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PL1991303T3 - Sposób i urządzenie do leczenia mikroskopowych nowotworów pozostałych w tkankach po resekcji chirurgicznej - Google Patents

Sposób i urządzenie do leczenia mikroskopowych nowotworów pozostałych w tkankach po resekcji chirurgicznej

Info

Publication number
PL1991303T3
PL1991303T3 PL07751865T PL07751865T PL1991303T3 PL 1991303 T3 PL1991303 T3 PL 1991303T3 PL 07751865 T PL07751865 T PL 07751865T PL 07751865 T PL07751865 T PL 07751865T PL 1991303 T3 PL1991303 T3 PL 1991303T3
Authority
PL
Poland
Prior art keywords
surgical resection
following surgical
tissues following
residual tumors
microscopic residual
Prior art date
Application number
PL07751865T
Other languages
English (en)
Inventor
Paul Goldfarb
Dietmar Rabussay
Original Assignee
Oncosec Medical Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncosec Medical Incorporated filed Critical Oncosec Medical Incorporated
Publication of PL1991303T3 publication Critical patent/PL1991303T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Surgical Instruments (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL07751865T 2006-03-03 2007-03-02 Sposób i urządzenie do leczenia mikroskopowych nowotworów pozostałych w tkankach po resekcji chirurgicznej PL1991303T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77874006P 2006-03-03 2006-03-03
PCT/US2007/005133 WO2007103070A2 (en) 2006-03-03 2007-03-02 Method and device for treating microscopic residual tumors remaining in tissues following surgical resection
EP07751865.2A EP1991303B1 (en) 2006-03-03 2007-03-02 Method and device for treating microscopic residual tumors remaining in tissues following surgical resection

Publications (1)

Publication Number Publication Date
PL1991303T3 true PL1991303T3 (pl) 2021-10-11

Family

ID=38475369

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07751865T PL1991303T3 (pl) 2006-03-03 2007-03-02 Sposób i urządzenie do leczenia mikroskopowych nowotworów pozostałych w tkankach po resekcji chirurgicznej

Country Status (12)

Country Link
US (4) US9037230B2 (pl)
EP (2) EP1991303B1 (pl)
JP (3) JP2009528131A (pl)
KR (2) KR101444471B1 (pl)
CN (2) CN102921102B (pl)
AU (1) AU2007224275B2 (pl)
CA (1) CA2644163C (pl)
DK (1) DK1991303T3 (pl)
ES (1) ES2874482T3 (pl)
NO (2) NO344476B1 (pl)
PL (1) PL1991303T3 (pl)
WO (1) WO2007103070A2 (pl)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102921102B (zh) 2006-03-03 2015-06-10 基因特伦尼克斯公司 用于治疗在外科切除术后残留在组织中的微小残余肿瘤的装置
US8349554B2 (en) * 2007-08-14 2013-01-08 Fred Hutchinson Cancer Research Center Needle array assembly and method for delivering therapeutic agents
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
AU2009243079A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US10448989B2 (en) 2009-04-09 2019-10-22 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
WO2009155526A2 (en) * 2008-06-20 2009-12-23 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
US8632534B2 (en) 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
WO2010138919A2 (en) 2009-05-28 2010-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
CA2689400C (en) * 2009-12-30 2023-01-10 Kenneth W. Adams Therapeutic agent delivery apparatus and process
KR20230151558A (ko) 2010-04-28 2023-11-01 이노비오 파마수티컬즈, 인크. 구강 점막 전기천공 장치 및 그 용도
US9700368B2 (en) 2010-10-13 2017-07-11 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
WO2012172424A1 (en) 2011-06-15 2012-12-20 Crontech Pharma Ab Injection needle and device
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
JP2014534864A (ja) 2011-10-28 2014-12-25 プレサージュ バイオサイエンシズ，インコーポレイテッド 薬物デリバリー方法
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
WO2015175570A1 (en) 2014-05-12 2015-11-19 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US12114911B2 (en) 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
US10287543B2 (en) * 2015-11-19 2019-05-14 Miltenyi Biotec, Gmbh Process and device for isolating cells from biological tissue
US20170232253A1 (en) * 2016-02-16 2017-08-17 Marcy C. Purnell Bioelectrodynamics Modulation Method
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
CA3082568A1 (en) 2017-11-15 2019-05-23 Alcyone Lifesciences, Inc. Therapy specific, pre-programmed auto injection device
CN112543661A (zh) * 2017-11-17 2021-03-23 艾伯维公司 治疗胶质母细胞瘤的方法
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
JP2021508533A (ja) 2017-12-26 2021-03-11 ギャラリー，インコーポレイテッド 様々な用途のためのエネルギー送達の最適化
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
US12214189B2 (en) 2019-07-24 2025-02-04 Virginia Tech Intellectual Properties, Inc. Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies
CN116509535B (zh) * 2023-03-14 2024-01-23 武汉金柏威光电技术有限公司 一种医用高频电刀

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747469A (en) * 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5702359A (en) 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US20030060434A1 (en) * 1997-02-18 2003-03-27 Loretta Nielsen Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
IL133708A0 (en) * 1997-06-30 2001-04-30 Rhone Poulence Rorer S A Improved method for transferring nucleic acid into multicelled eukaryotic organism cells and combination thereof
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6224019B1 (en) 1998-01-26 2001-05-01 Simula, Inc. Parachute landing velocity attenuator
US6208893B1 (en) * 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6104584A (en) * 1999-02-18 2000-08-15 Lucent Technologies, Inc. Voltage feedback inrush current limit circuit having increased tolerance for component value variation
JP2003527841A (ja) * 1999-12-23 2003-09-24 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド 三つ葉ドメイン含有ポリヌクレオチド、ポリペプチドおよび抗体
CA2401327C (en) 2000-03-03 2014-05-06 Valentis, Inc. Nucleic acid formulations comprising poly-amino acids for gene delivery and methods of use
US6428504B1 (en) 2000-04-06 2002-08-06 Varian Medical Systems, Inc. Multipurpose template and needles for the delivery and monitoring of multiple minimally invasive therapies
US20040092860A1 (en) * 2000-07-26 2004-05-13 Dev Nagendu B. Skin and muscle-targeted gene therapy by pulsed electrical field
CA2478614C (en) * 2001-03-13 2013-01-15 University Of South Florida Electromanipulation device and method
CN1638780A (zh) * 2001-12-14 2005-07-13 遗传电子公司 用脉冲电场进行颗粒辅助的多核苷酸免疫的方法
WO2003075978A2 (en) 2002-03-07 2003-09-18 Merck & Co., Inc. Clinical syringe with electrical stimulation aspects
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
ATE519499T1 (de) * 2002-05-10 2011-08-15 Agennix Inc Lactoferrin bei der behandlung maligner neoplasien und anderer hyperproliferativer erkrankungen
US20040014645A1 (en) * 2002-05-28 2004-01-22 Advisys, Inc. Increased delivery of a nucleic acid construct in vivo by the poly-L-glutamate ("PLG") system
JP4409239B2 (ja) * 2003-09-18 2010-02-03 テルモ株式会社 薬液注入装置
US7234824B2 (en) * 2003-09-22 2007-06-26 Langley Nicholas M Glare-elimination device for surgical microscopes
US20050209625A1 (en) * 2004-03-02 2005-09-22 Chan Frank A Method and apparatus for electrical stimulation to enhance lancing device performance
WO2006015299A2 (en) * 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US20070088345A1 (en) 2005-10-13 2007-04-19 Ust Inc. Applications of HIFU and chemotherapy
CN102921102B (zh) 2006-03-03 2015-06-10 基因特伦尼克斯公司 用于治疗在外科切除术后残留在组织中的微小残余肿瘤的装置
US7671095B2 (en) * 2006-05-31 2010-03-02 The Trustees Of The Boston University Films and particles
EP2066399B1 (en) * 2006-10-17 2018-10-03 Inovio Pharmaceuticals, Inc. Electroporation devices and methods of using same for electroporation of cells in mammals

Also Published As

Publication number Publication date
EP1991303B1 (en) 2021-05-05
EP1991303A2 (en) 2008-11-19
JP2009528131A (ja) 2009-08-06
ES2874482T3 (es) 2021-11-05
JP6174632B2 (ja) 2017-08-02
NO20084148L (no) 2008-11-13
KR101529448B1 (ko) 2015-06-18
JP2015213778A (ja) 2015-12-03
JP2013127000A (ja) 2013-06-27
US20210308451A1 (en) 2021-10-07
NO344476B1 (no) 2020-01-13
WO2007103070A3 (en) 2008-08-28
CN101426550B (zh) 2012-10-31
AU2007224275A1 (en) 2007-09-13
US20070239099A1 (en) 2007-10-11
US9037230B2 (en) 2015-05-19
CN102921102A (zh) 2013-02-13
NO20191102A1 (no) 2008-11-13
US11007365B2 (en) 2021-05-18
DK1991303T3 (da) 2021-06-07
CN102921102B (zh) 2015-06-10
KR101444471B1 (ko) 2014-09-24
AU2007224275B2 (en) 2012-04-12
CA2644163A1 (en) 2007-09-13
US20170216585A1 (en) 2017-08-03
WO2007103070A2 (en) 2007-09-13
CA2644163C (en) 2020-05-05
CN101426550A (zh) 2009-05-06
KR20140081894A (ko) 2014-07-01
EP3845269A1 (en) 2021-07-07
EP1991303A4 (en) 2012-01-18
US20120143120A1 (en) 2012-06-07
KR20090004890A (ko) 2009-01-12

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