RU2363361C2 - Nicotine entrapping agent and nicotine content decrease method - Google Patents

Abstract

FIELD: food industry. ^ SUBSTANCE: nicotine entrapping agent is water liquid composition with viscosity from 500 to 1000 mPas. It contains at least one polysaccharide chosen from group consisting of tamarind seeds gum, locust fruits gum, xanthum gum, tahr gum, guar gum, pectine, pullulan, psyllium gum, methyl cellulose, carboxymethylcel cellulose, hydroxypropylmethicellulose and carrageenan. ^ EFFECT: decrease of nicotine content in main smoke flow of tobacco product. ^ 14 cl, 8 dwg, 5 tbl

Description

The present invention relates to a nicotine-inhibiting agent and a smoking article used to reduce the nicotine content in the mainstream smoke of a tobacco product. The present invention also relates to a method for reducing the nicotine content and reducing the tar content in the mainstream smoke of a tobacco product by using a nicotine-inhibiting agent or smoking article.

It is believed that tobacco smoke contains about 4,000 types of chemicals, which are known to include harmful and carcinogenic substances. Typical examples of harmful substances contained in tobacco smoke are nicotine, tar and carbon monoxide. Numerous approaches have been developed to remove such harmful substances from tobacco smoke.

As an example of such approaches, a method has been proposed to reduce the nicotine content in inhaled tobacco smoke (i.e., in the mainstream smoke) by soaking the tobacco pipe filter with water so that the tobacco smoke contacts the water (see Patent Documents 1-3). This method is based on the solubility of nicotine in tobacco smoke in water. However, although a nicotine reduction effect can be expected from this method, there is the possibility that water containing harmful nicotine and tar can enter the mouth with smoke during smoking and enter the body.

Methods have been proposed to prevent or eliminate this difficulty, for example, a method in which a cigarette mouthpiece contains cyclodextrin and a water-absorbing polymer (Patent Document 4), and a method in which a porous polymer is used as a component of a smoking pipe filter, which is attached to the mouthpiece when used. parts of a cigarette (patent documents 5 and 6). In the latter method, however, the mouthpiece filter absorbs large amounts of water at high humidity, causing an increase in inspiratory resistance during smoking, thereby making smoking itself difficult.

In addition, wooden and plastic smoking cessation tubes are also known which include a filter containing a viscous liquid (Patent Document 7). This method, however, is difficult due to the fact that the device must be attached to the pipe when smoking. In addition, an agent for removing nicotine and tar (patent document 8) is also known, in which a thin coating of the gelled substance is applied to a filter or to the surface of a part of a cigarette inserted into the mouth, and the cigarette is smoked either directly or by inserting it into the tube. However, such a gelled substance does not penetrate the filter of the cigarette, so that the gelled substance remaining on the filter enters the mouth, causing an unpleasant sensation, making it also difficult to inhale.

One point to be made when approaching the removal of harmful substances, especially nicotine, from tobacco smoke is that smokers are nicotine-dependent. Smokers are usually mentally or physically dependent on nicotine, and therefore it is not necessarily preferable for smokers to drastically reduce their nicotine intake. Therefore, it is desirable that nicotine intake be lowered depending on the physical and mental state of the smoker. This should make it possible to gradually reduce or mitigate the psychological and physical dependence of the smoker on nicotine, giving them the opportunity, in the end, to quit smoking. Therefore, instead of reducing the amount of nicotine at the same time and equally for all smokers, there is a need for a method that would allow smokers themselves to regulate the flow of nicotine in accordance with their condition.

Patent Documents:

[1] Japanese Published Application 1973-53871;

[2] Japanese Published Application 1975-130579;

[3] Japanese Published Application 1987-198378;

[4] Japanese Published Application 1976-32799;

[5] Japanese Published Application 1987-179376;

[6] Published application of Japan 1972-30900;

[7] Japanese Published Application 1981-18583;

[8] Japanese Published Application 1986-177972.

An object of the present invention is to provide a nicotine-inhibiting agent and a nicotine-inhibiting article that can be used to reduce the nicotine content in the mainstream smoke of a tobacco product. Another objective of the present invention is to provide a method for reducing the nicotine and tar content in the mainstream smoke of a tobacco product by using a nicotine-inhibiting agent or smoking article.

The authors of the present invention conducted a thorough study to develop a method of reducing the nicotine content in the mainstream smoke of a tobacco product. As a result, it was found that an aqueous liquid composition with a viscosity adjusted to 500-3000 mPa · s and containing specific polysaccharides such as tamarind seed gum, xanthan gum, locust bean gum and the like is excellent in absorption and removing nicotine from the mainstream smoke of the tobacco product; and that smoking is hardly hindered by impregnating the filter of a tobacco product or smoking article with an aqueous liquid composition. In addition, the inventors have confirmed that using such a polysaccharide in combination with saccharide (saccharides), where required, it is possible to obtain an aqueous liquid composition that is not amenable to the effects of temperature fluctuations, long-term storage, etc. and has stable viscosity and quality throughout the changing seasons; and that the aqueous liquid composition may provide a suitable nicotine-reducing agent for implementing the aforementioned method for reducing nicotine content.

In addition, the inventors have confirmed that more nicotine can be removed from the mainstream smoke of a tobacco product by increasing the amount of aqueous liquid composition used (amount applied to the filter). This means that smokers can easily regulate the amount of nicotine that enters the body when inhaled while smoking, by selecting the amount of aqueous liquid composition used. That is, when using an aqueous liquid composition, the amount of nicotine inhaled into the body can be gradually reduced by gradually increasing the amount of the aqueous liquid composition used (amount applied to the filter) in accordance with the level of smoker's nicotine dependence. This alleviates nicotine addiction, which is a major problem in stopping smoking, allowing the smoker to finally quit smoking.

The present invention has been made based on these findings. The present invention provides the following implementation.

Item 1. Nicotine-inhibiting agent, which is an aqueous liquid composition having a viscosity of from 500 to 1000 MPa · s and containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, gum containers, guar gum, pectin, pullulan, psillia gum, methyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose and carrageenan.

Paragraph 2. Nicotine-inhibiting agent according to paragraph 1, wherein said at least one polysaccharide is selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tar gum, guar gum and pectin.

Clause 3. A nicotine-inhibiting agent according to Claim 1, wherein said at least one polysaccharide is selected from the group consisting of tamarind seed gum, locust bean gum and xanthan gum.

Clause 4. A nicotine-inhibiting agent according to Claim 1, further comprising at least one saccharide.

Clause 5. A nicotine-inhibiting agent according to Claim 4, wherein said at least one saccharide is selected from the group consisting of trehalose, starch syrup, sucrose, glucose, fructose, maltose, sorbitol, maltitol, lactitol, erythritol, xylitol and dextrin.

Paragraph 6. Nicotine-inhibiting agent according to paragraph 4, wherein said at least one saccharide is selected from the group consisting of trehalose and starch syrup.

Paragraph 7. Nicotine-inhibiting agent according to paragraph 1, which is used when it is held in the filter of a smoking article.

Item 8. A packaged nicotine-inhibiting agent comprising a nicotine-inhibiting agent poured into a container.

As a container, a liquid drip container can be successfully used.

Clause 9. Nicotine-reducing smoking article containing a filter containing a nicotine-inhibiting agent according to Claim 1.

Paragraph 10. Nicotine-reducing smoking article according to paragraph 9, comprising a mouthpiece body having an inhalation opening at one end and a tobacco product insertion hole at the other end and a filter provided in the mouthpiece housing and containing a nicotine-inhibiting agent according to paragraph 1.

Item 11. A nicotine-reducing smoking article in the form of a mouthpiece of a tobacco product, comprising a mouthpiece body having an inhalation opening at one end and a tobacco product insertion hole at the other end and a filter provided in the mouthpiece body, the mouthpiece of the tobacco product further comprising a removable cap with a clip on the side of the inhalation opening of the mouthpiece body and a removable cover on the side of the hole for inserting a tobacco product of the mouthpiece body.

Paragraph 12. Nicotine-reducing smoking article according to paragraph 11, wherein the filter contains a nicotine-inhibiting agent according to paragraph 1.

Clause 13. A method of reducing the nicotine content in the mainstream smoke of a tobacco product, comprising the step of passing the mainstream smoke of the tobacco product through a filter of a smoking article, said filter comprising a nicotine-delaying agent according to claim 1.

The use of the aqueous liquid composition (nicotine-inhibiting agent) of the present invention reduces not only the nicotine content, but also the resin content in the mainstream smoke of the tobacco product, as shown in Experimental Example 4 described hereinafter. Therefore, it can be said that the above-described “nicotine-inhibiting agent” and “nicotine-reducing smoking article” are also respectively “resin-reducing agent” and “resin-reducing smoking article” or, respectively, “nicotine and resin-reducing agent” and “” a nicotine and tar reducing smoking article. "From the point of view of reducing the tar content, the present invention provides the following methods.

Clause 14. A method of reducing tar in a mainstream smoke of a tobacco product, the method comprising the step of passing a mainstream smoke of tobacco product through a filter of a smoking article, wherein the filter contains an aqueous liquid composition (resin reducing agent) having a viscosity of from 500 to 1000 mPa c and containing at least one polysaccharide selected from the group consisting of tamarind gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psillia gum, me tyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose and carrageenan.

Further, as described above, the use of the nicotine-inhibiting agent (aqueous liquid composition) of the present invention makes it possible to reduce the smoker's nicotine dependence. From this point of view, the present invention provides the following methods.

Item 15. A method of reducing a nicotine addiction of a smoking habit, comprising forcing the subject to smoke using a smoking article comprising a filter containing an aqueous liquid composition (nicotine-inhibiting agent) having a viscosity of from 500 to 1000 mPa · s and containing at least one polysaccharide selected from the group consisting of tamarind seed gum, carob gum, xanthan gum, tare gum, guar gum, pectin, pullulan, psillia seed gum, methyl cellulose, carboxymethyl cellulose, g droksipropilmetiltsellyulozy and carrageenan

The present invention further provides the following uses of the aqueous liquid composition of the present invention.

Item 16. The use of an aqueous liquid composition having a viscosity of from 500 to 1000 MPa · s and containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tare gum, guar gum, pectin , pullulan, gum seeds of psillia, methyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose and carrageenan, for the preparation of a nicotine-inhibiting agent and / or reducing the gum content of the agent.

Clause 17. The use according to clause 16, wherein the aqueous liquid composition further comprises at least one saccharide.

Clause 18. The use according to clause 17, wherein said at least one saccharide is selected from the group consisting of trehalose, starch syrup, sucrose, glucose, fructose, maltose, sorbitol, maltitol, lactitol, erythritol, xylitol and dextrin.

Item 19. The use of an aqueous liquid composition having a viscosity of from 500 to 1000 MPa · s and containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tare gum, guar gum, pectin , pullulan, gum seeds of psillia, methyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose and carrageenan, to reduce the content of nicotine and / or resin.

Paragraph 20. Use according to paragraph 19, wherein the aqueous liquid composition further comprises at least one saccharide.

Clause 21. The use according to Claim 20, wherein said at least one saccharide is selected from the group consisting of trehalose, starch syrup, sucrose, glucose, fructose, maltose, sorbitol, maltitol, lactitol, erythritol, xylitol and dextrin.

Brief Description of the Drawings

Figure 1 is a plan view showing the appearance of the mouthpiece of a cigarette 1 in accordance with one embodiment of a nicotine-reducing smoking article of the present invention.

FIG. 2 is a plan view showing the appearance of the mouthpiece of a cigarette 11 in accordance with another embodiment of a nicotine-reducing smoking article of the present invention.

FIG. 3 is a side view of the mouthpiece of the cigarette 11 shown in FIG. 2.

FIG. 4 is a cross section along line III-III shown in FIG. 2.

FIG. 5 is a cross section along line IV-IV shown in FIG. 3.

FIG. 6 is a side view showing the mouthpiece of the cigarette of FIG. 2, having a lid 77 attached to the cap 66 by a clip.

FIG. 7 is a vertical cross section of FIG. 6.

FIG. 8 is a diagram showing a decrease in the percentage of nicotine and resin achieved using the nicotine-inhibiting agent (aqueous liquid composition) of the present invention (Experimental Example 4).

EXPLANATION OF NUMERIC DESIGNATIONS

one. Cigarette holder as an implementation of a nicotine-reducing smoking article of the present invention 2. Filter (holding part) 3. Mouthpiece body four. Inhalation hole 5. Cigarette insertion hole 6. Cap with clip 7. Cap 8. The tab for inserting the cap with a clip into the inhalation hole 9. Hole 10. Bezel eleven. Cigarette holder as another embodiment of a nicotine-reducing smoking article of the invention

BEST MODE FOR CARRYING OUT THE INVENTION

(1) Nicotine Reducing Agent

The nicotine-reducing agent of the invention, which is an aqueous liquid composition comprising at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, gum psillia seeds, methyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose and carrageenan.

Tamarind seed gum is an aqueous polysaccharide obtained from the seeds of Tamarindus grandiflora Pers., Which is a perennial dicotyledonous plant of the Fabaceous family. Locust bean gum is a polysaccharide derived from Ceratonia siliqua Linne seeds. Xanthan gum is a fermented polysaccharide produced by the microorganism Xanthomonas campestris . Tara gum is an aqueous polysaccharide derived from Actinidia callosa Lindl seeds. Guar gum is a polysaccharide derived from Cyamopsis tetragonoloba Taub, or an enzymatic degradation product (e.g., hemicellulase, etc.) of said polysaccharide. Pectin is a polysaccharide extracted from citrus fruits or apples using water, and contains methylated polygalacturonic acid as the main component. Pectin can be roughly subdivided into NM pectin (50% or more methylated galacturonic acids of the total galacturonic acid content) and LM pectin (below 50% of methylated galacturonic acids of the total galacturonic acid content), based on its degree of esterification (content of methoxy groups). Both NM pectin and LM pectin can be used in the present invention.

Pullulan is a polysaccharide produced by Aureobasidium pullulans (De Baryl Arn.), Psillia seed gum is a polysaccharide obtained from the seeds of Plantago ovata Forsk. and other plants of the same genus. Carrageenan is a polysaccharide extracted using water from thalli Chondrus crispus Lyngb., Gitartina tennela Harv., Euchema murickatum W. v. Bosse forma depaupaerata W. v. Bosse, Hypnea japonica Tanaka, etc. Carrageenan can be divided into three main categories: kappa (κ), iota (ι) and lambda (λ), and any of κ-carrageenan, ι-carrageenan and λ-carrageenan can be used in the invention, with λ-carrageenan being preferred .

These polysaccharides, as well as methyl cellulose, carboxymethyl cellulose and hydroxypropyl methyl cellulose, are widely produced industrially and are used as food additives such as thickeners, thickening stabilizers, and the like. The present invention can also use, without limitation, conventional industrial nutritional supplements, including tamarind gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psillia gum, methyl cellulose, carboxymethyl cellulose, hydroxypropylmethyl cellulose.

Preferred polysaccharides of these are tamarind gum, locust bean gum, xanthan gum, tara gum, guar gum and pectin, and tamarind gum, locust bean gum and xanthan gum are particularly preferred.

The nicotine-inhibiting agent of the invention is an aqueous liquid composition having a viscosity of from 500 to 3000 mPa · s. The viscosity used here was measured using a B-type rotational viscometer (used rotor No. 3 for a viscosity of 2000 MPa · s and below and rotor No. 4 for a viscosity above 2000 MPa · s) at 20 ° C and 60 rpm for one minute. The viscosity preferably ranges from 500 to 2500 MPa · s and more preferably from 1000 to 2500 MPa · s.

The way to bring the aqueous liquid composition to the viscosity values mentioned above is not limited, and the viscosity can be adjusted by the appropriate choice of solvent (s) to dilute the above polysaccharides by adjusting the ratios of the polysaccharides used, mixing with other components, etc.

The solvents used to dissolve the gum seeds of tamarind, xanthan gum, locust bean gum and other polysaccharides mentioned above are not limited as long as they are able to dissolve these substances. From the point of view of safety and convenience, the preferred solvent is water. Water can also be used in combination with ethanol, glycerin, and the like. in the range in which the effects of the invention are not attenuated.

The above polysaccharides (tamarind gum, locust bean gum, xanthan gum, packaging gum, guar gum, pectin, pullulan, psillia seed gum, methyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose and carrageenan may be used as an active ingredient) invention, or two or more of them can be used in combination, if required. Preferred combinations of these polysaccharides are (without limitation and as examples) tamarind gum and locust bean gum, tamarind gum and xanthan gum, locust bean gum and methyl cellulose, tamarind gum and tara gum and tamarind gum and guar gum.

The ratio of the above polysaccharides (tamarind gum, locust bean gum, xanthan gum, tar gum, guar gum, pectin, pullulan, psillia seed resin, methyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose or carrageenan) is a non-nicotine-containing liquid nicotine as long as the resulting nicotine-inhibiting agent (aqueous liquid composition) has the above viscosity from 500 to 3000 MPa · s, preferably from 500 to 2500 MPa · s, and more preferably from 1000 to 2500 MPa · s.

For example, the proportion of each polysaccharide that can be used in a 100% nicotine-inhibiting agent (aqueous liquid composition) is shown in Table 1.

Table 1 the weight.% Typical share Preferred
share More preferred
share Tamarind Seed Gum 1.5-3.0 1.5-2.5 2.0-2.5 Locust bean gum 0.5-1.5 0.5-1.25 0.75- Xanthan gum 0.5-3.0 0.5-2.5 1.0-2.5 Gum packaging 0.5-1.2 0.5-1.0 0.6-1.0 Guar gum 0.5-1.5 0.5-1.25 0.75- Pectin 4.0-10.0 4.0-8.0 5.0-8.0 Pullulan 15.0- 15.0- 17.5- Psillia seed gum 0.6-2.0 0.6-1.75 0.75- Cellulose 2.0-4.0 2.0-3.5 2.5-3.5 Carboxymethyl cellulose 1.5-3.0 1.5-2.5 2.0-2.5 Hydroxypropyl methylcellulose 2.0-5.0 2.0-4.0 3.0-4.0 Carrageenan 1.0-2.5 1.0-2.25 1.5-2.25

When using two or more of these components in combination, the ratio and amount of the combination can be determined based on the above mixing ratios as in the viscosity adjustment guide so that the nicotine-inhibiting agent (aqueous liquid composition) has the above viscosity from 500 to 3000 MPa · s, preferably from 500 to 2500 MPa · s and more preferably from 1000 to 2500 MPa · s. As mentioned above, when using tamarind seed gum and locust bean gum together, the ratio may be, for example, from 0.1 to 10 weight. parts and, preferably, from 0.2 to 5 weight. parts of carob fruit gum per 1 weight. a piece of tamarind seed gum. When using gum seeds of tamarind and xanthan gum, the ratio can be from 0.02 to 1 weight. parts and, preferably from 0.05 to 0.5 weight. parts of xanthan gum per 1 weight. a piece of tamarind seed gum. When using methyl cellulose and locust bean gum, the ratio can be from 0.2 to 20 weight. parts and, preferably, from 0.5 to 10 weight. parts of carob fruit gum per 1 weight. part of methyl cellulose. Further, when using the gum of tamarind seeds and gum containers together, the ratio can be from 0.1 to 10 weight. parts and, preferably, from 0.2 to 5 weight. parts of gum packaging for 1 weight. a piece of tamarind seed gum. When using the gum of tamarind seeds and guar gum, the ratio can be from 0.1 to 10 weight. parts and, preferably, from 0.2 to 5 weight. parts of guar gum per 1 weight. a piece of tamarind seed gum.

In addition to at least one polysaccharide selected from the group consisting of the aforementioned tamarind gum, carob gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psillia gum, methyl cellulose, carboxymethyl cellulose, hydroxypropylmethylene, carboxymethyl cellulose, hydroxypropylmethyl the nicotine-inhibiting agent of the invention may contain other saccharides in the range in which the effects of the invention do not diminish. When such saccharides are used in combination with the aforementioned polysaccharides, viscosity and viscosity stability can be improved, as well as a percentage reduction in nicotine and resin content.

Preferred examples of such saccharides for use in the invention include glucose, fructose, galactose, mannose, xylose, erythrose and the like monosaccharides and their reduced sugars (for example, sorbitol, xylitol, erythritol); trehalose, maltose, isomaltose, nigerose, cellobiose, sucrose, lactose and the like disaccharides and their reduced sugars (e.g. maltitol, lactitol); beet oligosaccharide, maltooligosaccharide, fructooligosaccharide, galactooligosaccharide, xyloooligosaccharide, lactosaccharose oligosaccharide and the like oligosaccharides and their reduced sugars; and dextrin, starch syrup and similar saccharides derived from starch, and their reduced sugars (e.g., reconstituted starch syrup).

Preferred examples include glucose, fructose and the like monosaccharides and their reduced sugars (sorbitol, xylitol, erythritol); trehalose, maltose, sucrose and the like disaccharides and their reduced sugars (maltitol, lactitol); dextrin and starch syrup. Particularly preferred are glucose and its reduced sugar (sorbitol), maltose and its reduced sugar (maltitol), trehalose, dextrin and starch syrup, and similar starch-derived saccharides (monosaccharides, oligosaccharides and their reduced products obtained by enzymatic or acid decomposition, enzymatic transfer and enzymatic binding of starch), and sorbitol, trehalose and starch syrup are especially preferred.

These saccharides can be used alone with the above polysaccharides, or two or more of any saccharides can be used in combination. Examples of preferred combinations are trehalose and starch syrup, sorbitol and starch syrup, etc.

The proportion of these saccharides in the nicotine-inhibiting agent (100 wt.%) According to the invention is not limited, but can be selected based on adjusting the viscosity so that the nicotine-inhibiting agent has a final viscosity in the range from 500 to 3000 mPa · s, preferably from 500 up to 2500 MPa · s and more preferably from 1000 to 2500 MPa · s. For example, when starch syrup and / or reconstituted starch syrup are used as saccharides, the proportion of these saccharides is usually from 5 to 60% by weight, preferably from 10 to 50% by weight and more preferably from 10 to 40% by weight. When saccharides other than these are used, the proportion of these saccharides is usually, for example, from 5 to 50% by weight, preferably from 10 to 40% by weight, and more preferably from 10 to 30% by weight.

In addition to the above components (polysaccharides and saccharides), the nicotine-inhibiting agent of the invention may optionally contain components having thickening properties at intervals in which the effect of the invention is not attenuated. Examples of such thickening components include cassia gum, glucomannan, deacylated gellan gum, natural type gellan gum, Bacillus natto gum, hydroxypropyl cellulose (HPC), polyvinyl pyrrolidone (PVP), alginate, alginic acid, gum gum, gum tragenediol, ginger gum soy polysaccharide, macrophomopsis gum, ramsan gum, velah gum, karaya gum, starch, modified starch, chemically modified starch, cellulose fermentation products, agar and the like thicken Components. Such components may be used singly, or any two or more of them may be used in combination. It is desirable that such components are water soluble. Gum, soy polysaccharide and karaya gum are preferred.

Further, in addition to the above components (polysaccharides and saccharides), the nicotine-inhibiting agent of the invention may optionally contain other components at intervals in which the effect of the invention is not attenuated. Examples of such components include sweeteners (e.g., sucralose, aspartame, potassium acesulfame, saccharin and similar highly intense sweeteners), natural and synthetic food colors, flavors, acidifiers (e.g., citric acid, tartaric acid, ascorbic acid and the like organic acids), preservatives (e.g. sodium benzoate, potassium sorbate, etc.), antioxidants (e.g. tea catechin, anthocyanin, isoflavone and similar polyphenols), plants and extracts from them (chamomile, Aloe arborescens Mill, Echinacea , hops ( Humulus lupulus ), Melissa ( Melissa officinalis ), etc.), amino acids, minerals and vitamins, etc. It is also desirable that these components are water soluble.

The nicotine-inhibiting agent of the invention can be prepared by dissolving in an aqueous solvent as an active ingredient at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tare gum, guar gum, pectin, pullulan, gums of seeds of psillia, methyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose and carrageenan, or a combination of at least one of these polysaccharides and at least one of the above x saccharides, or optionally, one of the aforementioned components. Dissolution can be carried out at elevated temperatures or with stronger heating.

The pH of the nicotine-inhibiting agent of the invention is not limited, and any value can be selected, with typical examples being slightly acidic with a pH of from 3 to 5 and, in particular, with a pH of from 3.5 to 4.5.

The nicotine-inhibiting agent (aqueous liquid composition) thus prepared according to the invention is used while being held in the filter of a smoking article. The method of its placement is not limited, and the nicotine-inhibiting agent is supplied to the filter in liquid form (for example, by infiltration), placed in the filter either in a wet or in a dry state. From the point of view of nicotine removal effects, it is preferred that the agent is placed in a wet state (infiltration).

Specific examples of a filter of smoking articles include filters at the ends of cigarettes and filters in tobacco pipes and cigarette holders placed on the respiratory end of a used cigarette. The method for placing a nicotine-inhibiting agent (aqueous liquid composition) in a filter of a smoking article is not limited. For example, the filter of a smoking article may be directly immersed in a nicotine-inhibiting agent (aqueous liquid composition) or the filter may be coated with a nicotine-inhibiting agent (aqueous liquid composition). However, for hygiene reasons, it is desirable that one (about 50 mg) to a few drops, preferably one to five drops of a nicotine-inhibiting agent (aqueous liquid composition), be dropped into the filter of a smoking article.

When the nicotine-inhibiting agent (aqueous liquid composition) of the invention is instilled onto a filter, as mentioned above, it is preferable, but not necessary, that the nicotine-inhibiting agent (aqueous liquid composition) of the invention easily forms droplets. Further, when the nicotine-inhibiting agent (aqueous liquid composition) of the invention is used in a filter, it is desirable, but not necessary, that the agent easily penetrate where it should be contained, and preferably diffuse through the filter. In addition, when the agent is held in the filter of the smoking article and the article is sucked in, it is preferable that the nicotine-inhibiting agent (aqueous liquid composition) of the invention does not cause problems, such as difficulty in suction due to the increased suction pressure or spraying of the agent from the filter into the mouth.

The nicotine-inhibiting agent (aqueous liquid composition) of the invention can provide the above characteristics when it includes at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tare gum, guar gum, pectin, pullulan, gum seeds of psillia, methyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose and carrageenan, optionally combined with the above saccharides, and prepared in the form of an aqueous liquid composition Having a viscosity of 500 to 3000 mPa.s, preferably from 500 to 2500 mPa · s and more preferably 1000 to 2500 mPas. The nicotine-inhibiting agent (aqueous liquid composition) of the invention, preferably having reduced viscosity changes caused by temperature and / or storage conditions, has stable viscosity and other properties throughout the year. Under this condition, the viscosity should not increase significantly during low winter temperatures, but should be kept such viscosity that instillation, filter penetration and smoking (puffing) could be performed without inconvenience.

It is contemplated that the nicotine-inhibiting agent (aqueous liquid composition) of the invention will typically be sold poured into a container. The container for containing the nicotine-inhibiting agent is not limited, however, as mentioned above, since instillation is the preferred method of using the nicotine-inhibiting agent of the invention, it is desirable to fill the agent in a dropper type container (for example, such as a dropper). A dropper type container is not limited as long as it is provided with an element by which liquid contents (aqueous liquid composition) can be supplied drop by drop. Suitable examples include containers, the entire body of which is a dropper dropper and which are capable of directly dropping contents (an aqueous liquid composition) through their opening, containers with a cap that acts as a dropper, by which the contents can be sucked and dripped, and so on. .P.

The size (volume) of the container for containing the nicotine-inhibiting agent is not limited, but from the point of view of the purpose of the invention, dosage and portability, it is desirable that the container has a capacity of usually from 1 to 100 ml, preferably from 2 to 20 ml.

(2) Nicotine-reducing smoking articles

The present invention provides nicotine-reducing smoking articles. Examples of nicotine-reducing smoking articles of the invention include smoking articles such as filter cigarettes and the like. (hereinafter referred to simply as “cigarettes”, to distinguish them from the instruments used for smoking, which are mentioned below); and tools used for smoking tobacco products (for example, paper-wrapped tobacco, crushed tobacco, cigar, etc.), such as smoking pipes (including long chubuk pipes, such as the Japanese kiseru pipe), cigarette holders (used when placed on the mouth end of cigarettes, for example, disposable cigarette holders), cartridges inserted into cigarette holders, etc. (hereinafter referred to simply as "tubes" to distinguish them from the above-defined cigarettes).

The pipe, as it is called here, includes at least a part for placing tobacco or a hole for inserting tobacco, an inhalation opening and a passage (pipe) for passing smoke from the tobacco-containing part or opening for inserting tobacco to the inhalation opening and an area (holding part) for retention of nicotine-inhibiting agent (aqueous liquid composition) according to the invention.

A smoking article of the invention is a nicotine-reducing smoking article in which the nicotine-inhibiting agent (aqueous liquid composition) of the invention is housed in a filter cigarette or in the holding portion of a tube, thereby reducing the amount of nicotine inhaled into the body while smoking.

There are no particular structural or material restrictions on the holding portion of the tube as long as the holding portion is positioned so that the mainstream smoke of the tobacco product passes through it and is configured such that the nicotine-inhibiting agent (aqueous liquid composition) of the invention can be held in her. The holding part may be formed, for example, by attaching a porous element made of paper, nonwoven fabric, fiber, sponge, etc., or by inserting such an element into that part through which the mainstream smoke of the tobacco product passes. Examples of materials for the holding portion include, but are not limited to, cellulose acetate, polyester fatty acid compounds, cellulose ethers, and the like.

In the pipe (smoking article) of the invention, the effects of nicotine removal are achieved by passing the mainstream smoke of the tobacco product through the holding portion in which the nicotine-inhibiting agent (aqueous liquid composition) is placed. Therefore, the holding portion of the tube can also be defined as a filter. In this sense, in this description, the tube holding portion and the cigarette filter can often be referred to collectively as the “smoking device filter”.

The filter capacity of the smoking device (cigarette filter and tube holding part) is not particularly limited. Preferably, the filter has a container capable of holding as much nicotine-inhibiting agent (aqueous liquid composition) as possible in a stable manner. However, if the filter has a container capable of holding at least about 50 to about 250 mg and preferably about 50 to about 150 mg of a nicotine-inhibiting agent (aqueous liquid composition), this is sufficient for normal use.

FIG. 1 shows the mouthpiece of cigarette 1, and FIG. 2-7 show the mouthpiece of a cigarette 11 as an embodiment of a nicotine-reducing smoking article of the invention, but the invention is not limited to them.

The mouthpiece of the cigarette 1 includes a mouthpiece housing 3 in which a filter 2 is provided, i.e. a retaining portion to retain a nicotine-inhibiting agent of the invention. The body of the mouthpiece 3 has an inhalation opening 4 at one end and an opening for inserting a cigarette 5 at the other end. In the body of the mouthpiece 3, the periphery and the adjacent region with the inhalation opening 4 are made flat to facilitate holding the mouthpiece of the cigarette between the lips. The mouthpiece of cigarette 1, shown as one embodiment of the nicotine-reducing smoking article of the invention, is configured such that the nicotine-inhibiting agent of the invention is preliminarily held on the filter.

Similarly, the mouthpiece of a cigarette 11 includes a body of the mouthpiece 3 in which a filter 2 is provided, i.e. a retaining portion to retain a nicotine-inhibiting agent of the invention. The mouthpiece of a cigarette 11, shown as one embodiment of the nicotine-reducing smoking article of the invention, may be configured such that the nicotine-inhibiting agent of the invention is preliminarily retained on the filter or placed in the filter and retained therein during use.

The structure of the cigarette holder 11 is described below with reference to FIG. 2-7.

The body of the mouthpiece 3 has an inhalation opening 4 at one end and an opening for inserting a cigarette 5 at the other end. In the body of the mouthpiece 3, the periphery and the adjacent region with the inhalation opening 4 are made flat to facilitate holding the mouthpiece of the cigarette between the lips. In the mouthpiece of the cigarette 11, one end of the body of the mouthpiece 3 may be further provided with a cap 6 with a removable clip, and the other end with a removable cover 7. In the embodiments shown in the figures, the cap 6 with a clip is attached to the end of the body of the mouthpiece 3 with an inhalation hole 4, and cover 7 - to the end of the body of the mouthpiece 3 with a hole for inserting a cigarette 5. The cap 6 with a clip has a protrusion for insertion into the inhalation hole 4.

Attaching a cap 6 with a clip and a cap 7 to the body of the mouthpiece 3 can prevent the agent from escaping during the infiltration of the nicotine-delaying agent into the filter. When not smoked, the clip of the cap 6 can be fastened to the chest pocket, etc. The clip cap 6 is preferably configured to be similar to those attached to conventional fountain pens.

The cap 6 with a clip and the cover 7 are made so as to attach and be removed. In the embodiment shown in the figures, the attachment can be accomplished by attaching the cap 7 to the opening 9 of the cap 6 with a clip. The lid 7 has a rim 10 that acts as a latch when the lid 7 is connected to the cap 6 with a clip and the clip is fixed to the chest pocket and the like, thereby preventing the loss of the lid 7.

(3) Method for reducing nicotine content in mainstream smoke of a tobacco product

The present invention provides a method for reducing nicotine content in which the nicotine content in the mainstream smoke of a tobacco product inhaled into the body can be significantly reduced by simply infiltrating the nicotine-inhibiting agent (aqueous liquid composition) of the invention into a filter of a smoking article. As shown in the experimental examples below, not only the nicotine content in the mainstream smoke of the tobacco product can be significantly reduced, but also the resin content. Thus, the present invention also provides a method for reducing tar in the mainstream smoke of a tobacco product.

As shown in the experimental examples, an increase in the amount of nicotine-inhibiting agent (aqueous liquid composition) in the filter leads to a greater decrease in the content of nicotine and tar in the mainstream smoke in proportion to an increase in the amount of nicotine-inhibiting agent. The amount of nicotine-inhibiting agent (aqueous liquid composition) retained in the filter is not particularly limited as long as it can successfully be retained in the filter. For example, this is usually a volume of from one to several drops (from about 50 mg to about several 100 mg), preferably from 1 to 5 drops (from about 50 mg to about 250 mg).

It is believed that the main reason that it is difficult to quit smoking is the physical and psychological dependence on nicotine, which is contained in the mainstream smoke of tobacco products. The method of reducing the nicotine content of the invention allows smokers to reduce the amount of nicotine ingested during smoking, thereby gradually reducing their nicotine dependence. In accordance with the nicotine-inhibiting agent of the invention, smokers themselves can select the amount of nicotine-inhibiting agent (amount contained in the filter), thereby controlling the amount of nicotine inhaled with the mainstream smoke. Therefore, smokers can gradually lower their nicotine intake according to the state of their nicotine addiction, as a result of which they successfully quit smoking.

Examples

Hereinafter, the present invention will be described more specifically with reference to the following experimental examples and examples, but the invention is not limited to them. In the following experimental examples and examples, all parts are parts by weight, unless otherwise indicated.

The products used in the following examples were obtained as follows. Products marked with "*" are registered trademarks of San-Ei Gen F.F.I., Inc. in Japan.

Tamarind seed gum: VIS TOP * D-2033, San-Ei Gen F.F.I., Inc.

Carob Gum: VIS TOP * D-30, San-Ei Gen F.F.I., Inc.

Xanthan Gum: SAN ACE * C, San-Ei Gen F.F.I., Inc.

Gum packaging: VIS TOP * D-2101, San-Ei Gen F.F.I., Inc.

Guar gum: VIS TOP * D-2029, San-Ei Gen F.F.I., Inc.

Pullulan: Pullulan PF-20 Hayashibara Co. Ltd.

Psilia Seed Gum: SOALLYUM PG-200, MRC Polysaccharide Co., Ltd.

NM pectin: VIS TOP * D-2220, San-Ei Gen F.F.I., Inc.

LM Pectin: VIS TOP * D-402, San-Ei Gen F.F.I., Inc.

λ-Carrageenan: CARRAGEENAN CSL-1, San-Ei Gen F.F.I., Inc.

Trehalose: Treha fine particles (trade name): Hayashibara Co. Ltd.

Starch Syrup (Starch Acid Sugar Syrup): Syrup low (trade name) Kogo Starch Co., Ltd.

Soybean Polysaccharide: SM-929 (trade name), San-Ei Gen F.F.I., Inc.

Trisodium citrate: Trisodium citrate F (trade name), San-Ei Gen F.F.I., Inc.

Glycine: Glycine P (trade name), Yuki Gosei Kogyo Co., Ltd.

L-ascorbic acid: Viscorin 80M (trade name), Daiichi Fine-chemicals, Co., Ltd.

Tea Catechin: Powder SD of Green Tea Extract, NO.16714, San-Ei Gen F.F.I., Inc.

Liquorice Powder: LICOZIN P-1 (trade name), Ikedatohka Industries Co., Ltd.

Experimental Example 1

(1) Preparation of an aqueous liquid composition

An aqueous liquid composition (examples 1-15) was prepared according to the recipe shown in table 1. More specifically, one or more of the polysaccharides shown in table 1 (tamarind gum, locust bean gum, xanthan gum, tara gum, guar gum, pullulan , psillia seed gum, NM-pectin, LM-pectin, carrageenan, carboxymethyl cellulose) together with trehalose were added to ion-exchanged water, and the mixture was dissolved by stirring under heating at 80 ° C for 10 minutes, however methyl cellulose (example 14) and hydroxypropy methyl cellulose (Example 15) was added, together with trehalose, to ion-exchanged water, and the mixture was dissolved by stirring while heating at 60 ° C. for 10 minutes and further stirred at 10 ° C. for 10 minutes.

An aqueous solution of sodium benzoate, an aqueous solution of citric acid, an aqueous solution of trisodium citrate and an aqueous solution of a dye (Red No. 2, Red No. 40) were added to each solution, and these solutions were prepared by dissolving in water purified by ion exchange in advance and then mixing. The total amount of each mixture was adjusted by ion-exchanged water to 100 wt.%, Obtaining aqueous liquid compositions (examples 1-15).

(2) Evaluation of the properties of aqueous liquid compositions

The viscosity (initial viscosity) of each aqueous liquid composition (examples 1-15) obtained as described above was measured using a B-type rotational viscometer (used rotor No. 3 for a viscosity of 2000 MPa · s and below and rotor No. 4 for a viscosity above 2000 MPa · s) at 20 ° С and 60 rpm for one minute. Aqueous liquid compositions were stored at 50 ° C. for 3 weeks and the viscosity (viscosity after storage) was measured under the same conditions as above. Residual viscosity (%) was calculated using the following equation, and viscosity stability was evaluated in accordance with the following criteria.

Residual viscosity (%) = (viscosity after storage / initial viscosity) × 100

<Viscosity Stability>

Residual viscosity (%) Rating Score 81% or higher

9 from 61 to 80%

6 from 41 to 60%

3 40% or lower H 0

(3) Organoleptic evaluation

The above aqueous liquid compositions (Examples 1-15) were adjusted to 20 ° C., and then two drops (about 100 mg) of one of each aqueous liquid composition were added to the filter tip of one tobacco product. The time taken for the liquid to penetrate into each filter was measured (evaluation of the liquid's penetration ability). It was believed that penetration was complete when liquid droplets adhering to the filter surface completely disappeared. After confirming that the liquid penetrated into each filter, an estimated smoking of each tobacco product was carried out to determine whether or not the liquid is pulled out into the mouth when the smoke of each tobacco product is inhaled (evaluation of the ability of the liquid to draw). Aqueous liquid compositions (examples 1-15) were evaluated by the same person for the ability of the liquid to penetrate and for the property of drawing fluid in accordance with the following criteria. The liquid drawing properties were evaluated by triple inhalation of the mainstream smoke.

<The ability of the liquid to penetrate the filter>

Penetration Time Rating Score 10 seconds or less

6 from 11 to 30 seconds

four from 31 to 60 seconds

2 61 seconds or less H 0

<Liquid drawing property>

Liquid Extraction Property Level Rating Score Almost absent

3 Weak

2 Some

one Clearly observable H 0

(4) Results

The evaluation results obtained in (2) and (3) above are also shown in table 2. The results evaluated based on the results obtained in (2) and (3) above, according to the following criterion, are also shown in table 2 as a comprehensive assessment .

<Comprehensive assessment>

Total points Rating from 15 to 18

from 11 to 14

from 7 to 10

from 0 to 6 H

table 2 Ingredients and Pricing Points Quantity (%) and evaluation results Examples one 2 3 four 5 6 7 8 9 10 eleven 12 13 fourteen fifteen Tamarind Seed Gum 1.8 1.4 1.4 Locust bean gum 1,0 0.2 Xanthan gum 1,2 0.2 Gum packaging 0.7 Guar gum 1,0 Pullulan eighteen Gum seed
psilia 0.8 Hm pectin 4.0 LM pectin 4,5 λ-carrageenan 1,6 Carboxymethyl cellulose
vine 1.8 Cellulose 2.5 Hydroxypropyl Methyl Cellulose 3.0 Trehalose 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 Sodium benzoate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Lemon acid 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Trisodium citrate 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 Red number 2 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Red number 40 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Viscosity (60 rpm) 1890 1480 1850 1920 1510 1440 1780 2300 1320 1280 1080 1020 2640 1220 1530 solution pH 3.60 3,59 3.89 3.56 3.69 3.60 3,59 3.91 3.73 3,59 4.46 4,50 3.92 3.60 3,58 Liquid penetration
to filter * 1

Fluid drawing property

Viscosity stability
* 3

Comprehensive Assessment
*four

Experimental Example 2

(1) Preparation of an aqueous liquid composition

An aqueous liquid composition (Examples 16-25) was prepared according to the formulation shown in Table 3. More specifically, tamarind seed gum, xanthan gum and one or more of the saccharides shown in Table 3 (trehalose, sucrose, glucose, fructose, maltose, sorbitol, maltitol, erythritol, xylitol, dextrin) was added to the ion-exchanged water, and the mixture was dissolved by stirring under heating at 80 ° C for 10 minutes. An aqueous solution of sodium benzoate, an aqueous solution of citric acid, an aqueous solution of trisodium citrate and an aqueous solution of a dye (Red No. 2, Red No. 40) were added to each solution, and these solutions were prepared by dissolving in water purified by ion exchange in advance and then mixing. The total amount of each mixture was adjusted by ion-exchanged water to 100 wt.%, Obtaining aqueous liquid compositions (examples 16-25).

(2) Evaluation of the properties of aqueous liquid compositions

In the same manner as in Experimental Example 1, the viscosity (initial viscosity) of each aqueous liquid composition (Examples 16-25) prepared as described above was measured.

Separately, in the same manner as in Experimental Example 1, viscosity was measured after storage at 50 ° C. for 3 weeks (viscosity after storage) to calculate residual viscosity (%), and storage stability of each aqueous liquid composition was evaluated.

(3) Organoleptic evaluation

In the same manner as in Experimental Example 1, one of each aqueous liquid composition obtained above (Examples 16-25 brought to 20 ° C.) was added to the filter tip of one tobacco product. The ability of a liquid to penetrate into each filter was evaluated (evaluation of the ability of a liquid to penetrate). In the same way as in experimental example 1, it was determined whether or not the liquid is drawn into the mouth when smoking each tobacco product (evaluation of the ability of the liquid to draw).

(4) Results

The evaluation results obtained in (2) and (3) above are shown in Table 3.

The results, estimated based on the results obtained in (2) and (3) above, according to the same criterion as in Experimental Example 1, are also shown in Table 3 as a comprehensive assessment.

Table 3 Ingredients and Pricing Points Quantities (%) and evaluation results Examples 16 17 eighteen 19 twenty 21 22 23 24 25 Tamarind Seed Gum 1,6 1,6 1,6 1,6 1,6 1,6 1,6 1,6 1,6 1,6 Xanthan gum 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Trehalose 25 Sucrose 25 Glucose 25 Fructose 25 Maltose 25 Sorbitol 25 Maltitol 25 Erythritol 25 Xylitol 25 Dextrin 25 Sodium benzoate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Lemon acid 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Trisodium citrate 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 Red number 2 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Red number 40 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Viscosity (60 rpm) 1590 1710 1440 1510 1640 1560 1800 1490 1490 1140 solution pH 3.62 3,58 3.56 3.67 3.60 3.70 3.66 3.66 3.69 3.74 Liquid penetration into the filter * 1

Liquid Extraction Property * 2

Viscosity Stability * 3

Comprehensive assessment * 4

Experimental Example 3

(1) Preparation of an aqueous liquid composition

The aqueous liquid composition (examples 26-29) was prepared according to the following procedure according to the formulations shown in table 4. The viscosity of each aqueous liquid composition obtained above was measured using a B-type rotational viscometer (rotor No. 3) at 20 ° C for 1 minutes.

(i) Example 26

Locust bean gum was added in small portions to water at room temperature with stirring, followed by heating. After reaching 90 ° C, the mixture was dissolved by additional stirring at 90 ° C for 10 minutes. Thereafter, trehalose was added to the mixture, followed by further stirring. Methyl cellulose was added in small portions to the mixture, and this mixture was cooled to 20 ° C. Citric acid, glycine, L-ascorbic acid, tea catechin, trisodium citrate, licorice powder and dye were added to the mixture. Citric acid, glycine, L-ascorbic acid and tea catechin were dissolved in small amounts of water before mixing. As for trisodium citrate and liquorice powder, trisodium citrate was dissolved in a small amount of water, and then liquorice powder was added to the solution and dissolved before use. After preparation, the mixture was adjusted with water to a total amount (100 wt.%). The adjusted solution was placed in a container, and then subjected to thermal pasteurization at 65 ° C for 10 minutes, obtaining an aqueous liquid composition (example 26).

(ii) Example 27

Tamarind gum and xanthan gum were added in small portions to water at a temperature of 80 ° C with stirring, and the mixture was dissolved by stirring at 80 ° C for 10 minutes (solution A). Separately, a mixture of soybean polysaccharide powder and trehalose was added in small portions to water at a temperature of 80 ° C with stirring, and the mixture was dissolved by stirring at 80 ° C. Glycine, adipic acid, L-ascorbic acid and tea catechin were added to this solution. Next, a solution obtained by adding liquorice powder to trisodium citrate dissolved in a small amount of water and dissolution was added, and a dye (solution B) was added. Solution A, solution B and starch syrup were mixed with stirring, and then the mixture was adjusted with water to a total amount (100 wt.%). The adjusted solution was placed in a container, after which it was subjected to thermal pasteurization at 65 ° C for 10 minutes, obtaining an aqueous liquid composition (example 27).

(iii) Example 28

The procedure of Example 27 was followed except that no guar gum was used, and an aqueous liquid composition was obtained (Example 28).

(iv) Example 29

The procedure of Example 27 was followed except that tamarind seed gum was not used and an aqueous liquid composition was obtained (Example 29).

Table 4 Example 26 Example 27 Example 28 Example 29 Tamarind Seed Gum 1,2 1,5 Locust bean gum 0.7 Xanthan gum 0.2 1,0 Cellulose 0.4 Trehalose 28.0 21.0 21.0 21.0 Starch syrup 10.0 10.0 10.0 Soya Bean Polysaccharide 1,0 1,0 1,0 Lemon acid 0.25 Trisodium citrate 0.05 0.05 0.05 0.05 Glycine 0.05 2.0 2.0 2.0 Adipic acid 0.55 0.55 0.55 L-ascorbic acid 0.05 0.1 0.1 0.1 Catechin Tea 0.05 0.05 0.05 0.05 Liquorice powder 0,025 0,025 0,025 0,025 Dye 0.25 0.25 0.25 0.25 Water by balance by balance by balance by balance Total amount 100.00 100.00 100.00 100.00 pH 3.3 3.9 3.9 3.9 Viscosity (MPa · s) 1640 1550 1510 1320

(2) Assessing the stability of viscosity of an aqueous liquid composition

From the above aqueous liquid compositions (Examples 26-29), the aqueous liquid composition of Example 26 was evaluated for liquid conditions by varying the temperature in the range from 10 to 40 ° C. As a result, the aqueous liquid composition of Example 26 remained smooth despite a temperature change (from 10 to 40 ° C.).

The aqueous liquid compositions of Examples 27-29 were stored at 37 ° C, and their viscosity was measured over time (after three days, seven days, ten days, 14 days, 21 days and 28 days of storage) in order to evaluate the stability of viscosity. The viscosity measurement conditions were the same as above. The results are shown in table 5. The viscosity stability is shown in residual viscosity (%) calculated according to the equation given in experimental example 1 (2).

Table 5 Storage period (days) Residual viscosity (%) after storage at 37 ° C Example 27 Example 28 Example 29 0 one hundred% one hundred% one hundred% 3 97% 93% 96% 7 97% 92% 95% 10 96% 91% 95% fourteen 96% 85% 99% 21 95% not measured 93% 28 one hundred% 82% 90%

The results shown in the above table allow us to see that the viscosity of the aqueous liquid compositions of examples 26-29, prepared using one or more substances from locust bean gum, tamarind seed gum and xanthan gum, did not change much with prolonged storage or with temperature and had almost the same values.

(3) Organoleptic evaluation

The aqueous liquid compositions (Examples 26-29) obtained above were brought to 20 ° C., and then two drops (about 100 mg) of one of each aqueous liquid composition were added to the filter tip of one tobacco product. The time required for liquid to penetrate into each filter was measured in the same way as in Experimental Example 1, thereby evaluating the liquid penetration ability (evaluation of the liquid penetration ability). After confirming that the liquid penetrated into each filter of each tobacco product, it was evaluated by smoking each tobacco product on a tightening force and to determine whether or not the liquid was drawn into the mouth. Each aqueous liquid composition was evaluated for the ability of the liquid to penetrate and the pulling force of the same person. Tightening force was evaluated by triple inhalation of the mainstream smoke. After smoking, the degree of color change of each filter was also observed.

(4) Results

When one of each aqueous liquid composition obtained in Examples 26-26 was instilled onto the mouthpiece of a filter of a single tobacco product, the aqueous liquid composition uniformly penetrated the filter in about 15 seconds. In addition, the aqueous liquid compositions of the invention did not cause problems, such as penetration of liquid into the mouth or difficulty breathing while smoking. Each filter blackened after smoking, which indicated that each filter captured more nicotine and tar than when it was not soaked in an aqueous liquid composition.

Experimental Example 4

Using the aqueous liquid composition (Example 27) prepared in Experimental Example 3, the effects of removing nicotine and resin from the aqueous liquid composition of the invention were evaluated.

More specifically, the aqueous liquid composition of Example 27 was instilled onto the tip of a tobacco product filter (Mild Seven Light, Japan Tobacco Inc .: nicotine content 0.7 mg, resin content 8 mg) in an amount of about 50 mg (one drop), about 100 mg (two drops) or about 150 mg (three drops), and the amounts of nicotine and tar contained in the smoke of the tobacco product were immediately measured. As comparative experiments, the amounts of nicotine and tar contained in the smoke of the comparative tobacco products were measured following the above procedure and using water (one drop, two drops or three drops) instead of the aforementioned aqueous liquid composition. The percentage reduction in nicotine (%) and the percentage reduction in resin (%) was calculated based on the amounts of nicotine and resin contained in the smoke of each tobacco product treated with the aforementioned aqueous liquid composition or water, when the amount of nicotine and the amount of resin of the tobacco product untreated with neither an aqueous liquid composition , nor water, was taken as 100%.

The amount of nicotine and the amount of tar contained in the smoke of the tobacco product was measured according to the method proposed by the notification of the Ministry of Finance of Japan No. 174, released in 1988, and shown below. In each experiment, ten tobacco products were used.

<Measurement of nicotine and resin>

1. Preparation of the tobacco product

Tobacco products for use in the above measurements were stored at a temperature of 22 ± 1 ° C and a humidity of 60 ± 2% for at least two days and up to seven days before use so that the condition of the tobacco product was suitable for measurement.

2. Devices and devices

(1) Smoking apparatus: type plunger pump

(2) Smoke collector: cigarette holder with fiberglass filter.

The filter has a diameter of 14 mm and a thickness of 1 to 2 mm and has an accumulation capacity of at least 99.9% of all dioctyl phthalate particles with a diameter of 0.3 μm or more at a speed of 140 mm / sec. The pressure loss of the filter at this speed is not more than 93 mm water column (900 Pa). The filter has an acrylate resin adhesive content of not more than 5%.

(3) Gas chromatography

(i) Conditions of gas chromatographic analysis for measuring moisture content

Column: a glass column with an internal diameter of 2-3 mm and a length of 1.2 to

1.8 m

Filler: Porapak G (manufactured by Waters) 80 to 100 mesh or fillers with equivalent or better performance

Temperature: thermostatic bath - from 170 to 180 ° С, injection device - from 230 to 250 ° С, detector - 250 ° С

Carrier gas: helium

Flow rate: 40 ml / min

Detector: thermal conductivity detector

(ii) Conditions for gas chromatography analysis for measuring nicotine content

Column: glass column with an internal diameter of 2-3 mm and a length of 1.8 to

2.7 m

Filler: obtained by applying to an acid-washed and distilled water Chromosorb W 60-80 mesh polyethylene glycol 20W (10 wt.%) And potassium hydroxide (2 wt.%) Or fillers with an equivalent or better characteristic

Temperature: thermostatic bath - from 170 to 180 ° С, injection device - from 230 to 250 ° С, detector - 250 ° С

Carrier gas: helium or nitrogen

Flow rate: 20 to 40 ml / min

Detector: flame ionization detector

3. Analysis and calculation

(1) Selection of raw resin

The mouth end of the measured tobacco product was inserted into the cigarette mouthpiece at 9 ± 1 mm. Smoking of the tobacco product was carried out under the following smoking conditions until the end length of the tobacco product reached 30 mm, and then the tar was collected (smoke particles of the tobacco product collected in the filter). The number of measurements of tobacco products that must be smoked to collect raw tar was 5 per smoking experiment.

<Smoking Conditions>

Smoking volume (smoke volume of a tobacco product inhaled with one smoking): 35 ± 0.3 ml

Smoking period (duration of one smoking): 2 ± 0.1 sec

Smoking interval (period between one smoking and the next smoking): 60 ± 1 sec

Smoking waveform (puff profile): a bell type in which the maximum flow rate occurs at 0.8-1.2 seconds after the start of smoking and the maximum flow rate is from 25 to 30 ml / sec.

(2) Measurement of the amount of raw resin.

The weight of the smoke collector before and after smoking was determined in units of 0.1 mg, and the amount of raw tar (mg / tobacco product) was calculated to the second decimal place based on the weight difference (the numbers below the third decimal place were omitted), according to the following equation:

Raw tar amount = [Weight (mg) of smoke collector after smoking - Weight (mg) of smoke collector before smoking] / [Number of smoked tobacco products]

(3) Preparation of sample solution

The filter, collecting the raw resin, deploy. The surface of the inner wall of the mouthpiece of the tobacco product is wiped with the back of the filter of the mouthpiece and additionally wiped with a quarter of the unused filter. These filters and 10 ml of extraction solvent [a mixed solvent of isopropanol, ethanol and anethole in a volume ratio of 4974: 25: 1, the same is used hereinafter] are placed in a vessel, followed by shaking, to obtain a sample solution.

(4) Measurement of moisture content in the raw resin

1 μl of the sample solution is introduced into the gas chromatograph. Then calculate the ratio of the peak area of moisture to the peak area of ethanol. The moisture content (mg / tobacco product) in the sample solution is calculated to the second decimal place (the numbers below the third decimal place were omitted) using the calibration curve obtained by method (6) (i) described below. The daily average amount of water contained in the filter is subtracted from the moisture content in the sample solution, measured above, to obtain the moisture content in the raw resin. The measurement is carried out twice for each sample solution, and the average of the measured values is calculated.

(5) Measurement of the nicotine content in the raw resin

1 μl of the sample solution is introduced into the gas chromatograph. Then calculate the ratio of the peak area of nicotine to the peak area of anethole. The nicotine content (mg / tobacco product) in the sample solution is rounded to the second decimal place (the numbers below the third decimal place are omitted) using the calibration curve obtained by method (6) (ii) described below. The measurement is carried out twice for each sample solution, and the average of the measured values is calculated.

(6) Obtaining a calibration curve

(i) Obtaining a calibration curve for water

10 ml of extraction solvent is added to each of at least four different amounts of distilled water, the amounts of which are determined so as to cover all the determined moisture contents in the raw resin, giving standard solutions. 1 μl of each standard solution is introduced into a gas chromatograph. Then calculate the ratio of the peak area of moisture to the peak area of ethanol. The procedure is carried out twice, obtaining a calibration curve based on the relationship between the ratio of the peak area and the amount of added water.

(i) Obtaining a calibration curve for nicotine

10 ml of extraction solvent is added to each of at least four different amounts of nicotine, the amounts of which are determined so as to cover all the determined nicotine content in the crude resin, giving standard solutions. 1 μl of each standard solution is introduced into a gas chromatograph. Then calculate the ratio of the peak area of nicotine to the peak area of anethole. The procedure is carried out twice, obtaining a calibration curve based on the relationship between the ratio of the peak area and the amount of nicotine.

(7) Resin Measurement

The amount of resin (mg / tobacco product) was determined by counting to the second decimal place of the value obtained by subtracting the amount of water and the amount of nicotine in the raw resin from the amount of the raw resin.

The results are shown in FIG. 8.

As is clear from FIG. 8, when a nicotine-inhibiting agent (aqueous liquid composition) according to the invention is used in the filter of a tobacco product, the amounts of both nicotine and resins contained in the mainstream smoke of the tobacco product are reduced by at least 50%. As also clear from FIG. 8, the effects of reducing the amounts of nicotine and resin achieved by the nicotine-inhibiting agent (aqueous liquid composition) of the invention are about 2-5 times greater than when only water is used. Furthermore, as shown in FIG. 8, the effects of reducing the amounts of nicotine and tar increase as the amount of the nicotine-inhibiting agent (aqueous liquid composition) used in the filter of the tobacco product increases. This shows that the amount of nicotine and tar that is contained in the mainstream smoke of the tobacco product can be controlled by setting the amount (amount applied to the filter) of the nicotine-inhibiting agent (aqueous liquid composition) of the invention.

Industrial applicability

As described above, the nicotine contained in the mainstream smoke of the tobacco product is effectively captured and removed by smoking by soaking the filter of the smoking article with the nicotine-inhibiting agent of the present invention. A preferred nicotine-inhibiting agent in accordance with the present invention contains a specific polysaccharide and has a suitable viscosity, therefore, such an agent is applied directly to the filter, and then it is quickly evenly distributed over the filter fibers and remains in the filter. This prevents the nicotine-inhibiting agent from getting into the mouth during smoking and allows the smoker to smoke, as usual, with low resistance to inhalation, while at the same time effectively removing nicotine.

In addition, the preferred nicotine-inhibiting agent in accordance with the present invention has a reduced viscosity change with temperature, therefore, it maintains a suitable viscosity under normal conditions of use without uncomfortable thickening at low temperatures in winter. Thus, the nicotine-inhibiting agent has the same viscosity as its viscosity in the open air, even in the open air in winter, making it difficult to bury it on the filter, therefore.

When using the nicotine-inhibiting agent of the present invention, nicotine and resins contained in the mainstream smoke of the tobacco product are effectively removed, so that nicotine and resins adhere to the filter of the smoking article in larger quantities than during normal smoking. Although the nicotine-inhibiting agent of the invention can be applied to a filter of a pipe for stopping smoking or to the mouthpiece of a cigarette, it can also be applied directly to a filter of a cigarette, thereby reducing the nicotine content in the mainstream smoke. In this case, the cigarette can be thrown out after smoking, which results in greater economic efficiency than using a pipe to quit smoking or a cigarette holder.

In addition, an increase in the amount of the nicotine-inhibiting agent of the invention in the smoking article increases the amount of nicotine trapped in the filter of the smoking article. Therefore, nicotine intake can be gradually reduced by increasing the amount of nicotine-inhibiting agent used so as to gradually alleviate the symptoms of nicotine addiction, while at the same time reducing or stopping smoking.

Claims (14)

1. Nicotine-inhibiting agent, which is an aqueous liquid composition having a viscosity of 500 to 1000 MPa · s and containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, container gum , guar gum, pectin, pullulan, psillia gum, methyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose and carrageenan. 2. The agent according to claim 1, wherein said at least one polysaccharide is selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tar gum, guar gum and pectin. 3. The agent according to claim 1, wherein said at least one polysaccharide is selected from the group consisting of tamarind seed gum, locust bean gum and xanthan gum. 4. The agent according to claim 1, further comprising at least one saccharide. 5. The agent according to claim 4, wherein said at least one saccharide is selected from the group consisting of trehalose, starch syrup, sucrose, glucose, fructose, maltose, sorbitol, maltitol, lactitol, erythritol, xylitol and dextrin. 6. The agent according to claim 4, in which said at least one saccharide is selected from the group consisting of trehalose and starch syrup. 7. The agent according to claim 1, which is used when holding it in the filter of a smoking article. 8. A packaged nicotine-inhibiting agent, comprising the nicotine-inhibiting agent of claim 1, poured into a container. 9. Reducing the nicotine content of a smoking article containing a filter containing a nicotine-inhibiting agent according to claim 1. 10. The product according to claim 9, containing a mouthpiece housing having an inhalation hole at one end and an insertion hole for a tobacco product at the other end, and a filter provided in the mouthpiece housing and containing the nicotine-inhibiting agent of claim 1. 11. A method of reducing the nicotine content in the mainstream smoke of a tobacco product, comprising the step of passing the mainstream smoke of the tobacco product through a filter of the smoking article, said filter comprising a nicotine-delaying agent according to claim 1. 12. A method of reducing the resin content in the mainstream smoke of a tobacco product, comprising the step of passing the mainstream smoke of the tobacco product through a filter of a smoking article, said filter comprising a nicotine-inhibiting agent according to claim 1. 13. The use of an aqueous liquid composition having a viscosity of 500 to 1000 MPa · s and containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tar gum, guar gum, pectin, pullulan, gum seeds of psillia, methyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose and carrageenan, for the preparation of a nicotine and / or resin inhibiting agent. 14. The use of an aqueous liquid composition having a viscosity of from 500 to 1000 MPa · s and containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tar gum, guar gum, pectin, pullulan, gums of the seeds of psillia, methyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose and carrageenan, to trap nicotine and / or resin.

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