PH31664A - Watersoluble azole antifungals. - Google Patents

Watersoluble azole antifungals.

Info

Publication number: PH31664A
Authority: PH; Philippines
Prior art keywords: hydrogen; 6alkyl; pct; image; watersoluble
Prior art date: 1994-01-24

Application number

PH49798A

Other languages

English (en)

Inventor

Heeres Jan

Eycken Van Der Luc Alfons Leo

Backx Leo Jacobus Josef

Odds Frank Christopher

Mesens Jean Louis

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-24

Filing date

1995-01-19

Publication date

1999-01-12

1995-01-19 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1999-01-12 Publication of PH31664A publication Critical patent/PH31664A/en

Links

KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 2
229940121375 antifungal agent Drugs 0.000 title 1
239000001257 hydrogen Substances 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000005059 halophenyl group Chemical group 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
External Artificial Organs (AREA)
Detergent Compositions (AREA)
Separation Of Suspended Particles By Flocculating Agents (AREA)
Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

PH49798A 1994-01-24 1995-01-19 Watersoluble azole antifungals. PH31664A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US18535294A	1994-01-24	1994-01-24

Publications (1)

Publication Number	Publication Date
PH31664A true PH31664A (en)	1999-01-12

Family

ID=22680644

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH49798A PH31664A (en)	1994-01-24	1995-01-19	Watersoluble azole antifungals.

Country Status (31)

Country	Link
US (1)	US5707977A (fr)
EP (1)	EP0741737B1 (fr)
JP (1)	JP3764750B2 (fr)
KR (1)	KR100352147B1 (fr)
CN (1)	CN1078210C (fr)
AT (1)	ATE186540T1 (fr)
AU (1)	AU688455B2 (fr)
CA (1)	CA2179640C (fr)
CY (1)	CY2176B1 (fr)
CZ (1)	CZ288544B6 (fr)
DE (1)	DE69513279T2 (fr)
DK (1)	DK0741737T3 (fr)
ES (1)	ES2141329T3 (fr)
FI (1)	FI116057B (fr)
GR (1)	GR3032550T3 (fr)
HU (1)	HU227281B1 (fr)
IL (1)	IL112413A (fr)
LV (1)	LV12634B (fr)
MY (1)	MY111814A (fr)
NO (1)	NO308412B1 (fr)
NZ (1)	NZ278882A (fr)
PH (1)	PH31664A (fr)
PL (1)	PL181947B1 (fr)
PT (1)	PT741737E (fr)
RU (1)	RU2156764C2 (fr)
SG (1)	SG48386A1 (fr)
SI (1)	SI0741737T1 (fr)
SK (1)	SK282059B6 (fr)
TW (1)	TW376385B (fr)
WO (1)	WO1995019983A1 (fr)
ZA (1)	ZA95521B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW457240B (en) *	1995-04-20	2001-10-01	Janssen Pharmaceutica Nv	Novel triazolones as apolipoprotein-B synthesis inhibitors
IL118464A (en) *	1995-06-02	2000-08-13	Schering Corp	(2R-cis)-4-¬4-¬4-¬4¬¬-5-(2',4 dihalophenyl)-tetrahydro-5-(1-H-1,2,4,triazol-1-yl-methyl)furan-3-yl(methoxy¾phenyl¾-1-piperazinyl¬phenyl2,4,dihydro2¬(5)-1-ethyl-2-(5)hydroxy propyl¾-3H-1,2,4-triazol-3-one and pharmaceutical compositions comprising them
ATE247108T1 (de) *	1995-06-19	2003-08-15	Schering Corp	Antifungale tetrahydrofurane
US5698557A (en) *	1995-06-19	1997-12-16	Schering Corporation	Hydroxy-substituted antifungals
GB9602080D0 (en) *	1996-02-02	1996-04-03	Pfizer Ltd	Pharmaceutical compounds
NZ328607A (en) *	1996-09-09	1999-08-30	Hoffmann La Roche	Heterocyclically substituted n-benzyl-azolium derivatives and fungicidal compositions
CA2269608A1 (fr)	1996-11-12	1998-05-22	Sepracor Inc.	2r,4s,s,s et 2s,4r,s,s hydroxy itraconazole
CN1237173A (zh) *	1996-11-12	1999-12-01	塞普拉科公司	2r,4s,r,r－和2s,4r,r,r－羟基伊曲康唑
CN1237174A (zh) *	1996-11-12	1999-12-01	塞普拉科公司	2r,4s,s,r－和2s,4r,s,r－羟基伊曲康唑
JP2001504121A (ja) *	1996-11-12	2001-03-27	セプラコール，インク．	２ｒ，４ｓ，ｒ，ｓ―および２ｓ，４ｒ，ｒ，ｓ―ヒドロキシイトラコナゾール―およびヒドロキシサパーコナゾール誘導体
BR9809744A (pt) *	1997-02-11	2000-06-20	Janssen Pharmaceutica Nv	Antifúngicos de azol contendo éster de aminoácido
CN100343249C (zh) *	1997-07-11	2007-10-17	詹森药业有限公司	2,4,4－三取代的1,3－二氧环戊烷抗真菌剂
TW593312B (en)	1997-07-11	2004-06-21	Janssen Pharmaceutica Nv	2,4,4-trisubstituted-1,3-dioxolane antifungals
PT1021439E (pt) *	1997-10-07	2004-07-30	Schering Corp	Polimorfo antifungico cristalino
EP0957101A1 (fr) *	1998-05-14	1999-11-17	Janssen Pharmaceutica N.V.	Azoles solubles dans l'eau, antifongiques à large spectre
US6265584B1 (en)	1998-05-22	2001-07-24	Bristol-Myers Squibb Company	Water soluble prodrugs of azole compounds
WO2000030655A1 (fr) *	1998-11-20	2000-06-02	Bristol-Myers Squibb Company	Promedicaments solubles a l'eau comprenant des composes de type azole
US6362172B2 (en) *	2000-01-20	2002-03-26	Bristol-Myers Squibb Company	Water soluble prodrugs of azole compounds
US6448401B1 (en) *	2000-11-20	2002-09-10	Bristol-Myers Squibb Company	Process for water soluble azole compounds
AR052342A1 (es) *	2004-12-21	2007-03-14	Janssen Pharmaceutica Nv	Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
JO2691B1 (en) *	2005-05-03	2013-03-03	ايساي آر آند دي مانجمنت كو.، ليمتد	Monolysine salts for azole compounds
RU2295958C1 (ru) *	2005-07-04	2007-03-27	Федеральное государственное унитарное предприятие "Центр по химии лекарственных средств" (ФГУП ЦХЛС-ВНИХФИ)	Фармацевтический состав для лечения грибковых заболеваний и способ его получения
WO2010027496A1 (fr) *	2008-09-08	2010-03-11	Wu Nian	Agents antifongiques à base de triazole
RU2563811C1 (ru) *	2014-08-08	2015-09-20	Федеральное государственное бюджетное учреждение науки Институт химической физики им. Н.Н. Семенова Российской академии наук (ИХФ РАН)	Фармацевтическая композиция для лечения грибковых заболеваний
CN106243087B (zh) *	2016-09-12	2018-10-09	三峡大学	一种三唑吡咯烷酮类杀菌剂，合成方法及其应用
CN111138421A (zh) *	2019-12-26	2020-05-12	上海英诺富成生物科技有限公司	抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4267179A (en) *	1978-06-23	1981-05-12	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (fr) *	1985-12-03	1991-11-26	Alfonsus Guilielmus Knaeps	Derives des ({4-¬4-(4-phenyl-1-piperazinyl)-phenoxymethyl\|- 1,3-dioxolan-2-yl}methyl)-1h-imidazoles et 1h-1,2,4-triazoles
US4791111A (en) *	1985-12-23	1988-12-13	Janssen Pharmaceutica, N.V.	[[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
NZ223799A (en) *	1987-03-25	1989-12-21	Janssen Pharmaceutica Nv	Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
US5039676A (en) *	1990-05-11	1991-08-13	Schering Corporation	Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
IL103558A0 (en) *	1991-10-30	1993-03-15	Schering Corp	Tri-substituted tetrahydrofuran antifungals
DE69428125T2 (de) *	1993-12-21	2002-05-02	Schering Corp., Kenilworth	Fungizide tetrahydrofurane

1995
- 1995-01-17 SI SI9530327T patent/SI0741737T1/xx unknown
- 1995-01-17 CN CN95191237A patent/CN1078210C/zh not_active Expired - Lifetime
- 1995-01-17 PT PT95906968T patent/PT741737E/pt unknown
- 1995-01-17 US US08/666,270 patent/US5707977A/en not_active Expired - Lifetime
- 1995-01-17 HU HU9602008A patent/HU227281B1/hu unknown
- 1995-01-17 PL PL95315558A patent/PL181947B1/pl unknown
- 1995-01-17 AT AT95906968T patent/ATE186540T1/de active
- 1995-01-17 CA CA002179640A patent/CA2179640C/fr not_active Expired - Lifetime
- 1995-01-17 RU RU96117244/04A patent/RU2156764C2/ru active
- 1995-01-17 DK DK95906968T patent/DK0741737T3/da active
- 1995-01-17 AU AU15355/95A patent/AU688455B2/en not_active Expired
- 1995-01-17 DE DE69513279T patent/DE69513279T2/de not_active Expired - Lifetime
- 1995-01-17 ES ES95906968T patent/ES2141329T3/es not_active Expired - Lifetime
- 1995-01-17 WO PCT/EP1995/000174 patent/WO1995019983A1/fr active IP Right Grant
- 1995-01-17 SG SG1996009270A patent/SG48386A1/en unknown
- 1995-01-17 SK SK896-96A patent/SK282059B6/sk not_active IP Right Cessation
- 1995-01-17 KR KR1019960703394A patent/KR100352147B1/ko not_active Expired - Lifetime
- 1995-01-17 NZ NZ278882A patent/NZ278882A/en not_active IP Right Cessation
- 1995-01-17 EP EP95906968A patent/EP0741737B1/fr not_active Expired - Lifetime
- 1995-01-17 JP JP51933795A patent/JP3764750B2/ja not_active Expired - Lifetime
- 1995-01-17 CZ CZ19961956A patent/CZ288544B6/cs not_active IP Right Cessation
- 1995-01-19 PH PH49798A patent/PH31664A/en unknown
- 1995-01-20 MY MYPI95000141A patent/MY111814A/en unknown
- 1995-01-23 IL IL11241395A patent/IL112413A/xx not_active IP Right Cessation
- 1995-01-23 TW TW084100675A patent/TW376385B/zh not_active IP Right Cessation
- 1995-01-23 ZA ZA95521A patent/ZA95521B/xx unknown
1996
- 1996-07-23 FI FI962947A patent/FI116057B/fi not_active IP Right Cessation
- 1996-07-23 NO NO963073A patent/NO308412B1/no not_active IP Right Cessation
2000
- 2000-02-02 GR GR20000400246T patent/GR3032550T3/el unknown
- 2000-06-16 CY CY0000029A patent/CY2176B1/xx unknown
- 2000-11-09 LV LVP-00-153A patent/LV12634B/en unknown

Also Published As

Publication number	Publication date
RU2156764C2 (ru)	2000-09-27
CY2176B1 (en)	2002-08-23
CZ288544B6 (cs)	2001-07-11
ZA95521B (en)	1996-07-23
IL112413A (en)	1999-11-30
JP3764750B2 (ja)	2006-04-12
HU9602008D0 (en)	1996-09-30
ES2141329T3 (es)	2000-03-16
FI116057B (fi)	2005-09-15
FI962947A7 (fi)	1996-07-23
SI0741737T1 (en)	2000-02-29
CN1078210C (zh)	2002-01-23
NO308412B1 (no)	2000-09-11
EP0741737A1 (fr)	1996-11-13
DE69513279T2 (de)	2000-07-13
US5707977A (en)	1998-01-13
LV12634A (lv)	2001-03-20
PL315558A1 (en)	1996-11-12
EP0741737B1 (fr)	1999-11-10
TW376385B (en)	1999-12-11
AU1535595A (en)	1995-08-08
DK0741737T3 (da)	2000-05-22
CN1138862A (zh)	1996-12-25
NZ278882A (en)	1997-06-24
SK89696A3 (en)	1998-02-04
AU688455B2 (en)	1998-03-12
KR100352147B1 (ko)	2002-11-11
PL181947B1 (en)	2001-10-31
LV12634B (en)	2001-07-20
MY111814A (en)	2001-01-31
SK282059B6 (sk)	2001-10-08
CA2179640A1 (fr)	1995-07-27
HUT75943A (en)	1997-05-28
HU227281B1 (en)	2011-01-28
ATE186540T1 (de)	1999-11-15
CA2179640C (fr)	2005-11-15
CZ195696A3 (en)	1997-02-12
GR3032550T3 (en)	2000-05-31
DE69513279D1 (de)	1999-12-16
SG48386A1 (en)	1998-04-17
IL112413A0 (en)	1995-03-30
JPH09508360A (ja)	1997-08-26
WO1995019983A1 (fr)	1995-07-27
NO963073D0 (no)	1996-07-23
NO963073L (no)	1996-07-23
PT741737E (pt)	2000-04-28
FI962947A0 (fi)	1996-07-23

Publication	Publication Date	Title
GR3032550T3 (en)	2000-05-31	Watersoluble azole antifungals
BG102077A (en)	1998-11-30	Isothiazolons
CA2285891A1 (fr)	1991-08-03	Antifongiques a base de triazole
MX9700340A (es)	1997-05-31	Agentes anti-helicobacter derivados sulfonamida de azolonas.
GB9121456D0 (en)	1991-11-27	Triazole antifungal agents
AU9426098A (en)	1999-04-27	Azetidinone derivatives for the treatment of hcmv infections
GB2211186B (en)	1991-07-31	Chemical compounds
DE69720715D1 (en)	2003-05-15	Hexahydro-pyrido (4,3-b)indolderivate als antipsychotische arzneimittel
DE69104475D1 (de)	1994-11-10	Harnstoffderivate, ihre herstellung und deren enthaltende arzneimittel.
TW350757B (en)	1999-01-21	Benzisoxazole derivatives and pesticidal compositions containing them
ES2112151A1 (es)	1998-03-16	Nuevos compuestos homoquirales para la preparacion de ketoconazol, terconazol y antifungicos relacionados, procedimiento para su fabricacion y utilizacion de los mismos.
TW354780B (en)	1999-03-21	2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents
AU6876896A (en)	1997-03-19	Carbamoylcarboxamides
MY130817A (en)	2007-07-31	Herbicides
TW269680B (fr)	1996-02-01
GR3025116T3 (en)	1998-01-30	Process for the preparation of n-carbonylarylimines useful for the synthesis of therapeutically active taxoids
MY118844A (en)	2005-01-31	2,4,4-trisubstituted-1,3-dioxolane antifungals
IL107389A (en)	1997-07-13	N-substituted carbonyloxyalkyl- pyrroles and insecticidal, acaricidal and molluscicidal compositions containing them
UA70917C2 (uk)	2004-11-15	Похідні оксадіазину, інсектицидна композиція та спосіб боротьби з комахами
TW358090B (en)	1999-05-11	<beta>-adrenergic agonists
AU4089989A (en)	1990-03-08	Alpha, alpha - disubstituted n-cycloalkylalkylbenzylamines, process for their preparation, their use as a medicament and their synthesis intermediates