+

SK1972003A3 - Acetamide derivatives and the use thereof as inhibitors of coagulation factors XA and VIIA - Google Patents

Acetamide derivatives and the use thereof as inhibitors of coagulation factors XA and VIIA Download PDF

Info

Publication number
SK1972003A3
SK1972003A3 SK197-2003A SK1972003A SK1972003A3 SK 1972003 A3 SK1972003 A3 SK 1972003A3 SK 1972003 A SK1972003 A SK 1972003A SK 1972003 A3 SK1972003 A3 SK 1972003A3
Authority
SK
Slovakia
Prior art keywords
group
acetamide
monosubstituted
cooa
coar
Prior art date
Application number
SK197-2003A
Other languages
English (en)
Slovak (sk)
Inventor
Werner Mederski
Horst Juraszyk
Dieter Dorsch
Christos Tsaklakidis
Johannes Gleitz
Christopher Barnes
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SK1972003A3 publication Critical patent/SK1972003A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/08—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK197-2003A 2000-07-29 2001-07-03 Acetamide derivatives and the use thereof as inhibitors of coagulation factors XA and VIIA SK1972003A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10037146A DE10037146A1 (de) 2000-07-29 2000-07-29 Acetamidderivate
PCT/EP2001/007594 WO2002010127A1 (fr) 2000-07-29 2001-07-03 Derives d'acetamide et leur utilisation en tant qu'inhibiteurs du facteur de coagulation xa et viia

Publications (1)

Publication Number Publication Date
SK1972003A3 true SK1972003A3 (en) 2003-06-03

Family

ID=7650757

Family Applications (1)

Application Number Title Priority Date Filing Date
SK197-2003A SK1972003A3 (en) 2000-07-29 2001-07-03 Acetamide derivatives and the use thereof as inhibitors of coagulation factors XA and VIIA

Country Status (18)

Country Link
US (1) US20030187037A1 (fr)
EP (1) EP1309549A1 (fr)
JP (1) JP2004505106A (fr)
KR (1) KR20030029531A (fr)
CN (1) CN1444561A (fr)
AR (1) AR029999A1 (fr)
AU (1) AU2001281941A1 (fr)
BR (1) BR0112813A (fr)
CA (1) CA2417427A1 (fr)
CZ (1) CZ2003465A3 (fr)
DE (1) DE10037146A1 (fr)
HU (1) HUP0301502A2 (fr)
MX (1) MXPA03000780A (fr)
NO (1) NO20030431D0 (fr)
PL (1) PL358756A1 (fr)
SK (1) SK1972003A3 (fr)
WO (1) WO2002010127A1 (fr)
ZA (1) ZA200301633B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200410921A (en) * 2002-11-25 2004-07-01 Hoffmann La Roche Mandelic acid derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19819548A1 (de) * 1998-04-30 1999-11-04 Merck Patent Gmbh Biphenylderivate
US6638980B1 (en) * 1999-05-24 2003-10-28 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
JP2003500387A (ja) * 1999-05-24 2003-01-07 シーオーアール セラピューティクス インコーポレイテッド Ｘａ因子の阻害剤
US6852761B2 (en) * 2000-03-13 2005-02-08 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade

Also Published As

Publication number Publication date
WO2002010127A1 (fr) 2002-02-07
CN1444561A (zh) 2003-09-24
CA2417427A1 (fr) 2003-01-27
AU2001281941A1 (en) 2002-02-13
DE10037146A1 (de) 2002-02-07
MXPA03000780A (es) 2003-06-04
JP2004505106A (ja) 2004-02-19
PL358756A1 (en) 2004-08-23
AR029999A1 (es) 2003-07-23
KR20030029531A (ko) 2003-04-14
US20030187037A1 (en) 2003-10-02
NO20030431L (no) 2003-01-28
EP1309549A1 (fr) 2003-05-14
HUP0301502A2 (hu) 2003-08-28
BR0112813A (pt) 2003-07-01
CZ2003465A3 (cs) 2003-05-14
ZA200301633B (en) 2004-06-22
NO20030431D0 (no) 2003-01-28

Similar Documents

Publication Publication Date Title
US20040038858A1 (en) Carboxamide derivatives and their use in the treatment of thromboembolic diseases and tumours
US7566789B2 (en) Benzimidazole derivatives
US20050203127A1 (en) 2-(Phenyl)-2h-pyrazole-3-carboxylic acid-n-4-(thioxo-heterocyclyl)-phenyl-amide derivatives and corresponding imino-heterocyclyl derivatives and relates compounds for use as inhibitors of the coagulation factors xa and/or viia for treating thromboses
JP4732757B2 (ja) カルボキサミド
SK13382003A3 (sk) Derivát kyseliny šťaveľovej, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje
SK12152001A3 (sk) Derivát pyrazol-3-ónu ako faktor Xa inhibítorov, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje
US7199133B2 (en) Derivatives of phenoxy-n-′4-(isothiazolindin-1, 1-dioxid-2yl)phenyll-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors
US7902223B2 (en) Phenyl derivatives as factor XA inhibitors
US6943179B2 (en) Biurethane derivatives
US20030176465A1 (en) Cyclic amino acid derivatives
US7183277B2 (en) Carboxylic acid amides
US20030162814A1 (en) N-substituted 1-amino-1,1-dialkylcarboxylic acid derivatives
US20030166694A1 (en) Glycinamides
SK1972003A3 (en) Acetamide derivatives and the use thereof as inhibitors of coagulation factors XA and VIIA
US20040092517A1 (en) Phenyl derivatives and their use in the treatment of thromboembolic disorders or tumours
SK1992003A3 (en) Urethane derivative, method for its preparation, its use and pharmaceutical composition comprising same
SK15522002A3 (sk) Derivát esteru kyseliny karbaminovej ako inhibítor faktora Xa, spôsob jeho prípravy, jeho použitia a farmaceutický prostriedok, ktorý ho obsahuje
US20050119316A1 (en) Semicarbazide derivatives and the use thereof as antithrombotics
SK492004A3 (en) Carbohydrate derivatives
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载