SI1368336T1 - S tiofenom substituirani aminski derivati kot inhibitorji glyt-1 - Google Patents

S tiofenom substituirani aminski derivati kot inhibitorji glyt-1

Info

Publication number: SI1368336T1
Authority: SI; Slovenia
Prior art keywords: glyt; inhibitors; substituted amine; amine derivatives; thiophene substituted
Prior art date: 2001-02-16

Application number

SI200230381T

Other languages

English (en)

Inventor

Ian Egle

William Delaney

Zhao-Qing Wang

Richard Schumacher

Allen T Hopper

Ashok Tehim

Shawn Maddaford

Original Assignee

Allelix Neuroscience Inc

Nps Allelix Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-16

Filing date

2002-02-15

Publication date

2006-10-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23026417&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1368336(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-02-15 Application filed by Allelix Neuroscience Inc, Nps Allelix Corp filed Critical Allelix Neuroscience Inc

2006-10-31 Publication of SI1368336T1 publication Critical patent/SI1368336T1/sl

Links

YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 2
150000001412 amines Chemical class 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
229930192474 thiophene Natural products 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000926 neurological effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Epoxy Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SI200230381T 2001-02-16 2002-02-15 S tiofenom substituirani aminski derivati kot inhibitorji glyt-1 SI1368336T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US26924101P	2001-02-16	2001-02-16
EP02702186A EP1368336B9 (en)	2001-02-16	2002-02-15	Thiophene substituted amine derivatives as glyt-1 inhibitors
PCT/CA2002/000176 WO2002066456A2 (en)	2001-02-16	2002-02-15	Thiophene substituted amine derivatives as glyt-1 inhibitors

Publications (1)

Publication Number	Publication Date
SI1368336T1 true SI1368336T1 (sl)	2006-10-31

Family

ID=23026417

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200230381T SI1368336T1 (sl)	2001-02-16	2002-02-15	S tiofenom substituirani aminski derivati kot inhibitorji glyt-1

Country Status (31)

Country	Link
US (1)	US6667336B2 (sl)
EP (1)	EP1368336B9 (sl)
JP (2)	JP2004523548A (sl)
KR (1)	KR100900020B1 (sl)
CN (1)	CN1219776C (sl)
AT (1)	ATE327986T1 (sl)
AU (1)	AU2002235682C1 (sl)
BG (1)	BG108164A (sl)
BR (1)	BR0207307A (sl)
CA (1)	CA2438367A1 (sl)
CY (1)	CY1105529T1 (sl)
CZ (1)	CZ20032503A3 (sl)
DE (1)	DE60211866T2 (sl)
DK (1)	DK1368336T3 (sl)
EA (1)	EA006636B1 (sl)
EE (1)	EE05329B1 (sl)
ES (1)	ES2266446T3 (sl)
HK (1)	HK1061025A1 (sl)
HR (1)	HRP20030696A2 (sl)
HU (1)	HUP0303185A3 (sl)
IL (1)	IL157194A (sl)
MX (1)	MXPA03007309A (sl)
NO (1)	NO329038B1 (sl)
NZ (1)	NZ527695A (sl)
PL (1)	PL365024A1 (sl)
PT (1)	PT1368336E (sl)
SI (1)	SI1368336T1 (sl)
SK (1)	SK287304B6 (sl)
UA (1)	UA75114C2 (sl)
WO (1)	WO2002066456A2 (sl)
ZA (1)	ZA200307201B (sl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6191165B1 (en) *	1996-05-31	2001-02-20	Allelix Neuroscience Inc.	Pharmaceutical for treatment of neurological and neuropsychiatric disorders
DK1830833T3 (da) *	2004-12-16	2010-05-17	Janssen Pharmaceutica Nv	Kombination af en glycintransportør (GLyT1) inhibitor og et antipsykotikum til behandling af symptomer på schizofreni samt dens fremstilling og anvendelse deraf
WO2008040669A2 (en) *	2006-10-02	2008-04-10	Janssen Pharmaceutica N.V.	Novel intermediates for the preparation of a glyt1 inhibitor
WO2008065500A2 (en) *	2006-11-30	2008-06-05	Pfizer Products Inc.	Heteroaryl amides as type i glycine transport inhibitors
CN103374057B (zh) *	2012-04-16	2015-08-19	中国医药集团总公司四川抗菌素工业研究所	一种对甘氨酸转运子具有抑制活性的化合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3010599A1 (de)	1979-03-22	1980-10-09	Continental Pharma	Derivate von glycinamid, deren herstellung und verwendung
BE885303A (fr)	1980-09-19	1981-03-19	Continental Pharma	Glycinamides
AU552050B2 (en)	1981-05-26	1986-05-22	Smithkline Beckman Corporation	N-substituted azeheterocyclic carboxylic acids and their esters
US4383999A (en)	1981-05-26	1983-05-17	Smithkline Beckman Corporation	Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
US4514414A (en)	1982-10-25	1985-04-30	Smithkline Beckman Corporation	N-Substituted pyrrolidineacetic acids and their esters
DK288385D0 (da)	1985-06-26	1985-06-26	Novo Industri As	Aminosyrederivater
US4772615A (en)	1985-11-08	1988-09-20	Warner-Lambert Company	Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
FI864246A (fi)	1985-11-08	1987-05-09	Warner Lambert Co	N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat.
EP0231996B1 (en)	1986-01-07	1993-10-06	Novo Nordisk A/S	Novel amino acid derivatives
JPH02129158A (ja)	1988-11-07	1990-05-17	Nippon Steel Corp	光学活性なグリシン誘導体及びその製造方法
IE913279A1 (en) *	1990-09-26	1992-04-08	Astra Ab	(2-Thienyl)alkylamine Derivatives Having Neuroprotective¹Properties
ES2036926B1 (es)	1991-08-08	1994-01-16	Uriach & Cia Sa J	"procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina".
WO1997020552A1 (en)	1995-12-07	1997-06-12	Albert Einstein College Of Medicine Of Yeshiva University	Treatment of negative and cognitive symptoms of schizophrenia with glycine and its precursors
US6191165B1 (en)	1996-05-31	2001-02-20	Allelix Neuroscience Inc.	Pharmaceutical for treatment of neurological and neuropsychiatric disorders
DE69736441T2 (de) *	1996-05-31	2007-07-19	Allelix Neuroscience Inc.	Pharmazeutische zusammensetzung zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
JP4425992B2 (ja) *	1996-07-22	2010-03-03	サファイアセラピューティクス，インコーポレイティド	成長ホルモン放出特性を有する化合物
CZ20002459A3 (cs) *	1998-01-09	2001-12-12	Pfizer, Inc.	Inhibitory matričních metaloproteinas, způsoby jejich výroby, farmaceutické kompozice a způsoby léčení na jejich bázi
US6103743A (en) *	1999-08-06	2000-08-15	Allelix Neuroscience, Inc.	Unsaturated amino acid derivatives

2002
- 2002-02-15 MX MXPA03007309A patent/MXPA03007309A/es active IP Right Grant
- 2002-02-15 DE DE60211866T patent/DE60211866T2/de not_active Expired - Lifetime
- 2002-02-15 AT AT02702186T patent/ATE327986T1/de not_active IP Right Cessation
- 2002-02-15 CN CNB028050819A patent/CN1219776C/zh not_active Expired - Fee Related
- 2002-02-15 SK SK1144-2003A patent/SK287304B6/sk not_active IP Right Cessation
- 2002-02-15 NZ NZ527695A patent/NZ527695A/en unknown
- 2002-02-15 SI SI200230381T patent/SI1368336T1/sl unknown
- 2002-02-15 CZ CZ20032503A patent/CZ20032503A3/cs unknown
- 2002-02-15 CA CA002438367A patent/CA2438367A1/en not_active Abandoned
- 2002-02-15 EA EA200300900A patent/EA006636B1/ru not_active IP Right Cessation
- 2002-02-15 KR KR1020037010609A patent/KR100900020B1/ko not_active Expired - Fee Related
- 2002-02-15 UA UA2003087630A patent/UA75114C2/uk unknown
- 2002-02-15 JP JP2002565971A patent/JP2004523548A/ja active Pending
- 2002-02-15 DK DK02702186T patent/DK1368336T3/da active
- 2002-02-15 EP EP02702186A patent/EP1368336B9/en not_active Expired - Lifetime
- 2002-02-15 ES ES02702186T patent/ES2266446T3/es not_active Expired - Lifetime
- 2002-02-15 PT PT02702186T patent/PT1368336E/pt unknown
- 2002-02-15 AU AU2002235682A patent/AU2002235682C1/en not_active Ceased
- 2002-02-15 WO PCT/CA2002/000176 patent/WO2002066456A2/en active IP Right Grant
- 2002-02-15 PL PL02365024A patent/PL365024A1/xx unknown
- 2002-02-15 BR BR0207307-2A patent/BR0207307A/pt not_active IP Right Cessation
- 2002-02-15 US US10/077,579 patent/US6667336B2/en not_active Expired - Fee Related
- 2002-02-15 HU HU0303185A patent/HUP0303185A3/hu unknown
- 2002-02-15 EE EEP200300394A patent/EE05329B1/xx not_active IP Right Cessation
2003
- 2003-07-31 IL IL157194A patent/IL157194A/en not_active IP Right Cessation
- 2003-08-15 NO NO20033634A patent/NO329038B1/no not_active IP Right Cessation
- 2003-09-01 HR HR20030696A patent/HRP20030696A2/xx not_active Application Discontinuation
- 2003-09-09 BG BG108164A patent/BG108164A/xx unknown
- 2003-09-15 ZA ZA200307201A patent/ZA200307201B/en unknown
2004
- 2004-06-08 HK HK04104072A patent/HK1061025A1/xx not_active IP Right Cessation
2006
- 2006-08-22 CY CY20061101160T patent/CY1105529T1/el unknown
2009
- 2009-11-09 JP JP2009255663A patent/JP2010059182A/ja active Pending

Also Published As

Publication number	Publication date
MXPA03007309A (es)	2004-06-30
NO329038B1 (no)	2010-08-02
EA200300900A1 (ru)	2004-02-26
US6667336B2 (en)	2003-12-23
HUP0303185A3 (en)	2008-12-29
JP2010059182A (ja)	2010-03-18
ES2266446T3 (es)	2007-03-01
HK1061025A1 (en)	2004-09-03
KR20040028719A (ko)	2004-04-03
NO20033634L (no)	2003-10-08
EP1368336B1 (en)	2006-05-31
DE60211866D1 (de)	2006-07-06
AU2002235682C1 (en)	2008-12-11
DE60211866T2 (de)	2007-06-14
EP1368336B9 (en)	2007-02-14
CY1105529T1 (el)	2010-07-28
IL157194A (en)	2006-12-31
NO20033634D0 (no)	2003-08-15
WO2002066456A2 (en)	2002-08-29
SK287304B6 (sk)	2010-06-07
AU2002235682B2 (en)	2007-04-26
CN1491221A (zh)	2004-04-21
BG108164A (en)	2004-07-30
EA006636B1 (ru)	2006-02-24
DK1368336T3 (da)	2006-10-02
EP1368336A2 (en)	2003-12-10
SK11442003A3 (sk)	2004-03-02
CN1219776C (zh)	2005-09-21
HRP20030696A2 (en)	2005-04-30
BR0207307A (pt)	2004-08-17
US20030176489A1 (en)	2003-09-18
EE200300394A (et)	2003-12-15
PT1368336E (pt)	2006-10-31
NZ527695A (en)	2005-05-27
CZ20032503A3 (cs)	2004-02-18
JP2004523548A (ja)	2004-08-05
UA75114C2 (en)	2006-03-15
EE05329B1 (et)	2010-08-16
PL365024A1 (en)	2004-12-27
WO2002066456A3 (en)	2002-10-17
HUP0303185A2 (hu)	2003-12-29
KR100900020B1 (ko)	2009-06-01
CA2438367A1 (en)	2002-08-29
ZA200307201B (en)	2004-07-28
ATE327986T1 (de)	2006-06-15

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WO2004022528A3 (en)	2004-05-21	Arylglycine derivatives and their use as glycine transport inhibitors
DE60104697D1 (de)	2004-09-09	Sulfonamid-derivate
WO2002085853A3 (en)	2002-12-19	Heterocyclylalkoxy-, -alkylthio- and -alkylaminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
CY1105529T1 (el)	2010-07-28	Αντικατεστημενα με θειοφαινιο παραγωγα αμυνης σαν glyt-1 αναστολεις
SE0100295D0 (sv)	2001-02-01	New compounds
ZA200400824B (en)	2004-07-20	Pyridin-2-yl-methlyamine derivatives for treating opioid dependence.
EP1210948B8 (en)	2007-07-04	Therapeutic peptide for nervous diseases
MY139844A (en)	2009-11-30	1,2,4-triaminobenzene derivatives and their uses thereof for the prevention, treatment and/or inhibition of disorders of the central nervous system