PE20071037A1 - SALTS AND FORMULATIONS OF 1- [5- (4-AMINO-7-ISOPROPYL-7H-PYRROLO [2,3-d] PYRIMIDIN-5-CARBONYL) -2-METOXY-PHENYL] -3- (2,4-DICHLORO -PHENIL) -UREA - Google Patents
SALTS AND FORMULATIONS OF 1- [5- (4-AMINO-7-ISOPROPYL-7H-PYRROLO [2,3-d] PYRIMIDIN-5-CARBONYL) -2-METOXY-PHENYL] -3- (2,4-DICHLORO -PHENIL) -UREAInfo
- Publication number
- PE20071037A1 PE20071037A1 PE2006001565A PE2006001565A PE20071037A1 PE 20071037 A1 PE20071037 A1 PE 20071037A1 PE 2006001565 A PE2006001565 A PE 2006001565A PE 2006001565 A PE2006001565 A PE 2006001565A PE 20071037 A1 PE20071037 A1 PE 20071037A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- urea
- metoxy
- pyrrolo
- pyrimidin
- Prior art date
Links
- -1 4-AMINO-7-ISOPROPYL-7H-PYRROLO [2,3-d] PYRIMIDIN-5-CARBONYL Chemical class 0.000 title abstract 3
- 239000004202 carbamide Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 2
- 229920000609 methyl cellulose Polymers 0.000 abstract 2
- 239000001923 methylcellulose Substances 0.000 abstract 2
- 235000010981 methylcellulose Nutrition 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 239000007962 solid dispersion Substances 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
REFERIDA A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UNA DISPERSION SOLIDA AMORFA DE 1-[5-(4-AMINO-7-ISOPROPIL-7H-PIRROLO[2,3-d]PIRIMIDIN-5-CARBONIL)-2-METOXI-FENIL]-3-(2,4-DICLORO-FENIL)-UREA Y UN POLIMERO PARA AUMENTAR LA CONCENTRACION TAL COMO ACETATO SUCCINATO DE HIDROXIPROPIL METILCELULOSA, EN DONDE DICHO COMPUESTO DE UREA COMPRENDE ENTRE 10% Y 40% EN PESO DE LA DISPERSION SOLIDA AMORFA. DICHA DISPERSION SOLIDA AMORFA ESTA MEZCLADA CON MAS POLIMEROS PARA AUMENTAR LA CONCENTRACION TALES COMO ACETATO DE HIDROXIPROPIL METIL CELULOSA, HIDROXIPROPIL METIL CELULOSA, HIDROXIPROPIL CELULOSA, METIL CELULOSA, HIDROXIETIL METIL CELULOSA, ENTRE OTROS. DICHA COMPOSICION FARMACEUTICA ES UTIL PARA EL TRATAMIENTO DE TRASTORNOS HIPERPROLIFERATIVOSREFERRING TO A PHARMACEUTICAL COMPOSITION INCLUDING AN AMORPHOUS SOLID DISPERSION OF 1- [5- (4-AMINO-7-ISOPROPIL-7H-PYRROLO [2,3-d] PYRIMIDIN-5-CARBONYL) -2-METOXY-PHENYL] - 3- (2,4-DICHLORO-PHENYL) -UREA AND A POLYMER TO INCREASE THE CONCENTRATION SUCH AS HYDROXYPROPYL METHYLCELLULOSE ACETATE SUCCINATE, WHERE SAID UREA COMPOUND INCLUDES BETWEEN 10% AND 40% BY WEIGHT OF THE DISPERSION SOLID. SAID AMORPHOUS SOLID DISPERSION IS MIXED WITH MORE POLYMERS TO INCREASE THE CONCENTRATION SUCH AS HYDROXYPROPYL METHYL CELLULOSE ACETATE, HYDROXYPROPYL METHYL CELLULOSE, HYDROXYPROPYL CELLULOSE, METHYL CELLULOSE, METHYL CELLULOSE. SAID PHARMACEUTICAL COMPOSITION IS USEFUL FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74907005P | 2005-12-09 | 2005-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071037A1 true PE20071037A1 (en) | 2007-11-19 |
Family
ID=38123252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001565A PE20071037A1 (en) | 2005-12-09 | 2006-12-06 | SALTS AND FORMULATIONS OF 1- [5- (4-AMINO-7-ISOPROPYL-7H-PYRROLO [2,3-d] PYRIMIDIN-5-CARBONYL) -2-METOXY-PHENYL] -3- (2,4-DICHLORO -PHENIL) -UREA |
Country Status (8)
| Country | Link |
|---|---|
| AR (1) | AR058293A1 (en) |
| DO (1) | DOP2006000271A (en) |
| GT (1) | GT200600496A (en) |
| NL (1) | NL2000337A1 (en) |
| PE (1) | PE20071037A1 (en) |
| TW (1) | TW200733965A (en) |
| UY (1) | UY29991A1 (en) |
| WO (1) | WO2007066189A2 (en) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090143423A1 (en) * | 2007-10-19 | 2009-06-04 | Abbott Gmbh & Co. Kg | Solid dispersion product containing n-aryl urea-based compound |
| AU2008313622A1 (en) * | 2007-10-19 | 2009-04-23 | Abbott Gmbh & Co. Kg | Solid dispersion product of N-aryl urea-based drugs |
| WO2010045542A2 (en) * | 2008-10-16 | 2010-04-22 | The Regents Of The University Of California | Fused ring heteroaryl kinase inhibitors |
| KR20120124428A (en) | 2009-12-30 | 2012-11-13 | 아르퀼 인코포레이티드 | Substituted pyrrolo-aminopyrimidine compounds |
| CN103037843A (en) * | 2010-06-23 | 2013-04-10 | 麦它波莱克斯股份有限公司 | Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-Yl-phenoxymethyl)-thiazol-2-Yl]-piperidin-1-Yl}-pyrimidine |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| EP2751112B1 (en) | 2011-09-02 | 2019-10-09 | The Regents of The University of California | Substituted pyrazolo[3,4-d]pyrimidines and uses thereof |
| US20140004192A1 (en) * | 2012-04-13 | 2014-01-02 | Ziopharm Oncology, Inc. | Pharmaceutical formulations of indibulin and uses thereof |
| US9611267B2 (en) | 2012-06-13 | 2017-04-04 | Incyte Holdings Corporation | Substituted tricyclic compounds as FGFR inhibitors |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| MX2015003874A (en) | 2012-09-26 | 2015-12-16 | Univ California | Modulation of ire1. |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| TWI715901B (en) | 2013-04-19 | 2021-01-11 | 美商英塞特控股公司 | Bicyclic heterocycles as fgfr inhibitors |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| ES2751669T3 (en) | 2015-02-20 | 2020-04-01 | Incyte Corp | Bicyclic heterocycles as FGFR inhibitors |
| MA41551A (en) | 2015-02-20 | 2017-12-26 | Incyte Corp | BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| CN107722012B (en) * | 2016-08-11 | 2020-05-29 | 斯福瑞（南通）制药有限公司 | Process for preparing 4-chloro-7H-pyrrolo [2,3-d ] pyrimidines |
| AR111960A1 (en) | 2017-05-26 | 2019-09-04 | Incyte Corp | CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION |
| SG11202010636VA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Solid forms of an fgfr inhibitor and processes for preparing the same |
| KR20210018264A (en) | 2018-05-04 | 2021-02-17 | 인사이트 코포레이션 | Salts of FGFR inhibitors |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| PE20221085A1 (en) | 2019-10-14 | 2022-07-05 | Incyte Corp | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| BR112022010664A2 (en) | 2019-12-04 | 2022-08-16 | Incyte Corp | DERIVATIVES OF A FGFR INHIBITOR |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| TW202304459A (en) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| JP2024522189A (en) | 2021-06-09 | 2024-06-11 | インサイト・コーポレイション | Tricyclic Heterocycles as FGFR Inhibitors |
| JP2025015449A (en) * | 2023-07-18 | 2025-01-30 | 信越化学工業株式会社 | Composition for solid dispersion, solid dispersion, and method of manufacturing solid dispersion |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE364374T1 (en) * | 1997-08-11 | 2007-07-15 | Pfizer Prod Inc | SOLID PHARMACEUTICAL DISPERSIONS WITH INCREASED BIOAVAILABILITY |
| UA80171C2 (en) * | 2002-12-19 | 2007-08-27 | Pfizer Prod Inc | Pyrrolopyrimidine derivatives |
-
2006
- 2006-11-24 WO PCT/IB2006/003416 patent/WO2007066189A2/en active Application Filing
- 2006-11-27 NL NL2000337A patent/NL2000337A1/en active Search and Examination
- 2006-12-05 DO DO2006000271A patent/DOP2006000271A/en unknown
- 2006-12-06 UY UY29991A patent/UY29991A1/en not_active Application Discontinuation
- 2006-12-06 PE PE2006001565A patent/PE20071037A1/en not_active Application Discontinuation
- 2006-12-07 AR ARP060105422A patent/AR058293A1/en unknown
- 2006-12-07 GT GT200600496A patent/GT200600496A/en unknown
- 2006-12-08 TW TW095145947A patent/TW200733965A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GT200600496A (en) | 2007-07-17 |
| UY29991A1 (en) | 2007-07-31 |
| TW200733965A (en) | 2007-09-16 |
| WO2007066189A3 (en) | 2008-08-14 |
| DOP2006000271A (en) | 2007-08-15 |
| WO2007066189A2 (en) | 2007-06-14 |
| AR058293A1 (en) | 2008-01-30 |
| NL2000337A1 (en) | 2007-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |