SI1154993T1 - Thioamide derivatives - Google Patents

Thioamide derivatives

Info

Publication number: SI1154993T1
Authority: SI; Slovenia
Prior art keywords: thioamide derivatives; vcam; vla; asthma; discovered
Prior art date: 1999-02-18

Application number

SI200030513T

Other languages

English (en)

Slovenian (sl)

Inventor

Kenneth Gregory Hull

Achytharao Sidduri

Jefferson Wright Tilley

Original Assignee

F. Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-18

Filing date

2000-02-10

Publication date

2004-12-31

2000-02-10 Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag

2004-12-31 Publication of SI1154993T1 publication Critical patent/SI1154993T1/xx

Links

150000003556 thioamides Chemical class 0.000 title 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 2
206010061218 Inflammation Diseases 0.000 abstract 1
208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
108010008212 Integrin alpha4beta1 Proteins 0.000 abstract 1
108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 abstract 1
102100023543 Vascular cell adhesion protein 1 Human genes 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
208000037976 chronic inflammation Diseases 0.000 abstract 1
208000037893 chronic inflammatory disorder Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/46—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Photoreceptors In Electrophotography (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Gyroscopes (AREA)
Liquid Crystal Substances (AREA)

SI200030513T 1999-02-18 2000-02-10 Thioamide derivatives SI1154993T1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US12047599P	1999-02-18	1999-02-18
EP00903680A EP1154993B1 (en)	1999-02-18	2000-02-10	Thioamide derivatives
PCT/EP2000/001058 WO2000048994A1 (en)	1999-02-18	2000-02-10	Thioamide derivatives

Publications (1)

Publication Number	Publication Date
SI1154993T1 true SI1154993T1 (en)	2004-12-31

Family

ID=22390545

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200030513T SI1154993T1 (en)	1999-02-18	2000-02-10	Thioamide derivatives

Country Status (29)

Country	Link
US (6)	US6288267B1 (da)
EP (1)	EP1154993B1 (da)
JP (1)	JP2002537286A (da)
KR (1)	KR100649819B1 (da)
CN (1)	CN1213025C (da)
AT (1)	ATE278664T1 (da)
AU (1)	AU773388B2 (da)
BR (1)	BR0008280A (da)
CA (1)	CA2362831C (da)
CZ (1)	CZ20012980A3 (da)
DE (1)	DE60014588T2 (da)
DK (1)	DK1154993T3 (da)
ES (1)	ES2228458T3 (da)
HK (1)	HK1044330A1 (da)
HR (1)	HRP20010595B1 (da)
HU (1)	HUP0200155A3 (da)
ID (1)	ID30129A (da)
IL (2)	IL144636A0 (da)
MA (1)	MA26769A1 (da)
NO (1)	NO20014018D0 (da)
NZ (1)	NZ513254A (da)
PL (1)	PL349461A1 (da)
PT (1)	PT1154993E (da)
RU (1)	RU2245874C2 (da)
SI (1)	SI1154993T1 (da)
TR (1)	TR200102399T2 (da)
WO (1)	WO2000048994A1 (da)
YU (1)	YU58701A (da)
ZA (1)	ZA200106180B (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6939855B2 (en)	1997-07-31	2005-09-06	Elan Pharmaceuticals, Inc.	Anti-inflammatory compositions and method
US6680195B1 (en) *	1997-11-26	2004-01-20	Inhibitex, Inc.	Extracellular matrix-binding proteins from staphylococcus aureus
US6521626B1 (en) *	1998-03-24	2003-02-18	Celltech R&D Limited	Thiocarboxamide derivatives
US6388084B1 (en)	1999-12-06	2002-05-14	Hoffmann-La Roche Inc.	4-pyridinyl-n-acyl-l-phenylalanines
US6380387B1 (en)	1999-12-06	2002-04-30	Hoffmann-La Roche Inc.	4-Pyrimidinyl-n-acyl-l phenylalanines
KR100900931B1 (ko) *	2000-01-26	2009-06-08	미쓰이 가가쿠 가부시키가이샤	올레핀 중합체 및 그의 제조 방법
EP1270547A4 (en)	2000-03-23	2005-07-13	Ajinomoto Kk	NEW PHENYL ALANIDE DERIVATIVES
US6960597B2 (en) *	2000-06-30	2005-11-01	Orth-Mcneil Pharmaceutical, Inc.	Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
DE50108104D1 (de) *	2000-09-14	2005-12-22	Gruenenthal Gmbh	Beta-thio-aminosäuren
US20090297611A1 (en) *	2003-07-31	2009-12-03	Robinson Cynthia B	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026879A1 (en) *	2003-07-31	2005-02-03	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050069227A1 (en) *	2003-09-29	2005-03-31	Mark Steele	Flexible package having integrated slit member
US20050176755A1 (en) *	2003-10-31	2005-08-11	Dyatkin Alexey B.	Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
KR20070004676A (ko) *	2004-02-10	2007-01-09	얀센 파마슈티카 엔.브이.	알파４ 인테그린의 길항제로서의 피리다지논
JP2007522224A (ja) *	2004-02-10	2007-08-09	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	α４インテグリン拮抗薬としてのピリダジノン尿素
CA2558893A1 (en) *	2004-03-10	2005-09-22	Merck & Co., Inc.	Vla-4 antagonists
EP1781686B1 (en) *	2004-08-16	2009-05-06	Merck & Co., Inc.	Vla-4 antagonists
US7641325B2 (en) *	2004-10-04	2010-01-05	Kodak Graphic Communications Group Canada	Non-conductive fluid droplet characterizing apparatus and method
WO2006081986A1 (en) *	2005-02-07	2006-08-10	F.Hoffmann-La Roche Ag	Bambuterol and integrin inhibitor combination
WO2006094640A2 (en) *	2005-03-04	2006-09-14	F.Hoffmann-La Roche Ag	Roflumilast and integrin inhibitor combination and method of treatment
CZ297581B6 (cs) *	2005-05-26	2007-01-10	Universita Karlova v Praze, Farmaceutická fakulta v Hradci Králové	Antimykotické a antimykobakteriální thiosalicylanilidy a způsob jejich přípravy
CN103265495B (zh)	2005-12-29	2016-11-16	莱西肯医药有限公司	多环氨基酸衍生物及其使用方法
WO2008103378A2 (en)	2007-02-20	2008-08-28	Merrimack Pharmaceuticals, Inc.	Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
EA026990B1 (ru) *	2007-11-07	2017-06-30	Селлдекс Терапьютикс Инк.	Антитела, связывающиеся с человеческой клеткой dec-205
ES2525065T3 (es)	2008-04-11	2014-12-17	Merrimack Pharmaceuticals, Inc.	Ligadores de seroalbúmina humana y sus conjugados
CN102282168A (zh)	2008-11-18	2011-12-14	梅里麦克制药股份有限公司	人血清白蛋白接头以及其结合物
US8343706B2 (en)	2010-01-25	2013-01-01	International Business Machines Corporation	Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same
US20150105278A1 (en)	2011-10-17	2015-04-16	Westfaelische Wilhelms-Universitaet Muenster	Methods or risk assessment of pml and related apparatus
US9345766B2 (en)	2012-08-30	2016-05-24	Merrimack Pharmaceuticals, Inc.	Combination therapies comprising anti-ERBB3 agents
CN119462635A (zh)	2018-10-30	2025-02-18	吉利德科学公司	作为α4β7整合素抑制剂的喹啉衍生物
KR102641718B1 (ko)	2018-10-30	2024-02-29	길리애드 사이언시즈, 인코포레이티드	알파4베타7 인테그린 억제제로서의 이미다조피리딘 유도체
KR102652797B1 (ko)	2018-10-30	2024-04-02	길리애드 사이언시즈, 인코포레이티드	알파4베타7 인테그린의 억제를 위한 화합물
WO2020092401A1 (en)	2018-10-30	2020-05-07	Gilead Sciences, Inc.	COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN
EP4013499A1 (en)	2019-08-14	2022-06-22	Gilead Sciences, Inc.	Compounds for inhibition of alpha 4 beta 7 integrin
CN113683499B (zh) *	2021-09-10	2024-01-30	上海皓鸿生物医药科技有限公司	一种制备杜韦利西布中间体的方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE584914A (da)	1958-11-24
US3527793A (en)	1967-08-18	1970-09-08	Bristol Myers Co	Phenylglycine derivatives
IT1190378B (it)	1985-06-21	1988-02-16	Isf Spa	Derivati pirrolidonici
US5039805A (en)	1988-12-08	1991-08-13	Hoffmann-La Roche Inc.	Novel benzoic and phenylacetic acid derivatives
US5463116A (en)	1991-07-30	1995-10-31	Ajinomoto Co., Inc.	Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
US5840732A (en)	1994-06-20	1998-11-24	Takeda Chemical Industries Ltd.	Imidazopyridine or imidazopyrimidine compounds, their production and use
US6306840B1 (en)	1995-01-23	2001-10-23	Biogen, Inc.	Cell adhesion inhibitors
US5804595A (en)	1995-12-05	1998-09-08	Regents Of The University Of Minnesota	Kappa opioid receptor agonists
DE19548709A1 (de)	1995-12-23	1997-07-03	Merck Patent Gmbh	Tyrosinderivate
DE69710319T2 (de) *	1996-03-29	2002-08-14	G.D. SEARLE & CO., CHICAGO	Para-substituierte phenylpropansäure derivate als integrin-antagonisten
JP2000506538A (ja)	1996-03-29	2000-05-30	ジー．ディー．サールアンドカンパニー	メタ―置換フェニレン誘導体
DE19654483A1 (de)	1996-06-28	1998-01-02	Merck Patent Gmbh	Phenylalanin-Derivate
JP2002512625A (ja) *	1997-05-29	2002-04-23	メルクエンドカンパニーインコーポレーテッド	細胞接着阻害薬としての複素環アミド化合物
EP0991619B1 (en) *	1997-06-23	2003-09-10	Tanabe Seiyaku Co., Ltd.	Inhibitors of alpha 4-beta 1 mediated cell adhesion
EP1001974B1 (en) *	1997-07-31	2006-05-24	Elan Pharmaceuticals, Inc.	4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by vla-4
BR9811594A (pt) *	1997-07-31	2000-09-05	Elan Pharm Inc	Compostos de dipeptìdeo sulfonilados que inibem adesão de leucócito mediada por vla-4
CA2291475A1 (en) *	1997-07-31	1999-02-11	Elan Pharmaceuticals, Inc.	Dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4
HU229362B1 (en) *	1997-08-22	2013-11-28	Hoffmann La Roche	N-alkanoylphenylalanine derivatives
US6229011B1 (en) *	1997-08-22	2001-05-08	Hoffman-La Roche Inc.	N-aroylphenylalanine derivative VCAM-1 inhibitors
CA2300121A1 (en) *	1997-08-22	1999-03-04	F. Hoffmann-La Roche Ag	N-alkanoylphenylalanine derivatives
HUP0101701A3 (en) *	1997-12-23	2003-02-28	Aventis Pharma Ltd West Mallin	Substituted betha-alanines and pharmaceutical compositions comprising them
JP2002504534A (ja)	1998-02-26	2002-02-12	セルテック・セラピューティクス・リミテッド	α４インテグリンの阻害剤としてのフェニルアラニン誘導体
US6521626B1 (en)	1998-03-24	2003-02-18	Celltech R&D Limited	Thiocarboxamide derivatives
GB9811159D0 (en)	1998-05-22	1998-07-22	Celltech Therapeutics Ltd	Chemical compounds

2000
- 2000-02-10 JP JP2000599735A patent/JP2002537286A/ja active Pending
- 2000-02-10 CN CNB008043973A patent/CN1213025C/zh not_active Expired - Fee Related
- 2000-02-10 RU RU2001124596/04A patent/RU2245874C2/ru not_active IP Right Cessation
- 2000-02-10 PT PT00903680T patent/PT1154993E/pt unknown
- 2000-02-10 ID IDW00200101770A patent/ID30129A/id unknown
- 2000-02-10 WO PCT/EP2000/001058 patent/WO2000048994A1/en active IP Right Grant
- 2000-02-10 TR TR2001/02399T patent/TR200102399T2/xx unknown
- 2000-02-10 DK DK00903680T patent/DK1154993T3/da active
- 2000-02-10 BR BR0008280-5A patent/BR0008280A/pt not_active Application Discontinuation
- 2000-02-10 AU AU25475/00A patent/AU773388B2/en not_active Ceased
- 2000-02-10 CZ CZ20012980A patent/CZ20012980A3/cs unknown
- 2000-02-10 NZ NZ513254A patent/NZ513254A/en unknown
- 2000-02-10 DE DE60014588T patent/DE60014588T2/de not_active Expired - Lifetime
- 2000-02-10 SI SI200030513T patent/SI1154993T1/xx unknown
- 2000-02-10 AT AT00903680T patent/ATE278664T1/de not_active IP Right Cessation
- 2000-02-10 KR KR1020017010495A patent/KR100649819B1/ko not_active Expired - Fee Related
- 2000-02-10 YU YU58701A patent/YU58701A/sh unknown
- 2000-02-10 IL IL14463600A patent/IL144636A0/xx active IP Right Grant
- 2000-02-10 PL PL00349461A patent/PL349461A1/xx not_active Application Discontinuation
- 2000-02-10 ES ES00903680T patent/ES2228458T3/es not_active Expired - Lifetime
- 2000-02-10 HU HU0200155A patent/HUP0200155A3/hu unknown
- 2000-02-10 CA CA002362831A patent/CA2362831C/en not_active Expired - Fee Related
- 2000-02-10 EP EP00903680A patent/EP1154993B1/en not_active Expired - Lifetime
- 2000-02-17 US US09/505,903 patent/US6288267B1/en not_active Expired - Fee Related
2001
- 2001-03-20 US US09/812,325 patent/US20020028933A1/en not_active Abandoned
- 2001-05-23 US US09/863,579 patent/US6458844B2/en not_active Expired - Fee Related
- 2001-05-23 US US09/863,567 patent/US6479666B2/en not_active Expired - Fee Related
- 2001-05-23 US US09/864,032 patent/US6426348B1/en not_active Expired - Fee Related
- 2001-05-23 US US09/864,104 patent/US6423728B1/en not_active Expired - Fee Related
- 2001-07-26 ZA ZA200106180A patent/ZA200106180B/en unknown
- 2001-07-30 IL IL144636A patent/IL144636A/en not_active IP Right Cessation
- 2001-08-08 MA MA26290A patent/MA26769A1/fr unknown
- 2001-08-10 HR HR20010595A patent/HRP20010595B1/xx not_active IP Right Cessation
- 2001-08-17 NO NO20014018A patent/NO20014018D0/no not_active Application Discontinuation
2002
- 2002-08-10 HK HK02105863A patent/HK1044330A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
US20020040148A1 (en)	2002-04-04
NZ513254A (en)	2003-10-31
EP1154993B1 (en)	2004-10-06
NO20014018L (no)	2001-08-17
DE60014588T2 (de)	2006-02-23
PL349461A1 (en)	2002-07-29
IL144636A0 (en)	2002-05-23
ZA200106180B (en)	2002-10-28
US20020010338A1 (en)	2002-01-24
NO20014018D0 (no)	2001-08-17
PT1154993E (pt)	2005-01-31
AU2547500A (en)	2000-09-04
HUP0200155A2 (en)	2002-06-29
CN1213025C (zh)	2005-08-03
DK1154993T3 (da)	2005-02-14
YU58701A (sh)	2004-05-12
US20020028933A1 (en)	2002-03-07
CZ20012980A3 (cs)	2002-04-17
CA2362831A1 (en)	2000-08-24
DE60014588D1 (en)	2004-11-11
US6458844B2 (en)	2002-10-01
EP1154993A1 (en)	2001-11-21
AU773388B2 (en)	2004-05-27
CA2362831C (en)	2008-10-07
HRP20010595A2 (en)	2002-08-31
US6423728B1 (en)	2002-07-23
MA26769A1 (fr)	2004-12-20
ATE278664T1 (de)	2004-10-15
US6426348B1 (en)	2002-07-30
KR100649819B1 (ko)	2007-02-28
CN1342140A (zh)	2002-03-27
RU2245874C2 (ru)	2005-02-10
BR0008280A (pt)	2001-11-06
JP2002537286A (ja)	2002-11-05
WO2000048994A1 (en)	2000-08-24
HUP0200155A3 (en)	2005-04-28
US20010041799A1 (en)	2001-11-15
ES2228458T3 (es)	2005-04-16
KR20010102243A (ko)	2001-11-15
TR200102399T2 (tr)	2002-01-21
US6479666B2 (en)	2002-11-12
IL144636A (en)	2007-06-17
ID30129A (id)	2001-11-08
US20020052508A1 (en)	2002-05-02
HK1044330A1 (en)	2002-10-18
HRP20010595B1 (en)	2006-02-28
US6288267B1 (en)	2001-09-11

Publication	Publication Date	Title
PL349461A1 (en)	2002-07-29	Thioamide derivatives
BG108806A (en)	2005-04-30	IIb/IIIa CELL ADHESION INHIIBITORS, METHOD FOR THE PRODUCTION, PHARMACEUTCIAL COMPOSITION AND ADMINISTRATION THEREOF
MXPA01008058A (es)	2004-04-05	Composiciones deinhibidor de cicloxigenasa-2 teniendo un rapido inicio de efecto terapeutico.
MY126972A (en)	2006-11-30	4-pyrimidinyl-n-acyl-l-phenylalanines
WO2005051906A3 (en)	2005-11-17	Heterocyclic inhibitors of mek and methods of use thereof
TW200716648A (en)	2007-05-01	Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia
BG105429A (en)	2001-12-29	4-amino-substituted-2-substituted-1,2,3,4- tetrahydroquinolines as cetp inhibitors
YU40502A (sh)	2005-03-15	4-piridinil-n-acil-l-fenilalanini
EP1539136A4 (en)	2006-10-18	PPAR ALPHA SELECTIVE COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS
AU2003224923A1 (en)	2003-10-27	Heterocyclic amide derivatives as cytokine inhibitors
CA2362833A1 (en)	2000-08-24	Phenylalaninol derivatives
PL1716147T3 (pl)	2008-03-31	Pochodne diazaspiropiperydyny jako inhibitory transportera 1 glicyny i transportera 2 glicyny
WO1998057910A3 (en)	1999-03-11	Cyclooxygenase-i selective inhibitors and the use thereof as analgesic, antiinflammatory and antiarthritic agents