RU2197997C2 - Device and method for making injections - Google Patents

Abstract

FIELD: medical engineering. SUBSTANCE: device has body and cartridge containing medicaments. The cartridge has anterior and posterior part determining general cartridge axis. The device has outlet opening for discharging medicaments in the anterior part, at least one movable wall between the anterior and posterior part, which movement enables causes medicament to move forwards or be extruded through the outlet opening. Piston rod has the first and the second end at least partially placed in the device body designed for giving way for matching with its first end to movable wall and causing the wall to move. Versions of the device are distinguished by driven and catching means design. The driven means are placed in the device body. They are usable for moving at least rod. The catching means are connected to body support cartridge or its envelope anterior part of which is separated from the body and the posterior one is brought close to the device body. The driven means move the catching means so that the cartridge moves forwards relative to the device body. Fixing members lock cartridge preventing from its movement in axial direction relative to the device body, determining in this way fixed cartridge position. The driven means move the piston rod the back position and position protruding forwards. EFFECT: safety and simplicity in making injections. 232 cl, 6 dwg

Description

The invention relates to a device for injection and a method of its action, and the device for injection is of the type that contains:
a) housing;
b) a cartridge in which a drug or preparation for preparation of a medicine is located and which has a front and a back defining a common axis of the cartridge, a drug outlet located in the front, and at least one movable wall located between the front and the back, and the movement of this wall causes the drug to move towards / or be forced out through the outlet;
c) a rod that is at least partially located inside the housing and can be mated and move the movable wall;
d) drive means located in the housing, designed to move at least one rod.

BACKGROUND OF THE INVENTION
Injection devices having a separate housing and replaceable cartridges have found wide application in many fields, for example, in drug delivery systems, due to the flexibility and economic advantages of the possibility offered by a reusable housing with a more or less advanced mechanism for preparing, dispensing, controlling and monitoring the injection procedure, since the distinctive features of the replaceable cartridge may be limited to those necessary for safety meat storage and simple withdrawal of pharmaceuticals, features which furthermore may be adapted for use by any individual type of medicament.

 In many inpatient facilities, such as hospitals, there are few design restrictions and the hull can have a very complex design in terms of mechanized manipulation tools, controlling actions using a processor and data collection, as well as possible types of interfaces for connecting to other possible equipment . Often the freedom of design choice is also used for the manufacture of a housing compatible with one or more existing or standardized cartridges, syringes or types of injection devices, thereby expanding the scope of the equipment and reducing the cost of fitting cartridges.

 For ambulatory purposes, design restrictions are more stringent, especially with respect to separately operating devices without connecting them to supporting systems. Restrictions on size and weight introduce restrictions on the number and complexity of functions that can be enabled for these devices to perform. Automation, as an alternative measure to increase safety and eliminate cases of misuse, is also limited due to the need for additional mechanized means and the range is limited due to the limited capacity of energy sources.

 Nevertheless, the devices must meet all standard safety and accuracy requirements, not only at the dosing stage itself, which should allow both the implementation of multiple injections of equal and constant quantities, and the precise setting of individual doses, as well as the correct sequence and the correct execution of preparatory steps, such as mixing, air removal and preliminary ejection. The problems become more pronounced when using pharmaceutical preparations that have a limited stability period, require preparatory steps immediately before use, or are sensitive to shear forces and require preparation and dosing under controlled mechanical conditions. Two- or multi-chamber cartridges are often used for drugs requiring a conversion step, for example, dissolving a stable lyophilized powder in an aqueous chamber with a solvent in another chamber. In addition to the additional preparatory stage, multi-chamber cartridges introduce special problems associated with efforts to reduce the size, since they are usually larger than single-chamber cartridges, partly due to the need for mixing space, and partly due to the need for additional walls and mixing structures.

 Although convenient and portable injection devices can be created with the minimum need for the means necessary to safely fulfill all of the above requirements and solve problems when used by specialist operators, the general tendency in long-term treatment is to shift the responsibility for taking medication to itself the patient, also in the case of treating a child or an incapacitated patient, for example, when using injection devices such as a pen. A high degree of automation and control is therefore desirable to eliminate errors not only when performing simple injection steps, but also when performing complex preparatory steps. Patients who are forced to take medications daily also have a legitimate need to provide comfort and use safe enough devices to be used in everyday life. The conflicting requirements for very complex, but at the same time small and convenient devices, did not receive a solution in the means known in this field.

 US Pat. Nos. 5,112,317 and 5,232,459 describe a typical multi-dose portable mechanical and manual device, the size of which is minimized by allowing the device to reduce its size in accordance with drug consumption in the first link — by linear, and in the second link — by threaded reduction of the part containing the ampoule , in the main part of the device. In order not to create problems during the injection, the dosing mechanism must necessarily operate in a discontinuous mode, inconvenient for further automation, and the resource requirement is in its size. No special features are provided to facilitate the implementation and guarantee the preparatory and initial stages before dosing. U.S. Pat. In order to protect the slow and careful process of overflowing the fluid contained inside, relative movement between the piston rod and the cartridge is carried out by moving the threaded parts. In addition to the general limitations mentioned above for further automation, there is nothing to improve the control system for switching from a drug conversion step to a dosing step.

 Injection devices with means of mechanization and automation are described in several previously published patents, for example, in US Pat. In general, these devices are either only suitable for use in inpatient facilities or, when they are offered for mobile use, they are inconvenient due to the small size of the cartridge compared to their overall size. They all differ in the lack of cartridge preparation by appropriate control means. Patent application WO 93/02720 describes a two-chamber cartridge type that can be used in a portable device. With the exception of the special needle pull mechanism, the conversion principle is completely normal without any use of automation capabilities.

 Accordingly, there remains a need for a portable injection device that assists patients in self-administering injections and relieves them of the burden of studying and monitoring in an environment that provides sufficient protection against the errors of each step in the drug regimen, preferably equipped with highly automated means, while satisfying the legitimate patient desires to have an easy-to-use and separate device. Although the present invention has more general application, it is mainly described so as to show the possibility of overcoming the disadvantages indicated here.

SUMMARY OF THE INVENTION
The main objective of the present invention is to overcome or reduce the influence of the above disadvantages of the known devices. A more special purpose is to create a convenient device with moderate dimensions, the mode of action of which is suitable for use on an outpatient basis. The next goal is to create a device that facilitates its use and reduces the risk of possible errors. Another goal is to create a device suitable for automation and mechanization of its actions. Another goal is to create a device with improved self-control capabilities. Another goal is to create a device with an improved preparatory operation. Another goal is the creation of such a device that is suitable for multi-chamber cartridges and simplifies the steps of drug conversion using such cartridges.

 These goals are achieved thanks to the characteristics and improvements set forth in the attached claims. In accordance with one aspect of the present invention, a device of the originally proclaimed type comprises gripping means for gripping and holding the cartridge, and drive means for moving the cartridge relative to the housing to a locking position at which the piston rod enters the cartridge. According to the method of action, the corresponding movement up to fixing moves the movable wall of the cartridge at least partially, after which the main dispensing releases can be made. The capture and movement of the cartridge relative to the housing in the inventive method allows for controlled introduction of the cartridge into the device. The presence of the piston rod in the cartridge after this step by itself locks the cartridge against lateral displacements in order to prevent an unintentional and dangerous internal procedural displacement, and this protective measure can be further developed by the use of locking means. The movement when moving the movable wall of the cartridge allows you to simply and under controlled conditions prepare the device for injection. Typically, such preparation is a process of related operations that is clearly different from the subsequent main operation of the injection. By moving the cartridge during this step, the final size of the device is established, which excludes the length required for preparation, and, in principle, the stroke length of the piston rod can be limited to the amount necessary to displace the final drug. The same features make it possible to use and benefit from the use of small cartridges. Axial locking allows you to switch control from the preparatory operation to the injection and ensures dimensional stability of the device during the final steps. The overall benefits described above are enhanced when combined with automation. The capture and movement with the help of drive means allows to provide a controlled and adapted to carry out the preparatory operation method, protected from errors, also when using very sensitive drugs. The movement, as such, facilitates the automatic determination of the characteristics of the cartridge, for example, its condition, contents, or any associated identification code, by the scanning action of even a stationary probe or sensor means. Saving dimensions and the possibility of using shorter piston rods allows the device to be used to perform additional functions without increasing bulk. Switching the control system from the preparatory operation to the injection is facilitated by a clear two-stage process and can even be mechanized, for example, if attached to the fixation step. With such a suitable control system, the same mechanical means can be used both for moving the cartridge and subsequent dosing, which greatly simplifies the internal design of the device.

 Further objectives and advantages of the present invention will become apparent upon reading the description below.

 DETAILED DESCRIPTION OF THE INVENTION

 The principles of the present invention can be used in injection devices or in systems in wide ranges for any type of chemical product supplied for any purpose. The invention was created primarily with the aim of using medical drugs and, for convenience, the present invention is described with reference to this field of use. For this purpose, the injection channel or conductive means may be in the form of a tube or catheter, needle or tubular means, or a system without a needle based on a fluid nozzle, or in the form of a gun for particulate matter with a liquid moving medium. The material in the cartridge must be ejected when moving the movable wall, and any material that meets this requirement can be used. Typically, the material is a liquid, and preferably a liquid, including materials that behave as liquids, such as emulsions or suspensions. This remark applies to the final drug, since other components, especially particulate matter, may be present before the final drug is obtained. It should be understood that the nature of the contents of the cartridge can include pharmaceutical preparations in a wide range and encompass, for example, natural components and biological fluids pre-filled or drawn into the cartridge, although in the most general case pharmaceutical preparations are factory-made preparations. The present invention provides particularly significant advantages when using sensitive compounds susceptible to decomposition or decomposition under mechanical stress, for example, large shearing forces. Compounds with a high molecular weight can be substances of this type, hormones with a high molecular weight, such as growth hormones. The present invention also makes it possible to achieve particular advantages when using pharmaceutical preparations that require a preparation step immediately prior to infusion, usually consisting in mixing two or more components, all of which may be liquids or may include solids, as when dissolving a lyophilic powder in a solvent, for example hormones or prostaglandins.

 The injection method may also vary widely and may include a fully continuous infusion, continuous infusion at a variable flow rate or intermittent infusion, or repeated injections with the same or different doses. The injection can be easily varied especially when the injection device is equipped with automatic means, which will be described below, and software or similar controls. The present invention provides particular benefits in performing intermittent infusions. Similarly, the present invention provides benefits, for example, when preparing in most infusion methods, also when it is intended to carry out only one dispensing operation, although it can provide particular advantages when the cartridges are adapted to more than one or to multiple separate doses of intermittent injection.

 As mentioned earlier, the type of injection device, which is the basis for ongoing improvements, contains at least a cartridge for a pharmaceutical product, a housing for at least a metering mechanism and a piston rod, which is broadly adapted to interface with / and move the movable wall of the cartridge .

 A cartridge for these purposes may generally include a vessel having a front and a back defining a common axis of the cartridge, a medication outlet located at the front, and at least one movable wall located at the rear wall, the movement of which forces the drug moves towards / or is forced out through the outlet. The shape of the vessel and the movable wall must be mutually consistent. The vessel may have a looser shape if the wall is flexible or the membrane is large, or the diaphragm can be adapted by moving or changing the shape in relation to the inner surface of the vessel, in which case a pillow of fluid or elastic material may be necessary between the wall and the piston rod for alignment applied pressure. However, it is preferable that the vessel has a substantially constant internal cross-section, along with a constant axis of the vessel between the front and back portions, which generally represent the shape of the tube, and more preferably the cross-section has the usual round shape, in which it is substantially degree cylindrical vessel. The movable wall is preferably substantially an object of constant shape, although it may be flexible, tightly adjacent to the inner surface of the vessel, but preferably of a piston type, of sufficient length to self-mount and withstand tipping over when moving along the vessel. The outlet at the front can be of any known design and can be directed sideways to provide the best access in certain applications, it can be located frontally, but not coaxially with the axis of the vessel, or more generally can be located frontally and coaxially. The outlet may be integral with the vessel, or in the normal case, the front edge of the cartridge may be equipped with a connecting device that is provided with a breakable or punctured seal that is punctured or pierced before connection.

 Typically, the described cartridges require several types of preparatory operations, depending on the movement of the movable wall, in order to readjust the device and enable repeatable and reproducible metering operations that meet high accuracy requirements. When moving the movable wall for the first time, it may be necessary to apply an unusually greater releasing force after storage to exceed both the resistance to internal shape change and the increased resistance to wall movement due to adhesion or lack of lubrication at the contact points. The same can be said for weaker regular injection forces, elastic and inelastic deformations and tolerances that must be aligned between the movable wall, cartridge housing, outlet aids, etc. The drugs themselves may contain compressible inclusions, such as gas bubbles. Deaeration and pre-ejection is necessary to remove gas in the compartments of the vessel and in the spaces to be filled, for example at the front seal, exhaust devices and the interior of the exhaust devices or needles.

 Known types of cartridges with two or multiple chambers, for example, for drugs that require mixing two or more components or the preceding compounds before infusion. The components are stored separately from each other using one or more intermediate walls of various known structures, and these walls divide the vessel into several chambers, sometimes located parallel to the axis of the cartridge, but most often sequentially along the axis. The unification of components can take place in the design of devices for punching, penetrating or opening valves in the intermediate walls, for example, by inserting a spike or needle through the front edge of the cartridge, through / / y the rear movable wall, or using means inside the cartridge (compare, for example, cited in patent application WO 93/02720). In another known device, the intermediate wall or walls are of the piston type, and the flow between the chambers is carried out by moving the piston to the bypass section, where the inner wall has one or more enlarged sections or repeating circumferential grooves and surfaces arranged in such a way that the flow is bypassed from the rear chamber to the front chamber when moving the rear movable wall (compare, for example, with the cited US patent 4968299 or applications WO 93/20868 and WO 95/11051). The chambers may contain gas, liquid or particulate matter. Usually at least one liquid is present. Most often, for pharmaceutical applications, only two chambers are used and they usually contain one liquid and one solid component, the latter being dissolved and converted during the mixing operation.

 The preparatory operation when using multi-chamber cartridges requires the completion of all the usual steps described above, although in a more complex form due to the presence of additional walls and cavities. To perform efficient mixing, typically the mixing space must be distributed in addition to the space occupied by the components. Powdered components in bulk form also require additional space occupied between the particles. The mixing step can lead to the formation of foam or gas inclusions that require space to soothe. Piston-type intermediate walls typically must be biased by at least their own length in order to reach an unsealed bypass position. In general, in multi-chamber type cartridges, the movable walls are required to report the amplitude of the large-length displacement at the preparation stage, both for mixing and subsequent deaeration, and they are particularly beneficial due to the advantages of the present invention.

 The size of the cartridge can vary, and these changes are highly dependent on the intended purpose, and it is difficult to set common range boundaries. Typical dimensions in preferred applications for self-administration of drugs using portable devices are for an internal diameter of 2-30 mm, preferably 3-20 mm. It is desirable to have a large length to diameter ratio, for example 2-20, and preferably 2.5-15, based on the size of the drug column after the preparatory operation, but before any dosing and expenditure operation. The length of the cartridges is distinctly longer due to at least the size of the piston, and in the case of using multi-chamber cartridges it is significantly longer for the above reasons, but the ratio of length to diameter is preferably kept within less than 20 times, and more preferably within less. than 10 times the mentioned ratio of columns.

 In addition to the minimum cartridge features described above, in accordance with the present invention, some structural structures may be required to provide gripping, moving, and fixing. To a limited extent, such structures can be placed on the inner surface of the cartridge vessel. In many cases, however, it is preferable to use the outer surface of the vessel. A single-wall cartridge can also be used, especially when using machined or molded wall materials, such as glass or polycarbonate. Greater universality of the design is achieved by using separate parts located on the outside of the cartridge vessel. Such constructions may be limited by the provisions required for these special structures, or may cover almost the entire vessel (compare with US patent 5435076) to form a sleeve or container for the vessel, for example, to provide additional protection or to allow free choice of the location of fixation of the vessel . The container may be equipped with a protrusion on top of the vessel for better direction and smallest dimensions, or a small gap may be left between them, for example, to accommodate vessels with different shapes, different diameters and lengths, or to allow the vessel to rotate freely in it. Structures for the aforementioned purposes may include slip zones adapted to grip or seal, grooves or other shapes for symmetrical arrangement without rotation to prevent rotation, but allowing axial movement, internal or external threads, both for fixing the cartridge and for moving it by using drive means with mating threads, flanges or protrusions for gripping or fixing, a socket or seat for seals. Details of these designs will be discussed below in connection with each functional embodiment. On parts of the sleeve or container, in particular, it may be necessary to use windows or places made using transparent, translucent, or other materials that provide visual monitoring or automatic sensory determination of the state of the vessel or contents of the vessel, or of any encoded states thereof. The individual parts, sleeves, or containers described herein are provided to allow the vessel to move at least in the axial direction. Accordingly, if the term “cartridge” is used somewhere here, this should be understood to mean any part accompanying the vessel at least partially in its axial movement relative to the housing between the gripping and fixing zones.

 The device body is a reference point for describing cartridge movements and piston rod movements and also a reference point for forces exerted by the drive means providing said movements, where a force is applied between the body and the movable and gripping part. The minimum functional requirement is that the housing provides support or is a platform for moving parts and drive means that communicate motion and transmit forces. As is the practice, however, it is preferable that the body form a container that at least partially encompasses the parts and preferably also to the extent that only special parts that are designed to control or control the operator protrude outward.

 Located y / or inside the housing are at least the piston rod, gripping means, locking means and drive means for moving parts. As will be described below, additional agents may be present, especially controlling and sensory agents.

 Although the housing may be large enough to protrude beyond the size of the cartridge after grasping and before moving, and in accordance with the fact that the movement takes place completely on top or inside the housing, it is preferable to maintain the size so that the housing ends near the cartridge axis with the distant edge of the cartridge before moving the cartridge. In the aforementioned direction and before moving, the cartridge accordingly forms a remote part of the entire device. Also after moving and when the cartridge is in a fixed position, the housing can end clearly close to the distant edge of the cartridge, for example, to reduce weight or facilitate visual inspection. Since the above considerations regarding preservation of size do not apply to the rear or fixed position, it may be preferable that the housing protrudes at least partially, and even more preferably extends almost completely along the cartridge in this position, for example, protection of the cartridge, to provide direction for the cartridge during movement or in its final position, or to create a place for placement of sensory means or detectors, which will be described below. The housing can here be shaped into a tube substantially or completely covering the cartridge, possibly with window openings, the openings being located near a distant edge and adapted to the shape and size of the cartridge. Also, in the absence of the protruding part of the housing described above, when the edges of the housing are located exactly near the distant edge of the cartridge, similar holes can be successfully created, especially when the housing is made in a preferred shape in the form of a container. In accordance with this, a general preference is given to creating a hole in the housing, and this hole covers the cartridge in whole or in part and in size and shape makes it possible to receive the cartridge and perform at least its movement inside it. Although it can be imagined that a portion of the housing protrudes into the interior of the cartridge vessel or between the vessel and the outer part, it is preferable that the entire cartridge, as defined, be covered by such an opening.

 If you want to minimize the overall size of the device, the parts of the housing protruding in the direction of the axis of the cartridge, but against the edge of the housing for receiving the cartridge, should be provided with as short protruding parts as possible. Rarely, the dimensions of the device before or during the preparatory operation create difficulties for the user, and the starting point for estimating the size, therefore, is the situation after the preparation operation and before spending. In the present device, the size may also be taken as the critical size when the cartridge is already fixed in the housing. This size can preferably be constant during the injection operations or can be reduced if the device is allowed to be shortened in accordance with the consumption of the drug, which is known per se, and in the latter case, the reference point is accepted before the first dosing operation. In these situations, the first value of interest is the maximum length of the housing along the axis of the cartridge or parallel to it when measured from the rear edge of the cartridge. Preferably, said size is 2-20 cm, it is better if it is 3-15 cm and best if it is 4-10 cm. The second value of interest is the ratio of the first value to the total stroke length when dosing, which it is advisable to have when using a particular type of cartridge. The ratio is preferably at least 1, often at least 1.2, even more preferably at least 1.5, but less than 10, better less than 7, and most preferably less than 5. The maximum size of the device perpendicular to the axis of the cartridge , generally smaller than the maximum size along the axis.

 The action of the piston rod is to mate and move the movable wall of the cartridge, and the piston rod is partially placed in / or near the housing. At least during batching operations, the piston rod must be axially moved relative to the housing between one or more distant positions and one or more protruding positions relative to the outlet of the cartridge. The piston rod can also be positioned so that it moves axially during the movement of the cartridge, in order to only increase or decrease its offset relative to the cartridge, for example, in connection with the pairing or disconnecting operations at the beginning or end of the movement, or for fine tuning when moving the movable wall to perform various phases of the preparatory operation during said movement of the cartridge. In general, it is preferable, however, to hold the stem substantially stationary in the axial direction relative to the housing during movement of the cartridge, thereby obtaining the smallest size and least complex mechanical structure and at the same time using gripping means to control the movement of the cartridge. In the retracted rear position, the piston rod or parts connected to it may protrude from / and protrude at the rear of the housing against the receiving front of the cartridge, for example, to minimize the size of the housing, but here it is preferable that it is inside the boundaries of the housing, to ensure the safest and most convenient action and to provide added space in case / or when performing additional auxiliary functions. Similarly, even in the retracted rear position, the front of the piston rod is located in the cavity of the cartridge after moving it, and at least some of these parts may protrude from the front of the housing, especially when the housing does not cover substantial parts of the cartridge, as explained above , but can also be completely located inside the case, especially when the case protrudes around the cartridge. Axial movements of the rod or the previously described limitations do not exclude that the rod can perform lateral or, in particular, rotational movements for other purposes, which will be discussed below.

 The piston rod must be stiff enough so that in the area of its front end it can move the movable wall when it is informed to move further back, and should be at least long enough and straight enough to pass through the cavity of the cartridge, and may have an additional length, the need for which is caused by drive means. In other aspects, the term “stem” should be understood in a broad sense, in which it can consist of one part or be a complex structure with parts attached to it, for example, for drive or control, but it should not contain parts that could not move along the axis. The front end of the stem must be mated to the movable wall so that it can perform at least a pushing motion, and to perform this motion, no physical devices are required at the movable wall, but only the end surface or the thrust part should create the desired uniform and distributed pressure, possibly , through depreciation, as described. If it is required to apply a pulling force to the movable wall, for example, to allow the drug or biological fluids to be sucked into the cartridge, the rod head designed for pairing must contain a physical device at the movable wall, which can be of any ordinary or known type , for example, based on friction, locking under pressure, undercutting, bayonet grips, threads or in the form of any other devices.

 Mechanisms for moving the piston rod forward in the axial direction typically include drive means and suitable means for mating on the rod to transmit force thereto, these means being mutually adapted and can take various forms, examples of which will be given below. It was previously said that any mating device mentioned here can be placed either on the stem itself or on a separate shaft, for example, substantially parallel to the rod, with a simple pushing device between them, as described as examples in several patents cited in the introduction. In order to preserve the dimensions and weight of the device, it is generally preferable to manufacture devices on the piston rod itself, and for convenience, a description will be given with reference to such a device. The stem can be mated simply by using a friction-based coupling, possibly reinforced by using a wedging action between the radially acting wedge and the axially groove in the stem, which is matched in shape, to which a driving force is applied. A simpler device can be obtained by providing the rod in the axial direction with a group of circular or one-sided transverse protrusions, grooves or teeth mated by using engagement structures on drive means, for example, a drive gear. Smaller forces must be created with drive means if the stem is threaded and driven using a conjugated screw-nut pair, due to the resulting gear ratio. The drive means can rotate the nut, for example, by means of a gear train, while the stem will keep it from rotating, or the drive means can rotate the rod itself, for example, by means of a drive wheel connected to it, while the threaded nut is kept from rotating . In all but the last examples above, it may be desirable to fix the stem, preventing its angular displacement and at the same time allowing it to move in the axial direction. This can be accomplished in many known ways by using non-rotating symmetrical parts on the stem, for example, one or more flat surfaces, grooves, etc., placed either on the outer surface of the stem or in the central hole in the stem, the part being axially constant transverse cross-section along the stem, or a non-rotating symmetrical part, for example, a protrusion mated with a matching axial groove on the mating part, for example, covering a sleeve or shaft in an axial hole. Parts can also serve as bearings for the stem alone or in addition to individual conventional bearings. Parts and bearings should provide almost coaxial arrangement of the rod with the axis of the cartridge, possibly within the tolerances at which adaptation to small discrepancies between them can be ensured.

 Drive means typically include motor means and an energy source. The words "motor means" should be understood as any gear necessary to communicate movement or perform specified functions. The motor means may be of any known type, for example, electric, hydraulic, pneumatic or mechanical. Electric motor means are preferred due to the simplicity and ease of monitoring. The energy source may be external and may include means for transmitting energy to the device, but in order to make the device truly portable, it is preferable to use an internal energy source. For the purposes of the present invention, "energy sources" should include any means of conversion or transformation necessary to provide energy in the form required for motor means, although it is preferable to choose an energy source so as to limit such conversions in the device. The energy source may direct manual energy, but preferably includes accumulated energy sources, for example pumping means, or pressure sources for pneumatic or hydraulic motor means, or spring systems for mechanical motor means. Capacitors or preferably batteries are suitable sources of energy for electric motor vehicles. You can use several motors or several sources of energy, for example, a combination of any of the mentioned means to drive various mechanical parts, tools or sensory means of the device, although it is generally preferable to use as little means as possible. In this context, the words "drive means" should be understood as all necessary means for activating the device, unless special means are clearly proposed.

 Movement from motor means can be reported to the piston rod in various places. Motor vehicles may be given the opportunity to follow the stem when moving it, which requires only one interface on the stem. Preferably, however, the motor means are permanently installed. The location of the mating point can, for example, be chosen close to the edge of the cartridge, which makes it possible to mate with the rod during the entire injection phase and makes it possible to use the space behind, for example, to create a shortened design. The mating point can also be selected at the opposite edge near the rear of the stem, which with fixed motor means requires some transmitting means, for example, a sleeve covering the rod, a shaft protruding through the axial hole in it or a pusher acting in a similar way.

 The minimum length of the piston rod, as already determined, corresponds to the desired dispensing stroke, possibly with an additional length, in order to ensure the possibility of mating, as described, for example, it should be at least 1.1 to 1.3, or preferably 1, 5 times the desired length for dosing. The minimum length may be useful, for example, if moving the movable wall of the cartridge during the preparatory operation up to the start of the batching operation when moving the cartridge is carried out using a piston shaft stationary in the axial direction, after which the metering operation is performed using the piston rod moving in the axial direction, when he stands in front of the stationary part through the use of any described drive mechanism. Preferably, the maximum length here substantially corresponds to the length of the stationary part. Usually a simpler and more accurate design is obtained if the piston rod is set to a minimum length corresponding to the desired movement during both the preparation and dosing operations, or preferably its full stroke inside the cartridge, again with the additional length required for activation, for example, it should be at least 1.1, 1.3, or preferably 1.5 times the length. The maximum length is preferably less than 4 times, and it is better if it is less than 3 times, and even better if it is less than 2 times this value. If desired, the stem may be telescopic within these limits.

 Typically, the gripping means in the present invention include connecting means and driving means, provided that the same means can perform both functions. Gripping means must have the ability to attach, hold and pull the cartridge relative to the housing. The exciting means can be completely different from the means acting as a piston rod, for example, in order to provide the possibility of high flexibility of the device. They can grab the cartridge inside it, in which case such means preferably partially cover the piston rod, thereby limiting the amount of space required. They can also capture the cartridge outside its channel, for example, on the outside or between the vessel and possible external parts, which allows the use of narrower cartridge channels. The gripping means can move the cartridge by moving it back along its own axis of movement in the same direction, or the gripping means can be stationary in the axial direction, but give a rotational movement, which is converted into axial movement of the cartridge using a screw-nut mechanism, and the cartridge it is possible to rotate relative to a stationary thread, but preferably there is another, inverse solution, in which the parts bearing the bearing and thread impart a rotational movement, while to hold the cartridge against angular movement.

The length of the gripping means may correspond to the stroke of the cartridge, preferably together with the added
length, for mating with the drive part, and this minimum length is usually used when the mating point with the drive part is close to the extreme rear point of travel of the cartridge, but the length of the gripping means may extend further backward, especially when the mating point with the drive part is located even further back although it is preferable not to retract it much further than the rear end of the piston rod in the retracted rear position. To perform the described actions, any proposed principles of the piston rod drive can be used. The drive means may include separate motor means for the gripping means and the piston rod, but it is preferable to use the same motor means that are designed to switch the interface between them. In general, the piston rod can be independently controlled in order to mate and move the movable wall for any desired operating procedure, the preferred operating procedure being, as defined above, in holding the piston rod in a fixed position, but with its front end will be in a position relative to the gripping means that it will perform at least part, and preferably substantially completely move the movable wall, is necessary The first step for carrying out the preparatory operation, the principle of a fixed rod, among other things, contributes to the improvement of the use of the same drive means and suitable means for switching both for moving the gripping means and for moving the piston rod.

 In order to reduce the mechanical part, reduce bulkiness and allow the use of narrower cartridges in the device, it is preferable to use the piston rod not only to manipulate the movable wall of the cartridge, but also by exciting means for moving the cartridge. A preferred way to accomplish this task is to allow the cartridge to move along / and along the piston rod while the piston rod is mating with the wall. Preferably, the relative movement between the cartridge and the piston rod is performed using threaded coupling between them. Although it would be more reasonable if the cartridge was a movable and rotatable part that would move along the threads of the piston rod part, at least kept from rotation; in general, a simpler design is possible if the piston rod is a rotatable part and the cartridge is kept from rotating, while it is allowed to axially move, for example, by any means described above. The threads on the piston rod can be located on a different part of the rod, different from the central part, inserted into the cavity of the cartridge vessel, for example, on a sleeve covering the said central part, which contributes to the free location of the threads of the cartridge, for example, on its outer side, and on the central part there may be no threads. The need for dimensions is reduced if the central part of the rod, which, according to the design, will at least partially enter the cavity of the cartridge vessel, is provided with threads. The possibilities described above for this design relate to the piston rod when it acts as an exciting means, moving cartridges and at least partially performing a preparatory operation. In order to carry out the subsequent operation of expenditure, any previously described method of moving the piston rod can be used completely independently of the method of action of the exciting means just described, which may require means of changing the nature of the movement. Even when using the same drive means, conditions are improved if the threads on the stem are used for both purposes. There are some advantages to using various types of threads, for example, left-handed threads and right-handed threads, respectively, for performing two operations, although it has been found that one but continuing thread provides a particularly smooth interaction.

 As previously explained, special means for connection may be (but need not be) provided for fastening the moving parts to the cartridge. Preferably, the housing or gripping means at least comprise guides for exposing the fresh cartridge to be inserted in both the transverse and axial directions to a position suitable for attachment. The described moving means may themselves act in such a way as to facilitate accession. In a preferred embodiment, for this case, the rod and cartridge assemblies are coupled by a threaded gear, which requires minimal auxiliary means for the locking mechanism that clearly performs this operation. One preferred auxiliary solution is to create a positive pressure between the threads of the stem and cartridge and this can be done by applying force and elasticity between them, preferably to the stem, for example in the form of a spring load. Another preferred auxiliary solution is to use a sufficient thread pitch so that more than one thread is mated, and preferably 2-4 independent and parallel, which provide equal circumferential mating opportunities for elements that create an appropriately distributed connection only by controlling the degree of rotation, the absence of which would require more sophisticated tools for monitoring axial distances. Another preferred auxiliary solution is to create at least one of the opposite threaded gripping ends with an inwardly directed conical surface to facilitate coaxial arrangement of the elements. Another preferred auxiliary solution is the manufacture of one of the mating threaded parts, preferably covering the threaded part, in accordance with the known method, in the form of an element having low elasticity and provided with protrusions instead of solid threads, and thus having the ability to accept opposite threads in a plurality of angular positions, possibly also mating with a certain locking surface between the elements for a certain axial location. Here again, attention should be paid to the fact that the threads on the cartridge part can be made on the cartridge vessel itself, or on its inner or outer surface, or on a separate part of the cartridge, the latter being preferred for many perfect configurations.

 Another approach to the attachment problem, preferred when the available space allows it, is to create a carriage for the cartridge, and this carriage forms part of the cartridge when it is moved and, accordingly, is a part of the cartridge in a certain sense, but this carriage is more or less permanently attached to the movable means or at least does not require any separate operation to be attached. In this embodiment, any of the pairing methods described above between the stem and the cartridge can be used to perform pairing between the stem and the carriage. Preferably, the carriage has guide means for fixing the cartridge in a certain and stable position in the axial direction relative to the carriage, and whenever any of the mechanisms described above for advancing forward requires it, to also help maintain a stable position in the angular direction of the cartridge, for example , grooves or any other means to ensure symmetry without rotation. Any known fixing means serving this purpose may be used. When using a suitable device design, the only operation the operator needs when inserting a cartridge or replacing a used cartridge with a new one is to ensure that the cartridge is correctly positioned on the carriage, and for this it is preferable to use simple locking means, such as a pusher, screw, bayonet mechanism, or any other known suitable means.

 After moving the cartridge should be fixed relative to the housing, at least for further movement in the axial direction, but it is also preferable that this requirement be met with respect to angular movements by using the fixing means of the device. Mentioned locking means can be made in any known form, for example, in the form of a screw, pusher, bayonet mechanism, mechanism based on a solenoid. However, it is preferable to obtain a benefit in performing the fixing operation by using the already existing gripping means in order to simplify the device and its method of operation. When there are gripping means acting separately from the piston rod, the minimum requirement is that these gripping means hold the cartridge stationary relative to the housing after the cartridge travel, in which case the locking means are limited by the controlling qualities necessary to maintain a stationary state. In addition, it is generally preferable to introduce additional locking means in addition to such exciting means. It is preferable to introduce at least a retaining surface on the housing, opposite which on the cartridge is a surface that is consistent with it, which borders positively on the first. Additional rotation-preventing fixation can be carried out using interacting axial protrusions on the boundary part by using friction in the case of threaded coupling, using a separately acting and controlled part, for example, a locking mechanism controlled by a solenoid, or in some other known manner. Completely independent locking means for the cartridge can be successfully used, for example, to provide additional security for the fixation, greater flexibility of the action, and especially when using the piston rod as a gripping means, in order to release it for the task of spending. Such means preferably fix, preventing both forward and reverse movements, and also preferably angular movements, for which any additional means mentioned above in connection with the gripping means can be used. Most preferred are locking means that act in such a way as to prevent movement in all three directions. An independent action can be carried out using processor or mechanical means, for example, it is possible to report movement to parts of the device at a certain relative position between them. The fixing means can carry out their functions in several positions along the path of the cartridge, and this option can be used to carry out the procedure for reducing the dimensions of the device also during the execution of the dosing or injection steps. A convenient way to accomplish this is to use gripping means separate from the piston rod and enable the cartridge to move and stop at multiple points to create multiple locking positions. A typical procedure would be to move the cartridge toward the housing toward the first locking position, move forward to displace it using the piston rod, move the cartridge towards the housing to a new locking position, move the piston to perform a new displacement operation, etc.

 The coordination between the parts of the device was determined in the description of the various variants of execution given under the assumption that a number of orders of action of the devices are possible. Generally speaking, a preferred method of action is to move the cartridge with its back toward the front of the housing while holding the piston rod substantially axially in a stationary state relative to the housing and for at least part of the movement cycle in conjunction with / and when moving the movable wall of the cartridge to perform at least partially the operation of preparing it, after which the cartridge is held stationary relative to the housing, while the piston rod moves t in an axial direction relative to the housing and in conjunction with the movable wall to perform at least the operations expenditure. Formally, the preparation stage may consist in orienting the cartridge with its front part from and its rear part toward the body. As shown, the movement of the cartridge may be intermittent or continuous with a variable or preferably with a constant speed. An advantage of the invention is that the movement can be controlled with respect to each target during preparation, and that a slow and smooth movement can be achieved when it is required, for example, by mixing components in two-chamber and multi-chamber cartridges. Similarly, the piston rod consumables can be performed intermittently or continuously at a constant or variable speed depending on the type of injection and the desired nature of the infusion. From this it follows that it is possible to carry out a single operation of expenditure with emptying the cartridge, although it is much more often required to perform several separate operations in which each dose can be set accurately and individually. Although it is possible to retract the piston rod from the movable wall during each expenditure operation with intermittent consumption, but for reasons and in accordance with a known method that can be performed using software, it is usually preferable to maintain the piston rod substantially in conjugate or end-to-end with a movable wall between performing separate expenditure operations.

 A particular safety advantage is achieved if funds are introduced or measures are taken to prevent cartridge release during the intermediate steps. If you can remove a cartridge, for example, during an expenditure operation and reinsert the same or a different cartridge, a dangerous situation may arise due to loss of control over the type and amount of the drug displaced during the expenditure operation, which should follow this . Therefore, it is preferable to prevent the cartridge from being released, at least when the piston rod is in the expendable position, it is also preferable to prevent the cartridge from being released during the cartridge preparation operation, and it is most preferable to prevent the cartridge from being released as soon as the cartridge has moved relative to the housing. In other words, it is preferable that when the device is started from any switching point from which various operations start counting, the release of the cartridge should not be possible until the device returns to the same switching point. The preferred switching point is the position of the piston rod in its retracted rear position and when the cartridge is in a distant position relative to the housing. In the normal operation of the device between the starting switching point and returning to the same switching point, the cartridge is already prepared and at least substantially empty as a result of performing one or more expenditure operations before returning the piston rod to the retracted rear position and removing the cartridge from the interface by moving him to a distant position. It is preferable, however, that the current cycle of the device could be interrupted by the will of the operator and the device could be returned to the switching point, for example, to adjust its operation. Prevention of release can be accomplished using processor controls, but it is preferable to use mechanical means. In this regard, the present invention provides assistance, since already when the cartridge is moving, the piston rod enters the cavity of the vessel, and the only further requirement is to fix it to prevent axial movement in the direction from the housing, which is carried out for other reasons, as explained previously with links to examples.

 The sequence of actions preferably includes steps and means for performing switching between the various phases. It is especially desirable to perform a controlled shift from performing the preparatory phase of the moving means when the cartridge is close to the housing, to the spending phase when the piston rod is moved to displace the contents of the cartridge. Accordingly, it is preferable to create a switching means adapted for termination, and more preferably also for blocking the movement of the gripping means by means of an action that takes them out of work, possibly also contributing to the physical fixation of the cartridge and, accordingly, being part of the fixing means and having the ability to release the piston rod to perform the expenditure operation due to the action that includes it in the work. Preferably, these actions are reversible in order to allow, for example, when the cartridge is already empty and the piston rod retracted to its position before the first expenditure operation, to perform the locking operation in the reverse order, and it is also preferable to block the movement of the piston rod due to the action that disables and releasing the gripping means to remove the cartridge from the housing by means of a deactivating action, possibly also contributing to the physical release of the cartridge. It is further convenient that decommissioning and putting into operation, respectively, occurred substantially simultaneously in the case of using software using tightly spaced signals and in the case of mechanical control using physically connected parts of the device, although even in this case it must a small backlash in the chain from the switching event to the operation of introduction and deactivation to be provided in order to provide the possibility of a sufficiently large fta at the last stage. It was also found that it is convenient to associate the aforementioned withdrawal and commissioning actions with fixing the cartridge either in its last / first movement relative to the housing or with the actual fixing / releasing of the cartridge.

 The aforementioned switching means can be completely implemented in the form of software for providing the greatest flexibility in the operating order of the device, equipped with available drive means that are complex enough to individually drive the various parts to perform their desired movements, for example, separate motor means and means for fixing and locking driven by solenoids. In order to ensure that the action is in exact accordance with the special relative positioning of the parts, sensory means or micro switches in critical positions for moving parts may also be required, for example, to determine the distant and approximate extreme positions of the piston rod and gripping means. Often, however, it is preferable to create mechanical means that facilitate the switching of control means to carry out the safest action, and they may be necessary if the same motor means should be used to perform various tasks, such as moving gripping means and then moving a separate piston rod, and if the piston rod should be able to perform both functions. Mechanical switching means can easily be arranged so that their switching can be carried out by moving parts in critical positions. Nothing prevents the use of combined software and hardware to ensure the greatest security and a wide range of actions.

 Switching the controls mentioned above usually requires determining the position of the corresponding parts used in the case of using triggers and means of communication to transfer this information to the means of introduction and decommissioning, respectively. The preferred switching position for the transition from the cartridge moving operation to the spending operation is the arrival of the cartridge approximately or exactly at its intended fixation position relative to the housing. Similarly, at the end of a full or intermittent cycle of action, when the reverse order of operations may be required, the preferred position for switching is the arrival of the piston rod approximately or exactly in its retracted rear position, corresponding to the state immediately before consumption. The actual determination can be carried out in various ways, for example using microswitches, when it is desirable to use electric means of transmitting information, or using mechanical means, for example, axial movement of the device following the axial movement of the switching part, converting the axial movement of the said switching part into radial movement, for example by using inclined surfaces or cam surfaces, transforming said is moved rotating the sensor part, the axis of which is either parallel or perpendicular to the axis of the moving part, by using a spiral, for example a helical gear, the movement of the cartridge to convert its rotational movement into transverse defining motion, for example, by creating a protruding or cam surface on the cartridge, by introducing a tapered fixing element into a groove or slot in the movable part when it is in a detectable position, or in some other way. Any element of the movable part, for example, a cartridge, gripping means or piston rod, can be used to determine the position, for example, its front part, its rear part or the middle part, and the corresponding element for determining is so located that they interact when the part is in the intended switching position, although it is preferable to use substantially the most protruding parts in front or behind structural members for this purpose.

 The transmission of the perceived switching event to means for introducing and taking out of operation, respectively, can also be accomplished in a number of different ways. Using control software, said transmission can be accomplished using processor means. In a preferred embodiment of the use of mechanical control, mechanical means are also used for transmission. Parts themselves can carry information. For example, the gripping means or piston rod, when used also as gripping means, can determine an increased displacement force when the cartridge is in contact with the locking surface, and an increased force can be used to disengage the gripping means and actuate the rod a piston for performing an expenditure operation. In general, it is preferable to use mechanical means of communication, independent of the parts controlled by the means themselves for putting into and out of work. Communication tools can have a different design, since they perform the required action of the introduction and removal from work. If the gripping means and the piston rod have independent motor means, then the communication means may activate or deactivate these motor means. If these same motor means are used to drive independent gripping means and the piston rod, then communication means can remove motor means and one of the parts from the interface and introduce the other part into the interface. If the piston rod also acts as a gripping means, it is preferable that the communication means fix the cartridge in the axial direction and at the same time release the piston rod and vice versa, it is preferable that the motor means are constantly engaged.

 The device in accordance with the invention can be connected with additional optional means for advanced action. The device can be equipped with means for determining the position, which provide the possibility of action at certain positions of the device, but prevent its action in other positions. For example, it is desirable that many operations in the preparatory phase, such as deaeration, preliminary ejection and possibly also conversion, be carried out with the needle pointing upward within certain limits and that means for determining the position can help prevent the inclusion and action of motor means to drive exciting means or the piston rod when deviating from a predetermined desired orientation of the needle tip up. Means for determining the position may take the form described in our simultaneously pending Swedish patent application SE 9503685-1 and incorporated into the description of this application by reference.

 It is also preferred that the device is equipped with sensory means for detecting at least one parameter of the introduced cartridge. The sensor means can check the type of cartridge in order to prevent the use of cartridges with mechanical parameters not intended for this device, filling them with drugs or their concentrations. The sensor means may also check or possibly read the cartridge code perceived by the machine. The sensor means may also check the condition or condition of the cartridge in order to notify the user or prevent the device from starting up if any imperfections, such as cracks or other mechanical defects of the cartridge, improper location or poor appearance of the pistons or walls, incomplete filling, discoloration, dirt, etc. The present invention allows to obtain certain advantages when using such sensory means. By moving the cartridge relative to the housing, it is possible to obtain a scanning action along the axis of the cartridge even when the sensor means is stationary relative to the housing, and use the same sensor means to determine several parameters. It is possible to adapt the speed of movement of the cartridge to the speed required for measuring by means of a sensor means and, for example, provide the possibility of intermittent movement and stops in critical positions. If at least partially the preparatory operation of the cartridge took place during the movement, then it is possible to provide the possibility of the development of the event in real time, for example, with the correct completion of the conversion or normal deaeration. Although movable sensory means can be used, it is preferable to use stationary sensory means for the above reasons. The arrangement of sensory means can be carried out by any method described in our patent application, filed and considered simultaneously with this application, entitled: "Device for filing and its method of action", introduced in the present description by reference.

 As already determined, the injection device can be equipped with processor means for performing the described actions, as well as additional functions. Preferably, the device is equipped with monitoring means in the form of keys or other means for entering the necessary commands. After introducing a fresh cartridge, the gripping means may be allowed to move in automatic mode, but it is preferable that the user enter a command to start the process of capturing the cartridge, start moving, and complete the preparation operation. The resolution signal may depend on the optionally installed sensor means that can signal the correct angular orientation of the device, as described previously. During the movement of the cartridge and the preparatory operation, the processor means can monitor based on the output signals from any installed sensor means and turn on the alarm or interrupt or reverse the device if any defects are detected. If switching or transition commands between the various phases described are performed using processor means, it may be necessary for the processor to receive an input signal about the spatial arrangement of the parts, and when the cartridge is in its fixed position, it should give an output command to take exciting tools out of operation , it is also possible a command to fix to individual locking means and at the same time or later a command to turn on the work for the piston rod to perform the flow operation Niya. With the appropriate design of mechanical means for controlling, as described earlier, it may be sufficient for the processor means to start the process and stop it when the piston rod is allowed to perform the expenditure operation, possibly after the preparatory expenditure action to complete deaeration or preliminary ejection, if these operations are not included in the training program. Before dosing for drug administration and expenditure, the desired dose should be established either separately for each injection, or for repeated identical doses. This dose setting can be pre-programmed in the device, possibly using a controlling processor for this, which receives information about the concentration of the drug in the cartridge and its type, or the dose value can be manually programmed by the user, possibly using a similar processor tool. At least one trigger or key switchable by the user must be provided for giving a command to start each drug administration operation, for which it is preferable that the processor includes motor means for signaling movement of the piston rod to perform the desired axial movement. Preferably, the reverse feed means are provided for detecting either actual displacement in the axial direction of the rod, or preferably to provide better resolution, the actual angular rotation of the motor or piston rod, if its rotational movement takes place. It is also preferable that the processor means maintain the magnitude of the amplitude with the volume completely consumed or the total displacement in the axial direction of the piston rod, set to correlate it with the full capacity of the cartridge, in order to prevent the release of incomplete doses when the contents of the cartridge are expended. In addition, a physical sensory means may be introduced to detect the presence of the piston rod at its extreme point of displacement, either in absolute form in a certain position or relative to the cartridge, for example, by determining the additional force when applying the piston rod to the edge of the cartridge. Any of these tools can be used either in automatic mode or after manual confirmation to initiate the reverse action, which consists in retracting the piston rod, removing the cartridge from its interface with the fixing means, and moving the cartridge to the far distant point, all this in order to bring the device back to its original state or the point of beginning of action. It is also preferable that the device be equipped with an interface for connecting to external data processing means, either for entering data into the device or for outputting information from the device, for example, data on the operating time and the number of doses dispensed.

 Preferred embodiments of the invention are described below with reference to the drawings.

Brief Description of the Drawings
In FIG. 1A - 1C depict a schematic diagram of a main device in three different stages of action.

 In FIG. 2 shows a device similar to that shown in FIG. 1, but with more detailed depiction of individual gripping means.

 In FIG. 3A-3F show a device based on separate gripping means and on a mechanical shift of the command means, with FIG. 3A-3D show various stages of action, and FIG. 3F is a detailed design of the device.

 In FIG. 4A to 4E show schematically a device based on combined piston rods and gripping means at various stages of operation.

 In FIG. 5A to 5E show a modification of the embodiment of FIG. 4, designed to provide automatic mechanical shift command means.

 In FIG. 6A to 6D show yet another device based on combined piston rods and gripping means with mechanical shear means.

Description of drawings
In FIG. 1A - 1C depict a schematic diagram of a main device in three different stages of action. The cartridge, generally indicated by 1, comprises an elongated sleeve 2, a leading edge 3 with an outlet 4, an open rear edge 5, and a piston 6 arranged to move within the cavity of the sleeve. More pistons may be available if the cartridge is a dual-chamber or multi-chamber type. The pumping or dosing part of the device, generally indicated by pos. 10, comprises a housing 11, a piston rod 12, gripping means 13, fixing means 14, and a control means block 15 shown in dashed lines. The piston rod 12 is designed to abut and move the piston 6 and is movable relative to the housing. Gripping means 13 are designed to interface with the cartridge 1 and move the cartridge at least in the direction of the housing with the rear edge 5 of the cartridge forward. The locking means 14 restrict the movement of the cartridge and can further ensure its positioning. The control means block 15 generally activates the piston rod 12 and the gripping means 13 so that they carry out their respective movements, and comprises a command means block for ensuring the correct sequence of actions.

 In the step of FIG. 1A, it is assumed that the first cartridge 1 is connected to the device 10 in such a way that the gripping means mates with the cartridge and that the piston rod located in the extreme rear position is close to / or abuts the piston 6 at its initial location in a new ( fresh) cartridge. In FIG. 1B shows the relative positions when the gripping means 13 pulled the cartridge 1 into the housing 11 so that its further movement in this direction was stopped by the locking means 14. The piston rod 12 is held in its extreme rear position, but it still forces the piston 6 to bias towards the front edge of the cartridge 1 as a result of the movement of the cartridge toward the piston rod 12. During this stage, the release of the medicine through the outlet 4 may take place, but preferably vital operation. In the step shown in FIG. 1C, the piston rod 12 was moved forward relative to the cartridge 1 and the housing 11, while the cartridge 1 was held in a stationary position relative to the housing 11 of the locking means 14. As a result, the piston rod 12 moved the piston 6 in the direction of its extreme forward position in the sleeve 2, and the piston rod may be in the intermediate extreme position. During this stage, the contents of the cartridge 1 could be ejected through the outlet 4. Various actions were coordinated using the control means unit 15. It seems that the reverse sequence can take place to enable the use of a new cartridge, i.e. move the piston rod 12 in the opposite direction to the position shown in FIG. 1B, release the locking means 14 and move the cartridge with its front edge forward from the housing 11 by activating the gripping means 13.

 In FIG. 2 shows a device 20 similar to that shown in FIG. 1, where similar parts are denoted by the same reference numbers, but exciting means are made separately and presented in more detail. The exciting means contain a sleeve 21 with internal threads 22, and the sleeve is axially fixed in the housing 11, but it can rotate under the influence of the control means 15. The cartridge 1 contains the corresponding external threads 23, as well as longitudinal grooves in the threads, paired with combined grooves structures 24 on the front surface 25 of the housing. The locking means 26 are here arranged as lateral inner surfaces on a rotatable sleeve 21. The piston rod 12 is the same here and acts the same as the piston rod shown in FIG. 1. The action stage shown in FIG. 2 occupies an intermediate position between the stages shown in FIG. 1A and 1B, respectively, i.e. the cartridge is pulled into the inside of the housing 11, but must be further advanced until the locking means 26 are reached. The gripping means shown in FIG. 2, they are driven by rotation of the sleeve 21, which forces the cartridge 1 to move axially by the interaction of the internal thread 22 of the sleeve 21 and the external thread 23 of the cartridge 1, while the grooves 25 and 24 respectively prevent the angular movement of the cartridge 1 relative to the housing 11. Movement can continue until the cartridge 1 abuts against the surface of the fixing means 26, where the fixing forces can reach a certain level, resulting in a bolted effect. Rotating the sleeve 21 in the opposite direction leads to the release of the cartridge 1 and to its extension from the housing 11. As shown in FIG. 1, the piston rod 12 can be held in a fixed state in its closest extreme position during the action of the gripping means.

 In FIG. 3A to 3F show a device based on separate gripping means and with a mechanical control means unit, with FIG. 3A-3D show various stages of action, and FIG. 3F shows device details. In FIG. 3A to 3E show a portion 30 of the metering device and a portion of the cartridge 31. The portion of the device comprises a chassis type housing 32 comprising a base 311 and two vertical walls 322 and 323 with bearing holes for mounting movable parts. A spring-loaded locking pin 324 is located at the wall 323, near the bearing bore therein. The movable parts comprise a spring-loaded part 33 with an axial end, a lead 34, a threaded sleeve 35 and a piston rod 36, these parts being shown in more detail in FIG. 3F. The axial end portion 33 comprises a pivot axis 331, a spring 332 and a fork 333 for mating with the end of the lead 34. The lead 34 comprises a pipe 341 adapted to receive the piston rod 36 with a guide groove 342, a gear wheel 343 and clutch pins 344 for connecting to threaded sleeve 35. The threaded sleeve 35 is provided with a flange 351 with structures for receiving the clutch pins 344, internal threads 352 located close to the flange, the pipe part 353 and the external threads 354 on the pipe part. The cartridge 31 has a trailing edge 311, internal threads 312 at the trailing edge for interfacing with external threads 354 on the sleeve 35, the container portion 313, the grooves 314, and the leading edge 315 located on the right. The cartridge 31 shown here may serve as a sheath for the syringe tube or may itself be used as a syringe tube. The piston rod 36 includes a driving pin 361, designed to interface with the guide groove 342, the axis of the rod 362 with external threads and the pusher 363 for coupling with the piston. In FIG. 3A shows assembled parts. The axial end portion 33 is mated to the end of the lead 34 housed in receptacle 333, and the engagement pins 344 at the other end of the lead 34 may or may not engage (as will be described in more detail below) with corresponding structures in the flange 351 of the threaded sleeve 35 The threaded sleeve 35 is inserted into the hole in the wall 323 so that its flange 351 abuts against the wall 323 and its pipe portion 353 protrudes away from the housing 32. The external threads 354 of the sleeve 35 are adapted to mate with the internal threads 312 of the cartridge 31 . Grooves 314 the cartridge are designed to interact with matching structures (not shown) on the housing 32 to prevent rotation of the cartridge 31. The piston rod 36 will pass through the lead tube 341 and through the threaded portion of the sleeve 353 so that the drive pin 361 passes into the guide grooves 342 of the lead 34 to ensure that the piston rod 36 rotates together with the leash 34, and so that the external threads of the rod 362 mate with the internal threads 352 on the sleeve 35, in order to ensure that this rod 36 would move axially and when rotating relative to the sleeve 35.

 The operation of the device is shown in FIG. 3A - 3E. In FIG. 3A shows the piston rod 36 in its retracted position and the internal threads 312 of the cartridge 31 are mated to the external threads 354 of the sleeve 35. The connecting pins 344 of the lead are mated to the sleeve 35 under the pressure of the spring 332, and when the lead 34 is rotated in the direction shown the arrow on the gear wheel 343, the lead 34, the sleeve 35 and the piston rod 36 all rotate together and the cartridge 31 is pulled to the housing 32 due to its threaded mate with the sleeve 35 and the fact that it is kept from rotation by the grooves 314 in the direction indicated the arrow on the cartridge 31. In FIG. 3B, the cartridge 31 is shown brought to / and resting against the wall 323. As it approaches, it presses the spring-loaded locking pin 324 through its hole in the wall in order to move the leash 34 against the action of the spring 332 and to remove the pins 344 from the interface with the sleeve 35. The leash and the piston rod 36 can now rotate freely relative to the sleeve 35 and its internal thread 352. The continued rotation of the gear 343 (see Fig. 3C) forces the piston rod 36 to move forward to perform injection by pairing the bolt-nut now fixed thread 352. FIG. 3D shows the device in the reverse sequence of operations performed by rotating the gear in the opposite direction, as shown by the arrow. Rotation causes the piston rod 36 to return almost to its rear position due to its mating with the thread 352. Further movement backward (see FIG. 3E) of the piston rod 36 is prevented by contact between the plunger 363 and the distal end of the sleeve 35, and thread mating 352 then leads the sleeve 35 to the beginning of rotation with the piston rod 36. The first exit from the interface of the cartridge 31 releases the locking pin 324, which is spring-loaded in this position, and allows permanent connection with the sleeve 35 using the connecting pins 344. Further rotation of the gear wheel 343 causes the cartridge 31 to move away from the housing 32 shown by the arrow.

Obviously, in the embodiment just described, the threaded sleeve 35 acts as a gripping means, the wall 323 acts as a locking means, possibly compatible with screwing threads, and the leash 34 acts as part of the control means for moving both the gripping means and the piston rod . The control means also comprise switching means in the form of the various described control means that provide the desired sequence of steps and reduce the control to rotation of the gear in one or the other direction, which can be done manually, but preferably by means of an electric motor through gears. Switching occurs (see Fig. 3B) when the cartridge 31 approaches the wall 323, and its transfer
includes a locking pin 324 and moving the leash in the axial direction, which, in turn, disengage the gripping means and allow the piston rod to move forward. In FIG. 3E switching occurs when the pusher 363 approaches the sleeve 35, which is converted into action, providing the inclusion of exciting means and the withdrawal of the piston rod.

 In FIG. 4A to 4E show schematically a device based on combined piston rods and gripping means at various stages of operation. The figures do not show any body, but only the main movable parts. To the right, the device contains a cartridge 41 having a flange 42 in the middle part with grooves (not shown). The shaft 43, which acts both as a piston rod and as a gripping means, has a drive wheel 44 that mates, for example, flat surfaces on the shaft to allow axial movement of the shaft, and a flange 45 at its rear. The shaft is provided with an external thread, in addition to smooth surfaces for the wheel 44, and, as shown in the embodiment of FIG. 3 is mated to a consistent internal thread in cartridge 41, the cartridge being prevented from rotating by interaction between grooves on flange 42 and similar structures on the housing. The shaft retainer 46 is movable up or down behind the flange 45 to either release or prevent the forward movement of the shaft 43. A similar cartridge retainer 47 is movable up and down and is located behind the middle cartridge flange 42 to either release or prevent it forward movement.

 In FIG. 4A, the latch 46 is actuated and the rotation of the shaft 43 causes the cartridge 41 to move in the direction of the arrow due to the mutual conjugation of the external thread on the shaft 43 and the internal thread in the cartridge 41. In FIG. 4B, the cartridge 41 has already reached its extreme rearward position and the latch 47 is now turned on to prevent it from moving forward, and at the same time, the latch 46 is turned off to allow forward movement of the shaft 43. In FIG. 4C, continued rotation of the shaft 43 in the same direction causes the shaft to move to its most forward position inside the cartridge 41, but the direction of rotation is now reversed to move the shaft 43 in the opposite direction, as shown by the arrow. In FIG. 4D, the shaft 43 has again reached its extreme rearward position and the latch 46 is activated to hold the shaft in this position, and at the same time, the latch 47 is released to allow forward movement of the cartridge 41, and continued rotation in the same direction as in FIG. . 4C, the cartridge moves in the direction of the arrow. In FIG. 4E, the cartridge 41 has come to its extreme forward position and the situation is the same as in FIG. 4A. The cartridge can be replaced with a new one and the cycle can be repeated. This embodiment shows that similar means can be used as piston rods and gripping means. The sequence of commands is controlled using latches 46 and 47, which, for example, can be performed electromechanically, for example, using solenoids, separately or in combination. The control system should only control the two latches and the rotation of the motor forward and backward, possibly using sensor elements to determine the extreme positions of the shaft and cartridge.

 In FIG. 5A - 5E show the same general embodiment as in FIG. 4, although with some schematic illustrative modifications, to provide a mechanical shift in command control. Key numbers from FIG. 4 are stored in FIG. 5. The lower surfaces of the shaft retainer 46 and cartridge retainer 47 were sharpened and placed under the action of springs, the pressure of which is directed downward, as shown by arrows 50 and 51. Such a device allows cartridge flange 42 to pass under retainer 47 and shaft flange 45 pass under the latch 46 when these parts are moved to the left in the figure, but prevents them from moving to the right. As best shown in FIG. 5B, the cartridge sensor 52, spring-loaded to the right, as shown by arrow 54, is positioned so that it is moved to the left by the cartridge, approaching its extreme rear position, and this movement is transmitted to the shaft retainer 46, which thereby rises due to the combined action of the inclined surface 53 and the corresponding surface of the latch 46. The movement of the cartridge in the axial direction necessary for the lifting action, shown pos. 55. As best shown in FIG. 5D, the shaft sensor 56, spring-loaded from left to right, as shown by arrow 58, is positioned so that it is shifted to the left by the shaft flange 45, which comes to its extreme rear position, and this movement is communicated to the cartridge latch 47, which thus rises due to the interaction of the inclined surface 57 and the corresponding surface of the retainer 47. The axial movement of the shaft necessary for lifting action is indicated by arrow 59. The described features are introduced in order to eliminate the need for a separate con trol behind the clamps 46 and 47 and reduce the necessary effect on the rotation of the shaft in either of two directions.

 The difference in the operation of this device from the device shown in FIG. 4 will be described below. The stage shown in FIG. 5A is performed in the same way as the stage shown in FIG. 4A, i.e. rotation of the shaft 43 causes the cartridge 41 to move to the left. In this embodiment, the cartridge latch 47 can slide along the cartridge until it is lifted by flange 42. In FIG. 5B, the cartridge 41 reaches its rear position and moves the sensor element 52 to the left, thereby raising the shaft lock 46 to release the shaft 43 for forward movement. During its movement, the cartridge flange 42 also passes by the cartridge retainer 47, which first rises and then falls behind the flange to prevent the cartridge from moving forward. In FIG. 5C shows the device at the same stage of operation as in FIG. 4C, i.e. continued rotation of the shaft 43 in the same direction as before causes the shaft to move forward to displace the contents of the cartridge. The shaft retainer 46 is held in the up position for the same reason as in the case illustrated in FIG. 5B while the cartridge 41 is held in its rearmost position. In FIG. 5D, as in FIG. 4D, rotation in the opposite direction leads to the retraction of the shaft 43 back to its extreme rear position. Here he presses the shaft sensor 56 on the front, and this movement translates into raising the cartridge lock 47, releasing the cartridge 41 for forward movement. In FIG. 5E, the continued rotation of the shaft 43 in the same direction brought the cartridge to the same position as in FIG. 5A. As soon as the cartridge leaves its extreme rear position, the cartridge sensor 52 moves forward, releasing the shaft lock 46, which goes down and locks the shaft 43, preventing it from moving forward. The latch 47 of the cartridge can occupy either the upper or lower position after the passage of the flange 42.

 In FIG. 6A to 6D show another device based on a combined piston rod and gripping means and with mechanical shear means. In FIG. 6A and 6B show two kinds of internal contents of a device without a case. In FIG. 6C shows the proximal neck portion of the cartridge used. In FIG. 6D shows an elongated view of the locking and sliding means of the device. In FIG. 6A and 6B show a cartridge 61, a guide tray connected to the housing, control means generally designated 63, a threaded shaft 64 acting as a piston rod, and gripping means, an assembly 65 following the shaft, and a locking mechanism 66. The portion of the cartridge 61 shown in the figure is an outer shell, inside which is placed a glass tube of a simple design with at least one piston. As best shown in FIG. 6C, the outer casing 611 comprises in its rear part a flange 612 of a slightly smaller diameter than the diameter of the main part 611, and a neck 613 designed to interface with the locking means. A hole 614 at the rear is provided with internal threads (not shown) for interfacing with the threaded shaft 64. The tray 62 has an inner contour of a semicircle in cross section consistent with the outer contour of the cartridge 61. The control means 63 include an electric motor 631 with a gear wheel 632 mated to a larger diameter gear wheel 633 connected to the gear shaft 634 mounted to the rear of the bearing 635 and to the front passing through an elongated cavity in the shaft 64, and the gear shaft 634 and the cavity of the shaft 64 mating, but non-circular cross section so that the shaft 64 was able to move in the axial direction while maintaining the action t pinion shaft 634. The shaft 64 is threaded for interfacing with the internal threads 61 and its rear part is rotatably connected to the assembly 65 following the shaft. The assembly 65 following the shaft comprises a bearing 651 in the wall 652 for the shaft 64 and two levers 653 protruding forward from the wall 652. As best shown in FIG. 6D, the levers 653 terminate with the upper bevels 654 and the lower retaining surfaces 655. The locking means include a retainer 661 located in the guide body and pressed to the lower position by a spring 662. The retainer 661 has an upper crosspiece 663 with lower beveled surfaces 664 for interfacing with the bevels 654 on the levers 653, and a lower crosspiece 665, which when lifted mates with the locking surfaces 655 on the levers 653 to block the forward movement of the levers. The lower crosspiece 665 is so wide that it fits into the groove of the neck 613 between the tube 611 and the flange 612 of the cartridge 61. The gap between the upper 663 and the lower 665 crosses is such as to allow the passage of levers 653. The support ring 666 is able to move slightly in the axial direction and it is compressed in the forward position by the spring 667 and stabilized in its movement by means of the conjugated antennae 668 of the ring and grooves 669 in the tray 62. The support ring 666 is coaxial with the cartridge 61 and has almost the same diameter as the flange 612 of the cartridge 61, and pre It is intended to hold the latch 661 in its upper position when the ring 666 is in its front position, but to allow the latch 661 to be pressed to its lower position, in the groove of the neck 613, when the ring 666 is pressed against the back of the cartridge 612 flange.

 The general nature of the operation of the device depicted in FIG. 6 is similar to the nature of the operation of the device of FIG. 4, i.e. the shaft 64 is rotated in the retracted position to bring the cartridge 61 back to the locked position, after which the shaft 64 is moved forward by continuing to rotate in the same direction to eject the contents of the cartridge 61, then the direction of rotation is reversed to bring the shaft 64 back into it retracted position, the cartridge 61 is released and then the cartridge 61 is removed while continuing to rotate the shaft 64 in the same direction. The means for fixing and displacing here are different from the means for the same purpose shown in FIG. 4, and their operation will now be described with reference to FIG. 6D. In the position shown in FIG. 6D, the shaft 65 (not shown) is almost in its extreme rearward position. The latch 661 abuts against the support ring 666, allowing the cartridge flange 612 to pass under the latch, and the lower crosspiece 665 is mated to the locking surface 655 of the levers 653 in order to prevent any forward movement of the follower unit 65 and the shaft 64. Rotation of the shaft 64 in the direction in which the cartridge is pulled back, allows the flange 612 of the cartridge 61 to pass under the raised retainer 661 to push back the support ring 666 and allow the retainer 661 to fall into the groove of the neck of the cartridge 613 and at the same time release l 64, giving him the opportunity to move forward. Reversing the direction of rotation of the shaft 64 introduces the parts 654 with the beveled edges of the levers 653 in conjunction with the inclined surfaces 664 of the upper crosspiece 663, forcing the latch to rise and exit the groove of the neck 613 and allowing the flange 612 and the support ring 666 to pass under the latch 661 and again lock the levers 653, preventing them from moving forward. Some possibility of play is provided to the shaft in the axial direction from providing complete freedom of movement of the cartridge to completely preventing movement of the shaft.

 The cycle of action can be started when the shaft 64 is in the extreme rear position, in which the latch 661 is raised to the upper position, locked with the support ring 666, pressed forward by the spring 667, blocking the movement of the shaft forward, but allowing the passage of the flange 612 of the cartridge 61. Even in the retracted position, the shaft protrudes sufficiently beyond the locking mechanism 66 and a cartridge can be attached to its end by rotating the shaft to mate with its internal threads. The rotation of the shaft forces the cartridge to move towards the locking mechanism, pass through the flange 612 under the retainer 661 while moving the support ring 666 backward and be blocked from further axial movement upon contact between the retainer and the main part 611 of the larger cartridge. The latch 661 can now fall down into the groove of the neck of the cartridge 613 to lock the cartridge and completely release the levers 653, allowing them to move forward. Continued rotation of the shaft in the same direction will move the shaft 64 and the follower assembly 65 forward to force out the contents of the cartridge. After crowding out, the rotation of the shaft 64 is reversed and the follower unit 65 and the shaft 64 are moved backward, while the cartridge 61 is still locked by the latch 661 in the lower position. When the shaft 64 and the follower assembly 65 approach their extreme rearward position, the inclined end parts 654 of the levers 653 interact with the beveled surfaces 664 of the upper crosspiece 663 and raise the latch 661, overcoming the action of the spring 662, withdrawing from the groove of the neck of the cartridge 613 and allowing the adjusting ring 666 and the cartridge flange 612 pass under the latch and so that the lower crosspiece 665 is almost mated with the locking surfaces 655 of the levers 653 to block the follower assembly 65 and the shaft 64, preventing any movement forward. Continued rotation of the shaft in the same direction leads to the movement of the now released cartridge 61 forward, with the support ring 666 extending beneath the retainer 661 to ensure its location until the cartridge can be removed. Obviously, the shaft 64 is thus blocked from axial movement until the cartridge comes to its fixed position by the latch 661 in its lower position, and that the cartridge cannot be moved in the axial direction until the shaft 64 and the follower the node 65 are in their extreme rear position, in which the latch 661 is raised to the upper position, and that there is no need for any other control actions other than rotating the shaft in one or the other direction.

 The exemplary embodiments are illustrative only and should not be taken in any way as limitations to the scope or generality of the present invention as defined by the claims.

Claims (232)

 1. An injection device comprising: a) a housing; b) a cartridge in which the drug or the preceding components for forming the drug is placed and which has a front and a back having a common axis with the cartridge, a drug outlet located in the front, and at least one movable wall located between the front part and the back part and having the ability to move to ensure the movement of the drug forward or to expel it through the outlet; c) a piston rod having a first end and a second end at least partially located in the housing and configured to interface with its first end with a movable wall and move it; d) drive means housed in the housing and designed to move at least the stem, characterized in that it contains a gripping means connected to the housing and designed to hold the cartridge or its casing so that its front part is separated from the housing and the back the part adjoins the case; drive means for moving the gripping means so as to move the cartridge with its back towards the front of the housing; fixing means for stopping the cartridge and preventing it from moving in the axial direction relative to the housing, thereby determining the fixed position of the cartridge; drive means configured to move the piston rod between at least one retracted position and at least one extended position, wherein the piston rod is located inside the cartridge when it is retracted relative to the cartridge in its fixed position.  2. The device according to p. 1, characterized in that the cartridge contains a vessel having a substantially constant internal cross section, and in that the movable wall is made of a piston type.  3. The device according to claim 1, characterized in that the cartridge is made of two-chamber or multi-chamber, and the chambers are separated by one or more intermediate walls and contain the previous components, which must be mixed before taking the medicine.  4. The device according to p. 1, characterized in that the cartridge contains a vessel having an inner diameter in the range from 2 to 20 mm and a length whose ratio to the inner diameter is more than 3.  5. The device according to claim 1, characterized in that the housing forms a container covering at least part of the piston rod, gripping means, fixing means and at least some part of the drive means.  6. The device according to claim 1, characterized in that the housing ends near the far end of the cartridge when the cartridge is held by means of gripping means before moving it.  7. The device according to p. 1, characterized in that the housing is located at least partially along the cartridge when it is in a fixed position.  8. The device according to claim 5, characterized in that the housing contains a hole covering the cartridge in whole or in part, which in size and shape allows receiving the cartridge and at least partially moving it inside the case.  9. The device according to claim 1, characterized in that the ratio of the length of the body along the axis of the cartridge to the total length of the column of drug in the cartridge before it is displaced is less than 10.  10. The device according to claim 1, characterized in that the second end of the piston rod in its retracted position is inside the housing.  11. The device according to claim 1, characterized in that the piston rod is threaded, at least in part, of its length, and the drive means for moving the piston contains a complete mechanism in the form of a screw and nut with a drive part.  12. The device according to claim 11, characterized in that in the mechanism of the screw and nut the drive means is arranged to rotate the nut and means are provided to prevent rotation of the piston rod.  13. The device according to claim 11, characterized in that in the mechanism of the screw and nut the drive means is arranged to rotate the piston rod and means are provided to prevent rotation of the nut.  14. The device according to claim 1, characterized in that the drive means includes a motor means.  15. The device according to 14, characterized in that the motor means comprises at least one electric motor.  16. The device according to claim 1, characterized in that the drive means includes an energy source containing stored energy.  17. The device according to clause 16, wherein the energy source contains at least one source of electrical energy.  18. The device according to claim 1, characterized in that the piston rod has a length that is less than the double length of the cartridge between the rear of the movable wall and the inner front of the cartridge.  19. The device according to claim 1, characterized in that the gripping means is made separately from the piston rod.  20. The device according to claim 19, characterized in that the drive means includes motor means for moving the gripping means or piston rod and switching means for switching the clutch between them.  21. The device according to claim 1, characterized in that the piston rod is designed as an exciting tool.  22. The device according to item 21, wherein the part of the piston rod and part of the cartridge contain the corresponding thread, and these parts are made with the possibility of mutual rotation to move the cartridge.  23. The device according to item 22, wherein the piston rod part is rotatable, and the cartridge part is not rotatable.  24. The device according to p. 22, characterized in that the threaded portion of the piston rod is made with the possibility of introducing it into the internal cavity of the cartridge during movement of the cartridge.  25. The device according to p. 22, characterized in that the thread on the piston rod is adapted to move the cartridge relative to the housing and to move the piston rod relative to the housing to perform a medication operation.  26. The device according A.25, characterized in that the drive means includes motor means adapted to ensure movement of either the cartridge or the piston rod, and the fact that it provides switching means for switching movements.  27. The device according to claim 1, characterized in that the gripping means comprises a connecting means and a drive means, and the connecting means is configured to attach the cartridge to the drive means.  28. The device according to item 27, wherein the connecting means includes a carriage for the cartridge, and the carriage is attached to the gripping means and contains locking means for attaching the cartridge to it with the possibility of detachment.  29. The device according to claim 1, characterized in that the fixing means can fix the cartridge, preventing it from moving in the axial direction relative to the housing, thereby determining the fixed position of the cartridge.  30. The device according to clause 29, wherein the fixing means is made with the possibility of fixing the cartridge to prevent movement along the axis and rotation.  31. The device according to clause 29, wherein the locking means prevents the cartridge from separating when it engages, and that control means are provided that prevent separation if the piston rod is not in its retracted position.  32. The device according to claim 1, characterized in that it comprises a means of switching, designed to perform at least once during the execution period of the switching cycle of the action of the gripping means that can move relative to the housing, and the piston rod, not having the ability displacement in the axial direction relative to the housing, to opposite or reverse actions.  33. The device according to p, characterized in that the switching means has the ability to respond to at least one trigger switch.  34. The device according to p. 33, characterized in that the switching means comprises a mechanical means of communication for matching switching signals to the means of switching on and off, respectively.  35. The device according to p. 32, characterized in that the drive means comprises motor means for moving the gripping means and the piston rod, and the switching means has the ability to switch their clutch.  36. The device according to claim 1, characterized in that the relative position between the piston rod in its retracted position and the cartridge in its fixed position is such that the piston rod is inside the cartridge beyond the initial position of the movable wall in the cartridge.  37. The device according to claim 1, characterized in that the fixing means is configured to provide several fixed positions along the path of movement of the cartridge.  38. The device according to § 39, wherein the gripping means separate from the piston rod are adapted to move and stop the cartridge in several positions to provide several fixed positions.  39. The device according to claim 1, characterized in that it comprises sensory positioning means with control means for turning the device on or off in predetermined states.  40. The device according to claim 1, characterized in that it contains a sensor element for determining at least one parameter of the cartridge.  41. An injection device comprising: a) a housing; b) a cartridge in which the drug or the preceding components for forming the drug is placed, and which has a front part and a rear part having a common axis with the cartridge, a drug outlet located in the front part, and at least one movable a wall located between the front and the back and having the ability to move to ensure the movement of the drug forward or displaces it through the outlet; c) a piston rod having a first end and a second end at least partially located in the housing and configured to interface with its first end with a movable wall and move it; d) drive means housed in the housing and designed to move at least the stem, characterized in that it contains a gripping means connected to the housing and designed to hold the cartridge or its casing so that its front part is separated from the housing and the back the part adjoins the case; drive means for moving the gripping means, having the ability to move the cartridge with its rear part forward relative to the housing; drive means configured to move the movable rod between at least one retracted position and at least one extended position; drive means comprising an electric motor.  42. The device according to paragraph 41, wherein the cartridge contains a vessel having a substantially constant internal cross section, and that the movable wall is made of a piston type.  43. The device according to paragraph 41, wherein the cartridge is made of two-chamber or multi-chamber, and the chambers are separated by one or more intermediate walls and contain the previous components, which must be mixed before taking the medicine.  44. The device according to paragraph 41, wherein the cartridge contains a vessel having an inner diameter in the range from 2 to 20 mm and a length whose ratio to the inner diameter is more than 3.  45. The device according to paragraph 41, wherein the housing forms a container covering at least a portion of the piston rod, gripping means, fixing means and at least some part of the drive means.  46. The device according to paragraph 41, wherein the housing ends near the far end of the cartridge when the cartridge is held by gripping means before moving it.  47. The device according to paragraph 41, wherein the housing is located at least partially along the cartridge when it is in a fixed position.  48. The device according to item 43, wherein the housing contains a hole covering the cartridge in whole or in part, which in size and shape allows receiving the cartridge and at least partially moving it inside the case.  49. The device according to paragraph 41, wherein the ratio of the length of the housing along the axis of the cartridge to the total length of the column of drug in the cartridge before its displacement is less than 10.  50. The device according to paragraph 41, wherein the second end of the piston rod in its retracted position is inside the housing.  51. The device according to paragraph 41, wherein the piston rod is threaded at least in part of its length, and the drive means for moving the piston comprises a mechanism in the form of a screw and a nut with a drive part.  52. The device according to p. 51, characterized in that in the mechanism of the screw and nut the drive means is arranged to rotate the nut and means are provided to prevent rotation of the piston rod.  53. The device according to p. 51, characterized in that in the mechanism of the screw and nut the drive means is arranged to rotate the piston rod and means are provided to prevent rotation of the nut.  54. The device according to paragraph 41, wherein the drive means includes a motor means.  55. The device according to paragraph 52, wherein the motor means comprises at least one electric motor.  56. The device according to paragraph 41, wherein the drive means includes an energy source containing stored energy.  57. The device according to p, characterized in that the energy source contains at least one source of electrical energy.  58. The device according to paragraph 41, wherein the piston rod has a length that is less than the double length of the cartridge between the rear of the movable wall and the inner front of the cartridge.  59. The device according to paragraph 41, wherein the exciting means is made separately from the piston rod.  60. The device according to p, characterized in that the drive means includes motor means for moving the gripping means or piston rod and switching means for switching the clutch between them.  61. The device according to item 43, wherein the piston rod is made as a gripping means.  62. The device according to p, characterized in that part of the piston rod and part of the cartridge contain the corresponding thread, and that these parts are made with the possibility of mutual rotation to move the cartridge.  63. The device according to item 62, wherein the part of the piston rod is rotatable, and the part of the cartridge is not rotatable.  64. The device according to p. 62, characterized in that the threaded portion of the piston rod is made with the possibility of introducing it into the internal cavity of the cartridge during movement of the cartridge.  65. The device according to p. 62, characterized in that the thread on the piston rod is adapted to move the cartridge relative to the housing and to move the piston rod relative to the housing to perform a medication operation.  66. The device according to p. 65, characterized in that the drive means includes motor means, adapted to ensure movement of either the cartridge or the piston rod, and the fact that it provides switching means for switching movements.  67. The device according to paragraph 41, wherein the gripping means comprises a connecting means and a drive means, and the connecting means is configured to attach the cartridge to the drive means.  68. The device according to p. 67, characterized in that the connecting means includes a carriage for the cartridge, and the carriage is attached to the gripping means and contains locking means for attaching to it a cartridge with the possibility of detachment.  69. The device according to paragraph 41, wherein the fixing means can fix the cartridge, preventing it from moving in the axial direction relative to the housing, thereby determining the fixed position of the cartridge.  70. The device according to p, characterized in that the fixing means is made with the possibility of fixing the cartridge to prevent movement along the axis and rotation.  71. The device according to p. 69, characterized in that the fixing means prevents the cartridge from separating when it engages, and that control means are provided that prevent separation if the piston rod is not in its retracted position.  72. The device according to paragraph 41, characterized in that it comprises a means of switching, designed to perform at least once during the period of the execution cycle of the switching action of the gripping means that can move relative to the housing, and the piston rod, not having the ability displacement in the axial direction relative to the housing, to opposite or reverse actions.  73. The device according to p. 72, characterized in that the switching means has the ability to respond to at least one trigger switch.  74. The device according to p. 73, wherein the switching means comprises mechanical communication means for matching switching signals to the on and off means, respectively.  75. The device according to p. 72, characterized in that the drive means comprises motor means for moving the gripping means and the piston rod, and the switching means has the ability to switch their clutch.  76. The device according to paragraph 41, wherein the relative position between the piston rod in its retracted position and the cartridge in its fixed position is such that the piston rod is inside the cartridge beyond the initial position of the movable wall in the cartridge.  77. The device according to paragraph 41, wherein the fixing means is configured to provide several fixed positions along the path of movement of the cartridge.  78. The device according to p, characterized in that the gripping means separate from the piston rod are arranged to move and stop the cartridge in several positions to provide several fixed positions.  79. The device according to p. 41, characterized in that it comprises sensory positioning means with control means for turning the device on or off in predetermined states.  80. The device according to paragraph 41, wherein it contains a sensor element for determining at least one parameter of the cartridge.  81. An injection device comprising: a) a housing; b) a cartridge in which the drug or the preceding components for forming the drug is placed, and which has a front part and a rear part having a common axis with the cartridge, a drug outlet located in the front part, and at least one movable a wall located between the front part and the rear part, and having the ability to move to ensure the movement of the drug forward or forcing it through the outlet; c) a piston rod having a first end and a second end at least partially located in the housing and configured to interface with its first end with a movable wall and move it; d) drive means housed in the housing and designed to move at least the stem, characterized in that it contains a gripping means connected to the housing and designed to hold the cartridge or its casing so that its front part is separated from the housing and the back the part adjoins the case; drive means for moving the gripping means, having the ability to move the cartridge with its rear part forward relative to the housing; drive means configured to move the movable rod between at least one retracted position and at least one extended position, wherein the piston rod is designed as a gripping means.  82. The device according to p, characterized in that the cartridge contains a vessel having a substantially constant internal cross section, and that the movable wall is made of a piston type.  83. The device according to p, characterized in that the cartridge is made of two-chamber or multi-chamber, and the cameras are separated by one or more intermediate walls and contain the previous components, which must be mixed before taking the medicine.  84. The device according to p, characterized in that the cartridge contains a vessel having an inner diameter in the range from 2 to 20 mm and a length, the ratio of which to the inner diameter is more than 3.  85. The device according to p, characterized in that the housing forms a container covering at least part of the piston rod, gripping means, fixing means and at least some part of the drive means.  86. The device according to p, characterized in that the housing ends near the far end of the cartridge when the cartridge is held by means of gripping means before moving it.  87. The device according to p, characterized in that the housing is located at least partially along the cartridge when it is in a fixed position.  88. The device according to p, characterized in that the housing contains a hole covering the cartridge in whole or in part, which in size and shape allows the cartridge to be received and at least partially move it inside the case.  89. The device according to p, characterized in that the ratio of the length of the housing along the axis of the cartridge to the total length of the column of drug in the cartridge before it is displaced is less than 10.  90. The device according to p, characterized in that the second end of the piston rod in its retracted position is located inside the housing.  91. The device according to p, characterized in that the piston rod is threaded at least in part of its length, and the drive means for moving the piston contains a mechanism in the form of a screw and nut with a drive part.  92. The device according to p. 91, characterized in that in the mechanism of the screw and nut the drive means is arranged to rotate the nut and means are provided to prevent rotation of the piston rod.  93. The device according to p. 91, characterized in that in the mechanism of the screw and nut the drive means is arranged to rotate the piston rod and means are provided to prevent rotation of the nut.  94. The device according to p, characterized in that the drive means includes a motor means.  95. The device according to p. 94, wherein the motor means comprises at least one electric motor.  96. The device according to p, characterized in that the drive means includes an energy source containing stored energy.  97. The device according to p, characterized in that the energy source contains at least one source of electrical energy.  98. The device according to p, characterized in that the piston rod has a length that is less than the double length of the cartridge between the rear of the movable wall and the inner front of the cartridge.  99. The device according to p, characterized in that the exciting means is made separately from the piston rod.  100. The device according to p. 99, characterized in that the drive means includes motor means for moving the gripping means or piston rod and switching means for switching the clutch between them.  101. The device according to p, characterized in that the piston rod is made as a gripping means.  102. The device according to p. 101, characterized in that the piston rod part and the cartridge part contain a corresponding thread, and that these parts are mutually rotatable to move the cartridge.  103. The device according to p. 102, characterized in that part of the piston rod is rotatable, and part of the cartridge is not rotatable.  104. The device according to p. 102, characterized in that the threaded portion of the piston rod is made with the possibility of introducing it into the internal cavity of the cartridge during movement of the cartridge.  105. The device according to p. 102, characterized in that the thread on the piston rod is adapted to move the cartridge relative to the housing and to move the piston rod relative to the housing to perform the medication operation.  106. The device according to p. 105, characterized in that the drive means includes motor means adapted to provide movement of either the cartridge or the piston rod, and the fact that it provides switching means for switching movements.  107. The device according to p, characterized in that the gripping means comprises a connecting means and a drive means, and the connecting means is configured to attach the cartridge to the drive means.  108. The device according to p. 107, characterized in that the connecting means includes a carriage for the cartridge, and the carriage is attached to the gripping means and contains locking means for attaching the cartridge to it with the possibility of detachment.  109. The device according to p. 81, characterized in that the fixing means can fix the cartridge, preventing it from moving in the axial direction relative to the housing, thereby determining the fixed position of the cartridge.  110. The device according to p. 109, characterized in that the fixing means is made with the possibility of fixing the cartridge to prevent movement along the axis and rotation.  111. The device according to p. 109, characterized in that the fixing means prevents the cartridge from separating when it engages, and that control means are provided that prevent separation if the piston rod is not in its retracted position.  112. The device according to p. 81, characterized in that it comprises a switching means for performing at least once during the period of the switching cycle the action of the gripping means having the ability to move relative to the housing and the piston rod, not having the ability to move in the axial direction relative to the housing, to opposite or reverse actions.  113. The device according to p. 112, characterized in that the switching means has the ability to respond to at least one trigger switch.  114. The device according to p. 113, wherein the switching means comprises mechanical communication means for matching switching signals to the on and off means, respectively.  115. The device according to p. 112, characterized in that the drive means comprises motor means for moving the gripping means and the piston rod, and the switching means has the ability to switch their clutch.  116. The device according to p, characterized in that the relative position between the piston rod in its retracted position and the cartridge in its fixed position is such that the piston rod is inside the cartridge beyond the initial position of the movable wall in the cartridge.  117. The device according to p, characterized in that the fixing means is configured to provide several fixed positions along the path of movement of the cartridge.  118. The device according to p. 117, characterized in that the gripping means separate from the piston rod are adapted to move and stop the cartridge in several positions to provide several fixed positions.  119. The device according to p, characterized in that it contains a touch positioning means with control means for turning the device on or off in predetermined states.  120. The device according to p, characterized in that it contains a sensor element for determining at least one parameter of the cartridge.  121. An injection device comprising: a) a housing; b) a cartridge in which the drug or the preceding components for forming the drug is placed and which has a front part and a rear part having a common axis with the cartridge, a drug outlet located in the front part, and at least one movable wall located between the front and rear and having the ability to move to ensure the movement of the drug forward or displaces it through the outlet; c) a piston rod having a first end and a second end at least partially located in the housing and configured to interface with its first end with a movable wall and move it; d) drive means housed in the housing and designed to move at least the stem, characterized in that it contains a gripping means connected to the housing and designed to hold the cartridge or its casing so that its front part is separated from the housing and the back the part adjoins the case; drive means for moving the gripping means, having the ability to move the cartridge with its rear part forward relative to the housing; drive means configured to move the movable rod between at least one retracted position and at least one extended position; and means for controlling switching between movements made by the drive means.  122. The device according to p. 121, characterized in that the cartridge contains a vessel having a substantially constant internal cross section, and in that the movable wall is made of a piston type.  123. The device according to p, characterized in that the cartridge is made of two-chamber or multi-chamber, and the chambers are separated by one or more intermediate walls and contain the previous components, which must be mixed before taking the medicine.  124. The device according to p. 121, characterized in that the cartridge contains a vessel having an inner diameter in the range from 2 to 20 mm and a length whose ratio to the inner diameter is more than 3.  125. The device according to p. 121, characterized in that the housing forms a container covering at least a portion of the piston rod, gripping means, fixing means and at least some part of the drive means.  126. The device according to p. 121, characterized in that the housing ends near the far end of the cartridge when the cartridge is held by gripping means before moving it.  127. The device according to p. 121, characterized in that the housing is located at least partially along the cartridge when it is in a fixed position.  128. The device according to p. 125, characterized in that the housing contains a hole covering the cartridge in whole or in part, which in size and shape allows receiving the cartridge and at least partially moving it inside the housing.  129. The device according to p. 121, characterized in that the ratio of the length of the housing along the axis of the cartridge to the total length of the column of drug in the cartridge before it is displaced is less than 10.  130. The device according to p. 121, characterized in that the second end of the piston rod in its retracted position is inside the housing.  131. The device according to p. 121, characterized in that the piston rod is threaded at least in part of its length, and the drive means for moving the piston comprises a mechanism in the form of a screw and a nut with a drive part.  132. The device according to p. 131, characterized in that in the mechanism of the screw and nut the drive means is configured to rotate the nut and means are provided to prevent rotation of the piston rod.  133. The device according to p, characterized in that in the mechanism of the screw and nut the drive means is arranged to rotate the piston rod and means are provided to prevent rotation of the nut.  134. The device according to p, characterized in that the drive means includes a motor means.  135. The device according to p, characterized in that the motor means comprises at least one electric motor.  136. The device according to p. 121, characterized in that the drive means includes an energy source containing stored energy.  137. The device according to p, characterized in that the energy source contains at least one source of electrical energy.  138. The device according to p. 121, characterized in that the piston rod has a length that is less than the double length of the cartridge between the rear of the movable wall and the inner front of the cartridge.  139. The device according to p, characterized in that the gripping means is made separately from the piston rod.  140. The device according to p. 139, characterized in that the drive means includes motor means for moving the gripping means or piston rod and switching means for switching the clutch between them.  141. The device according to p, characterized in that the piston rod is made as a gripping means.  142. The device according to p. 141, characterized in that part of the piston rod and part of the cartridge contain a corresponding thread, and that these parts are mutually rotatable to move the cartridge.  143. The device according to p, characterized in that part of the piston rod is rotatable, and part of the cartridge is not rotatable.  144. The device according to p. 142, characterized in that the threaded portion of the piston rod is made with the possibility of introducing it into the internal cavity of the cartridge during movement of the cartridge.  145. The device according to p. 142, characterized in that the thread on the piston rod is adapted to move the cartridge relative to the housing and to move the piston rod relative to the housing to perform a medication operation.  146. The device according to p, characterized in that the drive means includes motor means adapted to provide movement of either the cartridge or the piston rod, and in that it provides switching means for switching movements.  147. The device according to p, characterized in that the gripping means comprises a connecting means and a drive means, and the connecting means is configured to attach the cartridge to the drive means.  148. The device according to p. 147, characterized in that the connecting means includes a carriage for the cartridge, and the carriage is attached to the gripping means and contains locking means for attaching the cartridge to it with the possibility of detachment.  149. The device according to p. 121, characterized in that the fixing means can fix the cartridge, preventing its movement in the axial direction relative to the housing, thereby determining the fixed position of the cartridge.  150. The device according to p. 149, characterized in that the fixing means is made with the possibility of fixing the cartridge to prevent movement along the axis and rotation.  151. The device according to p. 149, characterized in that the fixing means prevents the cartridge from separating when it is engaged, and that control means are provided that prevent separation if the piston rod is not in its retracted position.  152. The device according to p. 121, characterized in that it comprises a means of switching, designed to perform at least once during the execution period of the switching cycle of the action of the gripping means, with the ability to move relative to the housing, and the piston rod, not having displacement in the axial direction relative to the housing, to opposite or reverse actions.  153. The device according to p, characterized in that the switching means has the ability to respond to at least one trigger switch.  154. The device according to p. 153, characterized in that the switching means comprises mechanical communication means for matching switching signals to the on and off means, respectively.  155. The device according to p. 152, characterized in that the drive means comprises motor means for moving the gripping means and the piston rod, and the switching means has the ability to switch their clutch.  156. The device according to p. 121, characterized in that the relative position between the piston rod in its retracted position and the cartridge in its fixed position is such that the piston rod is inside the cartridge beyond the initial position of the movable wall in the cartridge.  157. The device according to p, characterized in that the fixing means is configured to provide several fixed positions along the path of movement of the cartridge.  158. The device according to p, characterized in that the gripping means separate from the piston rod are adapted to move and stop the cartridge in several positions to provide several fixed positions.  159. The device according to p. 121, characterized in that it comprises sensory positioning means with control means for turning the device on or off in predetermined states.  160. The device according to p, characterized in that it contains a sensor element for determining at least one parameter of the cartridge.  161. A method for administering a drug using an injection device that comprises a) a housing; b) a cartridge in which the drug or the preceding components for forming the drug is placed and which has a front and a back having a common axis with the cartridge, a drug outlet located in the front, and at least one movable wall located between the front and back, the movement of which ensures the movement of the drug forward or displaces it through the outlet; c) a movable rod at least partially located in the housing and configured to interface with the movable wall and move it; d) drive means located in the housing and designed to move the rod, characterized in that it comprises the following steps: orienting the cartridge so that its front part is separated from the housing and the rear part is adjacent to the housing so that the cartridge is gripped or the cover of its casing ; intermittent or continuous movement of the cartridge backward relative to the housing and, at least during part of this movement, intermittent or continuous movement of the movable wall with a rod connected to it towards the front; fixing the cartridge in the housing so as to prevent further axial movement of the cartridge relative to the housing; moving the rod in the axial direction relative to the housing when it is connected to the movable wall to perform at least one metering movement displacing the drug through the outlet of the cartridge.  162. The method according to p, characterized in that it comprises a step during the movement of the cartridge and the movement of the movable wall, preparing the cartridge.  163. The method according to p, characterized in that the preparation step includes at least one action selected from the group including shearing and releasing the movable wall, restoration of gaps, deaeration and preliminary ejection.  164. The method according to p, characterized in that the cartridge is made of a two-chamber or multi-chamber type, wherein the chambers are separated by one or more intermediate walls, and the preparation includes a mixing step during the movement of the cartridge and moving the movable wall of the contents, at least at least two cameras.  165. The method according to p, characterized in that it comprises the step of converting the pharmaceutical preparation by dissolving the powder in a solvent.  166. The method according to p. 161, characterized in that at least part of the drive means applies a force between the housing and the movable or gripping part.  167. The method according to p, characterized in that the housing forms a container at least partially covering parts of the device and having a hole made so that it surrounds the cartridge in whole or in part, and containing the step of performing at least part of the movement cartridge axially through the hole.  168. The method according to p, characterized in that it comprises the step of changing the length, which is the maximum distance along the axis of the cartridge or parallel to it from the front of the cartridge to the rear of the housing, opposite its edge of the cartridge.  169. The method according to p, characterized in that it contains a step that allows to reduce the length while moving the cartridge.  170. The method according to p. 168, characterized in that it comprises the step of maintaining the length substantially constant after the fixing step has been completed and during displacement during dispensing.  171. The method according to p. 168, characterized in that it comprises the step of reducing the length, essentially, in accordance with the consumption of the drug after completing the fixation step and during movement during dosing.  172. The method according to p, characterized in that the step of reducing the length is performed by moving the cartridge between several fixed positions.  173. The method according to p, characterized in that it comprises the step of holding the piston rod essentially in the axial direction in a stationary state relative to the housing while moving the cartridge.  174. The method according to p, characterized in that it comprises the step of moving the piston rod relative to the housing during movement during dispensing.  175. The method according to p. 174, characterized in that the piston rod contains a thread that interacts with the corresponding matching part with the thread, and that the piston rod is moved in the axial direction by relative rotation between the piston rod and the matching part.  176. The method according to p, characterized in that the cartridge contains a threaded part and interacts with the corresponding matching threaded part, and that the cartridge is moved in the axial direction by relative rotation between the cartridge and the matching part.  177. The method according to p, characterized in that the matching part is a piston rod.  178. The method according to p. 161, characterized in that it comprises the step of moving the cartridge while holding the cartridge to prevent angular movement.  179. The method according to p, characterized in that the fixing step comprises fixing the cartridge to prevent angular movement.  180. The method according to p, characterized in that it includes the steps of retracting the piston rod, releasing the cartridge from fixing and moving the cartridge with its front part forward from the housing.  181. The method according to p, characterized in that perform several metering movements.  182. The method according to p, characterized in that it comprises the step of preventing the movement of the cartridge at a predetermined angular orientation of the device.  183. The method according to p. 161, characterized in that it comprises the step of sensing determining the type of cartridge, encoding the cartridge with respect to at least one state parameter of the cartridge or process in the cartridge.  184. The method according to p. 182, characterized in that it comprises the step of performing sensory determination while moving the cartridge.  185. A method for administering a drug using an injection device that comprises a) a housing; b) a cartridge in which the drug or the preceding components for forming the drug is placed and which has a front and a back having a common axis with the cartridge, a drug outlet located in the front, and at least one movable wall located between the front and back, the movement of which ensures the movement of the drug forward or displaces it through the outlet; c) a movable rod at least partially located in the housing and configured to interface with the movable wall and move it; d) drive means located in the housing and designed to move the rod, characterized in that it comprises the following steps: attaching the thread of the cartridge or its casing to the corresponding thread of the piston rod while the front of the cartridge is spaced and the rear is adjacent to the housing; intermittent or continuous movement of the cartridge backward relative to the housing and, at least during part of this movement, intermittent or continuous movement of the movable wall with a rod connected to it toward the front; displacement of the rod in the axial direction relative to the housing when it is connected to the movable wall, so as to perform at least one dispensing movement displacing the drug through the outlet of the cartridge.  186. The method according to p, characterized in that it comprises a step, during the movement of the cartridge and the movement of the movable wall, preparing the cartridge.  187. The method according to p, characterized in that the preparation step includes at least one action selected from the group comprising moving and releasing the movable wall, restoring the gaps, deaerating, and pre-ejecting.  188. The method according to p, characterized in that the cartridge is made of a two-chamber or multi-chamber type, the chambers being separated by one or more intermediate walls, and the preparation includes the step of mixing during the movement of the cartridge and moving the movable wall of the contents, at least , two cameras.  189. The method according to p, characterized in that it comprises the step of converting the pharmaceutical preparation by dissolving the powder in a solvent.  190. The method according to p. 185, characterized in that at least a portion of the drive means applies a force between the housing and the movable or gripping part.  191. The method according to p, characterized in that the housing forms a container at least partially covering parts of the device and having a hole made so that it surrounds the cartridge in whole or in part, and containing the step of performing at least a part of the movement cartridge axially through the hole.  192. The method according to p, characterized in that it comprises the step of changing the length, which is the maximum distance along the axis of the cartridge or parallel to it from the front of the cartridge to the rear of the housing, opposite its edge of the cartridge.  193. The method according to p, characterized in that it contains a step that allows to reduce the length while moving the cartridge.  194. The method according to p. 192, characterized in that it comprises the step of maintaining the length substantially constant after the fixing step has been completed and during displacement during dispensing.  195. The method according to p. 192, characterized in that it comprises the step of reducing the length, essentially, in accordance with the consumption of the drug after completing the fixation step and during movement during dosing.  196. The method according to p. 195, characterized in that the step of reducing the length is performed by moving the cartridge between several fixed positions.  197. The method according to p. 185, characterized in that it comprises the step of holding the piston rod essentially in the axial direction in a stationary state relative to the housing while moving the cartridge.  198. The method according to p, characterized in that it comprises the step of moving the piston rod relative to the housing during movement during dispensing.  199. The method according to p, characterized in that the piston rod comprises a thread cooperating with a corresponding matching part with the thread, and that the piston rod is axially moved by relative rotation between the piston rod and the matching part.  200. The method according to p, characterized in that the cartridge contains a threaded part and interacts with a corresponding matching threaded part, and that the cartridge is axially moved by relative rotation between the cartridge and the matching part.  201. The method according to claim 200, characterized in that the matching part is a piston rod.  202. The method according to p. 185, characterized in that it comprises the step of moving the cartridge while holding the cartridge to prevent angular movement.  203. The method according to p, characterized in that the fixing step comprises fixing the cartridge to prevent angular movement.  204. The method according to p. 185, characterized in that it includes the steps of retracting the piston rod, releasing the cartridge from fixing and moving the cartridge with its front part forward from the housing.  205. The method according to p, characterized in that they perform several metering movements.  206. The method according to p, characterized in that it comprises the step of preventing the movement of the cartridge at predetermined angular orientations of the device.  207. The method according to p. 185, characterized in that it comprises the step of sensing determining the type of cartridge, encoding the cartridge with respect to at least one state parameter of the cartridge or process in the cartridge.  208. The method according to p. 206, characterized in that it comprises the step of performing sensory determination while moving the cartridge.  209. A method for administering a drug using an injection device that comprises a) a housing; b) a cartridge in which a drug or preceding components for forming drugs is placed and which has a front and a back having a common axis with the cartridge, a drug outlet located in the front, and at least one movable wall located between the front and back, the movement of which ensures the movement of the drug forward or displaces it through the outlet; c) a movable rod at least partially located in the housing and configured to interface with the movable wall and move it; d) a drive means located in the housing and designed to move the rod, characterized in that it comprises the following steps: orienting the cartridge so that its front part is separated from the housing and the rear part is adjacent to the housing so that the cartridge or its housing is gripped; intermittent or continuous movement of the cartridge backward relative to the housing, and during at least part of this movement, intermittent or continuous movement of the movable wall by means of a rod connected to it towards the front, while fixing essentially the rod in the axial direction; moving the rod in the axial direction relative to the housing when connected to a movable wall to perform at least one dispensing movement displacing the drug through the outlet of the cartridge while fixing the cartridge essentially in the axial direction.  210. The method according to p. 209, characterized in that it comprises a step during the movement of the cartridge and the movement of the movable wall, preparing the cartridge.  211. The method according to p. 209, characterized in that the preparation step includes at least one action selected from the group including moving and releasing the movable wall, restoring the gaps, deaerating and pre-ejecting.  212. The method according to p. 209, characterized in that the cartridge is made of a two-chamber or multi-chamber type, the chambers being separated by one or more intermediate walls, and the preparation includes the step of mixing while the cartridge is moving and moving the movable wall of the contents, at least , two cameras.  213. The method according to p. 212, characterized in that it comprises the step of converting the pharmaceutical preparation by dissolving the powder in a solvent.  214. The method according to p. 209, characterized in that at least a portion of the drive means applies a force between the housing and the movable or gripping part.  215. The method according to p. 209, characterized in that the housing forms a container at least partially covering parts of the device and having a hole made so that it surrounds the cartridge in whole or in part, and containing the step of performing at least part of the movement cartridge axially through the hole.  216. The method according to p. 209, characterized in that it comprises the step of changing the length, which is the maximum distance along the axis of the cartridge or parallel to it from the front of the cartridge to the rear of the housing, opposite its edge of the cartridge.  217. The method according to p. 209, characterized in that it contains a step that allows to reduce the length while moving the cartridge.  218. The method according to p. 209, characterized in that it comprises the step of maintaining the length substantially constant after the fixing step has been completed and during displacement during dispensing.  219. The method according to p. 216, characterized in that it comprises the step of reducing the length, essentially, in accordance with the consumption of the drug after completing the fixation step and during movement during dosing.  220. The method according to p. 219, characterized in that the step of reducing the length is performed by moving the cartridge between several fixed positions.  221. The method according to p. 209, characterized in that it comprises the step of holding the piston rod essentially in the axial direction in a stationary state relative to the housing while moving the cartridge.  222. The method according to p. 209, characterized in that it comprises the step of moving the piston rod relative to the housing during movement during dispensing.  223. The method according to p. 222, characterized in that the piston rod contains a thread that interacts with the corresponding matching part with the thread, and that the piston rod is moved in the axial direction by relative rotation between the piston rod and the matching part.  224. The method according to p. 209, characterized in that the cartridge contains a threaded part and interacts with the corresponding matching threaded part, and that the cartridge is moved in the axial direction by relative rotation between the cartridge and the matching part.  225. The method according to p. 224, characterized in that the matching part is a piston rod.  226. The method according to p. 209, characterized in that it comprises the step of moving the cartridge while holding the cartridge to prevent angular movement.  227. The method according to claim 209, characterized in that the fixing step comprises fixing the cartridge to prevent angular movement.  228. The method according to claim 209, characterized in that it includes the steps of retracting the piston rod, releasing the cartridge from fixing, and moving the cartridge with its front part forward from the housing.  229. The method according to p. 209, characterized in that perform several metering movements.  230. The method according to p. 209, characterized in that it comprises the step of preventing the movement of the cartridge at a predetermined angular orientation of the device.  231. The method according to p. 209, characterized in that it comprises the step of sensing determining the type of cartridge, encoding the cartridge with respect to at least one state parameter of the cartridge or process in the cartridge.  232. The method according to p. 230, characterized in that it comprises the step of performing sensory determination while moving the cartridge.

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