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SI1169337T1 - Steroid nitrates for the treatment of oxidative injury and endothelial dysfunction - Google Patents

Steroid nitrates for the treatment of oxidative injury and endothelial dysfunction

Info

Publication number
SI1169337T1
SI1169337T1 SI200030523T SI200030523T SI1169337T1 SI 1169337 T1 SI1169337 T1 SI 1169337T1 SI 200030523 T SI200030523 T SI 200030523T SI 200030523 T SI200030523 T SI 200030523T SI 1169337 T1 SI1169337 T1 SI 1169337T1
Authority
SI
Slovenia
Prior art keywords
treatment
nitrates
steroid
endothelial dysfunction
oxidative injury
Prior art date
Application number
SI200030523T
Other languages
English (en)
Slovenian (sl)
Inventor
Soldato Piero Del
Original Assignee
Nicox S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox S.A. filed Critical Nicox S.A.
Publication of SI1169337T1 publication Critical patent/SI1169337T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
SI200030523T 1999-04-13 2000-04-11 Steroid nitrates for the treatment of oxidative injury and endothelial dysfunction SI1169337T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT1999MI000751A IT1311922B1 (it) 1999-04-13 1999-04-13 Composti farmaceutici.
PCT/EP2000/003238 WO2000061604A2 (fr) 1999-04-13 2000-04-11 Composes pharmaceutiques
EP00917075A EP1169337B1 (fr) 1999-04-13 2000-04-11 Steroids nitres pour le traitement des desordres causes par des oxydants et le disfonctionnement endothelial

Publications (1)

Publication Number Publication Date
SI1169337T1 true SI1169337T1 (en) 2005-04-30

Family

ID=11382683

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030523T SI1169337T1 (en) 1999-04-13 2000-04-11 Steroid nitrates for the treatment of oxidative injury and endothelial dysfunction

Country Status (25)

Country Link
US (3) US6909007B1 (fr)
EP (2) EP1169337B1 (fr)
JP (1) JP2002542162A (fr)
KR (2) KR100687821B1 (fr)
CN (2) CN1296380C (fr)
AT (1) ATE274521T1 (fr)
AU (2) AU766798B2 (fr)
BR (1) BR0009696A (fr)
CA (2) CA2370446C (fr)
DE (1) DE60013266T2 (fr)
DK (1) DK1169337T3 (fr)
ES (1) ES2226805T3 (fr)
HU (1) HUP0201872A3 (fr)
IL (2) IL145633A0 (fr)
IT (1) IT1311922B1 (fr)
MX (1) MXPA01010212A (fr)
NO (2) NO323374B1 (fr)
NZ (1) NZ514572A (fr)
PL (1) PL199579B1 (fr)
PT (1) PT1169337E (fr)
RU (1) RU2240325C2 (fr)
SI (1) SI1169337T1 (fr)
TR (2) TR200201899T2 (fr)
WO (1) WO2000061604A2 (fr)
ZA (1) ZA200108124B (fr)

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NZ519781A (en) 1999-12-23 2004-04-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
EP1406609B1 (fr) 2000-12-21 2006-09-06 Nitromed, Inc. Composes aryle substitues en tant que nouveaux inhibiteurs selectifs de la cyclo-oxygenase-2, compositions et methodes d'utilisation
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
EP1219306A1 (fr) * 2000-12-29 2002-07-03 Nicox S.A. Compositions contenant des cyclodextrines et des médicaments libérant le NO
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20020148A1 (it) 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
ITMI20021025A1 (it) * 2002-05-14 2003-11-14 Nicox Sa Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
JP2006501161A (ja) 2002-06-11 2006-01-12 ニトロメッド インク． ニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物ならびに使用方法
WO2004002420A2 (fr) 2002-06-28 2004-01-08 Nitromed, Inc. Inhibiteurs a selectivite cyclooxygenase-2 nitrosiles et/ou nitroses contenant une oxime et/ou une hydrazone, compositions et methodes d'utilisation correspondantes
CA2491127A1 (fr) 2002-07-03 2004-01-15 Nitromed, Inc. Composes anti-inflammatoires non-steroidiens nitroses, compositions et leur procede d'utilisation
JP2005538110A (ja) 2002-07-29 2005-12-15 ニトロメッド インコーポレーティッド シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途
KR20080039442A (ko) 2005-09-02 2008-05-07 니콕스 에스. 에이. 스테로이드 니트록시 유도체들
US8802726B2 (en) 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7645748B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol phosphorylnitroderivatives and use thereof
US7645749B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol nitroderivatives and use thereof
RU2442790C2 (ru) * 2007-02-05 2012-02-20 Никокс С.А. Стероиды, высвобождающие оксид азота
WO2009037584A2 (fr) * 2007-08-10 2009-03-26 Topigen Pharmaceuticals Inc. Combinaison de stéroïde nitrodérivé et bronchodilatateur pour le traitement d'une maladie respiratoire
US20090088411A1 (en) * 2007-08-31 2009-04-02 Topigen Pharmaceuticals Inc. No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
AU2008311824A1 (en) * 2007-10-19 2009-04-23 Burnham Institute For Medical Research Inhibitors of anti-apoptotic proteins
JP2011529933A (ja) 2008-08-05 2011-12-15 ニコックス エス エイ 網膜および黄斑の疾患の治療のための新規なｎｏ放出性ステロイド
AU2011243947A1 (en) 2010-04-23 2012-12-06 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
CU20110244A7 (es) 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
US9844599B2 (en) 2013-01-21 2017-12-19 Apparao Satyam Nitric oxide releasing produgs of therapeutic agents
KR101711513B1 (ko) * 2015-06-26 2017-03-02 주식회사 엘지생활건강 피부 개선용 조성물

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JPS5845724A (ja) * 1981-09-11 1983-03-17 Oriza Yuka Kk オリザノ−ル乳化液の製造法
FR2600653B1 (fr) 1986-06-24 1988-12-16 Pasteur Strasbourg Universite Composes de synthese associative d'acides amines soufres ou non soufres avec des derives du d-4 pregnene 3,20-dione ou avec des derives du d-1,4 pregnadiene 3,20-dione aux proprietes glucocorticoides et anti-inflammatoires, procedes d'obtention, compositions pharmaceutiques les contenant. proprietes pharmacologiques et applications
IT1204571B (it) 1987-05-08 1989-03-10 Chiesi Farma Spa Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche
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JP3108474B2 (ja) 1991-08-07 2000-11-13 日清製粉株式会社 活性型ビタミンｄ誘導体
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US5985862A (en) * 1996-05-02 1999-11-16 G.D. Searle & Co. Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
DE19634793A1 (de) * 1996-08-29 1998-03-05 Sanol Arznei Schwarz Gmbh S- und O-Nitratoacylverbindungen
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei

Also Published As

Publication number Publication date
NO20065784L (no) 2001-12-13
US20050176694A1 (en) 2005-08-11
CN1296380C (zh) 2007-01-24
EP1475386A3 (fr) 2011-12-28
HUP0201872A2 (en) 2002-10-28
EP1475386A2 (fr) 2004-11-10
KR100687821B1 (ko) 2007-02-28
CN1420891A (zh) 2003-05-28
DE60013266T2 (de) 2005-01-20
IT1311922B1 (it) 2002-03-20
EP1169337A2 (fr) 2002-01-09
AU2004200263B2 (en) 2006-05-04
WO2000061604A3 (fr) 2001-03-15
BR0009696A (pt) 2002-01-08
AU3820100A (en) 2000-11-14
ITMI990751A1 (it) 2000-10-13
US6909007B1 (en) 2005-06-21
IL175398A0 (en) 2006-09-05
PL199579B1 (pl) 2008-10-31
TR200201899T2 (tr) 2002-11-21
HUP0201872A3 (en) 2004-04-28
CA2586538C (fr) 2010-06-22
CN1916013A (zh) 2007-02-21
MXPA01010212A (es) 2002-09-18
DE60013266D1 (de) 2004-09-30
RU2240325C2 (ru) 2004-11-20
US7524836B2 (en) 2009-04-28
PT1169337E (pt) 2004-11-30
CA2586538A1 (fr) 2000-10-19
NO20014925D0 (no) 2001-10-10
ATE274521T1 (de) 2004-09-15
CA2370446A1 (fr) 2000-10-19
WO2000061604A2 (fr) 2000-10-19
CA2370446C (fr) 2008-03-25
TR200102929T2 (tr) 2002-04-22
NZ514572A (en) 2004-03-26
KR20060123788A (ko) 2006-12-04
KR100744701B1 (ko) 2007-08-02
JP2002542162A (ja) 2002-12-10
US7186708B2 (en) 2007-03-06
PL350775A1 (en) 2003-02-10
AU766798B2 (en) 2003-10-23
AU2004200263A1 (en) 2004-02-19
ES2226805T3 (es) 2005-04-01
ZA200108124B (en) 2003-03-26
EP1169337B1 (fr) 2004-08-25
US20070142342A1 (en) 2007-06-21
DK1169337T3 (da) 2004-12-06
KR20010108489A (ko) 2001-12-07
IL145633A0 (en) 2002-06-30
NO323374B1 (no) 2007-04-16
NO20014925L (no) 2001-12-13

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