PL2021078T3 - Siarczanowany kwas hialuronowy do leczenia degeneracyjnej choroby zwyrodnieniowej stawów - Google Patents

Siarczanowany kwas hialuronowy do leczenia degeneracyjnej choroby zwyrodnieniowej stawów

Info

Publication number: PL2021078T3
Authority: PL; Poland
Prior art keywords: hyaluronic acid; treating degenerative; degenerative osteoarthritis; sulphated hyaluronic; sulphated
Prior art date: 2006-05-31

Application number

PL07724845T

Other languages

English (en)

Inventor

Lanfranco Callegaro

Davide Renier

Original Assignee

Fidia Farm Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-05-31

Filing date

2007-05-03

Publication date

2015-08-31

2007-05-03 Application filed by Fidia Farm Spa filed Critical Fidia Farm Spa

2015-08-31 Publication of PL2021078T3 publication Critical patent/PL2021078T3/pl

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
230000003412 degenerative effect Effects 0.000 title 1
201000008482 osteoarthritis Diseases 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physical Education & Sports Medicine (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

PL07724845T 2006-05-31 2007-05-03 Siarczanowany kwas hialuronowy do leczenia degeneracyjnej choroby zwyrodnieniowej stawów PL2021078T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT000219A ITPD20060219A1 (it)	2006-05-31	2006-05-31	Composizioni farmaceutiche contenenti acido ialuronico solfatato nel trattamento dell'osteoartrosi
EP07724845.8A EP2021078B1 (en)	2006-05-31	2007-05-03	Sulphated hyaluronic acid for treating degenerative osteoarthritis
PCT/EP2007/003920 WO2007137674A1 (en)	2006-05-31	2007-05-03	Sulphated hyaluronic acid for treating degenerative osteoarthritis

Publications (1)

Publication Number	Publication Date
PL2021078T3 true PL2021078T3 (pl)	2015-08-31

Family

ID=38353080

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL07724845T PL2021078T3 (pl)	2006-05-31	2007-05-03	Siarczanowany kwas hialuronowy do leczenia degeneracyjnej choroby zwyrodnieniowej stawów
PL14173163T PL2786782T3 (pl)	2006-05-31	2007-05-03	Siarczanowany kwas hialuronowy do leczenia degeneracyjnej choroby zwyrodnieniowej stawów

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL14173163T PL2786782T3 (pl)	2006-05-31	2007-05-03	Siarczanowany kwas hialuronowy do leczenia degeneracyjnej choroby zwyrodnieniowej stawów

Country Status (14)

Country	Link
US (3)	US20090197807A1 (pl)
EP (2)	EP2786782B1 (pl)
JP (1)	JP5537933B2 (pl)
KR (1)	KR20090014359A (pl)
CN (1)	CN101454048B (pl)
AU (1)	AU2007268195A1 (pl)
CA (1)	CA2653660C (pl)
DK (1)	DK2021078T3 (pl)
ES (2)	ES2534763T3 (pl)
IT (1)	ITPD20060219A1 (pl)
MX (1)	MX2008015212A (pl)
PL (2)	PL2021078T3 (pl)
SI (2)	SI2786782T1 (pl)
WO (1)	WO2007137674A1 (pl)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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JP5088864B2 (ja) *	2007-03-16	2012-12-05	オリンパス株式会社	生体組織補填材とその製造方法
ES2658354T3 (es) *	2008-02-15	2018-03-09	Bone Therapeutics S.A.	Composición farmacéutica para el uso en el tratamiento y/o la prevención de enfermedades osteoarticulares
US8343942B2 (en)	2008-04-04	2013-01-01	University Of Utah Research Foundation	Methods for treating interstitial cystitis
KR101594552B1 (ko) *	2008-04-04	2016-02-17	유니버시티 오브 유타 리서치 파운데이션	알킬화된 반합성 글리코사미노글리코산 에테르 및 이의 제조 및 사용 방법
IT1393945B1 (it) *	2009-04-21	2012-05-17	Fidia Farmaceutici	Composizioni comprendenti acido ialuronico, acido ialuronico solfatato, calcio e vitamina d3 nel trattamento delle malattie osteoarticolari e muscoloscheletriche
IT1397246B1 (it) *	2009-05-14	2013-01-04	Fidia Farmaceutici	Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica
IT1397247B1 (it) *	2009-05-14	2013-01-04	Fidia Farmaceutici	Nuovi agenti regolatori dell'attivita' citochinica
US20120219554A2 (en)	2009-05-14	2012-08-30	Fidia Farmaceutici S.P.A.	Extracellular yaluronidase from streptomyces koganeiensis
IT1397522B1 (it) *	2009-12-21	2013-01-16	Solartium Entpr Ltd	Uso di una combinazione per il trattamento dell'osteoartrosi
US8546353B2 (en)	2010-05-06	2013-10-01	Glykos Finland Oy	Compounds and combinations
EP2384759A1 (en) *	2010-05-06	2011-11-09	Suomen Punainen Risti Veripalvelu	Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells
EP2688402B1 (en)	2011-03-23	2018-10-24	University of Utah Research Foundation	Means for treating or preventing urological inflammation
CN103796659A (zh) *	2011-07-13	2014-05-14	车比奥及戴奥斯泰有限公司	包含胶原、透明质酸衍生物和哺乳动物脐带来源干细胞的软骨细胞治疗物
TWI466675B (zh)	2011-09-16	2015-01-01	Univ China Medical	用於抑制發炎之醫藥組合物
ITPD20120098A1 (it) *	2012-03-30	2013-10-01	Fidia Farmaceutici	"nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico"
JP6208763B2 (ja) *	2012-09-20	2017-10-11	マクカイメモリアルホスピタル	変形性関節症を治療するためのｐｅｄｆ−由来のポリペプチドの使用
US20140186306A1 (en) *	2012-09-28	2014-07-03	Paul Ronald Plante	Novel ampk agonist compositions and methods of use
WO2014165513A2 (en) *	2013-04-02	2014-10-09	The Regents Of The University Of California	Ethylsulfonated hyaluronic acid biopolymers and methods of use thereof
KR101895950B1 (ko) *	2015-12-18	2018-09-06	(주)한국비엠아이	골관절염 치료를 위한 친수화된 설파살라진 및 히알루론산을 포함하는 조성물 및 이의제조방법
US20190091258A1 (en)	2016-03-02	2019-03-28	Bortek Bor Teknolojileri Ve Mekatronik Sanayi Ticaret Anonim Sirketi	Therapeutic mixtures for treating osteoarthritis comprising nano hexagonal boron nitride composition
TWI632915B (zh) *	2016-05-31	2018-08-21	大江生醫股份有限公司	用以治療關節炎之醫藥組成物
US11337994B2 (en)	2016-09-15	2022-05-24	University Of Utah Research Foundation	In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
WO2020055202A1 (ko) *	2018-09-13	2020-03-19	주식회사 엘지화학	황산화 히알루론산 기반의 하이드로겔 및 이를 포함하는 약제학적 조성물
CN111228653A (zh)	2018-11-13	2020-06-05	格莱科米拉治疗公司	用电离辐射加强癌症治疗的方法
WO2021133000A1 (ko) *	2019-12-23	2021-07-01	주식회사 엘지화학	항염 또는 항혈관신생용 약제학적 조성물

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LU85582A1 (fr)	1983-10-11	1985-06-04	Fidia Spa	Fractions d'acide hyaluronique ayant une activite pharmaceutique,procedes pour leur preparation et compositions pharmaceutiques les contenant
US4713448A (en)	1985-03-12	1987-12-15	Biomatrix, Inc.	Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
ITPD940054A1 (it)	1994-03-23	1995-09-23	Fidia Advanced Biopolymers Srl	Polisaccaridi solfatati
EP0754460B1 (en)	1995-02-07	2002-06-05	Shiseido Company Limited	Antiinflammatory agents
DK0971961T3 (da) *	1997-04-04	2003-03-24	Fidia Advanced Biopolymers Srl	N-sulfaterede hyaluronsyreforbindelser, derivater deraf og en fremgangsmåde til deres fremstilling
IT1294797B1 (it) *	1997-07-28	1999-04-15	Fidia Advanced Biopolymers Srl	Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante
US6476005B1 (en)	1998-03-24	2002-11-05	George D. Petito	Oral and injectable nutritional composition
US6645948B2 (en)	1998-03-24	2003-11-11	George D. Petito	Nutritional composition for the treatment of connective tissue
IT1302534B1 (it) *	1998-12-21	2000-09-05	Fidia Advanced Biopolymers Srl	Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
IT1306644B1 (it)	1999-04-08	2001-10-02	Fidia Advanced Biopolymers Srl	Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico.
US6288043B1 (en) *	1999-06-18	2001-09-11	Orquest, Inc.	Injectable hyaluronate-sulfated polysaccharide conjugates
JP2001163789A (ja) *	1999-12-13	2001-06-19	Maruho Co Ltd	マトリックスメタロプロテアーゼ阻害用医薬組成物
US6924273B2 (en)	2000-10-03	2005-08-02	Scott W. Pierce	Chondroprotective/restorative compositions and methods of use thereof
DE10053053A1 (de) *	2000-10-19	2002-05-16	Knoell Hans Forschung Ev	Pharmazeutische Formulierungen zur Hemmung von entzündlichen Arthritiden
US6607745B2 (en)	2001-05-18	2003-08-19	Harry Leneau	Ingestion of hyaluronic acid for improved joint function and health
MXPA01011542A (es)	2001-11-13	2003-05-22	Alcon Inc	Regeneracion del cartilago articular da°ado por la osteoartritis de grado i y ii, mediante la aplicacion intra-articular de una mezcla de hialuronato de sodio y de condroitin sulfato en un vehiculo de gel.
IL165910A0 (en) *	2002-07-03	2006-01-15	Pericor Science Inc	Compositions of hyaluronic acid and methods of use
CZ13928U1 (cs)	2003-10-08	2004-01-20	Cpn Spol. S R.O.	Dietetický přípravek pro prevenci a léčbu osteoporózy
ITPD20040053A1 (it) *	2004-02-27	2004-05-27	Fidia Advanced Biopolymers Srl	Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi

2006
- 2006-05-31 IT IT000219A patent/ITPD20060219A1/it unknown
2007
- 2007-05-03 JP JP2009512441A patent/JP5537933B2/ja not_active Expired - Fee Related
- 2007-05-03 MX MX2008015212A patent/MX2008015212A/es active IP Right Grant
- 2007-05-03 AU AU2007268195A patent/AU2007268195A1/en not_active Abandoned
- 2007-05-03 DK DK07724845T patent/DK2021078T3/en active
- 2007-05-03 CA CA2653660A patent/CA2653660C/en active Active
- 2007-05-03 ES ES07724845.8T patent/ES2534763T3/es active Active
- 2007-05-03 EP EP14173163.8A patent/EP2786782B1/en active Active
- 2007-05-03 WO PCT/EP2007/003920 patent/WO2007137674A1/en active Application Filing
- 2007-05-03 ES ES14173163.8T patent/ES2619309T3/es active Active
- 2007-05-03 PL PL07724845T patent/PL2021078T3/pl unknown
- 2007-05-03 EP EP07724845.8A patent/EP2021078B1/en active Active
- 2007-05-03 CN CN2007800196566A patent/CN101454048B/zh not_active Expired - Fee Related
- 2007-05-03 PL PL14173163T patent/PL2786782T3/pl unknown
- 2007-05-03 SI SI200731910A patent/SI2786782T1/sl unknown
- 2007-05-03 US US12/302,511 patent/US20090197807A1/en not_active Abandoned
- 2007-05-03 KR KR1020087029029A patent/KR20090014359A/ko not_active Ceased
- 2007-05-03 SI SI200731640T patent/SI2021078T1/sl unknown
2012
- 2012-03-01 US US13/410,227 patent/US8765714B2/en active Active
2014
- 2014-04-11 US US14/251,318 patent/US9295690B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2007137674A1 (en)	2007-12-06
CN101454048A (zh)	2009-06-10
HK1197040A1 (en)	2015-01-02
JP5537933B2 (ja)	2014-07-02
MX2008015212A (es)	2008-12-09
CA2653660C (en)	2014-07-29
ES2619309T3 (es)	2017-06-26
HK1123235A1 (en)	2009-06-12
DK2021078T3 (en)	2015-04-27
SI2021078T1 (sl)	2015-05-29
ITPD20060219A1 (it)	2007-12-01
PL2786782T3 (pl)	2017-08-31
CN101454048B (zh)	2013-06-19
AU2007268195A1 (en)	2007-12-06
US9295690B2 (en)	2016-03-29
EP2021078B1 (en)	2015-02-25
JP2009538840A (ja)	2009-11-12
US20090197807A1 (en)	2009-08-06
ES2534763T3 (es)	2015-04-28
US8765714B2 (en)	2014-07-01
EP2786782A1 (en)	2014-10-08
KR20090014359A (ko)	2009-02-10
CA2653660A1 (en)	2007-12-06
US20140221294A1 (en)	2014-08-07
EP2786782B1 (en)	2017-03-08
EP2021078A1 (en)	2009-02-11
US20120165254A1 (en)	2012-06-28
SI2786782T1 (sl)	2017-06-30

Publication	Publication Date	Title
PL2786782T3 (pl)	2017-08-31	Siarczanowany kwas hialuronowy do leczenia degeneracyjnej choroby zwyrodnieniowej stawów
PT2173324T (pt)	2019-07-09	Gel injetável de ácido hialurónico para tratamento de degenerescências articulares
EP1991365B8 (en)	2015-03-25	Methods for forming silver-nanoparticle treated surfaces
EP2231230A4 (en)	2013-01-23	ARTICULAR INJECTION SYSTEM
ZA201101055B (en)	2014-07-30	Compositions and methods for treating osteoarthritis
HRP20150148T1 (en)	2015-06-19	Method for processing biomaterials
ZA200903919B (en)	2010-06-30	Hyaluronic acid gel for intradermal injection
ZA200908898B (en)	2014-11-26	Dentifruce compositions for treating xerostomia
GB0602125D0 (en)	2006-03-15	Sensitizer-incorporated biomaterials
EP2117620A4 (en)	2010-12-01	PROTOELASTINE BIOMATERIALS FROM TROOELASTINE
EP2123631A4 (en)	2010-06-23	PROCESS FOR PRODUCTION OF -ALCOXYPROPIONAMIDE
GB0611210D0 (en)	2006-07-19	Process
PL2129760T3 (pl)	2017-01-31	Produkt do traktowania twardych powierzchni
PL2445510T3 (pl)	2018-06-29	Kompozycja do leczenia zwyrodnieniowych chorób stawów
GB0607394D0 (en)	2006-05-24	Process
GB0607395D0 (en)	2006-05-24	Process
PL2376121T3 (pl)	2016-12-30	Leczenie zapalenia kości i stawów
EP2322220A4 (en)	2012-08-29	THERAPEUTIC AGENT OR PREVENTIVE AGENT FOR ARTHROSIS
GB0611741D0 (en)	2006-07-26	Process
GB0604874D0 (en)	2006-04-19	Process
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