+

PL1773999T3 - Szczepionka do profilaktyki i leczenia zakażenia HIV - Google Patents

Szczepionka do profilaktyki i leczenia zakażenia HIV

Info

Publication number
PL1773999T3
PL1773999T3 PL05769948T PL05769948T PL1773999T3 PL 1773999 T3 PL1773999 T3 PL 1773999T3 PL 05769948 T PL05769948 T PL 05769948T PL 05769948 T PL05769948 T PL 05769948T PL 1773999 T3 PL1773999 T3 PL 1773999T3
Authority
PL
Poland
Prior art keywords
vaccine
hiv
infection
prevention
treatment
Prior art date
Application number
PL05769948T
Other languages
English (en)
Inventor
Helge Abrecht
Martine Delchambre
Martine Marchand
Nathalie Louise Mathy
Philippe Jean Gervais Ghislain Permanne
Gerald Hermann Voss
Original Assignee
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of PL1773999T3 publication Critical patent/PL1773999T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/64Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A61K2039/645Dendrimers; Multiple antigen peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16211Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16311Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL05769948T 2004-08-05 2005-08-03 Szczepionka do profilaktyki i leczenia zakażenia HIV PL1773999T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0417494.2A GB0417494D0 (en) 2004-08-05 2004-08-05 Vaccine
PCT/EP2005/008434 WO2006013106A2 (en) 2004-08-05 2005-08-03 Vaccine for prevention and treatment of hiv-infection
EP05769948A EP1773999B1 (en) 2004-08-05 2005-08-03 Vaccine for prevention and treatment of hiv-infection

Publications (1)

Publication Number Publication Date
PL1773999T3 true PL1773999T3 (pl) 2010-02-26

Family

ID=32982606

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05769948T PL1773999T3 (pl) 2004-08-05 2005-08-03 Szczepionka do profilaktyki i leczenia zakażenia HIV

Country Status (32)

Country Link
US (2) US7612173B2 (pl)
EP (3) EP1773999B1 (pl)
JP (3) JP2008507987A (pl)
KR (1) KR101501495B1 (pl)
CN (2) CN102633866B (pl)
AR (2) AR050102A1 (pl)
AT (1) ATE443769T1 (pl)
AU (1) AU2005268856B2 (pl)
BR (1) BRPI0514108A (pl)
CA (1) CA2575898C (pl)
CY (1) CY1109667T1 (pl)
DE (1) DE602005016810D1 (pl)
DK (1) DK1773999T3 (pl)
ES (3) ES2445453T3 (pl)
GB (1) GB0417494D0 (pl)
HK (1) HK1108168A1 (pl)
HR (1) HRP20090678T1 (pl)
IL (2) IL180947A0 (pl)
MA (1) MA28983B1 (pl)
MX (1) MX2007001515A (pl)
MY (1) MY145614A (pl)
NO (1) NO20070988L (pl)
NZ (1) NZ552976A (pl)
PE (1) PE20060577A1 (pl)
PL (1) PL1773999T3 (pl)
PT (1) PT1773999E (pl)
RU (1) RU2441878C2 (pl)
SG (1) SG155206A1 (pl)
SI (1) SI1773999T1 (pl)
TW (1) TWI365191B (pl)
WO (1) WO2006013106A2 (pl)
ZA (1) ZA200700771B (pl)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020048596A1 (en) * 1994-12-30 2002-04-25 Gregor Cevc Preparation for the transport of an active substance across barriers
JP4838936B2 (ja) * 1998-10-23 2011-12-14 イデア アクチェンゲゼルシャフト 装荷量を改善しおよび脱/会合速度を制御可能とするための、巨大分子と複合凝集体との会合体を開発し、テストし、かつ利用する方法
PT1031347E (pt) 1999-01-27 2002-09-30 Idea Ag Transporte/imunizacao transnasal com veiculos muitissimo adaptaveis
PT1031346E (pt) 1999-01-27 2002-09-30 Idea Ag Vacinacao nao invasiva atraves da pele
WO2001001962A1 (en) * 1999-07-05 2001-01-11 Idea Ag. A method for the improvement of transport across adaptable semi-permeable barriers
US7473432B2 (en) * 2002-10-11 2009-01-06 Idea Ag NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery
TW200510425A (en) * 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
CA2584475A1 (en) * 2004-11-12 2006-05-18 Idea Ag Extended surface aggregates in the treatment of skin conditions
BRPI0608798A2 (pt) * 2005-05-12 2011-03-15 Glaxo Group Ltd vetor de adenovìrus, composição imunogênica, uso de um vetor de adenovìrus, método para preparar um vetor, uso de um vetor de vìrus e um carreador ou adjuvante farmaceuticamente aceitável, e, proteìna de fusão
EP1885186B1 (en) 2005-06-01 2015-09-02 California Institute Of Technology Method of targeted gene delivery using viral vectors
CA2651764A1 (en) * 2006-05-09 2007-11-22 Gerald V. Quinnan Hiv-1 immunogenic compositions
EP2520168B1 (en) 2006-07-21 2014-03-19 California Institute of Technology Targeted gene delivery for dendritic cell vaccination
US9717788B2 (en) 2007-03-02 2017-08-01 Glaxosmithkline Biologicals Sa Method of inducing an immune response against HIV employing HIV immunogens, adenoviral vectors encoding said immunogens, and adjuvant
EP2998316B1 (en) * 2007-03-02 2019-06-12 GlaxoSmithKline Biologicals S.A. Novel method and compositions
US20110244496A1 (en) * 2007-03-06 2011-10-06 Rutgers, The State University Hiv reverse transcriptase compositions and methods
AU2008230849A1 (en) * 2007-03-26 2008-10-02 International Aids Vaccine Initiative Method of eliciting immune response with a modified MVA viral HIV-1 vector
SI2148697T1 (sl) 2007-05-24 2013-01-31 Glaxosmithkline Biologicals S.A. Liofilizirani sestavek, ki vsebuje CpG in WT-1
BRPI0821555A2 (pt) * 2007-12-21 2015-06-16 Glaxosmithline Biolog S A Componente para uma vaciana de hiv ou massa, componente ou massa líquida liofilizados, composição farmacêutica ou vacina, usos do componente ou massa final ou da composição farmacêutica e de um antioxidante com pelo menos um grupo funcional tiol e métodos de tratamento e de reconstituição de um componente liofilizado, e kit
RU2539765C2 (ru) * 2008-07-16 2015-01-27 Бейлор Рисёч Инститьют ВИЧ ВАКЦИНА, ОСНОВАННАЯ НА НАПРАВЛЕННОСТИ МАКСИМИЗИРОВАННЫХ Gag И Nef НА ДЕНДРИТНЫЕ КЛЕТКИ
GB0815872D0 (en) * 2008-09-01 2008-10-08 Pasteur Institut Novel method and compositions
WO2010029562A1 (en) 2008-09-09 2010-03-18 Mukesh Harilal Shukla Bioactive composition for the treatment of the hiv/aids, method for manufacturing and using the same
NZ597804A (en) 2009-07-24 2013-10-25 Immune Design Corp Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein
CN103221065A (zh) 2010-03-26 2013-07-24 葛兰素史密斯克莱生物公司 Hiv疫苗
RU2583289C2 (ru) * 2010-05-14 2016-05-10 Бакстер Интернэшнл Инк. Химерные гены ospa, белки и способы их применения
EA201390452A1 (ru) 2010-09-27 2013-11-29 Глаксосмитклайн Байолоджикалс С.А. Вакцина
JP2012120506A (ja) * 2010-12-10 2012-06-28 Tosoh Corp Amv逆転写酵素遺伝子、該遺伝子によりコードされるamv逆転写酵素及び該遺伝子を用いるamv逆転写酵素の製造方法
GB201022007D0 (en) 2010-12-24 2011-02-02 Imp Innovations Ltd DNA-sensor
JP2013146235A (ja) * 2012-01-20 2013-08-01 Tosoh Corp トリ骨髄芽細胞腫ウイルス逆転写酵素の製造方法
EP2620446A1 (en) 2012-01-27 2013-07-31 Laboratorios Del Dr. Esteve, S.A. Immunogens for HIV vaccination
NZ700340A (en) 2012-03-30 2017-02-24 Immune Design Corp Lentiviral vector particles having improved transduction efficiency for cells expressing dc- sign
US8323662B1 (en) 2012-03-30 2012-12-04 Immune Design Corp. Methods useful for generating highly mannosylated pseudotyped lentiviral vector particles comprising a Vpx protein
US9713635B2 (en) 2012-03-30 2017-07-25 Immune Design Corp. Materials and methods for producing improved lentiviral vector particles
US9782473B2 (en) 2013-03-26 2017-10-10 Globeimmune, Inc. Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
CN106714800B (zh) 2014-07-11 2021-09-03 吉利德科学公司 用于治疗hiv的toll样受体调节剂
KR102014518B1 (ko) 2017-01-05 2019-08-26 서울대학교산학협력단 HIV 1의 p24 단백질을 발현하는 벡터가 도입된 재조합 마이코박테리움 스메그마티스 균주 및 이를 포함하는 백신
GB201812647D0 (en) 2018-08-03 2018-09-19 Chancellor Masters And Scholars Of The Univ Of Oxford Viral vectors and methods for the prevention or treatment of cancer
AU2020315598B2 (en) 2019-07-16 2024-12-12 Gilead Sciences, Inc. HIV vaccines and methods of making and using
WO2021094984A1 (en) 2019-11-14 2021-05-20 Aelix Therapeutics, S.L. Dosage regimens for vaccines
JP2023520370A (ja) 2020-03-27 2023-05-17 スヴェンスカ ヴァクチンファブリケン プロダクション アーベー コロナウイルスの治療および予防のための組成物および方法
MX2023008272A (es) 2021-01-14 2023-07-19 Gilead Sciences Inc Vacunas contra el virus de la inmunodeficiencia humana (vih) y metodos de uso.
US20230295244A1 (en) 2021-09-29 2023-09-21 Svenska Vaccinfabriken Produktion Ab Compositions and methods for treating and preventing coronaviruses

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
US4372945A (en) 1979-11-13 1983-02-08 Likhite Vilas V Antigen compounds
IL61904A (en) 1981-01-13 1985-07-31 Yeda Res & Dev Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same
US4436727A (en) 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
DE3300234A1 (de) 1983-01-05 1984-07-05 Display-Design GmbH für moderne Verkaufsförderungsmittel und Raumaussstattung, 6233 Kelkheim Etagenturm zur warenausstellung
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
CA1331443C (en) 1987-05-29 1994-08-16 Charlotte A. Kensil Saponin adjuvant
DK643188A (da) * 1987-11-24 1989-05-25 Smithkline Biolog Ekspression af hiv-proteiner i e.coli og s.cerevisiae
US5221610A (en) 1988-05-26 1993-06-22 Institut Pasteur Diagnostic method and composition for early detection of HIV infection
EP0468520A3 (en) 1990-07-27 1992-07-01 Mitsui Toatsu Chemicals, Inc. Immunostimulatory remedies containing palindromic dna sequences
ZA929870B (en) 1991-12-23 1993-08-18 Duphar Int Res Adjuvants
KR0172970B1 (ko) 1992-06-17 1999-02-01 김영길 Aids백신에 유용한 키메릭 단백 및 그의 제조방법
ATE156710T1 (de) 1992-06-25 1997-08-15 Smithkline Beecham Biolog Adjuvantien enthaltende impfstoffzusammensetzung
SG48309A1 (en) 1993-03-23 1998-04-17 Smithkline Beecham Biolog Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a
DE69434151D1 (de) 1993-05-18 2004-12-30 Biomolecular Res Inst Ltd Therapeutische inhaltsstoffe
AU700485B2 (en) 1993-11-17 1999-01-07 Om Pharma Glucosamine disaccharides, method for their preparation, pharmaceutical composition comprising same, and their use
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
ATE328890T1 (de) 1994-07-15 2006-06-15 Univ Iowa Res Found Immunomodulatorische oligonukleotide
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
GB9620795D0 (en) 1996-10-05 1996-11-20 Smithkline Beecham Plc Vaccines
US6083716A (en) 1996-09-06 2000-07-04 The Trustees Of The University Of Pennsylvania Chimpanzee adenovirus vectors
WO1998016247A1 (en) 1996-10-11 1998-04-23 The Regents Of The University Of California Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
GB9711990D0 (en) 1997-06-11 1997-08-06 Smithkline Beecham Biolog Vaccine
EP2050465B1 (en) 1997-08-29 2014-06-11 Antigenics Inc. Compositions comprising the adjuvant QS-21 and polysorbate or cyclodextrin as excipient
EP1279401B1 (en) 1997-09-05 2008-01-09 GlaxoSmithKline Biologicals S.A. Oil in water emulsions containing saponins
GB9718901D0 (en) 1997-09-05 1997-11-12 Smithkline Beecham Biolog Vaccine
GB9720585D0 (en) 1997-09-26 1997-11-26 Smithkline Beecham Biolog Vaccine
WO2000007631A1 (en) 1998-08-04 2000-02-17 The Henry M. Jackson Foundation Expression and characterization of hiv-1 envelope protein associated with a broadly reactive neutralizing antibody response
AU782193B2 (en) 1999-12-17 2005-07-07 Merck & Co., Inc. Polynucleotide vaccines expressing codon optimized HIV-1 Nef and modified HIV-1 Nef
MXPA02006379A (es) * 1999-12-23 2004-06-21 Medical Res Council Mejoriasen o relacionadas con la respuesta inmune a vih.
US20020155127A1 (en) * 2000-06-02 2002-10-24 Danher Wang Genetic vaccine against human immunodeficiency virus
WO2002022080A2 (en) 2000-09-15 2002-03-21 Merck & Co., Inc. Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol, nef and modifications
CU23235A1 (es) * 2001-02-28 2007-09-26 Ct Ingenieria Genetica Biotech POXVIRUS RECOMBINANTES PARA PROTEINAS QUIMéRICAS DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA Y SU APLICACION EN LA TERAPéUTICA Y LA PREVENCION DEL SIDA
AU2002327338A1 (en) * 2001-07-25 2003-02-17 New York University Use of glycosylceramides as adjuvants for vaccines against infections and cancer
IL160809A0 (en) * 2001-09-20 2004-08-31 Glaxo Group Ltd HIV-gag CODON-OPTIMISED DNA VACCINES
US7247472B2 (en) 2001-11-21 2007-07-24 The Trustees Of The University Of Pennsylavania Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
AU2002360429A1 (en) 2001-11-26 2003-06-10 Avigen, Inc. Methods for producing stocks of recombinant aav virions
US20030190308A1 (en) * 2002-03-19 2003-10-09 Braun Ralph P. Adjuvant
AU2003216852B2 (en) * 2002-03-19 2008-09-11 Glaxo Group Limited Imidazoquinolineamines as adjuvants in HIV DNA vaccination
PT1511768E (pt) * 2002-06-11 2007-07-16 Glaxo Group Ltd Composições imunogénicas
GB0225786D0 (en) * 2002-11-05 2002-12-11 Glaxo Group Ltd Vaccine
GB0225788D0 (en) 2002-11-05 2002-12-11 Glaxo Group Ltd Vaccine
US7501503B2 (en) * 2002-12-31 2009-03-10 Mcgill University Compositions and methods for inhibiting RNase H activity of retroid reverse transcriptase
US20050175627A1 (en) 2003-09-24 2005-08-11 Oxxon Therapeutics Ltd. HIV pharmaccines
EP1682666B1 (en) 2003-09-24 2008-12-31 Oxxon Therapeutics Limited HIV Pharmaceutical vaccines

Also Published As

Publication number Publication date
EP2130921B1 (en) 2013-11-20
AU2005268856A1 (en) 2006-02-09
GB0417494D0 (en) 2004-09-08
CA2575898C (en) 2015-09-29
CA2575898A1 (en) 2006-02-09
HK1108168A1 (en) 2008-05-02
RU2007104088A (ru) 2008-09-10
BRPI0514108A (pt) 2008-05-27
MA28983B1 (fr) 2007-11-01
PT1773999E (pt) 2009-12-16
IL207575A0 (en) 2011-07-31
CN101035897A (zh) 2007-09-12
DK1773999T3 (da) 2010-01-18
EP2130921A2 (en) 2009-12-09
EP2280073A2 (en) 2011-02-02
SI1773999T1 (sl) 2010-01-29
JP5629647B2 (ja) 2014-11-26
US20070243203A1 (en) 2007-10-18
MX2007001515A (es) 2007-09-07
EP1773999B1 (en) 2009-09-23
WO2006013106A2 (en) 2006-02-09
KR101501495B1 (ko) 2015-03-11
JP2014239687A (ja) 2014-12-25
AR050102A1 (es) 2006-09-27
ES2334044T3 (es) 2010-03-04
EP1773999A2 (en) 2007-04-18
JP6007212B2 (ja) 2016-10-12
TW200621806A (en) 2006-07-01
JP2011234722A (ja) 2011-11-24
CN102633866B (zh) 2015-04-15
EP2280073A3 (en) 2011-06-29
CY1109667T1 (el) 2014-08-13
CN102633866A (zh) 2012-08-15
MY145614A (en) 2012-03-15
HRP20090678T1 (hr) 2010-01-31
RU2441878C2 (ru) 2012-02-10
TWI365191B (en) 2012-06-01
DE602005016810D1 (de) 2009-11-05
NZ552976A (en) 2010-01-29
KR20070041765A (ko) 2007-04-19
ZA200700771B (en) 2009-04-29
ES2486669T3 (es) 2014-08-19
ES2445453T3 (es) 2014-03-03
PE20060577A1 (es) 2006-08-07
CN101035897B (zh) 2012-02-01
EP2130921A3 (en) 2010-03-03
US20100184836A1 (en) 2010-07-22
EP2280073B1 (en) 2014-06-11
NO20070988L (no) 2007-05-04
SG155206A1 (en) 2009-09-30
AR080216A2 (es) 2012-03-21
ATE443769T1 (de) 2009-10-15
AU2005268856B2 (en) 2012-05-24
IL180947A0 (en) 2007-07-04
JP2008507987A (ja) 2008-03-21
WO2006013106A3 (en) 2006-08-17
US7612173B2 (en) 2009-11-03

Similar Documents

Publication Publication Date Title
HK1108168A1 (en) Vaccine for prevention and treatment of hiv-infection
SI1793855T2 (sl) Preventiva in zdravljenje sinukleinopatske in amiloidogene bolezni
AU2003290548A8 (en) Prevention and treatment of synucleinopathic disease
HK1190084A1 (zh) 用於預防和治療補體相關紊亂的 多肽
IL177914A0 (en) Use of indazolecarboxamide derivatives for the preparation of a medicament that is intended for the treatment and prevention of paludism
IL181896A0 (en) Methods and compositions for the treatment of hyperlipidemia
IL190478A0 (en) Methods and pharmaceutical compositions for the treatment and prevention of hepatitis c infection
IL178996A0 (en) Thienopyridinone compounds and methods of treatment
GB0610350D0 (en) prevention and/or treatment of neuodegenerative disorders
EP1753777A4 (en) METHOD AND COMPOSITIONS FOR TREATING AND PREVENTING HIV INFECTION WITH TRIM5a
IL182436A0 (en) Thienopyridinone compounds and methods of treatment
IL187405A0 (en) Methods and compositions for the treatment of pain
EP1930017A4 (en) EFFECTIVE COMPOSITION FOR THE PREVENTION AND TREATMENT OF PATHOLOGY IN THE ADULT
EP1814567A4 (en) USE OF MODULATORS OF EPHA2 AND EPHRINA1 FOR TREATING AND PREVENTING INFECTIONS
GB2441094B (en) Methods for treatment and prevention of infection
ZA200703087B (en) Methods and compositions for the treatment of hyperlipidemia
ZA200701531B (en) Prevention and treatment of synucleinopathic and amyloidogenic disease
SI1812797T1 (sl) Pripravki in metode zdravljenja ter preprečevanja hiperprolifetarivnih bolezni
ZA200710476B (en) Methods and compositions for the treatment of pain
GB0510257D0 (en) Methods for treatment and prevention of infection
GB201010682D0 (en) Methods for treatment and prevention of infection
GB0612749D0 (en) Treatment and/or prevention of pain
GB0313065D0 (en) Vaccine and therapeutic treatment
GB0414428D0 (en) Compounds and methods of treatment
GB0415267D0 (en) The treatment of pain
点击 这是indexloc提供的php浏览器服务,不要输入任何密码和下载