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RU2018146264A3 - - Google Patents

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Publication number
RU2018146264A3
RU2018146264A3 RU2018146264A RU2018146264A RU2018146264A3 RU 2018146264 A3 RU2018146264 A3 RU 2018146264A3 RU 2018146264 A RU2018146264 A RU 2018146264A RU 2018146264 A RU2018146264 A RU 2018146264A RU 2018146264 A3 RU2018146264 A3 RU 2018146264A3
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RU
Russia
Application number
RU2018146264A
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RU2018146264A (ru
RU2737737C2 (ru
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Publication of RU2018146264A publication Critical patent/RU2018146264A/ru
Publication of RU2018146264A3 publication Critical patent/RU2018146264A3/ru
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Publication of RU2737737C2 publication Critical patent/RU2737737C2/ru

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU2018146264A 2016-06-13 2017-06-08 АЛЬФА- И БЕТА-НЕНАСЫЩЕННОЕ АМИДНОЕ СОЕДИНЕНИЕ - ПРОИЗВОДНОЕ БЕНЗОТРИАЗОЛА, ПРИМЕНЯЕМОЕ В КАЧЕСТВЕ ИНГИБИТОРА TGF-βRI RU2737737C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610410554.8 2016-06-13
CN201610410554 2016-06-13
PCT/CN2017/087546 WO2017215506A1 (zh) 2016-06-13 2017-06-08 作为TGF-βR1抑制剂的苯并三氮唑衍生的α,β不饱和酰胺类化合物

Publications (3)

Publication Number Publication Date
RU2018146264A RU2018146264A (ru) 2020-07-15
RU2018146264A3 true RU2018146264A3 (ru) 2020-07-15
RU2737737C2 RU2737737C2 (ru) 2020-12-02

Family

ID=60664287

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018146264A RU2737737C2 (ru) 2016-06-13 2017-06-08 АЛЬФА- И БЕТА-НЕНАСЫЩЕННОЕ АМИДНОЕ СОЕДИНЕНИЕ - ПРОИЗВОДНОЕ БЕНЗОТРИАЗОЛА, ПРИМЕНЯЕМОЕ В КАЧЕСТВЕ ИНГИБИТОРА TGF-βRI

Country Status (14)

Country Link
US (1) US10548883B2 (ru)
EP (1) EP3470409B1 (ru)
JP (1) JP6954932B2 (ru)
KR (1) KR102412035B1 (ru)
CN (1) CN109415341B (ru)
AU (1) AU2017284124B2 (ru)
BR (1) BR112018075736B1 (ru)
CA (1) CA3027425C (ru)
DK (1) DK3470409T3 (ru)
ES (1) ES2787449T3 (ru)
PT (1) PT3470409T (ru)
RU (1) RU2737737C2 (ru)
WO (1) WO2017215506A1 (ru)
ZA (1) ZA201808618B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11236112B2 (en) 2017-12-13 2022-02-01 Genfleet Therapeutics (Shanghai) Inc. Crystal form and salt form of TGF-βRI inhibitor and preparation method therefor

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7147048B2 (ja) 2018-08-22 2022-10-04 クラヴィウス ファーマシューティカルズ,エルエルシー Tgf-ベータを阻害するための置換イミダゾールおよび処置方法
WO2020088526A1 (zh) * 2018-10-31 2020-05-07 南京明德新药研发有限公司 作为TGF-βR1激酶抑制剂的双环吡唑类化合物
AU2020257301A1 (en) 2019-04-18 2021-11-11 The Johns Hopkins University Substituted 2-amino-pyrazolyl-(1,2,4)triazolo(1,5a) pyridine derivatives and use thereof
CN112694477B (zh) * 2019-10-22 2024-02-06 四川科伦博泰生物医药股份有限公司 吡唑并环类化合物,包含其的药物组合物,其制备方法及其用途
WO2021136431A1 (zh) * 2019-12-31 2021-07-08 南京明德新药研发有限公司 苯并[d][1,2,3]三唑醚类化合物
WO2021190425A1 (zh) * 2020-03-24 2021-09-30 杭州阿诺生物医药科技有限公司 转化生长因子-β受体抑制剂
CN113698395B (zh) * 2020-05-22 2023-12-08 赛诺哈勃药业(成都)有限公司 转化生长因子受体拮抗剂、其制备方法和应用
CN112851695A (zh) * 2021-01-27 2021-05-28 复旦大学附属华山医院 甲酰胺类化合物在制备抗脊索肿瘤药物中的应用及试剂盒
CN115969801B (zh) * 2023-03-21 2023-08-25 劲方医药科技(上海)有限公司 用于癌症的药物组合物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100861630B1 (ko) * 2001-05-24 2008-10-07 일라이 릴리 앤드 캄파니 제약 제제로서의 신규 피롤 유도체
OA12929A (en) * 2002-09-18 2006-10-13 Pfizer Prod Inc Pyrazole derivatives as transforming growth (TGF) inhibitors.
US7405299B2 (en) 2002-11-27 2008-07-29 Eli Lilly And Company Compounds as pharmaceutical agents
CL2004000234A1 (es) 2003-02-12 2005-04-15 Biogen Idec Inc Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid
WO2006026305A1 (en) * 2004-08-31 2006-03-09 Biogen Idec Ma Inc Pyrimidinylpyrazoles as tgf-beta inhibitors
EP1973909A2 (en) 2005-12-22 2008-10-01 Biogen Idec MA Inc. Transforming growth factor modulators
WO2009009059A1 (en) * 2007-07-09 2009-01-15 Biogen Idec Ma Inc. Spiro compounds as antagonists of tgf-beta
US8080568B1 (en) 2010-06-29 2011-12-20 Ewha University - Industry Collaboration Foundation 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11236112B2 (en) 2017-12-13 2022-02-01 Genfleet Therapeutics (Shanghai) Inc. Crystal form and salt form of TGF-βRI inhibitor and preparation method therefor

Also Published As

Publication number Publication date
EP3470409B1 (en) 2020-02-12
EP3470409A1 (en) 2019-04-17
BR112018075736B1 (pt) 2024-01-23
KR20190017959A (ko) 2019-02-20
JP2019518066A (ja) 2019-06-27
RU2018146264A (ru) 2020-07-15
CA3027425A1 (en) 2017-12-21
BR112018075736A2 (pt) 2019-03-26
KR102412035B1 (ko) 2022-06-22
CA3027425C (en) 2023-08-15
US10548883B2 (en) 2020-02-04
AU2017284124B2 (en) 2021-06-03
CN109415341B (zh) 2021-02-26
CN109415341A (zh) 2019-03-01
ZA201808618B (en) 2019-08-28
ES2787449T3 (es) 2020-10-16
RU2737737C2 (ru) 2020-12-02
PT3470409T (pt) 2020-05-11
JP6954932B2 (ja) 2021-10-27
EP3470409A4 (en) 2019-05-08
AU2017284124A1 (en) 2019-01-24
WO2017215506A1 (zh) 2017-12-21
US20190151299A1 (en) 2019-05-23
DK3470409T3 (da) 2020-05-11

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