PT99998A - Metodo para a preparacao e utilizacao da 1-alfa,24-di-hidroxi-vitamina d2 - Google Patents

Metodo para a preparacao e utilizacao da 1-alfa,24-di-hidroxi-vitamina d2

Info

Publication number: PT99998A
Authority: PT; Portugal
Prior art keywords: vitamin; dihydroxy; proportional; converted; alpha
Prior art date: 1991-01-08

Application number

PT99998A

Other languages

English (en)

Other versions

PT99998B (pt

Inventor

Charles W Bishop

Joyce C Knutson

Robert M Moriarty

Raju Penmasta

Stephen Strugnell

Glenville Jones

Liang Guo

Original Assignee

Lunar Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-08

Filing date

1992-01-08

Publication date

1993-01-29

1992-01-08 Application filed by Lunar Corp filed Critical Lunar Corp

1993-01-29 Publication of PT99998A publication Critical patent/PT99998A/pt

1999-06-30 Publication of PT99998B publication Critical patent/PT99998B/pt

Links

MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 abstract 3
229960002061 ergocalciferol Drugs 0.000 abstract 3
MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 abstract 3
235000001892 vitamin D2 Nutrition 0.000 abstract 3
239000011653 vitamin D2 Substances 0.000 abstract 3
LHXJPXPNCMSHPV-KAOCCWGPSA-N (3s,9s,10r,13r,14r,17r)-17-[(e,2r,5s)-5-hydroxy-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@H](C)/C=C/[C@@](C)(O)C(C)C)CC[C@H]33)C)C3=CC=C21 LHXJPXPNCMSHPV-KAOCCWGPSA-N 0.000 abstract 2
OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 abstract 1
RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 abstract 1
HVAVRRBYXYEBNC-RKULPTJNSA-N 24-hydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/C(C)(O)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C HVAVRRBYXYEBNC-RKULPTJNSA-N 0.000 abstract 1
OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 abstract 1
DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 abstract 1
208000022458 calcium metabolism disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
208000017520 skin disease Diseases 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Nutrition Science (AREA)
Oncology (AREA)
Obesity (AREA)
Communicable Diseases (AREA)
Diabetes (AREA)
Hematology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PT99998A 1991-01-08 1992-01-08 Metodo para a preparacao e utilizacao da 1-alfa,24-di-hidroxi-vitamina d2 PT99998B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US63786791A	1991-01-08	1991-01-08

Publications (2)

Publication Number	Publication Date
PT99998A true PT99998A (pt)	1993-01-29
PT99998B PT99998B (pt)	1999-06-30

Family

ID=24557692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99998A PT99998B (pt)	1991-01-08	1992-01-08	Metodo para a preparacao e utilizacao da 1-alfa,24-di-hidroxi-vitamina d2

Country Status (14)

Country	Link
US (1)	US6211168B1 (pt)
EP (2)	EP0550702B1 (pt)
CN (3)	CN1032256C (pt)
AT (2)	ATE240736T1 (pt)
AU (1)	AU1247592A (pt)
DE (2)	DE69229103T2 (pt)
DK (1)	DK0550702T3 (pt)
ES (2)	ES2200238T3 (pt)
GR (1)	GR3030466T3 (pt)
MX (1)	MX9200070A (pt)
NZ (1)	NZ241255A (pt)
PT (1)	PT99998B (pt)
WO (1)	WO1992012165A1 (pt)
ZA (1)	ZA92108B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5602116A (en) *	1988-08-02	1997-02-11	Bone Care International, Inc.	Method for treating and preventing secondary hyperparathyroidism
US6538037B2 (en)	1991-01-08	2003-03-25	Bone Care International, Inc.	Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US20040009958A1 (en) *	1991-01-08	2004-01-15	Bone Care International, Inc.	Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
DE69325253T2 (de)	1992-08-28	1999-12-02	Bone Care International Inc., Madison	1alpha,24(s)-dihydroxy vitamin d2, seine synthese und verwendung
US5763429A (en) *	1993-09-10	1998-06-09	Bone Care International, Inc.	Method of treating prostatic diseases using active vitamin D analogues
US6376479B1 (en)	1995-04-03	2002-04-23	Bone Care International, Inc.	Method for treating and preventing hyperparathyroidism
US6242434B1 (en)	1997-08-08	2001-06-05	Bone Care International, Inc.	24-hydroxyvitamin D, analogs and uses thereof
US20020128240A1 (en) *	1996-12-30	2002-09-12	Bone Care International, Inc.	Treatment of hyperproliferative diseases using active vitamin D analogues
US6503893B2 (en)	1996-12-30	2003-01-07	Bone Care International, Inc.	Method of treating hyperproliferative diseases using active vitamin D analogues
US6573256B2 (en)	1996-12-30	2003-06-03	Bone Care International, Inc.	Method of inhibiting angiogenesis using active vitamin D analogues
US6566353B2 (en)	1996-12-30	2003-05-20	Bone Care International, Inc.	Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US20030129194A1 (en) *	1997-02-13	2003-07-10	Bone Care International, Inc.	Targeted therapeutic delivery of vitamin D compounds
US6929797B2 (en)	1997-02-13	2005-08-16	Bone Care International, Inc.	Targeted therapeutic delivery of vitamin D compounds
US6087350A (en) *	1997-08-29	2000-07-11	University Of Pittsburgh Of The Commonwealth System Of Higher Education	Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
AU762481C (en) *	1998-03-27	2004-08-19	Oregon Health Sciences University	Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders
ATE246172T1 (de)	1998-05-29	2003-08-15	Bone Care Int Inc	Verfahren zur herstellung von hydroxy-25-ene vitamin d verbindungen
IL153378A0 (en)	2000-07-18	2003-07-06	Bone Care Internat Inc	STABILIZED 1alpha-HYDROXY VITAMIN D
PL373677A1 (en)	2002-01-10	2005-09-05	Teva Pharmaceutical Industries Ltd.	Selective enzymatic esterification and solvolysis of epimeric vitamin d analog and separation of the epimers
US7148211B2 (en)	2002-09-18	2006-12-12	Genzyme Corporation	Formulation for lipophilic agents
US20060003950A1 (en) *	2004-06-30	2006-01-05	Bone Care International, Inc.	Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7094775B2 (en)	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents
TWI299333B (en) *	2004-07-01	2008-08-01	Teva Pharma	Crystalline forms of 1,24(s)-dihydroxy vitamin d2
CN101607931B (zh) *	2009-07-23	2012-01-11	青岛正大海尔制药有限公司	一种骨化三醇的制备方法
CN103122009B (zh) *	2013-01-09	2015-11-25	江苏吉贝尔药业股份有限公司	两种用于合成他卡西醇支链的重要中间体化合物
CN103012463B (zh) *	2013-01-17	2016-02-10	南京理工大学	(s)-3-甲基-2-(叔丁基二甲基硅氧基)-1-溴丁烷的合成方法
CN104496871B (zh) *	2014-12-22	2016-03-09	上海皓元生物医药科技有限公司	一种他卡西醇的制备方法
CN109627279A (zh) *	2019-02-01	2019-04-16	浙江花园营养科技有限公司	一种活性维生素d3中间体的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US467190A (en) *		1892-01-19		Bernard g
US4670190A (en) *	1973-01-10	1987-06-02	Hesse Robert H	1-α-hydroxy vitamin D compounds and process for preparing same
US3880894A (en)	1974-05-24	1975-04-29	Wisconsin Alumni Res Found	1,25-Dihydroxyergocalciferol
US4022891A (en) *	1974-06-18	1977-05-10	Teijin Limited	Novel 1α,24-dihydroxycholecalciferol compositions, novel precursors thereof, and processes for preparing them
US3970676A (en) *	1974-10-29	1976-07-20	The Upjohn Company	Novel process and intermediate compounds used is preparation of -Δ5,7- steroid dienes
GB1583749A (en) *	1976-06-03	1981-02-04	Res Inst Medicine Chem	Vitamin d derivatives
US4195027A (en) *	1978-01-16	1980-03-25	Wisconsin Alumni Research Foundation	Process for preparing 1α-hydroxylated compounds
US4225596A (en) *	1978-10-13	1980-09-30	Wisconsin Alumni Research Foundation	Method for treating calcium imbalance and improving calcium absorption in mammals
JPS55136229A (en) *	1979-04-10	1980-10-23	Teijin Ltd	Adjustment of bone metabolism in warm-blooded animal and drug for it
US4310511A (en) *	1980-10-02	1982-01-12	Massachusetts General Hospital	Sunscreen compositions containing Δ5,7 steroidal dienes
US4338250A (en) *	1981-04-27	1982-07-06	Wisconsin Alumni Research Foundation	1-Hydroxylation process
US4448721A (en) *	1982-09-20	1984-05-15	Wisconsin Alumni Research Foundation	Hydroxyvitamin D2 compounds and process for preparing same
US4610978A (en) *	1983-03-22	1986-09-09	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Compositions containing 1α-hydroxycholecalciferol for topical treatment of skin disorders and methods employing same
US4719205A (en)	1984-01-30	1988-01-12	Wisconsin Alumini Research Foundation	Side-chain unsaturated 1-hydroxyvitamin D compounds
US4588528A (en) *	1984-05-31	1986-05-13	Wisconsin Alumni Research Foundation	1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
US4728643A (en) *	1984-11-02	1988-03-01	The General Hospital Corporation	Method of treating psoriasis
KR940010767B1 (ko) *	1985-08-02	1994-11-11	레오 파마슈티칼스 프로덕츠 리미티드 에이/에스(레벤스 케미스케 파브리크 프로덕션 사크티에셀스카브)	신규 비타민 d 동족체
JPH0755960B2 (ja) *	1986-11-14	1995-06-14	日清製粉株式会社	ステロイド誘導体およびその製造方法
US4804502A (en) *	1988-01-20	1989-02-14	Hoffmann-La Roche Inc.	Vitamin D compounds
US5104864A (en) *	1988-08-02	1992-04-14	Bone Care International, Inc.	Method for treating and preventing loss of bone mass
US5242824A (en) *	1988-12-22	1993-09-07	Oncogen	Monoclonal antibody to human carcinomas
US5098899A (en) *	1989-03-06	1992-03-24	Trustees Of Boston University	Method for therapeutically treating psoriatic arthritis using vitamin D analogues and metabolites

1992
- 1992-01-07 WO PCT/US1992/000313 patent/WO1992012165A1/en active IP Right Grant
- 1992-01-07 DE DE69229103T patent/DE69229103T2/de not_active Expired - Lifetime
- 1992-01-07 ES ES98110802T patent/ES2200238T3/es not_active Expired - Lifetime
- 1992-01-07 ES ES92904947T patent/ES2134207T3/es not_active Expired - Lifetime
- 1992-01-07 AT AT98110802T patent/ATE240736T1/de not_active IP Right Cessation
- 1992-01-07 DE DE69233074T patent/DE69233074T2/de not_active Expired - Lifetime
- 1992-01-07 AU AU12475/92A patent/AU1247592A/en not_active Abandoned
- 1992-01-07 EP EP92904947A patent/EP0550702B1/en not_active Expired - Lifetime
- 1992-01-07 AT AT92904947T patent/ATE179604T1/de not_active IP Right Cessation
- 1992-01-07 DK DK92904947T patent/DK0550702T3/da active
- 1992-01-07 EP EP98110802A patent/EP0914825B1/en not_active Expired - Lifetime
- 1992-01-08 PT PT99998A patent/PT99998B/pt not_active IP Right Cessation
- 1992-01-08 CN CN92100866A patent/CN1032256C/zh not_active Expired - Lifetime
- 1992-01-08 MX MX9200070A patent/MX9200070A/es unknown
- 1992-01-08 NZ NZ241255A patent/NZ241255A/xx not_active IP Right Cessation
- 1992-01-08 ZA ZA92108A patent/ZA92108B/xx unknown
1995
- 1995-06-07 US US08/483,371 patent/US6211168B1/en not_active Expired - Lifetime
- 1995-11-10 CN CN95118187A patent/CN1078072C/zh not_active Expired - Lifetime
- 1995-11-10 CN CN95118188A patent/CN1071574C/zh not_active Expired - Lifetime
1999
- 1999-06-09 GR GR990401539T patent/GR3030466T3/el unknown

Also Published As

Publication number	Publication date
EP0914825A2 (en)	1999-05-12
WO1992012165A1 (en)	1992-07-23
PT99998B (pt)	1999-06-30
MX9200070A (es)	1992-07-01
GR3030466T3 (en)	1999-10-29
DE69233074D1 (de)	2003-06-26
NZ241255A (en)	1999-05-28
DE69229103T2 (de)	1999-10-14
ES2200238T3 (es)	2004-03-01
EP0550702A1 (en)	1993-07-14
US6211168B1 (en)	2001-04-03
DK0550702T3 (da)	1999-11-01
DE69229103D1 (de)	1999-06-10
ES2134207T3 (es)	1999-10-01
CN1071574C (zh)	2001-09-26
CN1143500A (zh)	1997-02-26
DE69233074T2 (de)	2004-03-18
EP0550702B1 (en)	1999-05-06
CN1078072C (zh)	2002-01-23
CN1133712A (zh)	1996-10-23
ZA92108B (en)	1992-10-28
ATE179604T1 (de)	1999-05-15
CN1067243A (zh)	1992-12-23
EP0914825A3 (en)	1999-05-19
ATE240736T1 (de)	2003-06-15
EP0550702A4 (en)	1994-06-08
EP0914825B1 (en)	2003-05-21
AU1247592A (en)	1992-08-17
CN1032256C (zh)	1996-07-10

Legal Events

Date

Code

Title

Description

1993-01-29

BB1A

Laying open of patent application

Effective date: 19920917

1999-06-30

FG3A

Patent granted, date of granting

Effective date: 19990312

2002-12-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20020930

Publication	Publication Date	Title
PT99998A (pt)	1993-01-29	Metodo para a preparacao e utilizacao da 1-alfa,24-di-hidroxi-vitamina d2
NO921955L (no)	1992-06-05	Nye d-vitaminforbindelser og fremgangsmaate til fremstilling av samme
MX9207382A (es)	1993-07-01	Nuevos compuestos que tienen actividad terapeutica intermediarios para su preparacion, proceso para obtencion de tales compuestos y formulacion farmaceutica que los contiene.
IT1276253B1 (it)	1997-10-27	Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi
HUT59313A (en)	1992-05-28	Process for producing pharmaceutical composition comprising flupirtin as active ingredient and suitable for combatting muscular tensions
MX16658A (es)	1993-11-01	Procedimiento para la preparacion de derivados delacido difosfonico producto obtenido y composicion farmaceutica para el tratamiento de desordenes en el metabolismo del calcio que lo incluye.
ES2052755T3 (es)	1994-07-16	Procedimiento de preparacion de una composicion a base de fases laminares lipidicas hidratadas o de liposomas.
DK155686A (da)	1986-10-05	Parathyroidhormonholdigt praeparat
HUT48196A (en)	1989-05-29	Process for producing benzocycloheptene derivatives and pharmaceuticals comprising such active ingredient
ES2123039T3 (es)	1999-01-01	Nuevas 3-(hidroxi-bencilidenil)-indolin-2-onas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
DK0614456T3 (da)	1999-12-06	1alfa,24(S)-dihydroxy-vitamin D2, dets fremstilling og anvendelse
WO1994005630B1 (en)	1994-04-14	1α,24(S)-DIHYDROXY VITAMIN D2, ITS FORMATION AND USE
PT92002A (pt)	1990-04-30	Processo para a preparacao de formulacoes dispensaveis que contem diclofenac
ES2041647T3 (es)	1993-12-01	Metodo para producir un compuesto de oseinahidroxiapatita.
ATE27456T1 (de)	1987-06-15	Kristallinische aenderungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate.
DE69214617D1 (de)	1996-11-21	26,27-Dimethylen-1-Alpha, 25-Dihydroxyvitamin-D2 und 26,27-Dihydroxyvitamin-D2 und Verfahren zu ihrer Herstellung
DK0486561T4 (da)	1999-04-26	Bukkalt præparat indeholdende S(+)-ketoprofen
ZA87685B (en)	1988-10-26	Phenylacetonitriles which are substituted by basic groups,their preparation and drugs containing these substances
ES2135500T3 (es)	1999-11-01	Producto farmaceutico para el tratamiento de trastornos de la piel.
BE899612A (fr)	1984-08-31	Derives 1 alpha, 25-dihydroxiles de la vitamine d2 et produits intermediaires pour leur preparation et compositions pharmaceutiques renfermant ces derives.
ES2006121A6 (es)	1989-04-01	Procedimiento para la preparacion de una composicion farmaceutica destinada al tratamiento de enfermedades cutaneas.
DE69307197D1 (de)	1997-02-20	Verwendung von 24,25-Dihydroxyvitamin-D3 zur Herstellung eines Arzneimittel zur Behandlung der Rachitis
MX9300136A (es)	1993-07-01	Alfa-aril-alfa-hidroxi-beta-imidazolinil-propionamidas, procedimiento para su obtencion y medicamentos que las contienen.
MX9305151A (es)	1994-05-31	Metodo para el tratamiento de enfermedades de la piel.
DE69108319D1 (de)	1995-04-27	Verfahren zur herstellung von vitamin-d2-verbindungen und ihrer 1-alpha hydrogenierten derivate.