RU2468791C2 - Composition, possessing adaptogenic, general tonic and working capacity-increasing acyion - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical industry and represents composition, which possesses adaptogenic, general tonic and working capacity-increasing action, which contains nicotineamide, alfa-tocopherol acetate, pyridoxine hydrochloride, riboflavin beta-carotene, folic acid, biotin, cyanocarbolomine, coenzyme Q10, potassium hydrogen orthophosphate, inositol, choline, soy lecithin, zinc gluconate, calcium pantothenate, thiamine hydrochloride, vitamin D, fructose, citric acid, ascorbic acid, preservative, sweetener, fragrance, water, components in composition being in specified weight ratio.

EFFECT: invention ensures increase of work capacity and endurance.

7 ex, 1 tbl

Description

The invention relates to the pharmaceutical industry, and in particular to compositions used to eliminate fatigue and fatigue, increase resistance to stress and as a tonic.

Known biologically active food supplement containing grape seed extract dipeptide carnosine in a volume of 49.9993% by weight, quercetin in a volume of 6% by weight, coenzyme Q10 in a volume of 4% by weight, organic selenium in a volume of 0.0007% by weight and gum arabic (fibregam) in the amount of 6.7% of the mass, and the grape seed extract is 33.3% of the mass. (Patent RU No. 2364258. Published. 08.20.2009).

Known biologically active food supplement (Patent RU No. 2352147. Publ. 20.04.2009), containing:

Bromelain 65.00-80.0 Sodium Ascorbate 30.00-45.00 Iron pyrophosphate 30.00-40.00 Solyanka Hill Extract 20.00-30.00 Papain 20.00-30.00 Zinc citrate 3H ₂ O 20.00-30.00 Borahelat 15.00-25.00 Sodium Metasilicate 15.00-25.00 Milk Thistle Extract 15.00-25.00 Quercetin 10.00-20.00 Routine 12.50-17.50 Ginkgo biloba extract May 7-12, 2005 Hesperidin 7.50-12.50 Nicotinamide 7.50-12.50 Tocopherol acetate 7.50-12.50 Superoxide dismutase 5.00-7.00 Retinol Acetate 2.00-3.50 Manganese sulfate H ₂ O 2.75-3.50 Dihydroquercetin 2.00-3.00 Calcium pantothenate 2.00-3.00 Copper citrate 1.00-1.75 Cholecalciferol 0.75-1.25 Pyridoxine hydrochloride 1.00-1.25 Riboflavin 0.75-1.20 Beta carotene 4.00-4.50 Thiamine mononitrate 0.50-1.00 Coenzyme Q10 0.50-0.75 Folic acid 0.075-0.125 Chromium Picolinate 0.175-0.225 Potassium iodate 0.10-0.15 Sodium Selenite 0.065-0.100 Sodium Molybdate 0.050-0.075 Ammonium vanadate 0.040-0.050 Biotin 0.020-0.030 Silver sulfate 0.0200-0.0250 Cyanocobalamin 0.0015-0.0020 filler up to 800

The disadvantages of this dietary supplement include the fact that it does not provide resistance to stress, does not have an adaptogenic effect. An object of the invention is the expansion and increase of pharmacological action.

The proposed technical problem is achieved due to the synergistic action of the ingredients of the composition contained in wt.% To 100%:

Potassium Hydroorthophosphate 0.01-9.0 Inositol 0.5-8 Choline 0.1-5 Soya lecithin 1-10 Zinc Gluconate 0.01-1.0 Coenzyme Q10 0.01-1.0 Nicotinamide (Vitamin B3) 0.01-2.0 Alpha Tocopherol Acetate (Vitamin E) 0.01-2.0 Calcium Pantothenate (Vitamin B5) 0.01-0.5 Pyridoxine Hydrochloride (Vitamin B6) 0.01-0.1 Riboflavin (Vitamin B2) 0.005-0.1 Thiamine Hydrochloride (Vitamin B1) 0.005-0.1 β-carotene (Vitamin A) 0.005-1.0 Folic Acid (Vitamin B9) 0.001-0.1 Biotin 0.0001-5.0 Vitamin D 0.0001-0.1 Cyanocobalamin (Vitamin B12) 0.00001-0.1 Fructose 1-27 Lemon acid 0.1-1 Ascorbic acid (Vitamin C) 0.01-5.0 Preservative 0.01-1.0 Sweetener 0.001-1.5 Flavoring 0.001-0.5 Water rest

The composition may further comprise a food coloring.

Choline citrate is preferred as a source of choline.

The composition may further comprise pharmaceutically and pharmacologically compatible minerals, carotenoids, and / or flavonoids, antioxidants, enzymes or other medicinal substances, amino acids, protein, vitamins, hormones (hormone-like substances) and sterols.

The water used as a solvent can be deionized, purified, injectable and of other quality that is approved for oral use.

It is preferable to carry out the production of the composition under sterile conditions (to increase the shelf life of the resulting composition (options).

For packaging the composition, it is preferable to use bottles of the minimum volume for the convenience of taking a single dose (for example, 11 ml bottles).

The technology is as follows.

Under sterile conditions, water is measured in which the following ingredients are dissolved in the following sequence:

Fructose, inositol, zinc gluconate, biotin, coenzyme Q10 and mix. Separately, in a small amount of water, triturated to a homogeneous mixture, dl-alpha-tocopherol acetate (vitamin E), β-carotene (vitamin A) and introduced into the main solution. The following ingredients are added: potassium hydroorthophosphate, choline citrate, soya lecithin, ascorbic acid (vitamin C), nicotinamide (Vitamin B3), calcium pantothenate (Vitamin B5), pyridoxine hydrochloride (Vitamin B6), riboflavin (Vitamin B2), thiamine hydrochloride B1), folic acid (Vitamin B9), vitamin D and cyanocobalamin (Vitamin B12), citric acid, a preservative (potassium sorbate, sodium benzoate), a sweetener (acesulfame potassium, sodium cyclamate, sodium saccharin) and flavoring. Thoroughly homogenize, bring the volume to the desired volume, the resulting solution is thoroughly mixed again, the mixture is passed through the homogenizer under high pressure, filtered and poured into containers.

An example of a specific implementation.

Example No. 1

In sterile conditions, water is measured in an amount of 50%, in which the following ingredients are dissolved in the following sequence:

Fructose 1%, inositol 0.5%, zinc gluconate 0.01%, biotin 0.0001%, coenzyme Q10 0.01% and mixed. Separately, in a small amount of water, triturated to a homogeneous mixture of dl-alpha-tocopherol acetate (vitamin E) 0.01%, β-carotene (vitamin A) 0.005% and introduced into the main solution. The following ingredients are added: potassium hydroorthophosphate 0.01%, choline 0.1%, soya lecithin 1%, ascorbic acid (vitamin C) 0.01%, nicotinamide (Vitamin B3) 0.01%, calcium pantothenate (Vitamin B5) 0 , 01%, pyridoxine hydrochloride (Vitamin B6) 0.01%, riboflavin (Vitamin B2) 0.005%, thiamine hydrochloride (Vitamin B1) 0.005%, folic acid (Vitamin B9) 0.001%, vitamin D 0.0001% and cyanocobalamin ( Vitamin B12) 0.00001%, citric acid 0.1%, preservative 0.01% (potassium sorbate 0.005%, sodium benzoate 0.005%), sweetener 0.001% (acesulfame potassium 0.0003%, sodium cyclamate 0.0003%, sodium saccharin 0.0001%) and flavor 0 , 001%. Thoroughly homogenize, bring the volume with water to the desired volume (up to 100%), the resulting solution is re-mixed thoroughly, pass the mixture through a homogenizer under high pressure, filtered and poured into containers.

Example No. 2

Under sterile conditions, 10% water is measured, in which the following ingredients are dissolved in the following sequence:

Fructose 27%, inositol 8%, zinc gluconate 1%, biotin 5%, coenzyme Q10 1% and mixed. Separately, in a small amount of water, triturated to a homogeneous mixture of dl-alpha-tocopherol acetate (vitamin E) 2%, β-carotene (vitamin A) 1% and introduced into the main solution. The following ingredients are added: potassium hydrogen phosphate 9%, choline 5%, soya lecithin 10%, ascorbic acid (vitamin C) 5%, nicotinamide (Vitamin B3) 2%, calcium pantothenate (Vitamin B5) 0.5%, pyridoxine hydrochloride (Vitamin B6) 0.1%, riboflavin (Vitamin B2) 0.1%, thiamine hydrochloride (Vitamin B1) 0.1%, folic acid (Vitamin B9) 0.1%, vitamin D 0.1% and cyanocobalamin (Vitamin B12 ) 0.1%, citric acid 1.0%, preservative 1% (potassium sorbate), sweetener 1.5% (sodium saccharinate) and flavor 0.5%. Thoroughly homogenize, bring the volume of the mixture with water to the desired volume (100%), the resulting solution is re-mixed thoroughly, pass the mixture through a homogenizer under high pressure, filter and pour into containers.

Example No. 3

In sterile conditions, water is measured in an amount of 20%, in which the following ingredients are dissolved in the following sequence:

Fructose 25%, inositol 0.5%, zinc gluconate 1%, biotin 0.5%, coenzyme Q10 0.5% and mixed. Separately, a small amount of water is triturated to a homogeneous mixture of dl-alpha-tocopherol acetate (vitamin E) 1%, β-carotene (vitamin A) 0.05% and introduced into the main solution. The following ingredients are added: potassium hydrogen phosphate 5%, choline 2%, soya lecithin 5%, ascorbic acid (vitamin C) 2%, 0.3%, nicotinamide (Vitamin B3) 0.25%, calcium pantothenate (Vitamin B5) 0.005% , pyridoxine hydrochloride (Vitamin B6) 0.0001%, riboflavin (Vitamin B2) 0.0001%, thiamine hydrochloride (Vitamin B1) 0.0001%, folic acid (Vitamin B9) 0.0001%, vitamin D 0.00001% and cyanocobalamin (Vitamin B12) 0.00001%, citric acid 0.3%, preservative 0.2% (potassium sorbate), sweetener 0.5% (sodium saccharinate), flavoring natural orange 0.5%, food coloring orange 0 , 01%. Thoroughly homogenize, bring the volume of the mixture with water to the desired volume (100%), the resulting solution is re-mixed thoroughly, pass the mixture through a homogenizer under high pressure, filter and pour into containers.

Example No. 4

In sterile conditions, water is measured in an amount of 50%, in which the following ingredients are dissolved in the following sequence:

Fructose 10%, inositol 2%, zinc gluconate 0.01%, biotin 0.5%, coenzyme Q10 0.05% and mixed. Separately, in a small amount of water, triturated to a homogeneous mixture of dl-alpha-tocopherol acetate (vitamin E) 0.01%, β-carotene (vitamin A) 0.01% and introduced into the main solution. The following ingredients are added: potassium hydroorthophosphate 0.01%, choline citrate 0.1%, soya lecithin 1%, ascorbic acid (vitamin C) 0.1%, nicotinamide (Vitamin B3) 0.01%, calcium pantothenate (Vitamin B5) 0.01%, pyridoxine hydrochloride (Vitamin B6) 0.01%, riboflavin (Vitamin B2) 0.01%, thiamine hydrochloride (Vitamin B1) 0.01%, folic acid (Vitamin B9) 0.01%, vitamin D 0.01% and cyanocobalamin (Vitamin B12) 0.0001%, citric acid 0.1%, preservative 0.5% (potassium sorbate 0.25%, sodium benzoate 0.25%), sweetener 1% (potassium acesulfame 0.3 %, sodium cyclamate 0.3%, sodium saccharin 0.4%) and flavor 0.001%. Thoroughly homogenize, bring the volume of the mixture with water to the desired volume (100%), the resulting solution is re-mixed thoroughly, pass the mixture through a homogenizer under high pressure, filter and pour into containers.

Example No. 5

In sterile conditions, water is measured in an amount of 45%, in which the following ingredients are dissolved in the following sequence:

Fructose 5%, inositol 8%, zinc gluconate 0.1%, biotin 10%, coenzyme Q10 0.5% and mixed. Separately, in a small amount of water, triturated to a homogeneous mixture of dl-alpha-tocopherol acetate (vitamin E) 1%, β-carotene (vitamin A) 0.1% and introduced into the main solution. The following ingredients are added: potassium hydrogen phosphate 0.1%, choline citrate 0.5%, soya lecithin 10%, ascorbic acid (vitamin C) 1%, nicotinamide (Vitamin B3) 0.1%, calcium pantothenate (Vitamin B5) 0, 1%, pyridoxine hydrochloride (Vitamin B6) 0.1%, riboflavin (Vitamin B2) 0.1%, thiamine hydrochloride (Vitamin B1) 0.1%, folic acid (Vitamin B9) 0.1%, vitamin D 0, 1% and cyanocobalamin (Vitamin B12) 0.1%, citric acid 1%, preservative 1% (potassium sorbate 0.5%, sodium benzoate 0.5%), sweetener 1.5% (acesulfame potassium 0.5%, sodium cyclamate 0.5%, sodium saccharin 0.5%) and flavor 0.5%. Thoroughly homogenize, bring the volume of the mixture with water to the desired volume (100%), the resulting solution is re-mixed thoroughly, pass the mixture through a homogenizer under high pressure, filter and pour into containers.

Example No. 6

In sterile conditions, water is measured in an amount of 45%, in which the following ingredients are dissolved in the following sequence:

Fructose 5%, inositol 8%, zinc gluconate 0.1%, biotin 10%, coenzyme Q10 0.5% and mixed. Separately, in a small amount of water, triturated to a homogeneous mixture of dl-alpha-tocopherol acetate (vitamin E) 1%, β-carotene (vitamin A) 0.1% and introduced into the main solution. The following ingredients are added: potassium hydrogen phosphate 0.1%, choline citrate 0.5%, soya lecithin 10%, ascorbic acid (vitamin C) 1%, nicotinamide (Vitamin B3) 0.1%, calcium pantothenate (Vitamin B5) 0, 1%, pyridoxine hydrochloride (Vitamin B6) 0.1%, riboflavin (Vitamin B2) 0.1%, thiamine hydrochloride (Vitamin B1) 0.1%, folic acid (Vitamin B9) 0.1%, vitamin D 0, 1%, cyanocobalamin (Vitamin B12) 0.1%, citric acid 1%, preservative 1% (potassium sorbate 0.5%, sodium benzoate 0.5%), sweetener 1.5% (acesulfame potassium 0.5%, sodium cyclamate 0.5%, sodium saccharin 0.5%) and flavor 0.5%. Thoroughly homogenize, bring the volume of the mixture with water to the desired volume (100%), the resulting solution is re-mixed thoroughly, pass the mixture through a homogenizer under high pressure, filter and pour into containers.

Example No. 7

Under sterile conditions, water is measured in an amount of 30%, in which the following ingredients are dissolved in the following sequence:

Sucrose 15%, Inositol 8%, Zinc gluconate 0.1%, Biotin 10%, Coenzyme Q10 0.5% and mixed. Separately, in a small amount of water, triturated to a homogeneous mixture of dl-alpha-tocopherol acetate (vitamin E) 1%, β-carotene (vitamin A) 0.1% and introduced into the main solution. The following ingredients are added: potassium hydrogen phosphate 0.1%, choline citrate 0.5%, soya lecithin 10%, ascorbic acid (vitamin C) 1%, nicotinamide (Vitamin B3) 0.1%, calcium pantothenate (Vitamin B5) 0, 1%, pyridoxine hydrochloride (Vitamin B6) 0.1%, riboflavin (Vitamin B2) 0.1%, thiamine hydrochloride (Vitamin B1) 0.1%, folic acid (Vitamin B9) 0.1%, vitamin D 0, 1% and cyanocobalamin (Vitamin B12) 0.1%, citric acid 1%, preservative 0.5% (potassium sorbate 0.25%, sodium benzoate 0.25%), sweetener 1% (potassium acesulfame 0.3%, sodium cyclamate 0.3%, sodium saccharin 0.4%) and flavor 0.001%. Thoroughly homogenize, bring the volume of the mixture with water to the desired volume (100%), the resulting solution is re-mixed thoroughly, pass the mixture through a homogenizer under high pressure, filter and pour into containers.

Next, the solution is supplied for packaging and packaging in a shipping container. The solution in appearance is a turbid dark orange liquid with a sour-sweet taste with a fragrant odor. Store in a dry, dark place at room temperature. Shelf life is 1.5 years.

The solution is recommended to take 11 ml once a day at night. There are no contraindications, with the exception of individual intolerance to the components.

All ingredients included are known and approved for use.

Contained in the composition of Coenzyme Q10 (ubiquinone) is an antioxidant involved in the production of 95% of all cell energy in the body. Taking Coenzyme Q10 reduces the risk of heart attack, slows down cell aging, helps to normalize blood pressure, and helps with various cardiac diseases, atherosclerosis, various forms of asthma, periodontal disease, obesity, and diabetes mellitus.

Inositol - has a membrane-protective, lipotropic, anti-atherosclerotic effect.

Choline citrate is a mediator of neuromuscular conjugation, in other words, it is with the help of acetylcholine that the impulse passes from the nerve to the muscles. Acetylcholine deficiency leads to weakness and fatigue.

In addition, choline citrate improves the absorption of magnesium. Choline citrate improves memory and cognitive function, as acetylcholine plays an important role in brain function.

Biotin is part of the enzymes that regulate protein and fat metabolism. To assess the adaptogenic effect that increases the rate of adaptation of the body to stresses, studies were conducted on mice and rats using generally accepted experimental techniques. Statistical processing of data is given using t-student test.

The effect of the composition on some indicators of the metabolism and functional state of rats under conditions of hyperthermia.

Male Wistar rats were overheated for 1 h at 40 ° C. The composition was administered orally at a dose of 20 ml / kg once 1 hour before hyperthermia. Under conditions of overheating in rats, the rectal temperature, relative adrenal mass, and plasma corticosterone level increased, which indicates a significant stress in the rats. Under these animal conditions, the need for energy supply increased, as evidenced by a decrease in glycogen content and the activity of glucose-6-phosphate dehydrogenase (G-6-FDH) and hexokinase (HA) carbohydrate metabolism enzymes in the liver.

The composition, without changing the direction of the stress reaction, significantly prevented a rise in rectal temperature, adrenal hypertrophy, an increase in plasma corticosterone, a decrease in these indicators of carbohydrate metabolism in the liver, which indicates an increase in the general non-specific resistance of the body to hyperthermia.

Studies have been conducted on the effects of the compositions on the physical performance of volunteers using the example of running at medium and long distances. The bench experiment consisted of determining the time (duration) of running on a treadmill with a stepwise increasing load to failure, as well as the speed of recovery after it and the state of lipid peroxidation of unsaturated fatty acids in the process of performing the above work in the experimental and control groups (10 people each each).

Volunteers were selected for approximately the same parameters (gender, age, sports qualifications and other characteristics).

A total of 10 men aged 19 to 26 years were examined. The control group received placebo 1 time per day for 10 days. Experienced group - accepted the proposed composition.

Before and after the experiment, the state of working capacity, recovery, the concentration of glucose, protein and urea in the blood, as well as the processes of spontaneous chemiluminescence in the urine and the concentration of malondialdehyde by conventional methods were determined.

The studies were performed in the initial state, on the 3rd, 5th and 10th day of administration, as well as 5 days after the drug was discontinued. Studies have shown an increase in performance and endurance when taking the proposed compositions on the third day.

The general strengthening effect was analyzed during the period of the epidemic by acute respiratory diseases (ARI), 4 groups of 5 people were formed.

Group 1 - healthy people, but suffering from frequent colds.

Group 2 - people after infection with residual signs of the disease (cough, runny nose).

3 group - healthy people control group.

Group 4 - people with residual signs of acute respiratory infections, control group.

People of group No. 1 took the proposed composition weekly night at 11 ml.

People of the 2 groups took 2 tablespoons 3 times a day.

People of groups 3 and 4 did not accept the composition.

The results are presented in table No. 1.

Thus, the claimed composition has an action that increases performance, endurance, as well as tonic and adaptogenic effect.

Table number 1 General strengthening activity of the proposed composition. Group number Positive results in% Negative results in% one one hundred - 2 one hundred - 3 95 5 four twenty 80

Claims (1)

A composition having an adaptogenic, general strengthening and working capacity enhancing effect, comprising nicotinamide, alpha-tocopherol acetate, pyridoxine hydrochloride, riboflavin, beta-carotene, folic acid, biotin, cyanocabalomine, coenzyme Q10, potassium cholonocinolate, calcium chloride, calcinolate, calcium chloride, and , calcium pantothenate, thiamine hydrochloride, vitamin D, fructose, citric acid, ascorbic acid, preservative, sweetener, flavor, water in the following proportions, wt.%:
Potassium Hydroorthophosphate 0.01-9.0 Inositol 0.5-8 Choline 0.1-5 Soya lecithin 1-10 Zinc Gluconate 0.01-1.0 Coenzyme Q10 0.01-1.0 Nicotinamide (Vitamin B3) 0.01-2.0 Alpha Tocopherol Acetate (Vitamin E) 0.01-2.0 Calcium Pantothenate (Vitamin B5) 0.01-0.5 Pyridoxine Hydrochloride (Vitamin B6) 0.01-0.1 Riboflavin (Vitamin B2) 0.005-0.1 Thiamine Hydrochloride (Vitamin B1) 0.005-0.1 β-carotene (Vitamin A) 0.005-1.0 Folic Acid (Vitamin B9) 0.001-0.1 Biotin 0.0001-5.0 Vitamin D 0.0001-0.1 Cyanocobalamin (Vitamin B12) 0.00001-0.1 Fructose 1-27 Lemon acid 0.1-1 Ascorbic acid (Vitamin C) 0.01-5.0 Preservative 0.01-1.0 Sweetener 0.001-1.5 Flavoring 0.001-0.5 Water Rest