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RU2115429C1 - Рекомбинантный иммунотоксин на основе дифтерийного токсина и интерлейкина-2 (дт 482-il2) и способ его получения - Google Patents

Рекомбинантный иммунотоксин на основе дифтерийного токсина и интерлейкина-2 (дт 482-il2) и способ его получения Download PDF

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Publication number
RU2115429C1
RU2115429C1 RU97111749A RU97111749A RU2115429C1 RU 2115429 C1 RU2115429 C1 RU 2115429C1 RU 97111749 A RU97111749 A RU 97111749A RU 97111749 A RU97111749 A RU 97111749A RU 2115429 C1 RU2115429 C1 RU 2115429C1
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RU
Russia
Prior art keywords
interleukin
fragment
apali
recombinant immunotoxin
cloning
Prior art date
Application number
RU97111749A
Other languages
English (en)
Russian (ru)
Other versions
RU97111749A (ru
Inventor
С.С. Маркин
В.Ю. Уваров
И.Г. Сивов
А.А. Ляшенко
М.П. Семенов
Original Assignee
Закрытое акционерное общество "Фосфосорб"
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Publication date
Application filed by Закрытое акционерное общество "Фосфосорб" filed Critical Закрытое акционерное общество "Фосфосорб"
Priority to RU97111749A priority Critical patent/RU2115429C1/ru
Priority to PCT/RU1997/000343 priority patent/WO1999004807A1/fr
Application granted granted Critical
Publication of RU2115429C1 publication Critical patent/RU2115429C1/ru
Publication of RU97111749A publication Critical patent/RU97111749A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
RU97111749A 1997-07-22 1997-07-22 Рекомбинантный иммунотоксин на основе дифтерийного токсина и интерлейкина-2 (дт 482-il2) и способ его получения RU2115429C1 (ru)

Priority Applications (2)

Application Number Priority Date Filing Date Title
RU97111749A RU2115429C1 (ru) 1997-07-22 1997-07-22 Рекомбинантный иммунотоксин на основе дифтерийного токсина и интерлейкина-2 (дт 482-il2) и способ его получения
PCT/RU1997/000343 WO1999004807A1 (fr) 1997-07-22 1997-11-03 Immunotoxine recombinante a base de toxine diphterique et d'interleukine -2 (dt482-il2), et procede de production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU97111749A RU2115429C1 (ru) 1997-07-22 1997-07-22 Рекомбинантный иммунотоксин на основе дифтерийного токсина и интерлейкина-2 (дт 482-il2) и способ его получения

Publications (2)

Publication Number Publication Date
RU2115429C1 true RU2115429C1 (ru) 1998-07-20
RU97111749A RU97111749A (ru) 1999-03-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU97111749A RU2115429C1 (ru) 1997-07-22 1997-07-22 Рекомбинантный иммунотоксин на основе дифтерийного токсина и интерлейкина-2 (дт 482-il2) и способ его получения

Country Status (2)

Country Link
RU (1) RU2115429C1 (fr)
WO (1) WO1999004807A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2140283C1 (ru) * 1998-12-15 1999-10-27 Товарищество с ограниченной ответственностью "Биотех" Фармацевтический препарат на основе интерлейкина-2 (варианты)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102327D0 (sv) * 2001-06-28 2001-06-28 Active Biotech Ab A novel engineered superantigen for human therapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2650183A1 (fr) * 1989-07-25 1991-02-01 Pasteur Institut Proteines immunostimulantes, anticorps monoclonaux et polyclonaux correspondants, hybridomes correspondants et application de ces produits a des fins therapeutiques et de diagnostic
US5061692A (en) * 1984-08-09 1991-10-29 Immunetech Pharmaceuticals Methods and compositions for the treatment of non-IgE-mediated diseases
RU2077585C1 (ru) * 1993-12-10 1997-04-20 Государственный научно-исследовательский институт прикладной микробиологии Рекомбинантная плазмидная днк рдти 23, способ получения рекомбинантной плазмидной днк рдти 23 и штамм бактерий escherichia coli, содержащий рекомбинантную плазмидную днк рдти 23 - продуцент слитого белка дтил 2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2091170A1 (fr) * 1990-09-06 1992-03-07 Marian L. Plunkett Utilisation de l'il-4 dans le traitement des tumeurs solides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061692A (en) * 1984-08-09 1991-10-29 Immunetech Pharmaceuticals Methods and compositions for the treatment of non-IgE-mediated diseases
FR2650183A1 (fr) * 1989-07-25 1991-02-01 Pasteur Institut Proteines immunostimulantes, anticorps monoclonaux et polyclonaux correspondants, hybridomes correspondants et application de ces produits a des fins therapeutiques et de diagnostic
RU2077585C1 (ru) * 1993-12-10 1997-04-20 Государственный научно-исследовательский институт прикладной микробиологии Рекомбинантная плазмидная днк рдти 23, способ получения рекомбинантной плазмидной днк рдти 23 и штамм бактерий escherichia coli, содержащий рекомбинантную плазмидную днк рдти 23 - продуцент слитого белка дтил 2

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2140283C1 (ru) * 1998-12-15 1999-10-27 Товарищество с ограниченной ответственностью "Биотех" Фармацевтический препарат на основе интерлейкина-2 (варианты)

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Publication number Publication date
WO1999004807A1 (fr) 1999-02-04

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