SE8304361D0 - Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives - Google Patents
Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivativesInfo
- Publication number
- SE8304361D0 SE8304361D0 SE8304361A SE8304361A SE8304361D0 SE 8304361 D0 SE8304361 D0 SE 8304361D0 SE 8304361 A SE8304361 A SE 8304361A SE 8304361 A SE8304361 A SE 8304361A SE 8304361 D0 SE8304361 D0 SE 8304361D0
- Authority
- SE
- Sweden
- Prior art keywords
- hydrogen
- derivatives
- different
- lower alkyl
- novel
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- 230000016571 aggressive behavior Effects 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000001914 calming effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- IVXQBCUBSIPQGU-UHFFFAOYSA-N piperazine-1-carboxamide Chemical compound NC(=O)N1CCNCC1 IVXQBCUBSIPQGU-UHFFFAOYSA-N 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/21—Radicals derived from sulfur analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8304361A SE8304361D0 (sv) | 1983-08-10 | 1983-08-10 | Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives |
| IL72563A IL72563A (en) | 1983-08-10 | 1984-08-01 | 1-piperazinecarboxamide derivatives,their preparation and pharmaceutical compositions containing them |
| DE8484850237T DE3480395D1 (en) | 1983-08-10 | 1984-08-02 | 1-piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions |
| PCT/SE1984/000269 WO1985000811A1 (fr) | 1983-08-10 | 1984-08-02 | Nouveaux derives de carboxamide de 1-piperazine |
| AU32111/84A AU569537B2 (en) | 1983-08-10 | 1984-08-02 | Novel 1-piperazinecarboxamide derivatives |
| HU843341A HU196977B (en) | 1983-08-10 | 1984-08-02 | Process for producing new 1-piperazin-carboxamide derivatives |
| AT84850237T ATE47850T1 (de) | 1983-08-10 | 1984-08-02 | 1-piperazinkarboxamid-derivate, verfahren zu ihrer herstellung und ihre verwendung in pharmazeutischen praeparaten. |
| EP84850237A EP0136274B1 (fr) | 1983-08-10 | 1984-08-02 | Dérivés de 1-pipérazinecarboxamide, procédé de leur préparation et leur utilisation dans des compositions pharmaceutiques |
| JP59503010A JPH0723364B2 (ja) | 1983-08-10 | 1984-08-02 | 新規な１−ピペラジンカルボキサミド誘導体 |
| NZ209166A NZ209166A (en) | 1983-08-10 | 1984-08-09 | 1-piperazinecarboxamides and pharmaceutical compositions |
| IE205084A IE58065B1 (en) | 1983-08-10 | 1984-08-09 | 1-Piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions |
| CA000460595A CA1253148A (fr) | 1983-08-10 | 1984-08-09 | Derives de 1-piperazinecarboxamide |
| ES535027A ES8705411A1 (es) | 1983-08-10 | 1984-08-09 | Procedimiento para preparar derivados de 1-piperazinacarboxamida |
| FI851350A FI80449C (fi) | 1983-08-10 | 1985-04-03 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-piperazinkarboxamidderivat. |
| DK157485A DK157864C (da) | 1983-08-10 | 1985-04-09 | Hidtil ukendte 1-piperazincarboxamidderivater substitueret paa det basiske nitrogenatom samt farmaceutiske praeparater og sammensaetninger indeholdende disse |
| NO851409A NO166410C (no) | 1983-08-10 | 1985-04-09 | Analogifremgangsmaate ved fremstilling av terapeutisk aktive 1-piperazinkarboksamidderivater. |
| ES552001A ES8704917A1 (es) | 1983-08-10 | 1986-02-14 | Procedimiento para prepararar derivados de 1-piperazinacarboximida. |
| ES556989A ES8802039A1 (es) | 1983-08-10 | 1986-08-01 | Procedimiento par preparar derivados de 1-piperazinacarboxamida |
| US07/227,420 US4935419A (en) | 1983-08-10 | 1988-07-29 | Novel 1-piperazinecarboxamide derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8304361A SE8304361D0 (sv) | 1983-08-10 | 1983-08-10 | Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE8304361D0 true SE8304361D0 (sv) | 1983-08-10 |
Family
ID=20352166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8304361A SE8304361D0 (sv) | 1983-08-10 | 1983-08-10 | Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4935419A (fr) |
| EP (1) | EP0136274B1 (fr) |
| JP (1) | JPH0723364B2 (fr) |
| AT (1) | ATE47850T1 (fr) |
| AU (1) | AU569537B2 (fr) |
| CA (1) | CA1253148A (fr) |
| DE (1) | DE3480395D1 (fr) |
| DK (1) | DK157864C (fr) |
| ES (3) | ES8705411A1 (fr) |
| FI (1) | FI80449C (fr) |
| HU (1) | HU196977B (fr) |
| IE (1) | IE58065B1 (fr) |
| IL (1) | IL72563A (fr) |
| NZ (1) | NZ209166A (fr) |
| SE (1) | SE8304361D0 (fr) |
| WO (1) | WO1985000811A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8500573D0 (sv) * | 1985-02-08 | 1985-02-08 | Ferrosan Ab | Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain |
| GB8713240D0 (en) * | 1987-06-05 | 1987-07-08 | Proteus Biotech Ltd | Hormones |
| CA1326451C (fr) * | 1988-01-26 | 1994-01-25 | Nippon Chemiphar Co., Ltd. | Agents therapeutiques pour maladies hepatiques avec derives de piperazine |
| US5795894A (en) * | 1995-05-02 | 1998-08-18 | Schering Corporation | Piperazino derivatives as neurokinn antagonists |
| US5719156A (en) * | 1995-05-02 | 1998-02-17 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| US5892039A (en) * | 1995-08-31 | 1999-04-06 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| US5869488A (en) * | 1996-05-01 | 1999-02-09 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| US5968929A (en) * | 1996-10-30 | 1999-10-19 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| CA2362494A1 (fr) | 1999-03-03 | 2000-09-08 | Merck & Co., Inc. | Inhibiteurs de prenyl-proteine transferases |
| CA2739291A1 (fr) * | 2008-10-15 | 2010-04-22 | Nitto Denko Corporation | Procede de preparation de conjugues de polyglutamate |
| BR112012013305A2 (pt) * | 2009-12-16 | 2016-03-01 | Nitto Denko Corp | processos para a preparação de ácido poliglutâmico |
| JP6334511B2 (ja) * | 2012-04-14 | 2018-05-30 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 新規方法 |
| IL296884B2 (en) | 2016-01-26 | 2024-05-01 | Intra Cellular Therapies Inc | Condensed heterocyclic converted gamma carbonyls for use in the treatment of central nervous system disorders |
| EP3562484B1 (fr) | 2016-12-29 | 2021-08-25 | Intra-Cellular Therapies, Inc. | Dérivés de pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline utiles dans les traitements de troubles du snc |
| WO2018126140A1 (fr) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Composés organiques |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3000892A (en) * | 1959-11-16 | 1961-09-19 | Paul A J Janssen | 1-aroylalkyl-4-aroylpiperazines |
| DE1670431A1 (de) * | 1966-03-04 | 1971-02-11 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung neuer Piperazin-Derivate |
| GB1143882A (fr) * | 1966-06-21 | |||
| GB1186495A (en) * | 1968-02-20 | 1970-04-02 | Delalande Sa | 0-[3-(4-Fluorobenzoyl) Proplyl]-4-Substituted Piperazines, their Acid Addition Salts and their method of preparation |
| FR2262521A1 (en) * | 1973-08-08 | 1975-09-26 | Delalande Sa | 3-(3,4,5-Trimethoxyphenyl)piperazines - with coronary vasodilator, hypotensive, antiinflammatory, analgesic, and antiulcer activity |
| JPS5143772A (en) * | 1974-09-26 | 1976-04-14 | Kyorin Seiyaku Kk | 11 * 33 fuenirupuropiru * 44 furoirupiperajinjudotaino seizoho |
| JPS50131974A (fr) * | 1974-03-06 | 1975-10-18 | ||
| AR207031A1 (es) * | 1974-03-06 | 1976-09-09 | Kyorin Seiyaku Kk | Procedimiento para preparacion de nuevos derivados de 1-(3-fenilpropil)-4-furoilpiperacina |
| JPS518283A (en) * | 1974-07-09 | 1976-01-23 | Kyorin Seiyaku Kk | 11 * 33 fuenirupuropiru * 44 karubamoirupiperajinjudotaino seizoho |
| JPS5346988A (en) * | 1976-10-07 | 1978-04-27 | Kyorin Seiyaku Kk | Piperadine derivative |
| NO154582C (no) * | 1978-10-20 | 1986-11-05 | Ferrosan Ab | Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider. |
| ATE10193T1 (de) * | 1980-06-16 | 1984-11-15 | Ab Ferrosan | Diphenylbutyl-1-acylpiperazine. |
| DE3276754D1 (en) * | 1981-12-02 | 1987-08-20 | Ferrosan Ab | 1-piperazinocarboxylates, process for their preparation and pharmaceutical compositions containing them |
-
1983
- 1983-08-10 SE SE8304361A patent/SE8304361D0/xx unknown
-
1984
- 1984-08-01 IL IL72563A patent/IL72563A/xx not_active IP Right Cessation
- 1984-08-02 AT AT84850237T patent/ATE47850T1/de not_active IP Right Cessation
- 1984-08-02 AU AU32111/84A patent/AU569537B2/en not_active Expired
- 1984-08-02 WO PCT/SE1984/000269 patent/WO1985000811A1/fr active IP Right Grant
- 1984-08-02 DE DE8484850237T patent/DE3480395D1/de not_active Expired
- 1984-08-02 EP EP84850237A patent/EP0136274B1/fr not_active Expired
- 1984-08-02 HU HU843341A patent/HU196977B/hu unknown
- 1984-08-02 JP JP59503010A patent/JPH0723364B2/ja not_active Expired - Lifetime
- 1984-08-09 CA CA000460595A patent/CA1253148A/fr not_active Expired
- 1984-08-09 NZ NZ209166A patent/NZ209166A/en unknown
- 1984-08-09 IE IE205084A patent/IE58065B1/en not_active IP Right Cessation
- 1984-08-09 ES ES535027A patent/ES8705411A1/es not_active Expired
-
1985
- 1985-04-03 FI FI851350A patent/FI80449C/fi not_active IP Right Cessation
- 1985-04-09 DK DK157485A patent/DK157864C/da not_active IP Right Cessation
-
1986
- 1986-02-14 ES ES552001A patent/ES8704917A1/es not_active Expired
- 1986-08-01 ES ES556989A patent/ES8802039A1/es not_active Expired
-
1988
- 1988-07-29 US US07/227,420 patent/US4935419A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0136274B1 (fr) | 1989-11-08 |
| JPH0723364B2 (ja) | 1995-03-15 |
| DK157864C (da) | 1990-07-23 |
| ATE47850T1 (de) | 1989-11-15 |
| NZ209166A (en) | 1987-07-31 |
| FI851350L (fi) | 1985-04-03 |
| IL72563A (en) | 1988-10-31 |
| IE842050L (en) | 1985-02-10 |
| DK157864B (da) | 1990-02-26 |
| IL72563A0 (en) | 1984-11-30 |
| HU196977B (en) | 1989-02-28 |
| ES8802039A1 (es) | 1988-03-16 |
| ES552001A0 (es) | 1987-04-16 |
| DK157485A (da) | 1985-04-09 |
| FI851350A0 (fi) | 1985-04-03 |
| ES556989A0 (es) | 1988-03-16 |
| ES8705411A1 (es) | 1987-05-01 |
| DK157485D0 (da) | 1985-04-09 |
| AU3211184A (en) | 1985-03-12 |
| ES535027A0 (es) | 1987-05-01 |
| ES8704917A1 (es) | 1987-04-16 |
| US4935419A (en) | 1990-06-19 |
| FI80449B (fi) | 1990-02-28 |
| EP0136274A1 (fr) | 1985-04-03 |
| DE3480395D1 (en) | 1989-12-14 |
| FI80449C (fi) | 1990-06-11 |
| CA1253148A (fr) | 1989-04-25 |
| AU569537B2 (en) | 1988-02-04 |
| WO1985000811A1 (fr) | 1985-02-28 |
| HUT37415A (en) | 1985-12-28 |
| IE58065B1 (en) | 1993-06-30 |
| JPS60501956A (ja) | 1985-11-14 |
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