PT83647B - Processo para a preparacao de novos derivados de benzimidazole com actividade farmacologica e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos derivados de benzimidazole com actividade farmacologica e de composicoes farmaceuticas que os contem

Info

Publication number: PT83647B
Authority: PT; Portugal
Prior art keywords: pharmaceutical compositions; compositions containing; pharmacological activity; benzimidazole derivatives; preparing new
Prior art date: 1985-10-29

Application number

PT83647A

Other languages

English (en)

Other versions

PT83647A (en

Inventor

Per Lennart Lindberg

Gunnel Elisabeth Sunden

Tomas Boerje Alminger

Hakan Sigurd Larsson

Original Assignee

Haessle Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-29

Filing date

1986-10-29

Publication date

1989-05-31

1986-10-29 Application filed by Haessle Ab filed Critical Haessle Ab

1986-11-01 Publication of PT83647A publication Critical patent/PT83647A/pt

1989-05-31 Publication of PT83647B publication Critical patent/PT83647B/pt

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
150000001556 benzimidazoles Chemical class 0.000 title 1
230000000144 pharmacologic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
239000004480 active ingredient Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)

PT83647A 1985-10-29 1986-10-29 Processo para a preparacao de novos derivados de benzimidazole com actividade farmacologica e de composicoes farmaceuticas que os contem PT83647B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8505112A SE8505112D0 (sv)	1985-10-29	1985-10-29	Novel pharmacological compounds

Publications (2)

Publication Number	Publication Date
PT83647A PT83647A (en)	1986-11-01
PT83647B true PT83647B (pt)	1989-05-31

Family

ID=20361960

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT83647A PT83647B (pt)	1985-10-29	1986-10-29	Processo para a preparacao de novos derivados de benzimidazole com actividade farmacologica e de composicoes farmaceuticas que os contem

Country Status (31)

Country	Link
US (1)	US5021433A (pt)
EP (2)	EP0221041A3 (pt)
JP (2)	JPH0780874B2 (pt)
KR (1)	KR950009858B1 (pt)
CN (1)	CN1022487C (pt)
AT (1)	ATE79619T1 (pt)
AU (1)	AU598491B2 (pt)
CS (1)	CS272767B2 (pt)
DD (1)	DD252375A5 (pt)
DE (1)	DE3686483T2 (pt)
DK (1)	DK320587D0 (pt)
EG (1)	EG17753A (pt)
ES (1)	ES2051696T3 (pt)
FI (1)	FI91151C (pt)
GR (1)	GR3006177T3 (pt)
HU (1)	HU198474B (pt)
IE (1)	IE59167B1 (pt)
IL (1)	IL80437A0 (pt)
IS (1)	IS1564B (pt)
JO (1)	JO1502B1 (pt)
LT (1)	LTIP1681A (pt)
LV (1)	LV10270B (pt)
MY (1)	MY101791A (pt)
NO (1)	NO171365C (pt)
NZ (1)	NZ218028A (pt)
PH (1)	PH25319A (pt)
PL (1)	PL150240B1 (pt)
PT (1)	PT83647B (pt)
SE (1)	SE8505112D0 (pt)
WO (1)	WO1987002668A1 (pt)
ZA (1)	ZA867716B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ222495A (en) *	1986-11-21	1991-04-26	Haessle Ab	Benzimidazole derivatives and pharmaceutical compositions
EP0436025A4 (en) *	1988-09-20	1991-09-11	Hisamitsu Pharmaceutical Co. Inc.	Novel dibenz b,e)oxepin derivatives
SE8804629D0 (sv) *	1988-12-22	1988-12-22	Ab Haessle	New therapeutically active compounds
IE64199B1 (en) *	1988-12-22	1995-07-12	Haessle Ab	Compound with gastric acid inhibitory effect and process for its preparation
US5049674A (en) *	1989-12-20	1991-09-17	Aktiebolaget Hassle	Therapeutically active fluoro substituted benzimidazoles
US4965269A (en) *	1989-12-20	1990-10-23	Ab Hassle	Therapeutically active chloro substituted benzimidazoles
US5274099A (en) *	1989-12-20	1993-12-28	Aktiebolaget Hassle	Therapeutically active fluoro substituted benzimidazoles
SE9002206D0 (sv) *	1990-06-20	1990-06-20	Haessle Ab	New compounds
PL165898B1 (pl) *	1990-06-20	1995-02-28	Astra Ab	Sposób wytwarzania nowych pochodnych dwualkoksyplrydynylobenzlmldazolu PL
ES2048109B1 (es) *	1992-07-20	1994-12-16	Espanola Prod Quimicos	Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
WO1995032957A1 (en) *	1994-05-27	1995-12-07	Astra Aktiebolag	Novel ethoxycarbonyloxymethyl derivatives of substituted benzimidazoles
US6093734A (en) *	1998-08-10	2000-07-25	Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin	Prodrugs of proton pump inhibitors
BR9912937A (pt) *	1998-08-10	2001-05-08	Partnership Of Michael E Garst	Pró-drogas de inibidores de bomba de prótons
US6852739B1 (en)	1999-02-26	2005-02-08	Nitromed Inc.	Methods using proton pump inhibitors and nitric oxide donors
US6369087B1 (en) *	1999-08-26	2002-04-09	Robert R. Whittle	Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
WO2002030920A1 (fr) *	2000-10-12	2002-04-18	Takeda Chemical Industries, Ltd.	Composes derives de benzimidazole, leur procede de production et leur utilisation
US20040248941A1 (en) *	2001-09-25	2004-12-09	Keiji Kamiyama	Benzimidazone compound, process for producing the same, and use thereof
WO2003106429A1 (ja) *	2002-06-14	2003-12-24	武田薬品工業株式会社	プロドラッグおよびその製造法
WO2004009583A2 (en) *	2002-07-19	2004-01-29	Garst Michael E	Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor
JP4634144B2 (ja)	2002-08-01	2011-02-16	ニコックスエスエー	ニトロソ化プロトンポンプ阻害剤、組成物および使用方法
MY148805A (en)	2002-10-16	2013-05-31	Takeda Pharmaceutical	Controlled release preparation
US8802139B2 (en) *	2003-06-26	2014-08-12	Intellipharmaceutics Corp.	Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
WO2005039640A1 (en) *	2003-10-03	2005-05-06	Allergan Inc.	Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs
US20050075371A1 (en) *	2003-10-03	2005-04-07	Allergan, Inc.	Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
EP1715854A2 (en) *	2004-02-18	2006-11-02	Allergan, Inc.	Prodrugs for the intravenous administration of proton pump inhibitors
EP1715861A2 (en) *	2004-02-18	2006-11-02	Allergan, Inc.	Compositions comprising prodrugs of proton pump inhibitors
EP1742630A4 (en) *	2004-04-16	2010-01-20	Santarus Inc	COMBINATION OF INHIBITOR OF PROTON PUMP, BUFFER AND PROKINETIC AGENT
DE602004022337D1 (de)	2004-04-28	2009-09-10	Hetero Drugs Ltd	Verfahren zur herstellung von pyridinylmethyl-1h-benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere
PT1748998E (pt)	2004-05-28	2010-03-24	Hetero Drugs Ltd	Novo processo de síntese estereoselectiva de sulfóxidos de benzimidazol
US8394409B2 (en) *	2004-07-01	2013-03-12	Intellipharmaceutics Corp.	Controlled extended drug release technology
US10624858B2 (en)	2004-08-23	2020-04-21	Intellipharmaceutics Corp	Controlled release composition using transition coating, and method of preparing same
US10064828B1 (en)	2005-12-23	2018-09-04	Intellipharmaceutics Corp.	Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
CN101453993A (zh) *	2006-04-03	2009-06-10	伊萨·奥迪迪	含有机溶胶涂层的受控释放递送物件
US10960077B2 (en)	2006-05-12	2021-03-30	Intellipharmaceutics Corp.	Abuse and alcohol resistant drug composition
WO2008036201A1 (en) *	2006-09-19	2008-03-27	Alevium Pharmaceuticals, Inc.	Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
WO2008057802A2 (en)	2006-10-27	2008-05-15	The Curators Of The University Of Missouri	Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same
US20080194307A1 (en) *	2007-02-13	2008-08-14	Jeff Sanger	Sports-based game of chance
JP2011512416A (ja)	2008-02-20	2011-04-21	ザ・キュレイターズ・オブ・ザ・ユニバーシティー・オブ・ミズーリ	オメプラゾール及びランソプラゾールの組合せと緩衝剤を含んでなる組成物とそれを使用する方法
AU2010339691B2 (en) *	2010-01-07	2015-04-02	Alkermes Pharma Ireland Limited	Prodrugs of heteraromatic compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE418966B (sv) *	1974-02-18	1981-07-06	Haessle Ab	Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
US4045564A (en) *	1974-02-18	1977-08-30	Ab Hassle	Benzimidazole derivatives useful as gastric acid secretion inhibitors
SE416649B (sv) *	1974-05-16	1981-01-26	Haessle Ab	Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (pt) *	1977-09-19	1981-07-25	Hoffmann La Roche
SE7804231L (sv) *	1978-04-14	1979-10-15	Haessle Ab	Magsyrasekretionsmedel
US4359465A (en) *	1980-07-28	1982-11-16	The Upjohn Company	Methods for treating gastrointestinal inflammation
CH644116A5 (de) *	1980-08-21	1984-07-13	Hoffmann La Roche	Imidazolderivate.
SE8300736D0 (sv) *	1983-02-11	1983-02-11	Haessle Ab	Novel pharmacologically active compounds
IL75400A (en) *	1984-06-16	1988-10-31	Byk Gulden Lomberg Chem Fab	Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
AU568441B2 (en) *	1984-09-24	1987-12-24	Upjohn Company, The	2-(pyridylalkenesulfinyl) benzimidazole derivatives
ZA856671B (en) *	1984-09-24	1986-04-30	Upjohn Co	N-substituted derivatives of 2-(pyridylaklenesulfinyl)benzimidazoles as gastric antisecretory agents

1985
- 1985-10-29 SE SE8505112A patent/SE8505112D0/xx unknown
1986
- 1986-10-09 ZA ZA867716A patent/ZA867716B/xx unknown
- 1986-10-22 EG EG661/86A patent/EG17753A/xx active
- 1986-10-22 NZ NZ218028A patent/NZ218028A/xx unknown
- 1986-10-23 IE IE280586A patent/IE59167B1/en not_active IP Right Cessation
- 1986-10-24 PH PH34408A patent/PH25319A/en unknown
- 1986-10-27 JO JO19861502A patent/JO1502B1/en active
- 1986-10-27 DD DD86295633A patent/DD252375A5/de not_active IP Right Cessation
- 1986-10-27 MY MYPI86000038A patent/MY101791A/en unknown
- 1986-10-28 AT AT86906498T patent/ATE79619T1/de not_active IP Right Cessation
- 1986-10-28 JP JP61505700A patent/JPH0780874B2/ja not_active Expired - Lifetime
- 1986-10-28 IL IL80437A patent/IL80437A0/xx not_active IP Right Cessation
- 1986-10-28 EP EP86850378A patent/EP0221041A3/en active Pending
- 1986-10-28 HU HU865443A patent/HU198474B/hu not_active IP Right Cessation
- 1986-10-28 DE DE8686906498T patent/DE3686483T2/de not_active Expired - Fee Related
- 1986-10-28 WO PCT/SE1986/000493 patent/WO1987002668A1/en active IP Right Grant
- 1986-10-28 AU AU65429/86A patent/AU598491B2/en not_active Ceased
- 1986-10-28 ES ES86906498T patent/ES2051696T3/es not_active Expired - Lifetime
- 1986-10-28 EP EP86906498A patent/EP0233284B1/en not_active Expired - Lifetime
- 1986-10-28 KR KR1019870700555A patent/KR950009858B1/ko not_active Expired - Lifetime
- 1986-10-28 IS IS3156A patent/IS1564B/is unknown
- 1986-10-29 PT PT83647A patent/PT83647B/pt not_active IP Right Cessation
- 1986-10-29 PL PL1986262105A patent/PL150240B1/pl unknown
- 1986-10-29 CS CS782686A patent/CS272767B2/cs unknown
- 1986-10-29 CN CN86107595A patent/CN1022487C/zh not_active Expired - Lifetime
1987
- 1987-06-24 DK DK320587A patent/DK320587D0/da not_active Application Discontinuation
- 1987-06-26 NO NO872686A patent/NO171365C/no unknown
- 1987-06-29 FI FI872864A patent/FI91151C/sv not_active IP Right Cessation
1988
- 1988-05-12 US US07/195,343 patent/US5021433A/en not_active Expired - Fee Related
1992
- 1992-11-05 GR GR920402498T patent/GR3006177T3/el unknown
1993
- 1993-06-30 LV LVP-93-856A patent/LV10270B/xx unknown
- 1993-12-28 LT LTIP1681A patent/LTIP1681A/xx not_active Application Discontinuation
1994
- 1994-12-21 JP JP6318132A patent/JPH0826014B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI91151B (fi)	1994-02-15
US5021433A (en)	1991-06-04
SE8505112D0 (sv)	1985-10-29
CN86107595A (zh)	1987-07-08
LTIP1681A (en)	1995-09-25
JPH07188216A (ja)	1995-07-25
JPS63501151A (ja)	1988-04-28
IE59167B1 (en)	1994-01-12
WO1987002668A1 (en)	1987-05-07
IE862805L (en)	1987-04-29
DK320587A (da)	1987-06-24
CS782686A2 (en)	1990-05-14
PT83647A (en)	1986-11-01
CS272767B2 (en)	1991-02-12
LV10270A (lv)	1994-10-20
CN1022487C (zh)	1993-10-20
JPH0780874B2 (ja)	1995-08-30
HUT43843A (en)	1987-12-28
DD252375A5 (de)	1987-12-16
IL80437A0 (en)	1987-01-30
JPH0826014B2 (ja)	1996-03-13
ATE79619T1 (de)	1992-09-15
ES2051696T3 (es)	1994-07-01
DK320587D0 (da)	1987-06-24
KR950009858B1 (ko)	1995-08-29
NO872686D0 (no)	1987-06-26
GR3006177T3 (pt)	1993-06-21
EP0221041A2 (en)	1987-05-06
DE3686483T2 (de)	1993-02-04
FI872864L (fi)	1987-06-29
PL262105A1 (en)	1988-08-18
EP0221041A3 (en)	1987-10-28
FI91151C (sv)	1994-05-25
NO872686L (no)	1987-06-26
EP0233284A1 (en)	1987-08-26
EG17753A (en)	1991-12-30
JO1502B1 (en)	1989-01-25
PH25319A (pt)	1991-04-30
KR870700620A (ko)	1987-12-30
ZA867716B (en)	1987-05-27
IS3156A7 (is)	1987-04-30
AU598491B2 (en)	1990-06-28
HU198474B (en)	1989-10-30
LV10270B (en)	1995-04-20
NO171365C (no)	1993-03-03
NZ218028A (en)	1990-02-26
NO171365B (no)	1992-11-23
AU6542986A (en)	1987-05-19
EP0233284B1 (en)	1992-08-19
FI872864A0 (fi)	1987-06-29
MY101791A (en)	1992-01-31
IS1564B (is)	1994-12-13
PL150240B1 (en)	1990-05-31
DE3686483D1 (de)	1992-09-24

Legal Events

Date

Code

Title

Description

1996-09-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960531

Publication	Publication Date	Title
PT83647B (pt)	1989-05-31	Processo para a preparacao de novos derivados de benzimidazole com actividade farmacologica e de composicoes farmaceuticas que os contem
PT95312A (pt)	1991-05-22	Processo para a preparacao de novos tienilcarboxilatos de aminoalcoois e dos seus produtos de quaternizacao, e de composicoes farmaceuticas que os contem
PT92437A (pt)	1990-05-31	Processo de preparacao de derivados da quinazolinona, dos seus intermediarios e de composicoes farmaceuticas que os contem
BG60102B2 (bg)	1993-10-29	Метод за получаване на 5-флуор-2(((4-циклопропил- метокси-2-пиридинил)метил)тионил)-1н-бензимидазол
PT92935A (pt)	1990-07-31	Processo para a preparacao de um composto de pirazolo-piridina e de composicoes farmaceuticas que o contem
PT83143B (pt)	1988-07-29	Processo para a preparacao de 1,4-dihidro-piridinas 2-substituidas com tiometilo e de composicoes farmaceuticas que as contem
ES2052603T3 (es)	1994-07-16	Derivados de bencimidazol, procedimiento para su produccion y composicion farmaceutica que los contienen.
PT96303A (pt)	1991-09-30	Processo para a preparacao de novos derivados do acido piperidinocarboxilico com accao anestesica local e analgesica e de composicoes farmaceuticas que os contem
PT82097B (pt)	1988-07-01	Processo para a preparacao de derivados de labdano e de composicoes farmaceuticas que os contem
PT99055A (pt)	1992-08-31	Processo para a preparacao de novas aminas alquil-heterociclicas e de composicoes farmaceuticas que as contem
PT81893B (pt)	1988-07-01	Processo para a preparacao de derivados de labdano e de composicoes farmaceuticas que os contem
SE8404065D0 (sv)	1984-08-10	Novel biologically active compounds
DK112287A (da)	1987-09-06	Anvendelse af 2-alkoxy-n-(1-azabicyclo-oe2,2,2aaoct-3-yl)-benzamider og -thiobenzamider samt farmaceutisk acceptable syreadditionssalte deraf som laegemidler
ES2059534T3 (es)	1994-11-16	Nuevos derivados benzopiranos antihipertensivos.
IT1224405B (it)	1990-10-04	Composti attivi sul sistema cardiovascolare
PT81843B (pt)	1988-05-27	Processo para a preparacao de derivados de imida ciclicos de 2-(4-butilpiperazinil-1)-piridinas com actividade antipsicotica e de composicoes farmaceuticas que os contem
PT82512B (pt)	1988-03-03	Processo para a preparacao de derivados de quinolilglicinamidas com actividade psicotropica e de composicoes farmaceuticas que os contem
ES2043943T3 (es)	1994-01-01	Procedimiento para la preparacion de compuestos con actividad analgesica central.
ATE27813T1 (de)	1987-07-15	N-substituierte 1-(4'-alkylsulfonylphenyl)-2amino-1,3-propanediol-derivate.
PT89353A (pt)	1989-12-29	Processo para a preparacao de derivados de cefalosporina com actividade antimicrobiana e de composicoes farmaceuticas que os contem
PT82175B (pt)	1988-07-29	Processo para preparacao de novos derivados de 3-piridilmetilnaftalina e de composicoes farmceuticas que os contem
IT1214729B (it)	1990-01-18	Derivati di acido tiofenacetico,procedimento per la loro preparazione, composizioni farmaceutiche che licontengono e loro impiego come medicamenti
PT89500A (pt)	1989-10-04	Processo para a preparacao de derivados de tetra-hidropiridina e de composicoes farmaceuticas que os contem
IT1224404B (it)	1990-10-04	Composti attivi sul sistema cardiovascolare
PT82257B (pt)	1988-07-29	Processo para a preparacao de 1,8-naftiridinonas substituidas e de composicoes farmaceuticas que as contem