PL3006458T3 - Zmutowane egzotoksyny Pseudomonas o zmniejszonej antygenowości - Google Patents
Zmutowane egzotoksyny Pseudomonas o zmniejszonej antygenowościInfo
- Publication number
- PL3006458T3 PL3006458T3 PL15191395T PL15191395T PL3006458T3 PL 3006458 T3 PL3006458 T3 PL 3006458T3 PL 15191395 T PL15191395 T PL 15191395T PL 15191395 T PL15191395 T PL 15191395T PL 3006458 T3 PL3006458 T3 PL 3006458T3
- Authority
- PL
- Poland
- Prior art keywords
- pes
- pseudomonas exotoxins
- mutated
- reduced antigenicity
- mutated pseudomonas
- Prior art date
Links
- 241000589516 Pseudomonas Species 0.000 title abstract 2
- 239000002095 exotoxin Substances 0.000 title abstract 2
- 231100000776 exotoxin Toxicity 0.000 title abstract 2
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70379805P | 2005-07-29 | 2005-07-29 | |
| EP15191395.1A EP3006458B1 (en) | 2005-07-29 | 2006-07-25 | Mutated pseudomonas exotoxins with reduced antigenicity |
| EP10179539.1A EP2332970B1 (en) | 2005-07-29 | 2006-07-25 | Mutated pseudomonas exotoxins with reduced antigenicity |
| EP06788523A EP1910407B1 (en) | 2005-07-29 | 2006-07-25 | Mutated pseudomonas exotoxins with reduced antigenicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3006458T3 true PL3006458T3 (pl) | 2018-05-30 |
Family
ID=37709138
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15191391T PL3006457T3 (pl) | 2005-07-29 | 2006-07-25 | Zmutowane egzotoksyny Pseudomonas o zmniejszonej antygenowości |
| PL15191388T PL3006456T3 (pl) | 2005-07-29 | 2006-07-25 | Zmutowane egzotoksyny pseudomonas o zmniejszonej antygenowości |
| PL15191395T PL3006458T3 (pl) | 2005-07-29 | 2006-07-25 | Zmutowane egzotoksyny Pseudomonas o zmniejszonej antygenowości |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15191391T PL3006457T3 (pl) | 2005-07-29 | 2006-07-25 | Zmutowane egzotoksyny Pseudomonas o zmniejszonej antygenowości |
| PL15191388T PL3006456T3 (pl) | 2005-07-29 | 2006-07-25 | Zmutowane egzotoksyny pseudomonas o zmniejszonej antygenowości |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8907060B2 (pl) |
| EP (6) | EP2332970B1 (pl) |
| AT (1) | ATE524489T1 (pl) |
| AU (1) | AU2006275865B2 (pl) |
| CA (2) | CA2941466C (pl) |
| ES (6) | ES2564092T3 (pl) |
| PL (3) | PL3006457T3 (pl) |
| WO (1) | WO2007016150A2 (pl) |
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| KR20140033391A (ko) | 2011-06-09 | 2014-03-18 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 면역원성이 보다 낮은 t 세포 및/또는 b 세포 에피토프를 갖는 슈도모나스 외독소 a |
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| ATE401348T1 (de) * | 1999-05-27 | 2008-08-15 | Us Gov Health & Human Serv | Immunokonjugate mit hoher bindungsaffinität |
| EP1263785A2 (en) | 1999-11-11 | 2002-12-11 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Mutated il-13 molecules and their uses |
| AU2001278898A1 (en) * | 2000-07-10 | 2002-01-21 | Xencor | Method for disigning protein libraries with altered immunogenicity |
| ZA200305980B (en) * | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
| US20030113350A1 (en) * | 2001-09-19 | 2003-06-19 | Fattom Ali I. | Glycoconjugate vaccines for use in immune-compromised populations |
| WO2003027135A2 (en) | 2001-09-26 | 2003-04-03 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services | Mutated anti-cd22 antibodies with increased affinity to cd22-expressing leukemia cells |
| CA2466443A1 (en) | 2001-11-09 | 2003-05-15 | Neopharm, Inc. | Selective treatment of il-13 expressing tumors |
| JP4813364B2 (ja) | 2003-11-25 | 2011-11-09 | アメリカ合衆国 | 突然変異型抗ｃｄ２２抗体および免疫複合体 |
| JP2010534061A (ja) * | 2007-07-20 | 2010-11-04 | ザ ジェネラル ホスピタル コーポレイション | 組換えコレラ菌外毒素 |
| ES2642516T3 (es) * | 2007-09-04 | 2017-11-16 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Supresiones en el dominio II de la exotoxina A de Pseudomonas que reducen la toxicidad no específica |
| CA2756393C (en) * | 2009-03-24 | 2017-06-20 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Anti-mesothelin antibodies |
| WO2011031441A1 (en) * | 2009-08-28 | 2011-03-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Therapy with a chimeric molecule and a pro-apoptotic agent |
| CN102655882B (zh) * | 2009-09-11 | 2014-11-19 | 美国政府健康及人类服务部 | 具有降低的免疫原性的改进的假单胞菌外毒素a |
| CA2800488A1 (en) * | 2010-05-26 | 2011-12-01 | Regents Of The University Of Minnesota | Single-chain variable fragment anti-cd133 antibodies and uses thereof |
| KR20140033391A (ko) * | 2011-06-09 | 2014-03-18 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 면역원성이 보다 낮은 t 세포 및/또는 b 세포 에피토프를 갖는 슈도모나스 외독소 a |
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2006
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2564092T3 (es) | 2016-03-17 |
| US8907060B2 (en) | 2014-12-09 |
| CA2616987C (en) | 2016-10-11 |
| ES2659039T3 (es) | 2018-03-13 |
| ES2702650T3 (es) | 2019-03-04 |
| EP3006457A1 (en) | 2016-04-13 |
| EP2332970B1 (en) | 2015-12-23 |
| EP3006456B1 (en) | 2018-09-19 |
| ES2372537T3 (es) | 2012-01-23 |
| EP1910407B1 (en) | 2011-09-14 |
| ES2660026T3 (es) | 2018-03-20 |
| EP2311854A1 (en) | 2011-04-20 |
| US20090142341A1 (en) | 2009-06-04 |
| AU2006275865A1 (en) | 2007-02-08 |
| ES2410783T3 (es) | 2013-07-03 |
| CA2941466A1 (en) | 2007-02-08 |
| WO2007016150A2 (en) | 2007-02-08 |
| WO2007016150A3 (en) | 2007-08-09 |
| EP3006456A1 (en) | 2016-04-13 |
| EP3006457B1 (en) | 2017-11-22 |
| EP1910407A2 (en) | 2008-04-16 |
| CA2616987A1 (en) | 2007-02-08 |
| PL3006456T3 (pl) | 2019-05-31 |
| ATE524489T1 (de) | 2011-09-15 |
| EP2332970A3 (en) | 2011-09-14 |
| CA2941466C (en) | 2019-12-03 |
| EP2332970A2 (en) | 2011-06-15 |
| EP3006458A1 (en) | 2016-04-13 |
| AU2006275865B2 (en) | 2012-06-28 |
| EP2311854B1 (en) | 2013-04-17 |
| EP3006458B1 (en) | 2017-11-22 |
| PL3006457T3 (pl) | 2018-05-30 |
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