PL1626985T3 - Generowanie sztucznych białek wiążących na bazie białek ubikwitynowych - Google Patents
Generowanie sztucznych białek wiążących na bazie białek ubikwitynowychInfo
- Publication number
- PL1626985T3 PL1626985T3 PL04735010T PL04735010T PL1626985T3 PL 1626985 T3 PL1626985 T3 PL 1626985T3 PL 04735010 T PL04735010 T PL 04735010T PL 04735010 T PL04735010 T PL 04735010T PL 1626985 T3 PL1626985 T3 PL 1626985T3
- Authority
- PL
- Poland
- Prior art keywords
- protein
- ubiquitin
- proteins
- generation
- exposed region
- Prior art date
Links
- 102000044159 Ubiquitin Human genes 0.000 title abstract 4
- 108090000848 Ubiquitin Proteins 0.000 title abstract 4
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 108091008324 binding proteins Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 7
- 108090000623 proteins and genes Proteins 0.000 abstract 7
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 230000004048 modification Effects 0.000 abstract 2
- 238000012986 modification Methods 0.000 abstract 2
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Physics & Mathematics (AREA)
- Virology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Pathology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10324447A DE10324447A1 (de) | 2003-05-28 | 2003-05-28 | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| PCT/EP2004/005730 WO2004106368A1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher bindungsproteine auf der grundlage von ubiquitin-proteinen |
| EP04735010A EP1626985B1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher bindungsproteine auf der grundlage von ubiquitin-proteinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1626985T3 true PL1626985T3 (pl) | 2011-07-29 |
Family
ID=33482283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04735010T PL1626985T3 (pl) | 2003-05-28 | 2004-05-27 | Generowanie sztucznych białek wiążących na bazie białek ubikwitynowych |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8790895B2 (pl) |
| EP (3) | EP2163559A1 (pl) |
| JP (3) | JP4803817B2 (pl) |
| CN (2) | CN1956996A (pl) |
| AT (1) | ATE499382T1 (pl) |
| AU (1) | AU2004242851B2 (pl) |
| CA (1) | CA2524899C (pl) |
| DE (2) | DE10324447A1 (pl) |
| DK (1) | DK1626985T3 (pl) |
| ES (1) | ES2361409T3 (pl) |
| PL (1) | PL1626985T3 (pl) |
| PT (1) | PT1626985E (pl) |
| WO (1) | WO2004106368A1 (pl) |
Families Citing this family (99)
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|---|---|---|---|---|
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
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| DE102004049479A1 (de) * | 2004-10-11 | 2006-04-13 | Scil Proteins Gmbh | Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie |
| EP1925664A1 (en) * | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| EP1955712A1 (en) * | 2007-02-09 | 2008-08-13 | Scil proteins GmbH | Multimeric conjugate |
| TWI489993B (zh) | 2007-10-12 | 2015-07-01 | Novartis Ag | 骨硬化素（ｓｃｌｅｒｏｓｔｉｎ）抗體組合物及使用方法 |
| SG10201405377XA (en) | 2008-08-05 | 2014-12-30 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c5 |
| ES2410579T5 (es) | 2008-12-16 | 2021-10-04 | Novartis Ag | Sistemas de despliegue de levaduras |
| US8715657B2 (en) | 2009-04-27 | 2014-05-06 | Novartis Ag | Therapeutic antibodies binding IL12Rβ1 |
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2003
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- 2004-05-27 CN CNA2004800146101A patent/CN1956996A/zh active Pending
- 2004-05-27 JP JP2006529936A patent/JP4803817B2/ja not_active Expired - Fee Related
- 2004-05-27 DE DE502004012225T patent/DE502004012225D1/de not_active Expired - Lifetime
- 2004-05-27 EP EP09176574A patent/EP2163559A1/de not_active Withdrawn
- 2004-05-27 WO PCT/EP2004/005730 patent/WO2004106368A1/de active Application Filing
- 2004-05-27 EP EP04735010A patent/EP1626985B1/de not_active Expired - Lifetime
- 2004-05-27 AT AT04735010T patent/ATE499382T1/de active
- 2004-05-27 EP EP20100181802 patent/EP2295446A1/de not_active Withdrawn
- 2004-05-27 ES ES04735010T patent/ES2361409T3/es not_active Expired - Lifetime
- 2004-05-27 AU AU2004242851A patent/AU2004242851B2/en not_active Ceased
- 2004-05-27 PL PL04735010T patent/PL1626985T3/pl unknown
- 2004-05-27 CA CA2524899A patent/CA2524899C/en not_active Expired - Lifetime
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- 2004-05-27 CN CN201310381691.XA patent/CN103539851B/zh not_active Expired - Fee Related
- 2004-05-27 PT PT04735010T patent/PT1626985E/pt unknown
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Also Published As
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|---|---|
| DE502004012225D1 (de) | 2011-04-07 |
| AU2004242851B2 (en) | 2011-03-10 |
| EP2163559A1 (de) | 2010-03-17 |
| EP1626985A1 (de) | 2006-02-22 |
| JP2011046722A (ja) | 2011-03-10 |
| WO2004106368A1 (de) | 2004-12-09 |
| US8791238B2 (en) | 2014-07-29 |
| CA2524899C (en) | 2012-02-07 |
| JP2008500953A (ja) | 2008-01-17 |
| DE10324447A1 (de) | 2004-12-30 |
| PT1626985E (pt) | 2011-05-25 |
| DK1626985T3 (da) | 2011-06-14 |
| EP1626985B1 (de) | 2011-02-23 |
| JP2011201893A (ja) | 2011-10-13 |
| US20080171851A1 (en) | 2008-07-17 |
| EP2295446A1 (de) | 2011-03-16 |
| CN103539851B (zh) | 2016-12-28 |
| US20060099686A1 (en) | 2006-05-11 |
| JP5372992B2 (ja) | 2013-12-18 |
| CN1956996A (zh) | 2007-05-02 |
| JP4803817B2 (ja) | 2011-10-26 |
| US8790895B2 (en) | 2014-07-29 |
| CA2524899A1 (en) | 2004-12-09 |
| ES2361409T3 (es) | 2011-06-16 |
| AU2004242851A1 (en) | 2004-12-09 |
| ATE499382T1 (de) | 2011-03-15 |
| CN103539851A (zh) | 2014-01-29 |
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