SE9003743D0 - Method and means for oligonucleotide synthesis - Google Patents

Method and means for oligonucleotide synthesis

Info

Publication number: SE9003743D0
Authority: SE; Sweden
Prior art keywords: pct; aralkyloxy; cycloalkyloxy; alkenyloxy; nucleoside
Prior art date: 1990-11-26

Application number

SE9003743A

Other languages

English (en)

Swedish (sv)

Inventor

L Holmberg

Original Assignee

Pharmacia Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-26

Filing date

1990-11-26

Publication date

1990-11-26

1990-11-26 Application filed by Pharmacia Ab filed Critical Pharmacia Ab

1990-11-26 Priority to SE9003743A priority Critical patent/SE9003743D0/xx

1990-11-26 Publication of SE9003743D0 publication Critical patent/SE9003743D0/xx

1991-11-25 Priority to EP91920800A priority patent/EP0514513B1/fr

1991-11-25 Priority to AT91920800T priority patent/ATE133684T1/de

1991-11-25 Priority to JP50010592A priority patent/JP3161730B2/ja

1991-11-25 Priority to US07/915,820 priority patent/US5589586A/en

1991-11-25 Priority to PCT/SE1991/000797 priority patent/WO1992009615A1/fr

1991-11-25 Priority to DE69116864T priority patent/DE69116864T2/de

1991-11-25 Priority to ES91920800T priority patent/ES2084839T3/es

Links

238000000034 method Methods 0.000 title 1
238000002515 oligonucleotide synthesis Methods 0.000 title 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000002102 aryl alkyloxo group Chemical group 0.000 abstract 2
125000004104 aryloxy group Chemical group 0.000 abstract 2
125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
239000002777 nucleoside Substances 0.000 abstract 2
125000003835 nucleoside group Chemical group 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005112 cycloalkylalkoxy group Chemical group 0.000 abstract 1
KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)

SE9003743A 1990-11-26 1990-11-26 Method and means for oligonucleotide synthesis SE9003743D0 (sv)

Priority Applications (8)

Application Number	Priority Date	Filing Date	Title
SE9003743A SE9003743D0 (sv)	1990-11-26	1990-11-26	Method and means for oligonucleotide synthesis
EP91920800A EP0514513B1 (fr)	1990-11-26	1991-11-25	Procede et systeme permettant de realiser la synthese d'oligonucleotides
AT91920800T ATE133684T1 (de)	1990-11-26	1991-11-25	Verfahren und mittel zur synthese von oligonukleotiden
JP50010592A JP3161730B2 (ja)	1990-11-26	1991-11-25	オリゴヌクレオチド合成の方法および手段
US07/915,820 US5589586A (en)	1990-11-26	1991-11-25	Nucleosides attached to a solid support through a 3'-silyl linkage and their use in oligonucleotide synthesis
PCT/SE1991/000797 WO1992009615A1 (fr)	1990-11-26	1991-11-25	Procede et systeme permettant de realiser la synthese d'oligonucleotides
DE69116864T DE69116864T2 (de)	1990-11-26	1991-11-25	Verfahren und mittel zur synthese von oligonukleotiden
ES91920800T ES2084839T3 (es)	1990-11-26	1991-11-25	Metodo y medios para sintesis de oligonucleotidos.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9003743A SE9003743D0 (sv)	1990-11-26	1990-11-26	Method and means for oligonucleotide synthesis

Publications (1)

Publication Number	Publication Date
SE9003743D0 true SE9003743D0 (sv)	1990-11-26

Family

ID=20380998

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE9003743A SE9003743D0 (sv)	1990-11-26	1990-11-26	Method and means for oligonucleotide synthesis

Country Status (8)

Country	Link
US (1)	US5589586A (fr)
EP (1)	EP0514513B1 (fr)
JP (1)	JP3161730B2 (fr)
AT (1)	ATE133684T1 (fr)
DE (1)	DE69116864T2 (fr)
ES (1)	ES2084839T3 (fr)
SE (1)	SE9003743D0 (fr)
WO (1)	WO1992009615A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5342631A (en) *	1992-12-29	1994-08-30	Wm. Wrigley Jr. Company	Wax-free chewing gum including special oligosaccharide binders
JPH06169754A (ja) *	1992-12-04	1994-06-21	Hideo Hirano	合成オリゴヌクレオタイドの精製装置
GB9307014D0 (en) *	1993-04-02	1993-05-26	Laporte Plc	Protecting group for use in oligodeoxyribonucleotide synthesis
SE9603171D0 (sv)	1996-08-30	1996-08-30	Marek Kwiatkowski	Solid phase synthesis
ES2114504B1 (es) *	1996-09-13	1999-02-01	Univ Madrid Autonoma	Metodo para la sintesis enzimatica de desoxioligonucleotidos en soporte solido.
SE9701783D0 (sv) *	1997-05-14	1997-05-14	Marek Kwiatkowski	In situ synthesis of oligonucleotides of inverse orientation
GB9815166D0 (en) *	1998-07-13	1998-09-09	Brax Genomics Ltd	Compounds for mass spectrometry
US6465628B1 (en)	1999-02-04	2002-10-15	Isis Pharmaceuticals, Inc.	Process for the synthesis of oligomeric compounds
ATE443071T1 (de) *	1999-02-05	2009-10-15	Ge Healthcare Bio Sciences	Verfahren zum entschützen von oligonukleotiden
GB9907245D0 (en) *	1999-03-29	1999-05-26	Goldsborough Andrew	Cleavage of nucleic acids from solid supports
SE9904506D0 (sv) *	1999-12-09	1999-12-09	Karolinska Innovations Ab	Method for immobilisation
US6768005B2 (en)	2000-12-20	2004-07-27	Avecia Limited	Process
EP1343802B1 (fr) *	2000-12-05	2012-05-30	Avecia Biotechnology Inc	Procede de preparation d'oligonucleotides
JPWO2002086160A1 (ja) *	2001-04-18	2004-08-12	三菱レイヨン株式会社	ハイブリダイゼーションプローブ
KR20040015107A (ko) *	2001-04-30	2004-02-18	아베시아 바이오테크놀러지, 아이엔씨.	고체 지지체 상에 올리뉴클레오티드의 고정화
US6818762B2 (en)	2001-05-25	2004-11-16	Maine Molecular Quality Controls, Inc.	Compositions and methods relating to nucleic acid reference standards
US8569516B2 (en) *	2001-09-07	2013-10-29	Elitech Holding B.V.	Compounds and methods for fluorescent labeling
US6972339B2 (en) *	2001-09-07	2005-12-06	Epoch Biosciences, Inc.	Compounds and methods for fluorescent labeling
US7345163B2 (en)	2002-08-28	2008-03-18	Quiatech Ab	Process for separating and deprotecting oligonucleotides
WO2005040357A2 (fr) *	2003-10-24	2005-05-06	Epoch Biosciences, Inc.	Composes et methodes destines a l'obtention d'un marquage fluorescent
US7612759B2 (en) *	2004-05-12	2009-11-03	Shimano Inc.	Cycle computer display apparatus
ES2461858T3 (es)	2004-08-13	2014-05-21	Epoch Biosciences, Inc.	Colorantes fluorescentes de fosfonato y conjugados
US8129517B1 (en)	2006-05-23	2012-03-06	Integrated Dna Technologies, Inc.	Labeled solid supports for organic synthesis
US8719695B2 (en)	2011-05-31	2014-05-06	Apple Inc.	Devices, methods, and graphical user interfaces for document manipulation
CA3011583C (fr)	2017-07-26	2021-01-26	Smith Industries, Inc. D/B/A Jay R. Smith Mfg. Co.	Caniveau de seuil de plateau incruste

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1159052A (fr) *	1980-02-29	1983-12-20	University Patents, Inc.	Methode de preparation d'oligonucleotides
FR2529892A1 (fr) *	1982-07-09	1984-01-13	Transgene Sa	Nouveau support pour la synthese des polynucleotides, en particulier par la methode triester et procede pour sa preparation
FR2584090B1 (fr) *	1985-06-27	1987-08-28	Roussel Uclaf	Nouveaux supports, leur preparation et les intermediaires obtenus, leur application a la synthese d'oligonucleotides et les nouveaux nucleosides et oligonucleotides relies aux supports ainsi obtenus

1990
- 1990-11-26 SE SE9003743A patent/SE9003743D0/xx unknown
1991
- 1991-11-25 AT AT91920800T patent/ATE133684T1/de not_active IP Right Cessation
- 1991-11-25 DE DE69116864T patent/DE69116864T2/de not_active Expired - Fee Related
- 1991-11-25 JP JP50010592A patent/JP3161730B2/ja not_active Expired - Lifetime
- 1991-11-25 EP EP91920800A patent/EP0514513B1/fr not_active Expired - Lifetime
- 1991-11-25 ES ES91920800T patent/ES2084839T3/es not_active Expired - Lifetime
- 1991-11-25 US US07/915,820 patent/US5589586A/en not_active Expired - Lifetime
- 1991-11-25 WO PCT/SE1991/000797 patent/WO1992009615A1/fr active IP Right Grant

Also Published As

Publication number	Publication date
US5589586A (en)	1996-12-31
JPH05503715A (ja)	1993-06-17
ES2084839T3 (es)	1996-05-16
EP0514513B1 (fr)	1996-01-31
EP0514513A1 (fr)	1992-11-25
JP3161730B2 (ja)	2001-04-25
DE69116864D1 (de)	1996-03-14
DE69116864T2 (de)	1996-09-12
ATE133684T1 (de)	1996-02-15
WO1992009615A1 (fr)	1992-06-11

Publication	Publication Date	Title
SE9003743D0 (sv)	1990-11-26	Method and means for oligonucleotide synthesis
DE69528839D1 (de)	2002-12-19	Reduzierung von nicht spezifischer hybridisierung unter verwendung neuer basenpaarschemata
ATE138652T1 (de)	1996-06-15	Aminoalkohole
DE69815342D1 (de)	2003-07-10	Sulfonatfreie cyaninfarbstoffe zur markierung von nukleosiden und nukleotiden
DE68905170D1 (de)	1993-04-08	Akyloxyalkylierte polyorganosiloxane enthaltende rasierzusammensetzung fuer die haut und verfahren zu ihrer herstellung.
HUT77176A (hu)	1998-03-02	Fényérzékeny védőcsoportot tartalmazó nukleozidszármazékok, eljárás előállításukra és alkalmazásuk
DE69401658D1 (de)	1997-03-13	Verwendung von deoxygalactonojirimycin derivaten zu hemmung der glycolipid synthese
CA2086908A1 (fr)	1993-07-09	N-phenyl-2-cyano-3-hydroxy-enamides substitues
HUP0001494A2 (hu)	2000-10-28	3-Fenoxi-, 3-dibenzo[a,d]cikloheptenil-oxi-, 3-dibenz[b,f]-[1,4]oxazepinil-oxi-1-amino-2-propanol-származékok és az ezeket tartalmazó gyógyszerkészítmények
BR1100991A (pt)	1999-10-13	Compostos, processo para preparação dos mesmos, medicamentos, e, compostos intermediários
DE58907421D1 (de)	1994-05-19	Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung und ihre Verwendung.
CA2036645A1 (fr)	1992-04-10	Polymeres contenant des antidegradants d'amines lies chimiquement
ATE13880T1 (de)	1985-07-15	N-2-hydroxypropyl-piperidine und verfahren zu ihrer herstellung.
ATE61369T1 (de)	1991-03-15	Verfahren zur herstellung von oximosilanen.
ATE85327T1 (de)	1993-02-15	Substituierte pyridylethanolamine, verfahren zu ihrer herstellung und ihre verwendung als leistungsfoerderer bei tieren.
BR9709791A (pt)	1999-08-10	Intermediários para a síntese de oligonucleotíedeos
BR9508729A (pt)	1997-11-11	Triarilmetanos e uso dos mesmos
AT387214B (de)	1988-12-27	Verfahren zur herstellung neuer n-substituierter, estergruppen enthaltender acrylamide
ATE63107T1 (de)	1991-05-15	Verfahren zur synthese von carbonsaeuren.
IT8720737A0 (it)	1987-06-01	Organo di supporto perl'ammortizzazione di vibrazioni orizzontali.
ATE71618T1 (de)	1992-02-15	2-anilino-chinoline, verfahren zu ihrer herstellung und diese enthaltende fungizide.
DE58905736D1 (de)	1993-11-04	Verbindungen mit mindestens drei funktionellen estergruppen und verfahren zu ihrer herstellung.
BR8905907A (pt)	1990-06-19	Processo para a preparacao de um composto
ATE80882T1 (de)	1992-10-15	(ethylenedioxo-3,3 zyclohexyl)-4 aketophenon und derivate davon, verfahren zu deren herstellung und verwendung dieser verbindungen.

SE9003743D0 - Method and means for oligonucleotide synthesis - Google Patents

Info

Links

Classifications

Landscapes

Priority Applications (8)

Applications Claiming Priority (1)

Publications (1)

Family

ID=20380998

Family Applications (1)

Country Status (8)

Families Citing this family (25)

Family Cites Families (3)

Also Published As

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