SK1272000A3 - Heterocyclic derivatives which inhibit factor xa - Google Patents

Heterocyclic derivatives which inhibit factor xa Download PDF

Info

Publication number: SK1272000A3
Authority: SK; Slovakia
Prior art keywords: group; alkyl; formula; carbon atoms; compound
Prior art date: 1997-07-29

Application number

SK127-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Roger James

Thorsten Nowak

Peter Warner

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-29

Filing date

1998-07-23

Publication date

2000-06-12

1998-07-23 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

2000-06-12 Publication of SK1272000A3 publication Critical patent/SK1272000A3/sk

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/18—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/08—Six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

SK127-2000A 1997-07-29 1998-07-23 Heterocyclic derivatives which inhibit factor xa SK1272000A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9715894.3A GB9715894D0 (en)	1997-07-29	1997-07-29	Heterocyclic derivatives
PCT/GB1998/002210 WO1999006371A1 (fr)	1997-07-29	1998-07-23	Derives heterocycliques inhibant le facteur xa

Publications (1)

Publication Number	Publication Date
SK1272000A3 true SK1272000A3 (en)	2000-06-12

Family

ID=10816578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK127-2000A SK1272000A3 (en)	1997-07-29	1998-07-23	Heterocyclic derivatives which inhibit factor xa

Country Status (23)

Country	Link
US (2)	US6458793B1 (fr)
EP (2)	EP1000033B1 (fr)
JP (1)	JP2001512103A (fr)
KR (1)	KR20010022108A (fr)
CN (1)	CN1265098A (fr)
AT (1)	ATE266007T1 (fr)
AU (1)	AU754747B2 (fr)
BR (1)	BR9811055A (fr)
CA (1)	CA2295945A1 (fr)
DE (1)	DE69823665T2 (fr)
DK (1)	DK1000033T3 (fr)
ES (1)	ES2219894T3 (fr)
GB (1)	GB9715894D0 (fr)
HU (1)	HUP0002528A3 (fr)
IL (1)	IL133516A0 (fr)
NO (2)	NO317419B1 (fr)
NZ (1)	NZ501778A (fr)
PL (1)	PL338355A1 (fr)
PT (1)	PT1000033E (fr)
RU (1)	RU2225404C2 (fr)
SK (1)	SK1272000A3 (fr)
TR (1)	TR200000223T2 (fr)
WO (1)	WO1999006371A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL115420A0 (en)	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
GB9602166D0 (en) *	1996-02-02	1996-04-03	Zeneca Ltd	Aminoheterocyclic derivatives
AP2000001889A0 (en)	1998-01-27	2000-09-30	Aventis Pharm Prod Inc	Substituted ozoazaheterocyclyl factor Xa inhibitors.
GB9809349D0 (en) *	1998-05-02	1998-07-01	Zeneca Ltd	Heterocyclic derivatives
WO1999057113A1 (fr) *	1998-05-02	1999-11-11	Astrazeneca Ab	Derives heterocycliques inhibant le facteur xa
GB9902989D0 (en)	1999-02-11	1999-03-31	Zeneca Ltd	Heterocyclic derivatives
DE19962924A1 (de)	1999-12-24	2001-07-05	Bayer Ag	Substituierte Oxazolidinone und ihre Verwendung
TWI290136B (en)	2000-04-05	2007-11-21	Daiichi Seiyaku Co	Ethylenediamine derivatives
US6670362B2 (en)	2000-09-20	2003-12-30	Pfizer Inc.	Pyridazine endothelin antagonists
DE10105989A1 (de)	2001-02-09	2002-08-14	Bayer Ag	Substituierte Oxazolidinone und ihre Verwendung
DE10129725A1 (de)	2001-06-20	2003-01-02	Bayer Ag	Kombinationstherapie substituierter Oxazolidinone
WO2003000657A1 (fr)	2001-06-20	2003-01-03	Daiichi Pharmaceutical Co., Ltd.	Derives de diamine
DE10134482A1 (de)	2001-07-16	2003-01-30	Bayer Ag	Substituierte Isoindole und ihre Verwendung
DE10137163A1 (de)	2001-07-30	2003-02-13	Bayer Ag	Substituierte Isoindole und ihre Verwendung
SI1569912T1 (sl)	2002-12-03	2015-09-30	Pharmacyclics Llc	Derivati 2-(2-hidroksibifenil-3-il)-1h-benzoimidazol-5-karboksamidina kot inhibitorji faktorja viia
DE10300111A1 (de) *	2003-01-07	2004-07-15	Bayer Healthcare Ag	Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
DE102004062475A1 (de) *	2004-12-24	2006-07-06	Bayer Healthcare Ag	Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (fr)	2005-01-31	2006-08-02	Bayer Health Care Aktiengesellschaft	Prevention et traitement de troubles thromboemboliques
DE102005045518A1 (de)	2005-09-23	2007-03-29	Bayer Healthcare Ag	2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
DE102005047558A1 (de) *	2005-10-04	2008-02-07	Bayer Healthcare Ag	Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
EP1934208B1 (fr)	2005-10-04	2011-03-23	Bayer Schering Pharma Aktiengesellschaft	Nouvelle forme polymorphe de 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide
DE102005047561A1 (de)	2005-10-04	2007-04-05	Bayer Healthcare Ag	Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
GB0813144D0 (en)	2008-07-17	2008-08-27	Glaxo Group Ltd	Novel compounds
GB0813142D0 (en)	2008-07-17	2008-08-27	Glaxo Group Ltd	Novel compounds
LT3993876T (lt)	2019-07-01	2024-11-11	Tonix Pharma Limited	Antikūnai prieš cd154 ir jų panaudojimas
MX2023008055A (es)	2021-01-06	2023-08-22	Tonix Pharma Ltd	Métodos para inducir tolerancia inmune con anticuerpos anti-cd154 modificados.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8905526D0 (en) *	1989-03-10	1989-04-19	Fujisawa Pharmaceutical Co	N-containing heterocyclic compounds,processes for the preparation thereof and composition comprising the same
US5541330A (en) *	1991-12-10	1996-07-30	Eastman Kodak Company	Ion-sensitive compounds
IL115420A0 (en)	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
GB9602166D0 (en)	1996-02-02	1996-04-03	Zeneca Ltd	Aminoheterocyclic derivatives
UA56197C2 (uk) *	1996-11-08	2003-05-15	Зенека Лімітед	Гетероциклічні похідні

1997
- 1997-07-29 GB GBGB9715894.3A patent/GB9715894D0/en active Pending
1998
- 1998-07-23 DE DE69823665T patent/DE69823665T2/de not_active Expired - Lifetime
- 1998-07-23 KR KR1020007000678A patent/KR20010022108A/ko not_active Ceased
- 1998-07-23 EP EP98935208A patent/EP1000033B1/fr not_active Expired - Lifetime
- 1998-07-23 IL IL13351698A patent/IL133516A0/xx unknown
- 1998-07-23 PT PT98935208T patent/PT1000033E/pt unknown
- 1998-07-23 AU AU84557/98A patent/AU754747B2/en not_active Ceased
- 1998-07-23 DK DK98935208T patent/DK1000033T3/da active
- 1998-07-23 SK SK127-2000A patent/SK1272000A3/sk unknown
- 1998-07-23 PL PL98338355A patent/PL338355A1/xx not_active Application Discontinuation
- 1998-07-23 EP EP03018010A patent/EP1367054A1/fr not_active Withdrawn
- 1998-07-23 CN CN98807641A patent/CN1265098A/zh active Pending
- 1998-07-23 CA CA002295945A patent/CA2295945A1/fr not_active Abandoned
- 1998-07-23 WO PCT/GB1998/002210 patent/WO1999006371A1/fr not_active Application Discontinuation
- 1998-07-23 BR BR9811055-1A patent/BR9811055A/pt not_active Application Discontinuation
- 1998-07-23 JP JP2000505130A patent/JP2001512103A/ja active Pending
- 1998-07-23 AT AT98935208T patent/ATE266007T1/de not_active IP Right Cessation
- 1998-07-23 ES ES98935208T patent/ES2219894T3/es not_active Expired - Lifetime
- 1998-07-23 US US09/463,625 patent/US6458793B1/en not_active Expired - Fee Related
- 1998-07-23 NZ NZ501778A patent/NZ501778A/en unknown
- 1998-07-23 TR TR2000/00223T patent/TR200000223T2/xx unknown
- 1998-07-23 RU RU2000104829/04A patent/RU2225404C2/ru not_active IP Right Cessation
- 1998-07-23 HU HU0002528A patent/HUP0002528A3/hu unknown
2000
- 2000-01-28 NO NO20000448A patent/NO317419B1/no unknown
2002
- 2002-06-27 US US10/180,337 patent/US20020193375A1/en not_active Abandoned
2004
- 2004-02-05 NO NO20040520A patent/NO20040520L/no unknown

Also Published As

Publication number	Publication date
HUP0002528A3 (en)	2002-09-30
WO1999006371A1 (fr)	1999-02-11
NO20000448D0 (no)	2000-01-28
NO317419B1 (no)	2004-10-25
DK1000033T3 (da)	2004-08-02
EP1367054A1 (fr)	2003-12-03
KR20010022108A (ko)	2001-03-15
RU2225404C2 (ru)	2004-03-10
PL338355A1 (en)	2000-10-23
DE69823665D1 (de)	2004-06-09
AU8455798A (en)	1999-02-22
EP1000033B1 (fr)	2004-05-06
CN1265098A (zh)	2000-08-30
AU754747B2 (en)	2002-11-21
NO20000448L (no)	2000-03-16
US6458793B1 (en)	2002-10-01
NZ501778A (en)	2001-09-28
GB9715894D0 (en)	1997-10-01
NO20040520L (no)	2004-02-05
US20020193375A1 (en)	2002-12-19
ES2219894T3 (es)	2004-12-01
TR200000223T2 (tr)	2000-07-21
JP2001512103A (ja)	2001-08-21
PT1000033E (pt)	2004-08-31
BR9811055A (pt)	2000-09-05
CA2295945A1 (fr)	1999-02-11
EP1000033A1 (fr)	2000-05-17
ATE266007T1 (de)	2004-05-15
HUP0002528A2 (hu)	2001-06-28
IL133516A0 (en)	2001-04-30
DE69823665T2 (de)	2005-04-28

Publication	Publication Date	Title
SK1272000A3 (en)	2000-06-12	Heterocyclic derivatives which inhibit factor xa
US6022869A (en)	2000-02-08	Aminoheterocyclic compounds with antithrombotic/anticoagulant effect
SK61399A3 (en)	2000-02-14	HETEROCYCLE DERIVATIVES WHICH INHIBIT FACTOR Xa
JP2000504337A (ja)	2000-04-11	抗血栓剤または抗凝固剤としてのアミノヘテロ環状誘導体
SK16512000A3 (sk)	2001-05-10	Heterocyklické deriváty inhibujúce faktor xa, farmaceutická kompozícia s ich obsahom a ich použitie
EP2138482A1 (fr)	2009-12-30	Composé hétérocyclique bicyclique
JP2002513782A (ja)	2002-05-14	Ｘａ因子を阻害する複素環誘導体
EP1015449B1 (fr)	2005-01-05	Derives de (hetero)aryle-sulfonamide, leur preparation et leur utilisation en tant qu'inhibiteurs du facteur xa
US6723723B1 (en)	2004-04-20	Heterocyclic derivatives as inhibitors of factor Xa
CZ2000293A3 (cs)	2000-06-14	Heterocyklické deriváty, které inhibují faktor Xa
MXPA00000505A (en)	2001-12-04	Heterocyclic derivatives which inhibit factor xa
CZ20004049A3 (cs)	2001-02-14	Heterocyklické deriváty inhibující faktor Xa
MXPA01008067A (es)	2002-03-26	Derivados heterociclicos como inhibidores del factor xa
MXPA99003712A (en)	1999-10-14	HETEROCYCLE DERIVATIVES WHICH INHIBIT FACTOR Xa