 title claims abstract description 27
STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 title claims abstract description 27
STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 title claims abstract description 27
STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 title claims abstract description 27
229960002646 scopolamine Drugs 0.000 title claims abstract description 27
239000013543 active substance Substances 0.000 title claims abstract description 24
230000001225 therapeutic effect Effects 0.000 title claims abstract description 17
239000010410 layer Substances 0.000 claims abstract description 26
239000012528 membrane Substances 0.000 claims abstract description 15
239000000853 adhesive Substances 0.000 claims abstract description 14
239000012790 adhesive layer Substances 0.000 claims abstract description 12
150000001412 amines Chemical class 0.000 claims abstract description 7
229920005601 base polymer Polymers 0.000 claims abstract description 5
239000005038 ethylene vinyl acetate Substances 0.000 claims abstract description 5
229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims abstract description 5
230000001681 protective effect Effects 0.000 claims abstract description 4
229920005573 silicon-containing polymer Polymers 0.000 claims abstract description 3
239000013464 silicone adhesive Substances 0.000 claims description 15
230000001070 adhesive effect Effects 0.000 claims description 11
239000002904 solvent Substances 0.000 claims description 6
239000000126 substance Substances 0.000 claims description 6
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 5
238000004519 manufacturing process Methods 0.000 claims description 5
230000035515 penetration Effects 0.000 claims description 4
ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical group CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 3
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 3
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 3
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 3
239000005642 Oleic acid Substances 0.000 claims description 3
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 3
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 3
238000000034 method Methods 0.000 claims description 3
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 3
229940055577 oleyl alcohol Drugs 0.000 claims description 3
XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 3
230000008569 process Effects 0.000 claims description 3
235000014113 dietary fatty acids Nutrition 0.000 claims description 2
239000000194 fatty acid Substances 0.000 claims description 2
229930195729 fatty acid Natural products 0.000 claims description 2
150000004665 fatty acids Chemical class 0.000 claims description 2
150000002191 fatty alcohols Chemical class 0.000 claims description 2
238000002844 melting Methods 0.000 claims description 2
230000008018 melting Effects 0.000 claims description 2
230000001105 regulatory effect Effects 0.000 claims description 2
230000002708 enhancing effect Effects 0.000 claims 1
239000000725 suspension Substances 0.000 claims 1
230000033228 biological regulation Effects 0.000 abstract description 3
239000004480 active ingredient Substances 0.000 description 17
IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 9
230000000694 effects Effects 0.000 description 7
210000003491 skin Anatomy 0.000 description 7
229920006267 polyester film Polymers 0.000 description 4
239000007787 solid Substances 0.000 description 4
229940117958 vinyl acetate Drugs 0.000 description 4
230000000052 comparative effect Effects 0.000 description 3
239000000203 mixture Substances 0.000 description 3
230000036470 plasma concentration Effects 0.000 description 3
229920001296 polysiloxane Polymers 0.000 description 3
238000001953 recrystallisation Methods 0.000 description 3
229910008051 Si-OH Inorganic materials 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
229910006358 Si—OH Inorganic materials 0.000 description 2
230000008901 benefit Effects 0.000 description 2
238000002425 crystallisation Methods 0.000 description 2
230000008025 crystallization Effects 0.000 description 2
239000003623 enhancer Substances 0.000 description 2
239000007888 film coating Substances 0.000 description 2
238000009501 film coating Methods 0.000 description 2
238000001727 in vivo Methods 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
238000003756 stirring Methods 0.000 description 2
230000009885 systemic effect Effects 0.000 description 2
229940100640 transdermal system Drugs 0.000 description 2
206010028813 Nausea Diseases 0.000 description 1
229920002367 Polyisobutene Polymers 0.000 description 1
206010040880 Skin irritation Diseases 0.000 description 1
206010047700 Vomiting Diseases 0.000 description 1
230000003466 anti-cipated effect Effects 0.000 description 1
230000003474 anti-emetic effect Effects 0.000 description 1
239000002111 antiemetic agent Substances 0.000 description 1
238000003556 assay Methods 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
238000010586 diagram Methods 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
206010013781 dry mouth Diseases 0.000 description 1
210000002615 epidermis Anatomy 0.000 description 1
229920001038 ethylene copolymer Polymers 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000000499 gel Substances 0.000 description 1
230000004313 glare Effects 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000011068 loading method Methods 0.000 description 1
238000005259 measurement Methods 0.000 description 1
239000012982 microporous membrane Substances 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
230000008693 nausea Effects 0.000 description 1
239000012454 non-polar solvent Substances 0.000 description 1
230000035699 permeability Effects 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
230000036556 skin irritation Effects 0.000 description 1
231100000475 skin irritation Toxicity 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000006211 transdermal dosage form Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Anesthesiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Otolaryngology (AREA)
Hospice & Palliative Care (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Media Introduction/Drainage Providing Device (AREA)

SK305-2000A 1997-09-04 1998-08-18 Transdermal therapeutic system containing the active substance scopolamine base SK3052000A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19738643A DE19738643C2 (de)	1997-09-04	1997-09-04	Transdermales therapeutisches System mit dem Wirkstoff Scopolaminbase und Verfahren zu seiner Herstellung
PCT/EP1998/005224 WO1999011265A1 (fr)	1997-09-04	1998-08-18	Systeme therapeutique transdermique contenant le principe actif scopolamine base

Publications (1)

Publication Number	Publication Date
SK3052000A3 true SK3052000A3 (en)	2000-12-11

Family

ID=7841162

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK305-2000A SK3052000A3 (en)	1997-09-04	1998-08-18	Transdermal therapeutic system containing the active substance scopolamine base

Country Status (22)

Country	Link
US (1)	US6537571B1 (fr)
EP (1)	EP1011674B1 (fr)
JP (1)	JP3834202B2 (fr)
KR (1)	KR100549846B1 (fr)
AT (1)	ATE214606T1 (fr)
AU (1)	AU738009B2 (fr)
CA (1)	CA2300339C (fr)
DE (2)	DE19738643C2 (fr)
DK (1)	DK1011674T3 (fr)
ES (1)	ES2174492T3 (fr)
HK (1)	HK1032194A1 (fr)
HU (1)	HUP0003480A3 (fr)
ID (1)	ID24266A (fr)
IL (1)	IL134418A (fr)
NO (1)	NO20000894L (fr)
NZ (1)	NZ502873A (fr)
PL (1)	PL339226A1 (fr)
PT (1)	PT1011674E (fr)
SK (1)	SK3052000A3 (fr)
TR (1)	TR200000407T2 (fr)
WO (1)	WO1999011265A1 (fr)
ZA (1)	ZA988052B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050013957A1 (en) *	2003-07-15	2005-01-20	Boris Leschinsky	Disposable medical article with multiple adhesives for skin attachment
DE102004020463A1 (de) *	2004-04-26	2005-11-10	Grünenthal GmbH	Wirkstoffabgabesystem aus einem wirkstoffhaltigen Pflaster und mindestens einem Wirkstoffabgaberegulierungsmittel
DE102004044578A1 (de) *	2004-09-13	2006-03-30	Lts Lohmann Therapie-Systeme Ag	Transdermales therapeutisches System mit einer Haftschicht, Verfahren zum Silikonisieren einer Rückschicht des Systems und Verwendung der Rückschicht
US20070010550A1 (en) *	2005-07-08	2007-01-11	The Board Of Regents Of The University Of Texas	Scopolamine to Reduce or Eliminate Hot Flashes, Night Sweats, and Insomnia
CN101431988A (zh) *	2006-02-27	2009-05-13	诺芬药品公司	包含东莨菪碱的透皮治疗系统
DE102006054732B4 (de) *	2006-11-21	2010-12-30	Lts Lohmann Therapie-Systeme Ag	Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren
KR101572721B1 (ko)	2013-10-14	2015-11-27	주식회사 엘지생활건강	히오신을 유효 성분으로 함유하는 피부 건조증 또는 피부 장벽 기능 개선용 조성물
US20180049999A1 (en) *	2015-04-14	2018-02-22	Atossa Genetics Inc.	Compositions and methods of treatment of breast disorders and estrogen-related disorders
BR112019023393A2 (pt) *	2017-06-26	2020-06-16	Lts Lohmann Therapie-Systeme Ag	Sistema terapêutico transdérmico contendo escopolamina e polímero híbrido de acrílico e silicone
DE102018118507A1 (de)	2018-07-31	2020-02-06	Lts Lohmann Therapie-Systeme Ag	Transdermales therapeutisches System zur Abgabe von Scopolamin ohne Membran

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US35474A (en) *		1862-06-03		Improved rocket-harpoon
US3797494A (en)	1969-04-01	1974-03-19	Alza Corp	Bandage for the administration of drug by controlled metering through microporous materials
US3903880A (en) *	1972-08-17	1975-09-09	Alza Corp	Intrauterine device for managing the reproductive process
US4573996A (en) *	1984-01-03	1986-03-04	Jonergin, Inc.	Device for the administration of an active agent to the skin or mucosa
US4655767A (en)	1984-10-29	1987-04-07	Dow Corning Corporation	Transdermal drug delivery devices with amine-resistant silicone adhesives
US4832953A (en)	1987-08-13	1989-05-23	Alza Corporation	Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
US5656286A (en) *	1988-03-04	1997-08-12	Noven Pharmaceuticals, Inc.	Solubility parameter based drug delivery system and method for altering drug saturation concentration
DE3908431A1 (de) *	1989-03-15	1990-09-27	Lohmann Therapie Syst Lts	Transdermales system mit gestufter wirkstoffabgabe und verwendung fuer die lokale oder systemische wirkstoffverabreichung
KR950703997A (ko)	1993-09-30	1995-11-17	야마구치 아쓰무	경피 흡수 제제(Percutaneously absorbable preparation)
US5714162A (en) *	1994-09-16	1998-02-03	Lts Lohmann Therapie-Systeme Gmbh & Co. Kg	Scopolamine patch
DE4438989C2 (de) *	1994-09-16	1999-02-25	Lohmann Therapie Syst Lts	Scopolaminpflaster
DE69616370T2 (de)	1995-12-01	2002-07-11	Alza Corp., Palo Alto	Verbessertes verfahren zur verhinderung der kristallbildung in einer dispersion eines flüssigen stoffes in einer matrix

1997
- 1997-09-04 DE DE19738643A patent/DE19738643C2/de not_active Expired - Fee Related
1998
- 1998-08-18 EP EP98946364A patent/EP1011674B1/fr not_active Expired - Lifetime
- 1998-08-18 HU HU0003480A patent/HUP0003480A3/hu unknown
- 1998-08-18 WO PCT/EP1998/005224 patent/WO1999011265A1/fr active IP Right Grant
- 1998-08-18 IL IL13441898A patent/IL134418A/en not_active IP Right Cessation
- 1998-08-18 DE DE59803454T patent/DE59803454D1/de not_active Expired - Lifetime
- 1998-08-18 JP JP2000508368A patent/JP3834202B2/ja not_active Expired - Lifetime
- 1998-08-18 KR KR1020007002299A patent/KR100549846B1/ko not_active Expired - Lifetime
- 1998-08-18 ID IDW20000299A patent/ID24266A/id unknown
- 1998-08-18 ES ES98946364T patent/ES2174492T3/es not_active Expired - Lifetime
- 1998-08-18 NZ NZ502873A patent/NZ502873A/en unknown
- 1998-08-18 US US09/485,912 patent/US6537571B1/en not_active Expired - Lifetime
- 1998-08-18 CA CA002300339A patent/CA2300339C/fr not_active Expired - Lifetime
- 1998-08-18 DK DK98946364T patent/DK1011674T3/da active
- 1998-08-18 TR TR2000/00407T patent/TR200000407T2/xx unknown
- 1998-08-18 PL PL98339226A patent/PL339226A1/xx unknown
- 1998-08-18 PT PT98946364T patent/PT1011674E/pt unknown
- 1998-08-18 SK SK305-2000A patent/SK3052000A3/sk unknown
- 1998-08-18 AT AT98946364T patent/ATE214606T1/de active
- 1998-08-18 AU AU93434/98A patent/AU738009B2/en not_active Ceased
- 1998-09-03 ZA ZA988052A patent/ZA988052B/xx unknown
2000
- 2000-02-23 NO NO20000894A patent/NO20000894L/no not_active Application Discontinuation
- 2000-12-23 HK HK00108393A patent/HK1032194A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2001514226A (ja)	2001-09-11
DE59803454D1 (de)	2002-04-25
ES2174492T3 (es)	2002-11-01
HUP0003480A3 (en)	2001-03-28
PL339226A1 (en)	2000-12-04
ZA988052B (en)	1999-03-05
DE19738643A1 (de)	1999-03-11
AU738009B2 (en)	2001-09-06
CA2300339A1 (fr)	1999-03-11
ATE214606T1 (de)	2002-04-15
EP1011674B1 (fr)	2002-03-20
ID24266A (id)	2000-07-13
HK1032194A1 (en)	2001-07-13
EP1011674A1 (fr)	2000-06-28
KR100549846B1 (ko)	2006-02-06
NZ502873A (en)	2001-07-27
TR200000407T2 (tr)	2000-08-21
NO20000894D0 (no)	2000-02-23
HUP0003480A2 (hu)	2001-02-28
CA2300339C (fr)	2007-07-17
AU9343498A (en)	1999-03-22
US6537571B1 (en)	2003-03-25
IL134418A (en)	2004-02-19
WO1999011265A1 (fr)	1999-03-11
DK1011674T3 (da)	2002-07-08
DE19738643C2 (de)	2001-10-04
NO20000894L (no)	2000-02-23
KR20010023647A (ko)	2001-03-26
PT1011674E (pt)	2002-08-30
IL134418A0 (en)	2001-04-30
JP3834202B2 (ja)	2006-10-18

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ZA200408523B (en)	2005-08-31	System for transdermal administering of rotigotine base
CA2861782C (fr)	2020-04-14	Systeme de traitement transdermique presentant une tendance reduite a la cristallisation spontanee
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