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RS50117B - Konjugati eritropoetina sa polietilenglikolom - Google Patents

Konjugati eritropoetina sa polietilenglikolom

Info

Publication number
RS50117B
RS50117B YUP-899/01A YUP89901A RS50117B RS 50117 B RS50117 B RS 50117B YU P89901 A YUP89901 A YU P89901A RS 50117 B RS50117 B RS 50117B
Authority
RS
Serbia
Prior art keywords
kilodaltons
ethylene glycol
glycoprotein
poly
group
Prior art date
Application number
YUP-899/01A
Other languages
English (en)
Inventor
Josef Burg
Bernd Hilger
Hans-Peter Josel
Original Assignee
F. Hoffmann-La Roche Ag.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag., filed Critical F. Hoffmann-La Roche Ag.,
Publication of YU89901A publication Critical patent/YU89901A/sh
Publication of RS50117B publication Critical patent/RS50117B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Konjugat, naznačen time, što obuhvata glikoprotein eritropoetina koji ima najmanje jednu slobodnu amino grupu i izabran je iz grupe koja se sastoji od humanog eritropoetina i njegovih analoga koji poseduju primarnu strukturu humanog eritropoetina, modifikovanu dodavanjem od 1 do 6 mesta glikozilacije ili rearanžmanima najmanje jednog mesta glikozilacije; pri čemu je navedeni glikoprotein kovalentno vezan za jednu do tri C1-C6- alkoksi poli(etilen glikol) grupe, pri čemu je svaka poli(etilen glikol) grupa kovalentno vezana za glikoprotein preko linkera formule -C(O)-X-S-Y, i pri čemu C(O) linkera formira amidnu vezu sa jednom od navedenih amino grupa, X je -(CH2)k- ili -CH2(O-CH2-CH2)k-, k ima vrednost od 1 do 10, Y je prosečna molekulska težina svakog poli(etilen glikol) ostatka je od 20 kilodaltona do 40 kilodaltona, a molekulska težina konjugata je od 51 kilodaltona do 175 kilodaltona. Prijava sadrži još 4 nezavisna i 30 zavisnih patentnih zahteva
YUP-899/01A 1999-07-02 2000-06-28 Konjugati eritropoetina sa polietilenglikolom RS50117B (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14224399P 1999-07-02 1999-07-02
US14745299P 1999-08-05 1999-08-05
US15145499P 1999-08-30 1999-08-30

Publications (2)

Publication Number Publication Date
YU89901A YU89901A (sh) 2004-05-12
RS50117B true RS50117B (sr) 2009-03-25

Family

ID=27385779

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-899/01A RS50117B (sr) 1999-07-02 2000-06-28 Konjugati eritropoetina sa polietilenglikolom

Country Status (33)

Country Link
US (1) US6340742B1 (sr)
EP (1) EP1196443B1 (sr)
JP (1) JP4190184B2 (sr)
KR (1) KR100510624B1 (sr)
CN (1) CN1194014C (sr)
AR (1) AR024879A1 (sr)
AT (1) ATE267840T1 (sr)
AU (1) AU768452B2 (sr)
BR (1) BRPI0012138B8 (sr)
CA (1) CA2378533C (sr)
CO (1) CO5180621A1 (sr)
CZ (1) CZ301833B6 (sr)
DE (1) DE60011087T2 (sr)
DK (1) DK1196443T3 (sr)
ES (1) ES2220501T3 (sr)
GC (1) GC0000196A (sr)
HK (1) HK1047597B (sr)
HR (1) HRP20010966B1 (sr)
HU (1) HU228478B1 (sr)
IL (2) IL146956A0 (sr)
JO (1) JO2291B1 (sr)
MA (1) MA26806A1 (sr)
MX (1) MXPA01012974A (sr)
MY (1) MY126776A (sr)
NO (1) NO20016304L (sr)
NZ (1) NZ516170A (sr)
PE (1) PE20010288A1 (sr)
PL (1) PL201754B1 (sr)
PT (1) PT1196443E (sr)
RS (1) RS50117B (sr)
TR (1) TR200103782T2 (sr)
TW (1) TWI266637B (sr)
WO (1) WO2001002017A2 (sr)

Families Citing this family (211)

* Cited by examiner, † Cited by third party
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