PL2967013T3 - Mysz, w której zachodzi ekspresja ograniczonego repertuaru lekkiego łańcucha immunoglobuliny - Google Patents

Mysz, w której zachodzi ekspresja ograniczonego repertuaru lekkiego łańcucha immunoglobuliny

Info

Publication number: PL2967013T3
Authority: PL; Poland
Prior art keywords: light chain; immunoglobulin light; mice expressing; chain repertoire; limited immunoglobulin
Prior art date: 2013-03-13

Application number

PL14717331T

Other languages

English (en)

Inventor

Robert Babb

John Mcwhirter

Lynn Macdonald

Sean Stevens

Samuel Davis

David R. Buckler

Karolina A. Meagher

Andrew J. Murphy

Original Assignee

Regeneron Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-03-13

Filing date

2014-03-13

Publication date

2019-07-31

2013-03-13 Priority claimed from US13/798,455 external-priority patent/US9796788B2/en

2014-03-13 Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.

2019-07-31 Publication of PL2967013T3 publication Critical patent/PL2967013T3/pl

Links

102000013463 Immunoglobulin Light Chains Human genes 0.000 title 1
108010065825 Immunoglobulin Light Chains Proteins 0.000 title 1
241000699670 Mus sp. Species 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Biotechnology (AREA)
Environmental Sciences (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Biodiversity & Conservation Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Husbandry (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

PL14717331T 2013-03-13 2014-03-13 Mysz, w której zachodzi ekspresja ograniczonego repertuaru lekkiego łańcucha immunoglobuliny PL2967013T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US13/798,455 US9796788B2 (en)	2010-02-08	2013-03-13	Mice expressing a limited immunoglobulin light chain repertoire
EP14717331.4A EP2967013B1 (en)	2013-03-13	2014-03-13	Mice expressing a limited immunoglobulin light chain repertoire
PCT/US2014/026040 WO2014160202A1 (en)	2013-03-13	2014-03-13	Mice expressing a limited immunoglobulin light chain repertoire

Publications (1)

Publication Number	Publication Date
PL2967013T3 true PL2967013T3 (pl)	2019-07-31

Family

ID=50483561

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL14717331T PL2967013T3 (pl)	2013-03-13	2014-03-13	Mysz, w której zachodzi ekspresja ograniczonego repertuaru lekkiego łańcucha immunoglobuliny
PL18210518.9T PL3501272T3 (pl)	2013-03-13	2014-03-13	Mysz eksprymująca ograniczony repertuar lekkiego łańcucha immunoglobuliny

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL18210518.9T PL3501272T3 (pl)	2013-03-13	2014-03-13	Mysz eksprymująca ograniczony repertuar lekkiego łańcucha immunoglobuliny

Country Status (27)

Country	Link
EP (4)	EP4545567A2 (pl)
JP (4)	JP6529957B2 (pl)
KR (2)	KR102295842B1 (pl)
CN (2)	CN105188357B (pl)
AU (3)	AU2014244020B2 (pl)
BR (1)	BR112015022034B1 (pl)
CA (1)	CA2903698C (pl)
CY (1)	CY1121545T1 (pl)
DK (2)	DK2967013T3 (pl)
ES (3)	ES2942413T3 (pl)
FI (1)	FI3501272T3 (pl)
HK (1)	HK1218493A1 (pl)
HR (2)	HRP20230490T1 (pl)
HU (2)	HUE044003T2 (pl)
IL (2)	IL240563B (pl)
LT (2)	LT2967013T (pl)
MX (3)	MX391010B (pl)
PL (2)	PL2967013T3 (pl)
PT (2)	PT3501272T (pl)
RS (2)	RS64185B1 (pl)
RU (1)	RU2689664C2 (pl)
SG (2)	SG11201506278RA (pl)
SI (2)	SI2967013T1 (pl)
SM (2)	SMT202300112T1 (pl)
TR (1)	TR201901668T4 (pl)
WO (1)	WO2014160202A1 (pl)
ZA (2)	ZA201505835B (pl)

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US20130045492A1 (en)	2010-02-08	2013-02-21	Regeneron Pharmaceuticals, Inc.	Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
KR102432611B1 (ko)	2010-02-08	2022-08-16	리제너론 파마슈티칼스 인코포레이티드	일반적인 경쇄 마우스
US9796788B2 (en)	2010-02-08	2017-10-24	Regeneron Pharmaceuticals, Inc.	Mice expressing a limited immunoglobulin light chain repertoire
ES2990067T3 (es)	2011-08-05	2024-11-28	Regeneron Pharma	Ratones con cadena ligera universal humanizada
JP6271435B2 (ja)	2011-10-17	2018-01-31	リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	限定された免疫グロブリン重鎖のマウス
ES2759617T3 (es)	2012-06-12	2020-05-11	Regeneron Pharma	Animales no humanos humanizados con loci restringidos de cadena pesada de inmunoglobulina
CN105734081A (zh) *	2013-02-20	2016-07-06	瑞泽恩制药公司	具有修饰的免疫球蛋白重链序列的非人类动物
MX2016012274A (es)	2014-03-21	2017-05-23	Regeneron Pharma	Animales no humanos que producen proteinas de union de dominio simple.
CN107438622A (zh)	2015-03-19	2017-12-05	瑞泽恩制药公司	选择结合抗原的轻链可变区的非人动物
WO2017123804A1 (en)	2016-01-13	2017-07-20	Regeneron Pharmaceuticals, Inc.	Rodents having an engineered heavy chain diversity region
EP3688029A1 (en) *	2017-09-29	2020-08-05	Regeneron Pharmaceuticals, Inc.	Bispecific antigen-binding molecules that bind a staphylococcus target antigen and a complement component and uses thereof
IL318469A (en)	2018-06-14	2025-03-01	Regeneron Pharma	Non-human animals capable of reorganizing transgenic DH-DH, and their uses
EP3897117A1 (en) *	2018-12-21	2021-10-27	Compass Therapeutics LLC	Transgenic mouse expressing common human light chain
CN112400022B (zh)	2019-02-18	2023-06-30	百奥赛图(北京)医药科技股份有限公司	具有人源化免疫球蛋白基因座的经遗传修饰的非人动物
CA3127153A1 (en)	2019-02-22	2020-08-27	Regeneron Pharmaceuticals, Inc.	Rodents having genetically modified sodium channels and methods of use thereof
KR20210095781A (ko)	2020-01-24	2021-08-03	주식회사 에이프릴바이오	항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
IL298632A (en)	2020-06-02	2023-01-01	Biocytogen Pharmaceuticals Beijing Co Ltd	Genetically modified non-human animals with common light chain immunoglobulin locus
KR20230124594A (ko)	2020-12-23	2023-08-25	리제너론 파마슈티칼스 인코포레이티드	막관통 단백질 및 이를 생산하는 세포에 결합하는 항체를 수득하는 방법
WO2022140219A1 (en)	2020-12-23	2022-06-30	Regeneron Pharmaceuticals, Inc.	Nucleic acids encoding anchor modified antibodies and uses thereof
CN114736927A (zh) *	2022-05-19	2022-07-12	东北大学	一种单抗克隆与表达载体的构建及应用
TW202430641A (zh) *	2023-01-18	2024-08-01	美商基利科學股份有限公司	人類免疫球蛋白二元輕鏈轉殖基因構築體及其用途

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US7041871B1 (en) *	1995-10-10	2006-05-09	Genpharm International, Inc.	Transgenic non-human animals capable of producing heterologous antibodies
US6774279B2 (en)	1997-05-30	2004-08-10	Carnegie Institution Of Washington	Use of FLP recombinase in mice
US6737056B1 (en)	1999-01-15	2004-05-18	Genentech, Inc.	Polypeptide variants with altered effector function
US7105348B2 (en)	2000-10-31	2006-09-12	Regeneron Pharmaceuticals, Inc.	Methods of modifying eukaryotic cells
US6596541B2 (en) *	2000-10-31	2003-07-22	Regeneron Pharmaceuticals, Inc.	Methods of modifying eukaryotic cells
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DK2041177T3 (da)	2006-06-02	2012-02-27	Regeneron Pharma	Højaffinitetsantistoffer mod human IL-6-receptor
ITMI20071522A1 (it)	2007-07-27	2009-01-28	Areta Internat S R L	Vaccino idiotipico
EP3456192A1 (en) *	2008-06-27	2019-03-20	Merus N.V.	Antibody producing non-human mammals
CN102292445B (zh) *	2008-12-18	2025-04-04	伊拉兹马斯大学鹿特丹医学中心	表达人源化抗体的非人转基因动物及其用途
SG176868A1 (en)	2009-06-26	2012-02-28	Regeneron Pharma	Readily isolated bispecific antibodies with native immunoglobulin format
KR102432611B1 (ko)	2010-02-08	2022-08-16	리제너론 파마슈티칼스 인코포레이티드	일반적인 경쇄 마우스
US20130045492A1 (en) *	2010-02-08	2013-02-21	Regeneron Pharmaceuticals, Inc.	Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
US20120021409A1 (en) *	2010-02-08	2012-01-26	Regeneron Pharmaceuticals, Inc.	Common Light Chain Mouse
PT2480676E (pt) *	2010-06-22	2016-06-09	Regeneron Pharma	Ratinhos expressando uma cadeia leve híbrida de imunoglobulina
KR102306967B1 (ko) *	2010-08-02	2021-10-01	리제너론 파아마슈티컬스, 인크.	Ｖｌ 도메인을 포함하는 결합 단백질을 생성하는 마우스
RU2460287C1 (ru) *	2011-03-29	2012-09-10	Государственное образовательное учреждение высшего профессионального образования "Российский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО РГМУ Росздрава)	Трансгенная мышь, предназначенная для моделирования состояний, угрожающих развитием синдрома внезапной сердечной смерти при дистрофин-дефицитной кардиомиопатии
ES2990067T3 (es) *	2011-08-05	2024-11-28	Regeneron Pharma	Ratones con cadena ligera universal humanizada
GB201122047D0 (en) *	2011-12-21	2012-02-01	Kymab Ltd	Transgenic animals

2014
- 2014-03-13 PT PT182105189T patent/PT3501272T/pt unknown
- 2014-03-13 DK DK14717331.4T patent/DK2967013T3/en active
- 2014-03-13 HR HRP20230490TT patent/HRP20230490T1/hr unknown
- 2014-03-13 PL PL14717331T patent/PL2967013T3/pl unknown
- 2014-03-13 KR KR1020157026152A patent/KR102295842B1/ko active Active
- 2014-03-13 DK DK18210518.9T patent/DK3501272T5/da active
- 2014-03-13 MX MX2020010837A patent/MX391010B/es unknown
- 2014-03-13 ES ES18210518T patent/ES2942413T3/es active Active
- 2014-03-13 EP EP24223729.5A patent/EP4545567A2/en active Pending
- 2014-03-13 FI FIEP18210518.9T patent/FI3501272T3/fi active
- 2014-03-13 LT LTEP14717331.4T patent/LT2967013T/lt unknown
- 2014-03-13 SG SG11201506278RA patent/SG11201506278RA/en unknown
- 2014-03-13 MX MX2015012539A patent/MX357308B/es active IP Right Grant
- 2014-03-13 AU AU2014244020A patent/AU2014244020B2/en active Active
- 2014-03-13 WO PCT/US2014/026040 patent/WO2014160202A1/en active Application Filing
- 2014-03-13 KR KR1020217027031A patent/KR102424756B1/ko active Active
- 2014-03-13 LT LTEP18210518.9T patent/LT3501272T/lt unknown
- 2014-03-13 SM SM20230112T patent/SMT202300112T1/it unknown
- 2014-03-13 PL PL18210518.9T patent/PL3501272T3/pl unknown
- 2014-03-13 RS RS20230350A patent/RS64185B1/sr unknown
- 2014-03-13 ES ES23151398T patent/ES3013063T3/es active Active
- 2014-03-13 TR TR2019/01668T patent/TR201901668T4/tr unknown
- 2014-03-13 SG SG10201801101QA patent/SG10201801101QA/en unknown
- 2014-03-13 JP JP2016502035A patent/JP6529957B2/ja active Active
- 2014-03-13 MX MX2018008279A patent/MX377146B/es unknown
- 2014-03-13 CA CA2903698A patent/CA2903698C/en active Active
- 2014-03-13 SM SM20190196T patent/SMT201900196T1/it unknown
- 2014-03-13 CN CN201480013894.6A patent/CN105188357B/zh active Active
- 2014-03-13 HU HUE14717331A patent/HUE044003T2/hu unknown
- 2014-03-13 EP EP14717331.4A patent/EP2967013B1/en active Active
- 2014-03-13 CN CN201810439928.8A patent/CN108611369B/zh active Active
- 2014-03-13 PT PT14717331T patent/PT2967013T/pt unknown
- 2014-03-13 SI SI201431079T patent/SI2967013T1/sl unknown
- 2014-03-13 HU HUE18210518A patent/HUE061977T2/hu unknown
- 2014-03-13 ES ES14717331T patent/ES2712207T3/es active Active
- 2014-03-13 BR BR112015022034-7A patent/BR112015022034B1/pt active IP Right Grant
- 2014-03-13 SI SI201432022T patent/SI3501272T1/sl unknown
- 2014-03-13 EP EP18210518.9A patent/EP3501272B1/en active Active
- 2014-03-13 EP EP23151398.7A patent/EP4218409B1/en active Active
- 2014-03-13 RU RU2015143110A patent/RU2689664C2/ru active
- 2014-03-13 RS RS20190467A patent/RS58669B1/sr unknown
2015
- 2015-08-13 ZA ZA2015/05835A patent/ZA201505835B/en unknown
- 2015-08-13 IL IL240563A patent/IL240563B/en active IP Right Grant
2016
- 2016-06-06 HK HK16106453.9A patent/HK1218493A1/zh unknown
2018
- 2018-08-13 ZA ZA2018/05369A patent/ZA201805369B/en unknown
2019
- 2019-01-18 JP JP2019006738A patent/JP6790136B2/ja active Active
- 2019-04-05 CY CY20191100383T patent/CY1121545T1/el unknown
- 2019-04-16 HR HRP20190706TT patent/HRP20190706T1/hr unknown
- 2019-08-14 JP JP2019148806A patent/JP7010902B2/ja active Active
2020
- 2020-05-19 AU AU2020203238A patent/AU2020203238B2/en active Active
- 2020-07-29 JP JP2020128111A patent/JP2020182490A/ja active Pending
2021
- 2021-02-15 IL IL280892A patent/IL280892B2/en unknown
2023
- 2023-05-04 AU AU2023202783A patent/AU2023202783A1/en active Pending

Also Published As

Publication number	Publication date
BR112015022034B1 (pt)	2023-02-28
EP4218409A3 (en)	2023-08-30
MX2020010837A (es)	2022-03-28
HUE061977T2 (hu)	2023-09-28
CN105188357A (zh)	2015-12-23
WO2014160202A4 (en)	2014-11-13
LT3501272T (lt)	2023-03-27
AU2020203238A1 (en)	2020-06-11
EP4218409B1 (en)	2025-02-12
IL240563A0 (en)	2015-09-24
SI3501272T1 (sl)	2023-05-31
SI2967013T1 (sl)	2019-03-29
SG10201801101QA (en)	2018-04-27
CA2903698C (en)	2023-02-28
MX357308B (es)	2018-07-04
ES3013063T3 (en)	2025-04-10
EP4545567A2 (en)	2025-04-30
JP2019213549A (ja)	2019-12-19
EP2967013A1 (en)	2016-01-20
SG11201506278RA (en)	2015-09-29
KR102295842B1 (ko)	2021-08-31
IL280892A (en)	2021-04-29
IL240563B (en)	2021-03-25
MX377146B (es)	2025-03-07
FI3501272T3 (fi)	2023-04-06
ES2942413T3 (es)	2023-06-01
RU2019115237A (ru)	2019-06-11
CA2903698A1 (en)	2014-10-02
CN108611369A (zh)	2018-10-02
ZA201505835B (en)	2019-09-25
BR112015022034A2 (pt)	2017-08-29
MX391010B (es)	2025-03-21
DK3501272T5 (da)	2024-09-02
JP2020182490A (ja)	2020-11-12
JP6790136B2 (ja)	2020-11-25
SMT202300112T1 (it)	2023-05-12
HK1218493A1 (zh)	2017-02-24
ZA201805369B (en)	2021-08-25
KR20150126871A (ko)	2015-11-13
RS58669B1 (sr)	2019-06-28
IL280892B1 (en)	2023-01-01
CN108611369B (zh)	2022-08-26
AU2014244020B2 (en)	2020-06-04
MX2015012539A (es)	2016-06-28
PT2967013T (pt)	2019-04-03
JP6529957B2 (ja)	2019-06-12
EP4218409C0 (en)	2025-02-12
LT2967013T (lt)	2019-04-25
PT3501272T (pt)	2023-03-29
AU2020203238B2 (en)	2023-04-13
ES2712207T3 (es)	2019-05-09
HRP20230490T1 (hr)	2023-08-04
AU2014244020A1 (en)	2015-09-24
EP3501272B1 (en)	2023-03-01
RS64185B1 (sr)	2023-05-31
TR201901668T4 (tr)	2019-02-21
WO2014160202A1 (en)	2014-10-02
CY1121545T1 (el)	2020-05-29
NZ711776A (en)	2021-09-24
HRP20190706T1 (hr)	2019-10-18
CN105188357B (zh)	2018-04-24
SMT201900196T1 (it)	2019-05-10
JP2016512034A (ja)	2016-04-25
PL3501272T3 (pl)	2023-07-03
EP4218409A2 (en)	2023-08-02
JP2019076109A (ja)	2019-05-23
IL280892B2 (en)	2023-05-01
AU2023202783A1 (en)	2023-05-25
DK2967013T3 (en)	2019-03-11
RU2015143110A (ru)	2017-04-18
KR102424756B1 (ko)	2022-07-25
RU2689664C2 (ru)	2019-05-28
EP2967013B1 (en)	2019-01-16
DK3501272T3 (da)	2023-04-03
KR20210107911A (ko)	2021-09-01
EP3501272A1 (en)	2019-06-26
JP7010902B2 (ja)	2022-02-10
HUE044003T2 (hu)	2019-09-30

Publication	Publication Date	Title
IL280892A (en)	2021-04-29	Mice expressing a restricted immunoglobulin light chain repertoire
HK1218550A1 (zh)	2017-02-24	常見輕鏈小鼠
HUE041878T2 (hu)	2019-06-28	Humanizált fõ hisztokompatibilitási komplexet expresszáló egerek
HK1211336A1 (zh)	2016-05-20	照明裝置
GB2520939B (en)	2017-02-08	A Platform
GB201312495D0 (en)	2013-08-28	A capo
GB201305228D0 (en)	2013-05-01	A Chain
GB201304231D0 (en)	2013-04-24	A Chain
GB201300689D0 (en)	2013-02-27	A Chain
GB2512339B (en)	2015-09-30	A capo
FR3003924B1 (fr)	2016-09-09	Transmission a variation continue
UY4364S (es)	2014-10-31	Configuración ornamental aplicada a un envase
UY4363S (es)	2014-10-31	Configuración ornamental aplicada a un envase
UY4362S (es)	2014-10-31	Configuración ornamental aplicada a un envase
FI20155875L (fi)	2015-11-26	Prosessi hiilivetyjen valmistamiseksi
ZA201404694B (en)	2015-08-26	A traffic light
TH148594B (th)	2016-04-07	เชนไกด์
GB201302164D0 (en)	2013-03-27	A sheath