PL1999109T3 - Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych - Google Patents

Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych

Info

Publication number: PL1999109T3
Authority: PL; Poland
Prior art keywords: binding; amyloid plaques; styrylpyridine; imaging amyloid; compounds
Prior art date: 2006-03-30

Application number

PL07753982T

Other languages

English (en)

Inventor

Hank F Kung

Mei-Ping Kung

Original Assignee

Univ Pennsylvania

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-30

Filing date

2007-03-26

Publication date

2012-05-31

2007-03-26 Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania

2012-05-31 Publication of PL1999109T3 publication Critical patent/PL1999109T3/pl

Links

208000037259 Amyloid Plaque Diseases 0.000 title abstract 5
BIAWAXVRXKIUQB-UHFFFAOYSA-N 2-(2-phenylethenyl)pyridine Chemical class C=1C=CC=CC=1C=CC1=CC=CC=N1 BIAWAXVRXKIUQB-UHFFFAOYSA-N 0.000 title abstract 3
238000003384 imaging method Methods 0.000 title abstract 3
238000000034 method Methods 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
102000009091 Amyloidogenic Proteins Human genes 0.000 abstract 1
108010048112 Amyloidogenic Proteins Proteins 0.000 abstract 1
238000004220 aggregation Methods 0.000 abstract 1
230000002776 aggregation Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Optics & Photonics (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Neurology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Communicable Diseases (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL07753982T 2006-03-30 2007-03-26 Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych PL1999109T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US78715606P	2006-03-30	2006-03-30
EP07753982A EP1999109B1 (en)	2006-03-30	2007-03-26	Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
PCT/US2007/007400 WO2007126733A2 (en)	2006-03-30	2007-03-26	Styrylpyridine derivatives and their use for binding and imaging amyloid plaques

Publications (1)

Publication Number	Publication Date
PL1999109T3 true PL1999109T3 (pl)	2012-05-31

Family

ID=38326579

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL07753982T PL1999109T3 (pl)	2006-03-30	2007-03-26	Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych
PL11152124T PL2363392T3 (pl)	2006-03-30	2007-03-26	Styrylopirydynowe pochodne i ich zastosowanie do wiązania i obrazowania płytek amyloidowych

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL11152124T PL2363392T3 (pl)	2006-03-30	2007-03-26	Styrylopirydynowe pochodne i ich zastosowanie do wiązania i obrazowania płytek amyloidowych

Country Status (34)

Country	Link
US (3)	US7687052B2 (pl)
EP (3)	EP2363391A1 (pl)
JP (1)	JP5290954B2 (pl)
KR (1)	KR101376807B1 (pl)
CN (1)	CN101522624B (pl)
AT (1)	ATE539060T1 (pl)
AU (1)	AU2007243712B2 (pl)
BR (1)	BRPI0710225B1 (pl)
CA (1)	CA2644530C (pl)
CR (1)	CR10329A (pl)
CY (3)	CY1113048T1 (pl)
DK (2)	DK2363392T3 (pl)
EA (1)	EA017898B1 (pl)
EC (1)	ECSP088783A (pl)
ES (2)	ES2378785T3 (pl)
FR (1)	FR13C0034I2 (pl)
GT (1)	GT200800201A (pl)
HR (2)	HRP20120135T1 (pl)
HU (2)	HUE032660T2 (pl)
IL (1)	IL193567A (pl)
LT (1)	LT2363392T (pl)
LU (1)	LU92232I2 (pl)
MX (1)	MX2008012527A (pl)
NO (2)	NO342090B1 (pl)
NZ (1)	NZ570887A (pl)
PL (2)	PL1999109T3 (pl)
PT (2)	PT1999109E (pl)
RS (2)	RS52222B (pl)
SG (1)	SG173338A1 (pl)
SI (2)	SI1999109T1 (pl)
TW (1)	TWI399366B (pl)
UA (1)	UA97802C2 (pl)
WO (1)	WO2007126733A2 (pl)
ZA (1)	ZA200807955B (pl)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5290954B2 (ja) *	2006-03-30	2013-09-18	ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア	スチリルピリジン誘導体及びアミロイド斑を結合させ画像化するためのその使用
JP5322180B2 (ja) *	2007-07-04	2013-10-23	国立大学法人東北大学	フッ素およびヒドロキシ基で置換されたアルコキシ基を有するｐｅｔプローブ
JP5603855B2 (ja) *	2008-04-04	2014-10-08	アビッドレディオファーマシューティカルズ、インク．	神経変成疾患の放射性薬剤による画像化
ES2620402T3 (es) *	2008-12-31	2017-06-28	Avid Radiopharmaceuticals, Inc.	Sintesis de estirilpiridinas radiomarcadas con 18F a partir de precursores de tosilato y composiciones farmacéuticas estables de las mismas
CN102471177A (zh) *	2009-07-10	2012-05-23	拜耳医药股份有限公司	低至中压液相色谱在放射性示踪剂纯化中的应用
US20120263646A1 (en)	2009-10-15	2012-10-18	Guerbet	Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
EP2515948A1 (en) *	2009-12-23	2012-10-31	Piramal Imaging SA	Formulations suitable for pet imaging with hydrophobic pet agents
WO2011141515A1 (en)	2010-05-14	2011-11-17	Bayer Pharma Aktiengesellschaft	Diagnostic agents for amyloid beta imaging
TWI504414B (zh)	2010-06-04	2015-10-21	Bayer Schering Pharma Ag	生產Ｆ－１８標記之Ａβ配位體之方法
JP2013527211A (ja) *	2010-06-04	2013-06-27	ピラマルイメージングソシエテアノニム	Ｆ−１８標識アミロイド・ベータ・リガンドの製造方法
EP2575898B8 (en) *	2010-06-04	2021-04-21	Life Molecular Imaging SA	Method for production of f-18 labeled amyloid beta ligand
CN103269724B (zh)	2010-06-04	2017-06-23	皮拉马影像股份公司	生产F‑18标记的β‑淀粉样蛋白配体的方法
CN101891674B (zh) *	2010-06-24	2012-11-14	山东大学	4-苯乙烯基吡啶类化合物及其制备方法与应用
EP2627361B1 (en) *	2010-10-12	2017-09-20	Mayo Foundation For Medical Education And Research	Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
US20140079635A1 (en) *	2011-03-30	2014-03-20	Case Western Reserve University	Molecular probes for detecting lipid composition
CN106729771A (zh)	2011-04-21	2017-05-31	加利福尼亚大学董事会	官能化磁性纳米颗粒及在淀粉样沉积物和神经原纤维缠结成像中用途
AU2012324940A1 (en)	2011-10-19	2014-04-17	Piramal Imaging Sa	Improved method for production of F-18 labeled Abeta ligands
CN109125745B (zh)	2012-04-10	2022-07-26	蓝瑟斯医学影像公司	放射性药物合成方法
JP6099045B2 (ja) *	2013-04-30	2017-03-22	国立大学法人京都大学	トリアゾロピリミジン誘導体化合物
JP6041751B2 (ja) *	2013-05-07	2016-12-14	日本メジフィジックス株式会社	スチリルピリジン誘導体化合物
JP2014218454A (ja) *	2013-05-07	2014-11-20	日本メジフィジックス株式会社	スチリルピリジン誘導体化合物
CN103645254B (zh) *	2013-11-28	2015-01-07	江苏省原子医学研究所	一种Aβ斑块显像剂前体AV45的含量分析方法
SG10201805628TA (en)	2014-05-13	2018-08-30	Hoffmann La Roche	Deuterated heterocyclic compounds and their use as imaging agents
US10478513B2 (en)	2015-08-18	2019-11-19	The Regents Of The University Of Califonia	Nitroxide containing amyloid binding agents for imaging and therapeutic uses
US10300155B2 (en)	2015-12-31	2019-05-28	Washington University	Alpha-synuclein ligands
CN109400615B (zh) *	2017-08-18	2021-07-16	上海交通大学医学院附属新华医院	一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
CN108299287A (zh) *	2018-01-02	2018-07-20	北京师范大学	与Aβ斑块具有高亲和力的N2S2类吡啶基苯乙烯化合物
CN114805190A (zh) *	2022-06-08	2022-07-29	吉林大学第一医院	一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法
WO2024107620A1 (en)	2022-11-14	2024-05-23	Eli Lilly And Company	Polymorphic forms of florbetapir precursor av-105

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992000963A1 (en) *	1990-07-12	1992-01-23	Yoshitomi Pharmaceutical Industries, Ltd.	Styryl compounds and use thereof as medicine
JPH0545875A (ja) *	1991-08-08	1993-02-26	Konica Corp	感光性組成物
US6020436A (en) *	1993-03-09	2000-02-01	The Chromaline Corporation	Photosensitive resin composition
TW544448B (en) *	1997-07-11	2003-08-01	Novartis Ag	Pyridine derivatives
WO2001070667A1 (fr) *	2000-03-22	2001-09-27	Bf Research Institute, Inc.	Sonde de diagnostic par image, a base d'azobenzene substitue ou d'un analogue de celui-ci, pour les maladies imputables a l'accumulation d'amyloide et composition pour le diagnostic par image le contenant
US8007954B2 (en)	2000-11-09	2011-08-30	The Trustees Of The University Of Pennsylvania	Use of sulfur-containing fuels for direct oxidation fuel cells
JP2002182254A (ja)	2000-12-18	2002-06-26	Fuji Photo Film Co Ltd	非線形光学材料とその製造方法
ES2435070T3 (es) *	2001-08-27	2013-12-18	The Trustees Of The University Of Pennsylvania	Derivados de estilbeno y su uso para unión y formación de imágenes de placas amiloides
AU2003248623B2 (en)	2002-06-06	2009-05-14	The Trustees Of The University Of Pennsylvania	Ceramic anodes and method of producing the same
WO2004016271A1 (en) *	2002-08-14	2004-02-26	Axxima Pharmaceuticals Ag	Pyrimidones as antiviral agents
JP4482352B2 (ja)	2004-03-11	2010-06-16	本田技研工業株式会社	固体高分子型燃料電池
CA2591534C (en) *	2004-12-17	2013-08-06	The Trustees Of The University Of Pennsylvania	Stilbene derivatives and their use for binding and imaging amyloid plaques
WO2006078384A2 (en) *	2004-12-17	2006-07-27	The Trustees Of The University Of Pennsylvania	Stilbene derivatives and their use
US20070031328A1 (en) *	2005-06-24	2007-02-08	Kung Hank F	Radiolabeled-pegylation of ligands for use as imaging agents
JP5290954B2 (ja) *	2006-03-30	2013-09-18	ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア	スチリルピリジン誘導体及びアミロイド斑を結合させ画像化するためのその使用
US20080253967A1 (en) *	2007-04-13	2008-10-16	Kung Hank F	Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques

2007
- 2007-03-26 JP JP2009502912A patent/JP5290954B2/ja active Active
- 2007-03-26 PL PL07753982T patent/PL1999109T3/pl unknown
- 2007-03-26 EA EA200870389A patent/EA017898B1/ru not_active IP Right Cessation
- 2007-03-26 EP EP11152115A patent/EP2363391A1/en not_active Withdrawn
- 2007-03-26 PL PL11152124T patent/PL2363392T3/pl unknown
- 2007-03-26 BR BRPI0710225-9A patent/BRPI0710225B1/pt active IP Right Grant
- 2007-03-26 PT PT07753982T patent/PT1999109E/pt unknown
- 2007-03-26 SG SG2011048477A patent/SG173338A1/en unknown
- 2007-03-26 SI SI200730865T patent/SI1999109T1/sl unknown
- 2007-03-26 WO PCT/US2007/007400 patent/WO2007126733A2/en active Application Filing
- 2007-03-26 ES ES07753982T patent/ES2378785T3/es active Active
- 2007-03-26 AT AT07753982T patent/ATE539060T1/de active
- 2007-03-26 ES ES11152124.1T patent/ES2628882T3/es active Active
- 2007-03-26 DK DK11152124.1T patent/DK2363392T3/en active
- 2007-03-26 NZ NZ570887A patent/NZ570887A/en unknown
- 2007-03-26 UA UAA200812698A patent/UA97802C2/uk unknown
- 2007-03-26 MX MX2008012527A patent/MX2008012527A/es active IP Right Grant
- 2007-03-26 DK DK07753982.3T patent/DK1999109T3/da active
- 2007-03-26 CN CN2007800116909A patent/CN101522624B/zh active Active
- 2007-03-26 LT LTEP11152124.1T patent/LT2363392T/lt unknown
- 2007-03-26 AU AU2007243712A patent/AU2007243712B2/en active Active
- 2007-03-26 EP EP07753982A patent/EP1999109B1/en active Active
- 2007-03-26 US US11/727,401 patent/US7687052B2/en active Active
- 2007-03-26 EP EP11152124.1A patent/EP2363392B1/en active Active
- 2007-03-26 HU HUE11152124A patent/HUE032660T2/en unknown
- 2007-03-26 RS RS20120077A patent/RS52222B/en unknown
- 2007-03-26 PT PT111521241T patent/PT2363392T/pt unknown
- 2007-03-26 RS RS20170578A patent/RS56171B1/sr unknown
- 2007-03-26 CA CA2644530A patent/CA2644530C/en active Active
- 2007-03-26 SI SI200731938T patent/SI2363392T1/sl unknown
- 2007-04-26 TW TW096114833A patent/TWI399366B/zh active
2008
- 2008-08-05 US US12/186,072 patent/US8506929B2/en active Active
- 2008-08-20 IL IL193567A patent/IL193567A/en active IP Right Grant
- 2008-09-16 ZA ZA2008/07955A patent/ZA200807955B/en unknown
- 2008-09-29 KR KR1020087023884A patent/KR101376807B1/ko active Active
- 2008-09-30 GT GT200800201A patent/GT200800201A/es unknown
- 2008-09-30 CR CR10329A patent/CR10329A/es unknown
- 2008-09-30 EC EC2008008783A patent/ECSP088783A/es unknown
- 2008-10-29 NO NO20084590A patent/NO342090B1/no active Protection Beyond IP Right Term
2012
- 2012-02-10 HR HR20120135T patent/HRP20120135T1/hr unknown
- 2012-03-07 CY CY20121100225T patent/CY1113048T1/el unknown
2013
- 2013-01-07 US US13/735,609 patent/US8840866B2/en active Active
- 2013-06-26 LU LU92232C patent/LU92232I2/fr unknown
- 2013-06-26 FR FR13C0034C patent/FR13C0034I2/fr active Active
- 2013-06-27 HU HUS1300028C patent/HUS1300028I1/hu unknown
- 2013-06-27 CY CY2013024C patent/CY2013024I2/el unknown
2017
- 2017-06-06 HR HRP20170857TT patent/HRP20170857T1/hr unknown
- 2017-06-22 CY CY20171100664T patent/CY1119048T1/el unknown
2018
- 2018-09-11 NO NO2018030C patent/NO2018030I1/no unknown

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Publication number	Publication date
PT2363392T (pt)	2017-06-15
ATE539060T1 (de)	2012-01-15
US8506929B2 (en)	2013-08-13
WO2007126733A3 (en)	2008-03-06
DK2363392T3 (en)	2017-07-03
BRPI0710225A2 (pt)	2011-08-02
NO2018030I1 (no)	2018-09-11
PL2363392T3 (pl)	2017-10-31
US20090123369A1 (en)	2009-05-14
US8840866B2 (en)	2014-09-23
EA017898B1 (ru)	2013-04-30
TWI399366B (zh)	2013-06-21
CA2644530C (en)	2015-05-19
CN101522624B (zh)	2013-11-06
EP1999109B1 (en)	2011-12-28
EP1999109A2 (en)	2008-12-10
CY2013024I1 (el)	2015-11-04
EP2363392A1 (en)	2011-09-07
RS56171B1 (sr)	2017-11-30
EP2363392B1 (en)	2017-05-03
CY1113048T1 (el)	2015-11-04
NO342090B1 (no)	2018-03-19
HRP20120135T1 (hr)	2012-03-31
ES2628882T3 (es)	2017-08-04
US20130129624A1 (en)	2013-05-23
US20080038195A1 (en)	2008-02-14
CR10329A (es)	2008-10-29
HRP20170857T1 (hr)	2017-12-01
EP2363391A1 (en)	2011-09-07
ES2378785T3 (es)	2012-04-17
RS52222B (en)	2012-10-31
JP5290954B2 (ja)	2013-09-18
CY2013024I2 (el)	2015-11-04
SI1999109T1 (sl)	2012-04-30
US7687052B2 (en)	2010-03-30
MX2008012527A (es)	2008-10-14
NO20084590L (no)	2008-12-29
FR13C0034I2 (fr)	2014-03-07
DK1999109T3 (da)	2012-04-02
FR13C0034I1 (pl)	2013-08-09
NZ570887A (en)	2011-05-27
ZA200807955B (en)	2012-11-28
CN101522624A (zh)	2009-09-02
GT200800201A (es)	2009-08-20
LT2363392T (lt)	2017-07-25
BRPI0710225B1 (pt)	2021-07-13
SI2363392T1 (sl)	2017-09-29
TW200838852A (en)	2008-10-01
HUE032660T2 (en)	2017-10-30
EA200870389A1 (ru)	2009-04-28
CA2644530A1 (en)	2007-11-08
SG173338A1 (en)	2011-08-29
IL193567A0 (en)	2009-05-04
AU2007243712A1 (en)	2007-11-08
ECSP088783A (es)	2008-10-31
LU92232I2 (fr)	2013-08-26
LU92232I9 (pl)	2019-01-15
HUS1300028I1 (hu)	2017-08-28
AU2007243712B2 (en)	2013-01-10
KR101376807B1 (ko)	2014-03-20
KR20080106564A (ko)	2008-12-08
CY1119048T1 (el)	2018-01-10
PT1999109E (pt)	2012-03-16
IL193567A (en)	2014-03-31
UA97802C2 (uk)	2012-03-26
WO2007126733A2 (en)	2007-11-08
JP2009532349A (ja)	2009-09-10

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